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Basic Research

The potential neuroprotective role of mesenchymal stem cell-derived exosomes in cerebellar cortex lipopolysaccharide-induced neuroinflammation in rats: a histological and immunohistochemical study

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Pages 159-173 | Received 20 Nov 2019, Accepted 03 Feb 2020, Published online: 10 Feb 2020

References

  • Hussein OA. Effect of genistein on the cerebellar cortex of adult male albino rats with streptozotocin-induced diabetes mellitus: a histological and immunohistochemical study. Egypt J Histol. 2015;38:778–792.
  • Bassiouny HS, Ahmed NA, Yousry MM, Hisham NM. Comparative histological study on the effect of ginger versus α-lipoic acid on the cerebellum of a male albino rat model of induced diabetes. Egypt J Histol. 2016;39:341–352.
  • Garcia IJP, Kinoshita PF, Braga I, et al. Ouabain attenuates the oxidative stress induced by lipopolysaccharides in the cerebellum of rats. J Cell Biochem. 2017;119(2):2156–2167.
  • Mohamed HK, Mohamed HZ. A histological and immunohistochemical study on the possible protective role of silymarin on cerebellar cortex neurotoxicity of lactating albino rats and their pups induced by gibberellic acid during late pregnancy and early postnatal period. Egypt J Histol. 2018;41:345–371.
  • Selim AS, Selim AO. Effect of streptozotocin-induced diabetes mellitus on the cerebellar cortex of adult male albino rats: histological and immunohistochemical study. Egypt J Histol. 2013;36:103–113.
  • Isaac MR, Saad SA. Effect of formaldehyde inhalation on the structure of cerebellar cortex of adult male albino rats. Egypt J Histol. 2018;41:520–532.
  • Korish AA, Arafa MM. Propolis derivatives inhibit the systemic inflammatory response and protect hepatic and neuronal cells in acute septic shock. Braz J Infect Dis. 2011;15:332–338.
  • Anwar MM, Ali OS, Ahmed LR, Badawi AM, Eltablawy NA. Regulation of miRNA-124, nuclear factor-Kappa B and β-Catenin expression in response to novel therapeutic protocol in LPS induced Alzheimer’s disease in rats. Res Neurosci. 2018;7:4–30.
  • Fyiad AA, Abd El-Kader MA, Abd El-Haleem AH. Modulatory effects of pomegranate juice on nucleic acids alterations and oxidative stress in experimentally hepatitis rats. Life Sci J. 2012;9:676–682.
  • Chen Y, Jin S, Teng X, et al. Hydrogen sulfide attenuates LPS-induced acute kidney injury by inhibiting inflammation and oxidative stress. Oxid Med Cell Longev. 2018;2018:1–10.
  • Esfandiari E, Ghanadian M, Rashidi B, Mokhtarian A, Vatankhah AM. The effects of acorus calamus L. in preventing memory loss, anxiety, and oxidative stress on lipopolysaccharide-induced neuroinflammation rat models. Int J Prev Med. 2018;9:1–8.
  • Olatunji BP, Fasola TR, Onasanwo SA, Akinyemi AJ, Adeniyi PA, Ishola AO. neuronal alterations and antioxidant status of lipopolysaccharide induced neuronal damage in mice: efficacy of three medicinal plants. J App Pharm Sci. 2017;7:156–162.
  • Prakash R, Sandhya E, Ramya N, et al. Neuroprotective activity of Ethanolic extract of Tinospora cordifolia on LPS induced neuroinflammation. Transl Biomed. 2017;8(135):1–8.
  • El Maadawi ZM. conditioned medium derived from salidroside-pretreated mesenchymal stem cell culture ameliorates mouse lipopolysaccharide-induced cerebral neuroinflammation- histological and immunohistochemical Study. Int J Stem Cells. 2017;10:60–68.
  • Ebrahim N, Mostafa O, El Dosoky RE, et al. Human mesenchymal stem cell-derived extracellular vesicles/estrogen combined therapy safely ameliorates experimentally induced intrauterine adhesions in a female rat model. Stem Cell Res Ther. 2018;9(175):1–15.
