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Original Articles: Clinical Research

Vitiligo – The story from within: A transmission electron microscopic study before and after narrow-band ultraviolet B

, PhD, , PhD, , PhD & , PhD
Pages 265-275 | Received 15 Jun 2016, Accepted 27 Jul 2016, Published online: 03 Sep 2016

References

  • Mohammed GF, Gomaa AH, Al-Dhubaibi MS. Highlights in pathogenesis of vitiligo. World J Clin Cases 2015;16:221–30.
  • Boniface K, Rezvani HR, Seneschal J, Taïeb A. Comment: the mystery of melanocyte demise in vitiligo. Exp Dermatol 2015. doi:10.1111/exd.12659.
  • Kim DW, Jeon BJ, Hwang NH, Kim MS, Park SH, Dhong ES, Yoon ES, Lee BI. Adipose-derived stem cells inhibit epidermal melanocytes through an interleukin-6-mediated mechanism. Plast Reconstr Surg 2014;134(3):470–80.
  • Arora AK, Dogra S. Narrowband ultraviolet B and beyond: evolving role of phototherapy in vitiligo. Pigment Int 2015;2:9–20.
  • Dell’ Anna ML1, Mastrofrancesco A, Sala R, Venturini M, Ottaviani M, Vidolin AP, Leone G, Calzavara PG, Westerhof W, Picardo M. Antioxidants and narrow band-UVB in the treatment of vitiligo: a double-blind placebo controlled trial. Clin Exp Dermatol 2007;32(6):631–6.
  • Njoo M, Das P, Bos J, Westerhof W. Association of the kobner phenomenon with disease activity and therapeutic responsiveness in vitiligo vulgaris. Arch Dermatol 1999;135(4):407.
  • Kawakami T, Hashimoto T. Disease severity indexes and treatment evaluation criteria in vitiligo. Dermatol Res Pract 2011;2011:750342.
  • Yones SS, Palmer RA, Garibaldinos TM, Hawk JL. Randomized double-blind trial of treatment of vitiligo: efficacy of psoralen-UV-A therapy vs Narrowband-UV-B therapy. Arch Dermatol 2007;143(5):578–84.
  • Alghamdi KM, Kumar A, Taïeb A, Ezzedine K. Assessment methods for the evaluation of vitiligo. J Eur Acad Dermatol Venereol 2012;26(12):1463–71.
  • Hayat MA. Basic technique for transmission electron microscopy, 1st ed., Academic Press, Inc.: Florida, 1986; pp.1–10.
  • Emsley R, Dunn G, White IR. Mediation and moderation of treatment effects in randomised controlled trials of complex interventions. Stat Methods Med Res 2010;19:237–270.
  • Bennett DC and Lamoreux ML. The color loci of mice-a genetic century. Pigment Cell Res 2003;16(4):333–44.
  • Yoshida Y, Hachiya A, Sriwiriyanont P, Ohuchi A, Kitahara T, Takema Y, Visscher MO, Boissy RE. Functional analysis of keratinocytes in skin color using a human skin substitute model composed of cells derived from different skin pigmentation types. FASEB J 2007;21(11):2829–39.
  • Yamamoto O, Bhawan J. Hara M. Gilchrest BA. Keratinocyte degeneration in human facial skin: Documentation of new ultrastructural markers for photodamage and their improvement during topical tretinoin therapy. Exp Dermatol 1995;4:9–19.
  • Boissy R. Histology of vitiliginous skin. In Hann SK, Nordlund J, eds. Vitiligo a monograph on the basic and clinical science. Blackwell Science Ltd.: Oxford, 2000: 23–34.
  • Prignano F, Pescitelli L, Becatti M, Di Gennaro P, Fiorillo C, Taddei N and Lotti T. Ultrastructural and functional alterations of mitochondria in perilesional vitiligo skin. J Dermatol Sci 2009;54:157–67.
  • Prignano F, Ricceri F, Bianchi B, Guasti D, Bonciolini V, Lotti T and Pimpinelli N.Dendritic cells: ultrastructural and immunophenotypical changes upon nb-UVB in vitiligo skin. Arch Dermatol Res 2011;303:231–8.
  • Tobin DJ, Swanson NN, Pittelkow MR, Peters EM, Schallreuter KU. Melanocytes are not absent in lesional skin of long duration vitiligo. J Pathol 2000;191(4):407–16.
  • Anbar TS, El-Sawy AE, Attia SK, Barakat MT, Moftah NH, El-Ammawy TS, Abdel-Rahman AT and El-Tonsy MH. Effect of PUVA therapy on melanocytes and keratinocytes in nonsegmental vitiligo: histopathological, immunohistochemical and ultrastructural study. Photodermatol Photoimmunol Photomed 2012;28:17–25.
  • Machado Filho CD, Almeida FA, Proto RS, Landman G. Vitiligo: analysis of grafting versus curettage alone, using melanocyte morphology and reverse transcriptase polymerase chain reaction for tyrosinase mRNA. Sao Paulo Med J 2005;123(4):187–91.
