171
Views
0
CrossRef citations to date
0
Altmetric
Basic Research

Ultrastructural GABA immunogold labeling in the substantia nigra pars reticulata of kindled genetic absence epilepsy rats

, , , , , & show all
Pages 379-386 | Received 30 Sep 2020, Accepted 15 Oct 2020, Published online: 29 Oct 2020

References

  • Eskazan E, Onat FY, Aker R, Oner G. Resistance to propagation of amygdaloid kindling seizures in rats with genetic absence epilepsy. Epilepsia. 2002;43(10):1115–1119. doi:10.1046/j.1528-1157.2002.35601.x.
  • Onat FY, Eskazan E, Aker R. Experimental absence versus amygdaloid kindling. In: Corcoran M, Moshe SL, eds. Advances in Behavioral Biology. Kindling 6. USA: Springer; 2005:55,37–48.
  • Arakaki T, Mahon S, Charpier S, Leblois A, Hansel D. The role of striatal feedforward inhibition in the maintenance of absence seizures. J Neurosci. 2016;36:9618–9632. doi:10.1523/JNEUROSCI.0208-16.2016.
  • Meeren H, van Luijtelaar G, Lopes da Silva F, Coenen A. Evolving concepts on the pathophysiology of absence seizures: the cortical focus theory. Arch Neurol. 2005;62:371–376.
  • Polack PO, Mahon S, Chavez M, Charpier S. Inactivation of the somatosensory cortex prevents paroxysmal oscillations in cortical and related thalamic neurons in a genetic model of absence epilepsy. Cereb Cortex. 2009;19:2078–2091. doi:10.1093/cercor/bhn237.
  • Danober L, Deransart C, Depaulis A, Vergnes M, Marescaux C. Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog Neurobiol. 1998;55:27–57.
  • Depaulis A, David O, Charpier S. The genetic absence epilepsy rat from Strasbourg as a model to decipher the neuronal and network mechanisms of generalized idiopathic epilepsies. J Neurosci Meth. 2016;260:159–174. doi:10.1016/j.jneumeth.2015.05.022.
  • Bertram EH. Temporal lobe epilepsy: where do the seizures really begin? Epilepsy Behav. 2009;14(Suppl.1):32–37. doi:10.1016/j.yebeh.2008.09.017.
  • McIntyre DC, Poulter MO, Gilby K. Kindling: some old and some new. Epilepsy Res. 2002;50:79–92.
  • Engel J Jr. Introduction to temporal lobe epilepsy. Epilepsy Res. 1996;26(1):141–150. doi:10.1016/S0920-1211(96)00043-5.
  • Dray A. The physiology and pharmacology of mammalian basal ganglia. Prog Neurobiol. 1980;14(4):211–335. doi:10.1016/0301-0082(80)90017-9.
  • Moshe SL, Sperber EF. Substantia nigra-mediated control of generalized seizures. In: Avoli M, Gloor P, Kostopoulos G, Naquet R, eds. Generalized Epilepsy, Neurobiological Approaches. Boston, USA: Birkhauser; 1990:355–367.
  • Gulcebi M, Akman O, Carcak N, Karamahmutoglu T, Onat F. Evaluation of GAD67 immunoreactivity in the region of substantia nigra pars reticulata in resistance to development of convulsive seizure in genetic absence epilepsy rats. North Clin Istanb. 2017;3:161–167. doi:10.14744/nci.2016.16056.
  • Veliskova J, Moshe SL. Update on the role of substantia nigra pars reticulata in the regulation of seizures. Epilepsy Curr. 2006;6:83–87.
  • Iadarola MJ, Gale K. Substantia nigra: site of anticonvulsant activity mediated by g-aminobutyric acid. Science. 1982;218:1237–1240.
  • Veliskova J, Claudio OI, Galanopoulou AS, et al. Developmental aspects of the basal ganglia and therapeutic perspectives. Epileptic Disord. 2002;4:73–82.
  • Deniau JM, Chevalier G. Disinhibition as a basic process in the expression of striatal functions. II. The striato-nigra influence on thalamocortical cells of the ventromedial thalamic nucleus. Brain Res. 1985;334:227–233.
  • Niemi-Junkola UJ, Westby MGW. Spatial variation in the effects of inactivation of substantia nigra on neuronal activity in rat superior colliculus. Neurosci Lett. 1998;241:175–179.
  • Nicolson A, Chadwick DW, Smith DF. The coexistence of idiopathic generalized epilepsy and partial epilepsy. Epilepsia. 2004;45:682–685.
  • Racine RJ. Modification of seizure activity by electrical stimulation. I. After-discharge threshold. Electroencephalogr Clin Neurophysiol. 1972a;32:269–279.
  • Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol. 1972b;32:281–294.
  • Akman O, Gulcebi MI, Carcak N, et al. The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy. Epilepsia. 2015;56:1793–1802. doi:10.1111/epi.13204.
  • Loscher W, Schwark WS. Evidence for impaired GABAergic activity in the substantia nigra of amygdaloid kindled rats. Brain Res. 1985;339:146–150.
  • Loscher W, Schwark WS. Further evidence for abnormal GABAergic circuits in amygdala-kindled rats. Brain Res. 1987;420:385–390.
  • Veliskova J, Miller AM, Nunes ML, Brown LL. Regional neural activity within the substantia nigra during peri-ictal fluorothyl generalized seizure stages. Neurobiol Dis. 2005;20:752–759.
  • Castillo CG, Mendoza S, Saavedra J. Giordano M Lack of effect of intranigral transplants of a GABAergic cell line on absence seizures. Epilepsy Behav. 2010;18:358–365. doi:10.1016/j.yebeh.2010.06.005.
  • Nail-Boucherie K, Le-Pham BT, Gobaille S, Maitre M, Aunis D, Depaulis A. Evidence for a role of the parafascicular nucleus of the thalamus in the control of epileptic seizures by the superior colliculus. Epilepsia. 2005;46:141–145.
  • Nail-Boucherie K, Le-Pham BT, Marescaux C, Depaulis A. Suppression of absence seizures by electrical and pharmacological activation of the caudal superior colliculus in a genetic model of absence epilepsy in the rat. Exp Neurol. 2002;177:503–514.
  • Deransart C, Le BT, Marescaux C, Depaulis A. Role of the subthalamo-nigral input in the control of amygdala-kindled seizures in the rat. Brain Res. 1998;807:78–83.
  • Kokaia M, Aebischer P, Elmer E, et al. Seizure suppression in kindling epilepsy by intracerebral implants of GABA- but not by noradrenaline-releasing polymer matrices. Exp Brain Res. 1994;100:385–394.
  • Castillo CG, Mendoza-Trejo S, Aguilar MB, Freed WJ, Giordano M. Intranigral transplants of a GABAergic cell line produce long-term alleviation of established motor seizures. Behav Brain Res. 2008;193:17–27. doi:10.1016/j.bbr.2008.04.023.
  • Loscher W, Ebert U, Lehmann H, Rosenthal C, Nikkhah G. Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra. J Neurosci Res. 1998;51:196–209.
  • Thompson KW, Suchomelova LM. Transplants of cells engineered to produce GABA supress spontaneous seizures. Epilepsia. 2004;45:4–12.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.