  • Sayed AA, EL-Deek SE, EL-Baz MA, et al. Exosomes derived from bone marrow mesenchymal stem cells restore cisplatin induced ovarian damage by promoting stem cell survival, meiotic, and apoptotic markers. Glo Adv Res J Med Med Sci. 2017;6(6):116–130.
  • Ismail DI, Aboulkhair AG. Histological evaluation of the emerging role of adipose stem cells-derived exosomes in cutaneous wound healing in albino rats. Egypt J Histol. 2018;41:459–472.
  • Perrotta I, Aquila S. Exosomes in human atherosclerosis: an ultrastructural analysis study. Ultrastruct Pathol. 2016;40:101–106.
  • El-Mahalaway AM, El-Azab NEE, Abdrabbo M, et al. Comparative light and electron microscopic study on the therapeutic efficacy of adipose derived stem cells versus exosomes for experimentally induced acute corneal injuries in rats. Stem Cell Res Ther. 2018;8(431):1–12.
  • Faruk EM, El Desoky RE, El-Shazly AM, Taha NM. Does exosomes derived bone marrow mesenchymal stem cells restore ovarian function by promoting stem cell survival on experimentally induced polycystic ovary in adult female albino rats? (Histological and immunohistochemical study). Stem Cell Res Ther. 2018;8:1–7.
  • Ebrahim N, Ahmed IA, Hussien NI, et al. Mesenchymal stem cell-derived exosomes ameliorated diabetic nephropathy by autophagy induction through the mTOR signaling pathway. Cells. 2018;7(226):1–26.
  • El-Azab NE, El-Mahalaway AM, Mostafa O, Sabry D. Histological and immunohistochemical study of the potential therapeutic impacts of bone marrow mesenchymal stem cells and exosomes for sciatic nerve crush injury model in rats. J Histotechnol. 2018;41:160–176.
  • Abdel Mohsen MA, Sabry MM. histological study on the effect of adipose mesenchymal stem cells derived microvesicles and the role of its RNA content on experimentally-induced ulcerative colitis in albino rats. Egypt J Histol. 2019;42:496–512.
  • Reza-Zaldivar EE, Hernández-Sapiéns MA, Gutiérrez-Mercado YK, et al. Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease. Neural Regen Res. 2019;14(9):1626–1634.
  • Tamura R. Uemoto S and Tabata Y. Immunosuppressive effect of mesenchymal stem cell derived exosomes on a concanavalin A-induced liver injury mode. Inflamm Regen. 2016;36:1–12.
  • Salem M, Helal O, Metwaly H. Histological and immunohistochemical study of the role of stem cells, conditioned medium and microvesicles in treatment of experimentally induced acute kidney injury in rats. Med J Cairo Univ. 2017;1:70–83.
  • Nassar W, El-Ansary M, Sabry D. Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases. Biomater Res. 2016;20:1–11.
  • Hajrasouliha AR, Jiang G, Lu Q. Exosomes from retinal astrocytes contain antiangiogenic components that inhibit laser-induced choroidal neovascularization. J Biol Chem. 2013;288:8058–28067.
  • Gasparotto J, Ribeiro CT, Bortolin RC, et al. Anti-RAGE antibody selectively blocks acute systemic inflammatory responses to LPS in serum, liver, CSF and striatum. Brain Behav Immun. 2017;62:124–136.
  • Aslankoc R, Savran M, Ozmen O, Asci S. Hippocampus and cerebellum damage in sepsis induced by lipopolysaccharide in aged rats - Pregabalin can prevent damage. Biomed Pharmacother. 2018;108:1384–1392.
  • Bancroft JD, Layton C. The hematoxylin and eosin, connective and mesenchymal tissues with their stains. In: Suvarna SK, Layton C, Bancroft JD, eds. Bancroft’s Theory and Practice of Histological Techniques. 7th ed. Philadelphia: Churchill Livingstone; 2013:173–212.
  • Jackson P, Blythe D. Immunohistochemical techniques [chapter 8]. In: Suvarna SK, Layton C, Bancroft JD, eds. Theory and Practice of Histological Techniques. 7th ed. Philadelphia: Churchill Livingstone of Elsevier; 2013:381–434.
  • Hayat MA. Chemical fixation. In: Hayat MA, ed. Principles and Techniques of Electron Microscopy: Biological Applications. 4th ed. Edinburg, UK: Cambridge University Press; 2000:4–85.
  • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351–:358.
