Ultrastructural evidence for presenсe of gap junctions in rare case of pleomorphic xanthoastrocytoma

References

• Kepes JJ, Rubinstein LJ, Eng LF. Pleomorphic xanthoastrocytoma: a distinctive meningocerebral glioma of young subjects with relatively favorable prognosis: a study of 12 cases. Cancer. 1979;44:1839–1852.
   PubMed Web of Science ®Google Scholar
• Giannini C, Scheithauer BW, Burger PC, et al. Pleomorphic xanthoastrocytoma: what do we really know about it? Cancer. 1999;85:2033–2045. https://doi.org/10.1002/(SICI)1097-0142(19990501)85:9<2033::AID-CNCR22>3.0.CO;2-Z.
   PubMed Web of Science ®Google Scholar
• Moosa A, Willie E. Focal epileptogenic lesions. Dulac O, Lassonde M, Sarnat HB, eds. Handbook of Clinical Neuroligy. Vol. 111. Amsterdam: Elsevier. 2013; 493–510.
   Google Scholar
• Louis DN, Perry A, Reifenberger G, et al. The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 2016;131(6):803–820. doi:10.1007/s00401-016-1545-1.
   PubMed Web of Science ®Google Scholar
• Korshunov A, Golanov A. Pleomorphic xanthoastrocytomas: immunohistochemistry, grading and clinico-pathologic correlations. An analysis of 34 cases from a single Institute. J Neurooncol. 2001;52(1):63–72. doi:10.1023/A:1010648006319.
   PubMed Web of Science ®Google Scholar
• Ida CM, Rodriguez FJ, Burger PC, et al. Pleomorphic xanthoastrocytoma: natural history and long-term follow-up. Brain Pathol. 2015;25(5):575–586. doi:10.1111/bpa.12217.
   PubMed Web of Science ®Google Scholar
• Kordek R, Biernat W, Sapieja W, Alwasiak J, Liberski PP. Pleomorphic xanthoastrocytoma with a gangliogliomatous component: an immunohistochemical and ultrastructural study. Acta Neuropathol. 1995;89:194–197. doi:10.1007/BF00296366.
   PubMed Web of Science ®Google Scholar
• Vajtai I, Varga Z, Aguzzi A. Pleomorphic xanthoastrocytoma with gangliogliomatous component. Pathol Res Pract. 1997;193(9):617–621. doi:10.1016/S0344-0338(97)80039-8.
   PubMed Web of Science ®Google Scholar
• Hirato J, Nakazato Y, Ogawa A. Expression of non –glial intermediate filament proteins in gliomas. Clin Neuropathol. 1994;13:1–11.
   PubMed Web of Science ®Google Scholar
• Giannini C, Scheithauer BW, Lopes MB, Hirose T, Kros JM, VandenBerg SR. Immunophenotype of pleomorphic xanthoastrocytoma. Am J Surg Pathol. 2002;26(4):479–485. doi:10.1097/00000478-200204000-00010.
   PubMed Web of Science ®Google Scholar
• Hirose T, Giannini C, Scheithauer BW. Ultrastructural features of pleomorphic xanthoastrocytoma: a comparative study with glioblastoma multiforme. Ultrastruct Pathol. 2001;25(6):469–478. doi:10.1080/019131201753343502.
   PubMed Web of Science ®Google Scholar
• Nakamura S, Furuichi M, Yoshida K. Pleomorphic xanthoastrocytoma: ultrastructural study and origin of the tumor. Neuropathology. 1998;18:62–66. doi:10.1111/neu.1998.18.issue-1.
   Web of Science ®Google Scholar
• Beckmann A, Hainz N, Tschernig T, Meier C. Facets of Communication: gap junction ultrastructure and function in cancer stem cells and tumor cells. Cancers (Basel). 2019;11:288. doi:10.3390/cancers11030288.
   Web of Science ®Google Scholar
• Tabernero A, Gangoso E, Jaraíz-Rodríguez M, Medina JM. The role of connexin43-Src interaction in astrocytomas: A molecular puzzle. Neuroscience. 2016;323:183–194. doi:10.1016/j.neuroscience.2015.02.029.
   PubMed Web of Science ®Google Scholar
• Wang J, Yang ZY, Guo YF, Kuang JY, Bian XW, Yu SC. Targeting different domains of gap junction protein to control malignant glioma. Neuro Oncol. 2018;20(7):885–896. doi:10.1093/neuonc/nox207.
