Resveratrol reduces light and electron microscopic changes in acetaminophen-induced hepatotoxicity in rats: Role of iNOS expression

References

• Ghosh A, Sil PC. Antioxidative effect of a protein from Cajanus indicus L against acethaminophen-induced hepato-nephro toxicity. J Biochem Mol Biol. 2007;40(6):1039–1049.
   PubMedGoogle Scholar
• Galal RM, Zaki HF, Seif El-Nasr MM, Agha AM. Potential protective effect of honey against paracetamol-induced hepatotoxicity. Arch Iran Med. 2012;15(11):674–680.
   PubMed Web of Science ®Google Scholar
• Chen X, Sun C-K, Han G-Z, et al. Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression. World J Gastroenterol. 2009;15(15):1829–1835. .
   PubMed Web of Science ®Google Scholar
• Singh SK, Rajasekar N, Raj NAV, Paramaguru R. Hepatoprotective and antioxidant effects of Amorphophallus campanulatus against acetaminophen­induced hepatotoxicity in rats. Int J Pharm Pharm Sci. 2011;3(2):202–205.
   Google Scholar
• Ilbey YO, Ozbek E, Cekmen M, et al. Melatonin prevents acetaminophen-induced nephrotoxicity in rats. Int Urol Nephrol. 2009;41:695–702.
   PubMed Web of Science ®Google Scholar
• Gamal El-Din AM, Mostafa AM, Al-Shabanah OA, Al-Bekairi AM, Nagi MN. Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice. Pharmacological Res. 2003;48:631–635.
   PubMed Web of Science ®Google Scholar
• Cao Y, Fu Z-D, Wang F, Lıu H-Y, Han R. Anti-angiogenic activity of resveratrol, a natural compound from medicinal plants. J Asian Nat Prod Res. 2005;7(3):205–213.
   PubMed Web of Science ®Google Scholar
• Yar AS, Menevse S, Alp E, Helvacioglu F, Take G. The effects of resveratrol on cyclooxygenase-1 and cyclooxygenase-2 mRNA and protein levels in diabetic rat kidneys. Mol Biol Rep. 2010;37:2323–2331.
   PubMed Web of Science ®Google Scholar
• Szkudelski T. Resveratrol-induced inhibition of insulin secretion from rat pancreatic islets: Evidence for pivotal role of metabolic disturbances. Am J Physiol Endocrinol Metab. 2007;293:901–907.
   PubMed Web of Science ®Google Scholar
• Hung L-M, Chen J-K, Huang -S-S, Lee R-S, Su M-J. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc Res. 2000;47:549–555.
   PubMed Web of Science ®Google Scholar
• Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA. 1987;84:9265–9269.
   PubMed Web of Science ®Google Scholar
• Nathan C. Nitric oxide as a secretory product of mammalian cells. Faseb J. 1992;6:3051–3064.
   PubMed Web of Science ®Google Scholar
• Hibbs JBJ, Taintor RR, Vavrin Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Sci. 1987;235:473–476.
   PubMed Web of Science ®Google Scholar
• Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl Daspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA. 1995;92:7162–7166.
   PubMed Web of Science ®Google Scholar
• Dincel GC, Kul O. eNOS and iNOS trigger apoptosis in the brains of sheep and goats naturally infected with the border disease virus. Histol Histopathol. 2015;30(10):1233–1242.
   Google Scholar
• Brookes PS, Salinas EP, Darley-Usmar K, et al. Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release. J Biol Chem. 2000;275:20474–20479.
   PubMed Web of Science ®Google Scholar
• Moriya R, Uehara T, Nomura Y. Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells. FEBS Lett. 2000;484:253–260.
   PubMed Web of Science ®Google Scholar
• Özer MA, Polat N, Özen S, et al. Effects of molsidomine on retinopathy and oxidative stress ınduced by radiotheraphy in rat eyes. Curr Eye Res. 2017;42(5):803–809.