  • Beutler E, Duron O, Kelly MB. Improved method for the determination of blood glutathione. Lab Clin Med. 1963;61:882–888.
  • Aebi H. Catalase in Vitro. In: Packer L, ed. Methods Enzymol. New York: Academic Press; 1984:121–126.
  • Batista CR, Gomes GF, Jalil EC, Fiebich BL. Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration. Int J Mol Sci. 2019;20:1–31.
  • Abd El Fattah LI, Zickri MB, Abdel Aal L, Heikal O, Osama E. The effect of thymoquinone, α7 receptor agonist and α7 receptor allosteric modulator on the cerebral cortex in experimentally induced Alzheimer’s disease in relation to MSCs activation. Int J Stem Cells. 2016;9:230–238.
  • Abdel-Aziz HM. Mekawy NH and Ibrahem NE. Histological and immunohistochemical study on the effect of zinc oxide nanoparticles on cerebellar cortex of adult male albino rats. Egypt J Histol. 2019;42:23–34.
  • Sorrenti V, Contarini G, Sut S, et al. Curcumin prevents acute neuroinflammation and long-term memory impairment induced by systemic lipopolysaccharide in mice. Front Pharmacol. 2018;9(183):1–12.
  • Bank WA, Gray AM, Erickson MA, Salameh TS. Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit. J Neuroinflammation. 2015;12:1–15.
  • Kassab AA. Wheat germ oil attenuates deltamethrin-induced injury in rat cerebellar cortex: histological and immunohistochemical study. Egypt J Histol. 2018;41:181–191.
  • Abd El-Wahed NA, Geith EZ, Kalleny NK, Abd Al-Khalek HA. The effect of diet coke and monosodium glutamate on the cerebellar cortex of adult male albino rats. Histological and immunohistochemical study. Egypt J Histol. 2019;42:437–452.
  • Shah ML, Park DJ, Kang JB, Kim MO, Koh PO. Baicalin attenuates lipopolysaccharide induced neuroinflammation in cerebral cortex of mice via inhibiting nuclear factor kappa B (NF-κB) activation. J Vet Med Sci. 2019;81:1359–1367.
  • Kapoor M, Sharma N, Nehru B. Spinach leaf extract ameliorates multiple organ dysfunction induced by lipopolysaccharide exposure in animal model of parkinson’s disease. Alzheimers Parkinsons Dis. 2017;3:001–009.
  • Liu W, Bai X, Zhang A, Huang J, Xu S, Zhang J. Role of exosomes in central nervous system diseases. Front Mol Neurosci. 2019;12:1–13.
  • Alzahrani FA. Melatonin improves therapeutic potential of mesenchymal stem cells-derived exosomes against renal ischemia-reperfusion injury in rats. Am J Transl Res. 2019;11:2887–2907.
  • Riva P, Battaglia C, Venturin M. Emerging role of genetic alterations affecting exosome biology in neurodegenerative diseases. Int J Mol Sci. 2019;20:1–20.
  • Zuo R, Liu M, Wang Y, Li J. BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/β-catenin signaling. Stem Cell Res Ther. 2019;10:1–13.
  • Saeedi S, Israel S, Nagy C, Turecki G. The emerging role of exosomes in mental Disorders. Transl Psychiatry. 2019;9:1–11.
  • Abd El Salam S, Faruk EM, Fouad H, Nafie NY. Effects of mesenchymal stem cells and their derived microvesicles on pulmonary toxicity induced by petrol exhaust nanoparticle; histological and immuno-histochemical study. Ann Res Rev Biol. 2019;31:1–14.
  • Xin H, Li Y, Cui Y, Yang JJ. Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab. 2013;13:1711–1715.
  • Zhang Y, Chopp M, Meng Y, et al. Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury. J Neurosurg. 2015;122(4):856–867.
  • Takeda YS, Xu Q. Neuronal differentiation of human mesenchymal stem cells using exosomes derived from differentiating neuronal cells. PLoS ONE. 2015;10:e0135111:1–15.
  • Marote A, Teixeira FG, Mendes-Pinheiro B, Salgado AJ. MSCs-derived exosomes: cell-secreted nanovesicles with regenerative potential. Front Pharmacol. 2016;7:1–8.
  • Bodega G, Alique M, Puebla L, Carracedo J, Ramírez R. Microvesicles: ROS scavengers and ROS producers. J Extracell Vesicles. 2019;8:1–10.

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