   PubMed Web of Science ®Google Scholar
• Fukuda T. Structural organization of the dendritic reticulum linked by gap junctions in layer 4 of the visual cortex. Neuroscience. 2017;340:76–90. doi:10.1016/j.neuroscience.2016.10.050.
   PubMed Web of Science ®Google Scholar
• Nagy JI, Rash JE. Connexins and gap junctions of astrocytes and oligodendrocytes in the CNS. Brain Res Brain Res Rev. 2000;32(1):29–44.doi:10.1016/S0165-0173(99)00066-1.
   PubMedGoogle Scholar
• Dere E, Zlomuzica A. The role of gap junctions in the brain in health and disease. Neurosci Biobehav Rev. 2012;36(1):206–217. doi:10.1016/j.neubiorev.2011.05.015.
   PubMed Web of Science ®Google Scholar
• Sin WC, Aftab Q, Bechberger JF, Leung JH, Chen H, Naus CC. Astrocytes promote glioma invasion via the gap junction protein connexin43. Oncogene. 2016;35(12):1504–1516. doi:10.1038/onc.2015.210.
   PubMed Web of Science ®Google Scholar
• Hong X, Sin WC, Harris AL, Naus CC. Gap junctions modulate glioma invasion by direct transfer of microRNA. Oncotarget. 2015;6(17):15566–15577. doi:10.18632/oncotarget.v6i17.
   PubMedGoogle Scholar
• Kirichenko E, Savchenko AF, Kozachenko DV, Matsonis AE, Logvinov AK. Ultrastructural identification of gap junctions in glial tumors of the human brain. Arch Pathol. 2017;79(1):3–11 doi:10.17116/patol20177913-11.
   Google Scholar
• Kepes JJ, Louis DN, Giannini C, Paulus W. Pleomorphic xanthoastrocytoma. In: Kleihues P, Cavenee WK, eds. Pathology and Genetics of Tumors of the Nervous System. Lyon, France: International Agency on Cancer; 2000:52–54.
   Google Scholar
• Schindler G, Capper D, Meyer J, et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol. 2011;121:397–405. doi:10.1007/s00401-011-0802-6.
   PubMed Web of Science ®Google Scholar
• Dias-Santagata D, Lam Q, Vernovsky K, et al. BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. PLoS One. 2011;6:e17948. doi:10.1371/journal.pone.0017948.
   PubMed Web of Science ®Google Scholar
• Bettegowda C, Agrawal N, Jiao Y, et al. Exomic sequencing of four rare central nervous system tumor types. Oncotarget. 2013;4:572–583. doi:10.18632/oncotarget.v4i4.
   PubMedGoogle Scholar
• Ida CM, Vrana JA, Rodriguez FJ, et al. Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma. Acta Neuropathol Commun. 2013;1:20. doi:10.1186/2051-5960-1-20.
   PubMed Web of Science ®Google Scholar
• Lohkamp LN, Schinz M, Gehlhaar C, et al. MGMT promoter methylation and BRAF V600E mutations are helpful markers to discriminate pleomorphic xanthoastrocytoma from giant cell glioblastoma. PLoS One. 2016;11(6):e0156422. doi:10.1371/journal.pone.0156422.
   PubMed Web of Science ®Google Scholar
• Erlandson RA. Diagnostic Transmission Electron Microscopy of Tumors: With Clinicopathological, Immunohistochemical, and Cytogenetic Correlations. New York: Raven Press; 1994.
   Google Scholar
• Weldon-Linne CM, Victor TA, Groothuis DR, Vick NA. Pleomorphic xanthoastrocytoma. Ultrastructural and immunohistochemical study of a case with a rapidly fatal outcome following surgery. Cancer. 1983;52(11):2055–2063. doi:10.1002/()1097-0142.
   PubMed Web of Science ®Google Scholar
• Powell SZ, Yachnis AT, Rorke LB, Rojiani AM, Eskin TA. Divergent differentiation in pleomorphic xanthoastrocytoma: evidence for a neuronal element and possible relationship to ganglion cell tumors. Am J Surg Pathol. 1996;20:80–85. doi:10.1097/00000478-199601000-00009.
   PubMed Web of Science ®Google Scholar
• Martinez-Diaz H, Kleinschmidt-demasters BK, Powell SZ, Yachnis AT. Giant cell glioblastoma and pleomorphic xanthoastrocytoma show immunohistochemical profiles for neuronal antigens and p53 but share reactivity for class III beta-tubulin. Arch Pathol Lab Med. 2003;127(9):1187–1191. doi:10.1043/1543-2165(2003)127<1187:GCGAPX>2.0.CO;2.