   PubMed Web of Science ®Google Scholar
• Gul M, Kayhan B, Elbe H, Dogan Z, Otlu A. Histological and biochemical effects of dexmedetomidine on liver during an ınflammatory bowel disease. Ultrastruct Pathol. 2015;39(1):6–12.
   PubMed Web of Science ®Google Scholar
• Uchiyama M, Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem. 1978;86(1):271–278.
   PubMed Web of Science ®Google Scholar
• Ellman GL. Tissue sulphydryl groups. Arch Biochem Biophys. 1959;82:70–77.
   PubMed Web of Science ®Google Scholar
• Sun Y, Oberly LW, Li Y. A simple method for clinical assay of SOD. Clin Chem. 1988;34:479–500.
   Web of Science ®Google Scholar
• Lowry O, Rosenbraugh N, Farr L, Rondell R. Protein measurement with the folin-phenol reagent. J Biol Chem. 1951;183:265–275.
   Google Scholar
• Casado A, De La Torre R, Lopéz-Fernández E. Antioxidant enzyme levels in red blood cells from cataract patients. Gerontol. 2001;47:186–188.
   PubMed Web of Science ®Google Scholar
• Wang Y, Jiang Y, Fan X, et al. Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1–p53 signaling pathways. Toxicol Lett. 2015;236:82–89.
   PubMed Web of Science ®Google Scholar
• Khayyat A, Tobwala S, Hart M, Ercal N. N-acetylcysteine amide, a promising antidote for acetaminophen toxicity. Toxicol Lett. 2016;241:133–142.
   PubMed Web of Science ®Google Scholar
• Placke ME, Ginsberg GL, Wyand SD, Cohen SD. Ultrastructural changes during acute acetaminophen-induced hepatotoxicity in the mouse: a time and dose study. Toxicol Pathol. 1987;15:431–438.
   PubMed Web of Science ®Google Scholar
• Dash DK, Yeligar VC, Nayak SS, et al. Evaluation of hepatoprotective and antioxidant activity of Ichnocarpus frutescens (Linn.) R.Br. on paracetamol-induced hepatotoxicity in rats. Trop J Pharm Res. 2007 September;6(3):755–765.
   Web of Science ®Google Scholar
• Hussaın L, Ikram J, Rehman K, Tarıq M, Ibrahım M, Akash MSH. Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity. Turk J Biol. 2014;38:396–402.
   Web of Science ®Google Scholar
• Wu Y-L, Pıao D-M, Han X-H, Nan J-X. Protective effects of salidroside against acetaminophen-ınduced toxicity in mice. Biol Pharm Bull. 2008;31(8):1523–1529.
   PubMed Web of Science ®Google Scholar
• Polat M, Cerrah S, Albayrak B, et al. Assessing the effect of leptin on liver damage in case of hepatic injury associated with paracetamol poisoning. Gastroenterol Res Pract. 2015;357360. DOI:10.1155/2015/357360
   PubMed Web of Science ®Google Scholar
• Pang C, Zheng Z, Shi L, et al. Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system. Free Radic Biol Med. 2016;91:236–246.
   PubMed Web of Science ®Google Scholar
• Sener G, Toklu HZ, Sehirli AO, Velioğlu-Oğünç A, Cetinel S, Gedik N. Protective effects of resveratrol against acetaminophen-induced toxicity in mice. Hepatol Res. 2006;35(1):62–68.
   PubMed Web of Science ®Google Scholar
• McGill MR, Du K, Weemhoff JL, Jaeschke H. Critical review of resveratrol in xenobiotic-induced hepatotoxicity. Food Chem Toxicol. 2015;86:309–318.
   PubMed Web of Science ®Google Scholar
• Dalaklioglu S, Genc GE, Aksoy NH, Akcit F, Gumuslu S. Resveratrol ameliorates methotrexate-induced hepatotoxicity in rats via inhibition of lipid peroxidation. Hum Exp Toxicol. 2013;32(6):662–671.
   PubMed Web of Science ®Google Scholar
• Chan CC, Cheng LY, Lin CL, Huang YH, Lin HC, Lee FY. The protective role of natural phytoalexin resveratrol on inflammation, fibrosis and regeneration in cholestatic liver injury. Mol Nutr Food Res. 2011;55(12):1841–1849.
