References
- Yamashita T, Wang XW. Cancer stem cells in the development of liver cancer. J Clin Invest. 2013;123:1911–1918.
- Goutté N, Sogni P, Bendersky N, Barbare J, et al. Geographical variations in incidence, management and survival of hepatocellular carcinoma in a Western country. J Hepatol. 2017;66:537–544.
- Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer. J Clin. 2011;61:69–90.
- Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB. Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study. Gastroenterol 2004;127:1372–1380.
- El-Shamy A, Eng FJ, Doyle EH, et al. A cell culture system for distinguishing hepatitis C viruses with and without liver cancer-related mutations in the viral core gene. J Hepatol. 2015;63:1323–1333.
- Webster DP, Klenerman P, Dusheiko GM. Hepatitis C. Lancet 2015;385:1124–1135.
- Yan M, Ha J, Aguilar M, et al. Birth cohort-specific disparities in hepatocellular carcinoma stage at diagnosis, treatment, and long-term survival. J Hepatol. 2016;64:326–332.
- Sherman M. Hepatocellular carcinoma: epidemiology, surveillance, and diagnosis. Semin Liv Dis. 2010;30:3–16.
- Aleman S, Rahbin N, Welland O, et al. A risk for hepatocellular carcinoma persists long-term after sustained virologic response in patients with hepatitis C-associated liver cirrhosis. Clin infect Dis. 2013;57:230–236.
- Schmidt WN, Nelson DR, Pawlotsky JM, Sherman KE, Thomas DL, Chung RT. Direct-acting antiviral agents and the path to interferon independence. Clin Gastroenterol Hepatol. 2014;12:728–737.
- Saran U, Humar B, Kolly P, Dufour JF. Hepatocellular carcinoma and lifestyles. J Hepatol. 2016;64:203–204.
- Forner A, Vilana R, Ayuso C, et al. Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatol. 2008;47:97–104.
- Van der Meer AJ, Feld JJ, Hofer H, Almasio PL, et al. Risk of cirrhosis-related complications in patients with advanced fibrosis following hepatitis C virus eradication. J Hepatol. 2017;66:485–493.
- Park JW, Chen M, Colombo M, et al. Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study. Liver Int. 2015;35:2155–2166.
- Rowe IA, Sherman M. Capitalising on improved rates of diagnosis of early hepatocellular carcinoma. J Hepatol. 2016;64:260–261.
- EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2012;56:908–943.
- You MW, Kim SY, Kim KW, et al. Recent advances in the imaging of hepatocellular carcinoma. Clin Mol Hepatol. 2015;21:95–103.
- Roncalli M, Terracciano L, Tommaso L, David E, M.iver C. precancerous lesions and hepatocellular carcinoma: the histology report. Dig Liver Dis. 2011;43S:S361–S372.
- Brunt EM. Histopathologic features of hepatocellular carcinoma. Clin Liver Dis. 2012;1:194–199.
- Kondo F, Fukusato T, Kudo M. Pathological diagnosis of benign hepatocellular nodular lesions based on the new World Health Organization classification. Oncology 2014;87:37–49.
- Schlageter M, Terracciano LM, D’Angelo S, Sorrentino P. Histopathology of hepatocellular carcinoma. World J Gastroenterol. 2014;20:15955–15964.
- Kendrey, G. Structure and importance of intranuclear inclusions in thioacetamide hepatocarcinogenesis. Acta Morph Acad Sci Hung. 1968;16:53–63.
- Heindryckx F, Isabelle Colle I, Vlierberghe HV. Experimental mouse models for hepatocellular carcinoma research. Int J Exp Pathol. 2009;90:367–386.
- Schaff ZS, Lapis K, Safax YL. The ultrastructure of primary hepatocellular cancer in man. Virchows Arch Abt A Path Anat. 1971;352:340–358.
- Isomura T, Nakashima T. Ultrastructure of human hepatocellular carcinoma. Pathol Int. 1980;30:713–726.
- Torimura T, Ueno T, Inuzuka S, et al. Ultrastructural Observation on hepatocellular carcinoma -correlation of tumor grade and degree of atypia of cell organelles by morphometry. Med Electron Microsc. 1993;26:19–28.
- Zhu LX, Liu Y, Fan ST. Ultrastructural study of the vascular endothelium of patients with spontaneous rupture of hepatocellular carcinoma. Asian J Surg. 2002;25:157–162.
- Bedossa P, Bioulac-Sage P, Callard P, et al. The French METAVIR cooperative study group intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. J Hepatol. 1994;20:15–20.
- INTERNATIONAL WORKING PARTY (IWP). Terminology of nodular hepatocellular lesions. Hepatology 1995;22:983–993.
- International Consensus Group for Hepatocellular Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia. Hepatology 2009;49:658–664.
- Facciorusso A, Antonino M, Del Prete V, Neve V, Scavo MP, Barone M. Are hematopoietic stem cells involved in hepatocarcinogenesis? Hepatobiliary Surg Nutr. 2014;3:199–206.
