The osmotic demyelination syndrome: the resilience of thalamic neurons is verified with transmission electron microscopy

References

• Adams V, Mancall EL. Osmotic demyelination syndrome. Am J Med Sci. 1959;339:561–567.
   Google Scholar
• Newell KL, Kleinschmidt-Demasters BK. Central pontine myelinolysis autopsy: a twelve-year retrospective analysis. J Neurol Sci. 1996;142(1–2):134–139. doi:10.1016/0022-510X(96)00175-X.
   PubMed Web of Science ®Google Scholar
• Martin RJ. Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes. J Neurol Neurosurg Psychiatry. 2004;75(suppl 3):iii 22–iii28. doi:10.1136/jnnp.2004.045906.
   Web of Science ®Google Scholar
• Abbott R, Silber E, Felber J, Ekpo E. Osmotic demyelination syndrome. BMJ. 2005;331(7520):829–830. doi:10.1136/bmj.331.7520.829.
   PubMed Web of Science ®Google Scholar
• Tullu MS, Deshmukh I, Muranjan MN, Kher AS, Lahiri KR. Extrapontine myelinolysis in a child with nephrotic syndrome. Pediatr Neurol. 2010;43(2):139–141. doi:10.1016/j.pediatrneurol.2010.04.006.
   PubMed Web of Science ®Google Scholar
• Zhu R-J, Lv Z-S, Shan C-L, Xu M-W, Luo B-Y. Pure word deafness associated with extrapontine myelinolysis. J Zhejiang Univ Sc B. 2010;11(11):842–847. doi:10.1631/jzus.B1000200.
   PubMed Web of Science ®Google Scholar
• Alleman AM. Osmotic demyelination syndrome: central pontine myelinolysis and extrapontine myelinolysis. Semin Ultrasound CT MR. 2014;35(2):153–159. doi:10.1053/j.sult.2013.09.009.
   PubMed Web of Science ®Google Scholar
• Singh TD, Fugate JE, Rabinstein AA. Central pontine and extrapontine myelinolysis: a systematic review. Eur J Neurol. 2014;21(12):1443–1450. doi:10.1111/ene.12571.
   PubMed Web of Science ®Google Scholar
• Laureno R, Karp BI. Myelinolysis after correction of hyponatremia. Ann Intern Med. 1997;126(1):57–62. doi:10.7326/0003-4819-126-1-199701010-00008.
   PubMed Web of Science ®Google Scholar
• Babanrao SA, Prahladan A, Kalidos K, Ramachandran K. Osmotic myelinolysis: does extrapontine myelinolysis precede central pontine myelinolysis? Report of two cases and review of literature. Indian J Radiol Imaging. 2015;25(2):177–183. doi:10.4103/0971-3026.155870.
   PubMedGoogle Scholar
• Laureno R, Lamotte G, Mark AS. Sequential MRI in pontine and extrapontine myelinolysis following rapid correction of hyponatremia. BMC Res Notes. 2018;11(1):707. doi:10.1186/s13104-018-3816-5.
   PubMedGoogle Scholar
• Gocht A, Colmant HJ. Central pontine and extrapontine myelinolysis: a report of 58 cases. Clin Neuropathol. 1987;6:262–270.
   PubMed Web of Science ®Google Scholar
• Brunner JE, Redmond JM, Haggar AM, Kruger DF, Elias SB. Central pontine myelinolysis and pontine lesions after rapid correction of hyponatremia: a prospective magnetic resonance imaging study. Ann Neurol. 1990;27(1):61–66. doi:10.1002/ana.410270110.
   PubMed Web of Science ®Google Scholar
• Kimura K, Yasaka M, Terasaki S, Oita J, Yamaguchi T. A case of central pontine and extra-pontine myelinolysis demonstrated by magnetic resonance imaging. Rinsho Shinkeigaku. 1991: 31(11): 1202–1207. Article in Japanese
   PubMedGoogle Scholar
• Yuh WT, Simonson TM, D’Alessandro MP, Smith KS, Hunsicker LG. Temporal changes of MR findings in central pontine myelinolysis. AJNR Am J Neuroradiol. 1995;16:975–977.
   PubMed Web of Science ®Google Scholar
• Cramer SC, Stegbauer KC, Schneider A, et al. Decreased diffusion in central pontine myelinolysis. AJNR Am J Neuroradiol. 2001;22(8):1476–1479.
   PubMed Web of Science ®Google Scholar
• Ruzek KA, Campeau NG, Miller GM. Early diagnosis of central pontine myelinolysis with diffusion-weighted imaging. AJNR Am J Neuroradiol. 2004;25:210–213.
   PubMed Web of Science ®Google Scholar
• Hagiwara K, Okada Y, Shida N, Yamashita Y. Extensive central and extrapontine myelinolysis in a case of chronic alcoholism without hyponatremia: a case report with analysis of serial MR findings. Intern Med. 2008;47(5):431–435. doi:10.2169/internalmedicine.47.0634.
   PubMed Web of Science ®Google Scholar
• Dujmović I, Vitas J, Zlatarić N, Drulović J. Central pontine myelinolysis in a chronic alcoholic: a clinical and brain magnetic resonance imaging follow-up. Vojnosanit Pregl. 2013;70(8):785–788. doi:10.2298/VSP1308785D.
   PubMed Web of Science ®Google Scholar
• Bhatia S, Kapoor AK, Sharma A, Gupta R, Kataria S. Cerebral encephalopathy with extrapontine myelinolysis in a case of postpartum hypernatremia. Indian J Radiol Imaging. 2014;24(1):57–60. doi:10.4103/0971-3026.130697.
   PubMedGoogle Scholar
• Zunga PM, Farooq O, Dar MI, et al. Extra pontine osmotic demyelination syndrome. Ann Neurosci. 2015;22:51–53.