   PubMed Web of Science ®Google Scholar
• Chan CC, Lee KC, Huang YH, Chou CK, Lin HC, Lee FY. Regulation by resveratrol of the cellular factors mediating liver damage and regeneration after acute toxic liver injury. J Gastroenterol Hepatol. 2014;29(3):603–613.
   PubMed Web of Science ®Google Scholar
• Lee ES, Shin MO, Yoon S, Moon JO. Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. Arch Pharm Res. 2010;33(6):925–932.
   PubMed Web of Science ®Google Scholar
• Oliva J, French BA, Li J, Bardag-Gorce F, Fu P, French SW. Sirt1 is involved in energy metabolism: The role of chronic ethanol feeding and resveratrol. Exp Mol Pathol. 2008;85(3):155–159.
   PubMed Web of Science ®Google Scholar
• Tunali-Akbay T, Sehirli O, Ercan F, Sener G. Resveratrol protects against methotrexate-induced hepatic injury in rats. J Pharm Pharm Sci. 2010;13(2):303–310.
   PubMed Web of Science ®Google Scholar
• Nivet-Antoine V, Cottart CH, Lemaréchal H, et al. Trans-resveratrol downregulates Txnip overexpression occurring during liver ischemia-reperfusion. Biochimie. 2010;92(12):1766–1771.
   PubMed Web of Science ®Google Scholar
• Roy S, Sannigrahi S, Majumdar S, Ghosh B, Sarkar B. Resveratrol regulates antioxidant status, inhibits cytokine expression and restricts apoptosis in carbon tetrachloride induced rat hepatic injury. Oxid Med Cell Longev. 2011;2011:703676.
   PubMed Web of Science ®Google Scholar
• Velioglu-Ogunc A, Sehirli O, Toklu H, et al. Resveratrol protects against irradiation-induced hepatic and ileal damage via its antioxidative activity. Free Rad Res. 2009;43:1060–1071.
   PubMed Web of Science ®Google Scholar
• Du K, McGill MR, Xie Y, Bajt ML, Jaeschke H. Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity. Food Chem Toxicol. 2015;81:62–70.
   PubMed Web of Science ®Google Scholar
• Kuvandik G, Duru M, Nacar A, et al. Effects of erdosteine on acetaminophen-induced hepatotoxicity in rats. Toxicol Pathol. 2008;36:714–719.
   PubMed Web of Science ®Google Scholar
• Gardner CR, Laskin JD, Dambach DM, et al. Reduced hepatotoxicity of acetaminophen in mice lacking ınducible nitric oxide synthase: potential role of tumor necrosis factor-α and interleukin-10. Toxicol Appl Pharmacol. 2002;184:27–36.
   PubMed Web of Science ®Google Scholar
• Kamanakaa Y, Kawabatab A, Matsuyaa H, Tagaa C, Sekiguchib F, Kawao N. Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat. Life Sci. 2003;74:793–802.
   PubMed Web of Science ®Google Scholar
• Gardner CR, Heck DE, Yang CS, et al. Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat. Hepatol. 1998;26:748–754.
   Web of Science ®Google Scholar
• Hinson JA, Bucci TJ, Irwin LK, Michael SL, Mayeux PR. Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice. Nitric Oxide: Biol Chem. 2002;6(2):160–167.
   PubMed Web of Science ®Google Scholar
• Zhao YL, Zhou GD, Yang HB, et al. Rhein protects against acetaminophen-induced hepatic and renal toxicity. Food Chem Toxicol. 2011;49(8):1705–1710.
   PubMed Web of Science ®Google Scholar
• Mutlib AE, Shockcor J, Espina R, et al. Disposition of glutathione conjugates in rats by a novel glutamic acid pathway: Characterization of unique peptide conjugates by liquid chromatography/mass spectrometry and liquid chromatography/NMR. J Pharm Exp Ther. 2000;235:25–32.
   Google Scholar