- Ghadially FN, Parry EW. Ultrastructure of a human hepatocellular carcinoma and surrounding non-neoplastic liver. Cancer (Philad) 1966;19:1989–2004.
- Sobaniec-Lotowska ME, Lotowska JM, Lebensztejn DM. Ultrastructure of oval cells in children with chronic hepatitis B, with special emphasis on the stage of liver fibrosis: the first pediatric study. World J Gastroenterol. 2007;13:2918–2922.
- Mansy SS, ElKhafif NA, AbelFatah AS, Yehia HA, Mostafa I. Hepatic stellate cells and fibrogenesis in hepatitis C virus infection: an ultrastructural insight. Ultrastruct Pathol. 2010;34:62–67.
- Bioulac-Sage P, Cubel G, Balabaud C, Zucman-Rossi J. Revisiting the pathology of resected benign hepatocellular nodules using new immunohistochemical markers. Semin Liver Dis. 2011;31:91–103.
- El-Serag HB. Hepatocellular carcinoma. N Engl J Med. 2011;365:1118–1127.
- Park YN. Update on precursor and early lesions of hepatocellular carcinomas. Arch Pathol Lab Med. 2011;135:704–715.
- Paradis V. Histopathology of hepatocellular carcinoma. Recent results. Cancer Res. 2013;190:21–32.
- Mansy SS, Nosseir MM, Othman MM, et al. Spotlight on the three main hepatic fibrogenic cells in HCV-infected patients: multiple immunofluorescence and ultrastructure study. Ultrastruct Pathol. 2016;40:276–287.
- Kudo M. Early Hepatocellular carcinoma: definition and diagnosis. Liver Cancer 2013;2:69–72.
- Yin C, Evason KJ, Asahina K, Didier YR, Stainier DYR. Hepatic stellate cells in liver development, regeneration, and cancer. J Clin Invest. 2013;123:1902–1910.
- Liu WH, Ren LN, Chen T, Liu LY, Tang LJ. Stages based molecular mechanisms for generating cholangiocytes from liver stem/progenitor cells. World J Gastroenterol. 2013;19:7032–7041.
- Kordes C, Sawitza I, Götze S, Herebian D, Häussinger D. Hepatic stellate cells contribute to progenitor cells and liver regeneration. J Clin Invest. 2014;124:5503–5515.
- Wang Y, Yao HL, Cui CB, et al. Paracrine signals from mesenchymal cell populations govern the expansion and differentiation of human hepatic stem cells to adult liver fates. Hepatology 2010;52:1443–1454.
- Duncan AW, Dorrell C, Grompe M. Stem cells and liver regeneration. Gastroenterol 2009;137(2):466–481.
- Conigliaro A, Brenner DA, Kisseleva T. Hepatic progenitors for liver disease: current position. Stem Cells Cloning 2010;3:39–47.
- Cardinale V, Wang Y, Carpino G, et al. Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes and pancreatic islets. Hepatology 2011;54:2159–2172.
- Kordes C, Häussinger D. Hepatic stem cell niches. J Clin Invest. 2013;123:1874–1880.
- Okusaka T, Okada S, Ueno H, et al. Satellite lesions in patients with small hepatocellular carcinoma with reference to clinicopathological features. Cancer 2002;95:1931–1937.
- Sasaki A, Kai S, Iwashita Y, Hirano S, Ohta M, Kitano S. Microsatellite distribution and indication for loco regional therapy in small hepatocellular carcinoma. Cancer 2005;103:299–306.
- Yang W, Wang C, Lin Y, et al. OV6+tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma. J Hepatol. 2012;57:613–620.
- Hu W, Pang X, Guo W, Wu L, Bin Zhang B. Relationship of different surgical margins with recurrence-free survival in patients with hepatocellular carcinoma. Int J Clin Exp Pathol. 2015;8:3404–3409.
- Ma S, Chan KW, Hu L, et al. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterol 2007;132:2542–2556.
- Ziol M, Nault JC, Aout M, et al. Intermediate hepatobiliary cells predict an increased risk of hepatocarcinogenesis in patients with hepatitis C virus-related cirrhosis. Gastroenterol 2010;139:335–343.
- Teng IW, Hou PC, Lee KD, et al. Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells. Cancer Res. 2011;71:4653–4663.
- Lee JS, Heo J, Libbrecht L, et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med. 2006;12:410–416.
- Forner A, LIovet JM, Bruix J. Hepatocellular carcinoma. Lancet 2012;379:1245–1255.
- Clouston AD, Powell EE, Walsh MJ, Richardson MM, Demetris AJ, Jonsson JR. Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis. Hepatology 2005;41:809–818.
- Millano G, Turato C, Quarta S, et al. Hepatic progenitor cells express SerpinB3. BMC Cell Biol. 2014;15:5–14.
- Ghadially FN. Ultrastructural Pathology of the Cell and Matrix, 2nd edition. Beccles and London: William Clowes (Beccles). Limited, 1982.
- Mansy SS, Ahmed S. Abdelfatah AS, H. Hassanein MH. HCV has transforming potential to retrovirus: an ultrastructure hypothesis. Ultrastruct Pathol. 2009;33:21–27.