   PubMed Web of Science ®Google Scholar
• Furuta A, Takahashi H, Ikuta F, Onda K, Takeda N, Tanaka R. Temporal lobe tumor demonstrating ganglioglioma and pleomorphic xanthoastrocytoma components. J Neurosurg. 1992;77:143–147. doi:10.3171/jns.1992.77.1.0143.
   PubMed Web of Science ®Google Scholar
• Lindboe C, Cappelen J, Kepes JJ. Pleomorphic xanthoastrocytoma as a component of a cerebellar ganglioglioma: case report. Neurosurgery. 1992;31:353–355. doi:10.1227/00006123-199208000-00023.
   PubMed Web of Science ®Google Scholar
• Lach B, Duggal N, DaSilva VF, Benoit BG. Association of pleomorphic xanthoastrocytoma with cortical dysplasia and neuronal tumors. A report of three cases. Cancer. 1996;78(12):2551–2563. doi:10.1002/(SICI)1097-0142(19961215)78:12<2551::AID-CNCR15>3.0.CO;2-V.
   PubMed Web of Science ®Google Scholar
• Osswald M, Jung E, Sahm F, et al. Brain tumour cells interconnect to a functional and resistant network. Nature. 2015;528(7580):93–98. doi:10.1038/nature16071.
   PubMed Web of Science ®Google Scholar
• Sin WC, Crespin S, Mesnil M. Opposing roles of connexin43 in glioma progression. Biochim Biophys Acta. 2012;1818(8):2058–2067. doi:10.1016/j.bbamem.2011.10.022.
   PubMed Web of Science ®Google Scholar
• Sinyuk M, Mulkearns-Hubert EE, Reizes O, Lathia J. Cancer connectors: connexins, gap junctions, and communication. Front Oncol. 2018;8. doi:10.3389/fonc.2018.00646. eCollection 2018.
   PubMed Web of Science ®Google Scholar
• Crespin S, Bechberger J, Mesnil M, Naus CC, Sin WC. The carboxy-terminal tail of connexin43 gap junction protein is sufficient to mediate cytoskeleton changes in human glioma cells. J Cell Biochem. 2010;110(3):589–597. doi:10.1002/jcb.22554.
   PubMed Web of Science ®Google Scholar
• Uzu M, Sin WC, Shimizu A, Sato H. Conflicting roles of connexin43 in tumor invasion and growth in the central nervous system. Int J Mol Sci. 2018;19:1159. doi:10.3390/ijms19041159.
   Web of Science ®Google Scholar
• Matsuuchi L, Naus CC. Gap junction proteins on the move: connexins, the cytoskeleton and migration. Biochim Biophys Acta. 2013;1828(1):94–108. doi:10.1016/j.bbamem.2012.05.014.
   PubMed Web of Science ®Google Scholar
• Yusubalieva GM, Baklaushev VP, Gurina OI, et al. Treatment of poorly differentiated glioma using a combination of monoclonal antibodies to extracellular connexin-43 fragment, temozolomide, and radiotherapy. Bull Exp Biol Med. 2014;157(4):510–515. doi:10.1007/s10517-014-2603-0.
   PubMed Web of Science ®Google Scholar
• Gangoso E, Thirant C, Chneiweiss H, Medina JM, Tabernero A. A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype. Cell Death Dis. 2014;5:e1023. doi:10.1038/cddis.2013.560.
   PubMed Web of Science ®Google Scholar
• Fouladi M, Jenkins J, Burger P, et al. Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection. Neuro Oncol. 2001;3(3):184–192. doi:10.1093/neuonc/3.3.184.
   PubMed Web of Science ®Google Scholar
• de Tella OI Jr, Herculano MA, Prandini MN, Stavale JN, Aguiar PH. Malignant transformation of pleomorphic xanthoastrocytoma: case report. Arq Neuropsiquiatr. 2003;61(1):104–106. doi:10.1590/S0004-282X2003000100020.
   PubMed Web of Science ®Google Scholar
• Vu TM, Liubinas SV, Gonzales M, Drummond KJ. Malignant potential of pleomorphic xanthoastrocytoma. J Clin Neurosci. 2012;19(1):12–20. doi:10.1016/j.jocn.2011.07.015.
   PubMed Web of Science ®Google Scholar