  • Gauthier Y, Cario Andre M, Taieb A. A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhagy? Pigment Cell Res 2003;16:322–32.
  • Gauthier Y, Cario-Andre M, Lepreux S, Pain C, Taïeb A. Melanocyte detachment after skin friction in non lesional skin of patients with generalized vitiligo. Br J Dermatol 2003;148(1):95–101.
  • Ricard AS, Pain C, Daubos A, Ezzedine K, Lamrissi-Garcia I, Bibeyran A, Guyonnet-Dupérat V, Taieb A, Cario-André M. Study of CCN3 (NOV) and DDR1 in normal melanocytes and vitiligo skin. Exp Dermatol 2012;21:411–6.
  • Wang CQ, Cruz-Inigo AE, Fuentes-Duculan J, Moussai D, Gulati N, Sullivan-Whalen M, Gilleaudeau P, Cohen JA, Krueger JG. Th17 cells and activated dendritic cells are increased in vitiligo lesions. PLoS One 2011;6:e18907.
  • Panuncio AL, Vignale R. Ultrastructural studies in stable vitiligo. Am J Dermatopathol 2003;25(1):16–20.
  • Lee AY, Youm YH, Kim NH, Yang H, Choi WI. Keratinocytes in the depigmented epidermis of vitiligo are more vulnerable to trauma (suction) than keratinocytes in the normally pigmented epidermis, resulting in their apoptosis. Br J Dermatol 2004;151(5):995–1003.
  • Lee AY. (2012) Role of keratinocytes in the development of vitiligo. Ann Dermatol 2012;24(2):115–25. doi: 10.5021/ad.2012.24.2.115.
  • Hirobe T. Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes. Pigment Cell Res 2005;18:2–12.
  • Yu HS. Melanocyte destruction and repigmentation in vitiligo: a model for nerve cell damage and regrowth. J Biomed Sci 2002;9:564–573.
  • Ross MH, Pawlina W. Histology: A text and atlas with correlated cell and molecular biology. Wolters Kluwer, Philadelphia, PA; 2011; 136.
  • El-Darouti MA, Marzouk SA, Azzam O, Fawzi MM, Abdel-Halim MR, Zayed AA, Leheta TM. Vitiligo vs. hypopigmented mycosis fungoides (histopathological and immunohistochemical study, univariateanalysis). Eur J Dermatol 2006;16(1):17–22.
  • Chung H, Jung H, Lee JH, Oh HY, Kim OB, Han IO, Oh ES. Keratinocyte-derived Laminin-332 Protein Promotes Melanin Synthesis via Regulation of Tyrosine Uptake. J Biol Chem 2014;289:21751–9.
  • Duval C, Cohen C, Chagnoleau C, Flouret V, Bourreau E and Bernerd F. Key regulatory role of dermal fibroblasts in pigmentation as demonstrated using a reconstructed skin model: impact of photo-aging. PLoS One 2014;9:e114182.
  • Kumar R, Parsad D, Kanwar AJ, Kaul D. Altered levels of Ets-1 transcription factor and matrix metalloproteinases in melanocytes from patients with vitiligo. Br J Dermatol 2011;165(2):285–91.
  • Lindner D, Zietsch C, Becher PM, Schulze K, Schultheiss HP, Tschöpe C, Westermann D. Differential expression of matrix metalloproteases in human fibroblasts with different origins. Biochem Res Int 2012;2012:875742.
  • Virador VM, Muller J, Wu X, Abdel-Malek ZA, Yu ZX, Ferrans VJ, Kobayashi N, Wakamatsu K, Ito S, Hammer JA, Hearing VJ. Influence of alpha-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes. FASEB J 2002;16(1):105–7.
  • Archambault, Yaar M, Gilchrest BA. Keratinocytes and fibroblasts in a human skin equivalent model enhance melanocyte survival and melanin synthesis after ultraviolet irradiation. J Invest Dermatol 1995 104(5):859–67.
  • Wu CS, Yu CL, Wu CS, Lan CC, Yu HS. Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytes. Exp Dermatol 2004;13:755–63.
  • Wu CS, Lan CC, Yu HS. Narrow-band UVB irradiation stimulates the migration and functional development of vitiligo-IgG antibodies-treated pigment cells. J Eur Acad Dermatol Venereol 2012;26:456–64.
  • Falabella R. Vitiligo: Problems and surgical solutions. In: Lotti T, Hercogovà J, eds. Vitiligo. problems and solutions. New York, Basel: Marcel Dekker; 2004; 293–312.
  • Yoshihisa Y, Norisugi O, Matsunaga K, Nishihira J, Shimizu T. Involvement of MIF in basement membrane damage in chronically UVB-exposed skin in mice. PLoS One 2014;9(2):e89569.

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