   PubMed Web of Science ®Google Scholar
• Barhaghi K, Molchanova-Cook O, Rosenburg M, et al. Osmotic demyelination syndrome revisited: review with neuroimaging. J La State Med Soc. 2017;169(4):89–93.
   PubMedGoogle Scholar
• Garg P, Aggarwal A, Malhotra R, Dhall S. Osmotic demyelination syndrome - evolution of extrapontine before pontine myelinolysis on magnetic resonance imaging. J Neurosci Rural Pract. 2019;10(1):126–135. doi:10.4103/jnrp.jnrp_240_18.
   PubMed Web of Science ®Google Scholar
• Adrogué HJ, Madias NE. Hyponatraemia. N Engl J Med. 2000;342(21):1581–1589. doi:10.1056/NEJM200005253422107.
   PubMed Web of Science ®Google Scholar
• King JD, Rosner MH. Osmotic demyelination syndrome. Am J Med Sci. 2010;339(6):561–567. doi:10.1097/MAJ.0b013e3181d3cd78.
   PubMed Web of Science ®Google Scholar
• Aratani S, Hara M, Nagahama M, et al. A low initial serum sodium level is associated with an increased risk of overcorrection in patients with chronic profound hyponatremia: a retrospective cohort analysis. BMC Nephrol. 2017;18(1):316.doi:10.1186/s12882-017-0732-1.
   PubMed Web of Science ®Google Scholar
• George JC, Zafar W, Bucaloiu ID, Chang AR. Risk factors and outcomes of rapid correction of severe hyponatremia. Clin J Am Soc Nephrol. 2018;13(7):984–992. doi:10.2215/CJN.13061117.
   PubMed Web of Science ®Google Scholar
• Woodfine JD, van Walraven C. Criteria for hyponatremic overcorrection: systematic review and cohort study of emergently ill patients. J Gen Intern Med. 2020;35(1):315–321. doi:10.1007/s11606-019-05286-y.
   PubMed Web of Science ®Google Scholar
• Crismale JF, Meliambro KA, DeMaria S Jr, et al. Prevention of the osmotic demyelination syndrome after liver transplantation: a multidisciplinary perspective. Am J Transplant. 2017;17(10):2537–2545. doi:10.1111/ajt.14317.
   PubMed Web of Science ®Google Scholar
• Filippatos TD, Makri A, Elisaf MS, Liamis G. Hyponatremia in the elderly: challenges and solutions. Clin Interv Aging. 2017;12:1957–1965. doi:10.2147/CIA.S138535.
   PubMed Web of Science ®Google Scholar
• Aegisdottir H, Cooray C, Wirdefeldt K, Piehl F, Sveinsson O. Incidence of osmotic demyelination syndrome in Sweden: a nationwide study. Acta Neurol Scand. 2019;140(5):342–349. doi:10.1111/ane.13150.
   PubMed Web of Science ®Google Scholar
• Adams RD, Victor M, Mancall EL. Central pontine myelinosis: a hitherto undescribed disease occurring in alcoholic and malnourished patients. Arch Neurol Psychiatry. 1959;81(2):154–172. doi:10.1001/archneurpsyc.1959.02340140020004.
   PubMedGoogle Scholar
• Mascalchi M, Cincotta M, Piazzini M. Case report: MRI demonstration of pontine and thalamic myelinolysis in a normonatremic alcoholic. Clin Radiol. 1993;47(2):137–138. doi:10.1016/S0009-9260(05)81191-2.
   PubMed Web of Science ®Google Scholar
• Kelly J, Wassif W, Mitchard J, Gardner WN. Severe hyponatraemia secondary to beer potomania complicated by central pontine myelinolysis. Int J Clin Pract. 1998;52:585–587.
   PubMed Web of Science ®Google Scholar
• Liamis GL, Milionis HJ, Rizos EC, et al. Mechanisms of hyponatraemia in alcohol patients. Alcohol. 2000;35(6):612–622. doi:10.1093/alcalc/35.6.612.
   Web of Science ®Google Scholar
• Mochizuki H, Masaki T, Miyakawa T, et al. Benign type of central pontine myelinolysis in alcoholism – clinical, neuroradiological and electrophysiological findings. J Neurol. 2003;250(9):1077–1083. doi:10.1007/s00415-003-0157-6.
   PubMed Web of Science ®Google Scholar
• Uchino A, Yuzuriha T, Murakami M, et al. Magnetic resonance imaging of sequelae of central pontine myelinolysis in chronic alcohol abusers. Neuroradiology. 2003;45(12):877–880. doi:10.1007/s00234-003-1095-9.
   PubMed Web of Science ®Google Scholar
• Kuhn J, Harzheim A, Bewermeyer H. Central pontine myelinolysis with a hyperintense lesion in diffusion weighted MRI: overview by means of a case report. Röntgenpraxis. 2005;56(1):21–27. Article in German. doi:10.1016/j.rontge.2005.05.002.
   PubMedGoogle Scholar
• An JY, Park SK, Han SR, Song IU. Central pontine and extrapontine myelinolysis that developed during alcohol withdrawal, without hyponatremia, in a chronic alcoholic. Intern Med. 2010;49(6):615–618. doi:10.2169/internalmedicine.49.3069.
   PubMed Web of Science ®Google Scholar
• Malhotra K, Ortega L. Central pontine myelinolysis with meticulous correction of hyponatraemia in chronic alcoholics. BMJ Case Rep. 2013;1–3. [ pii: bcr2013009970]. doi:10.1136/bcr-2013-009970.
   Google Scholar
• Lodhi MU, Saleem TS, Kuzel AR, et al. Beer potomania - a syndrome of severe hyponatremia with unique pathophysiology: case studies and literature review. Cureus. 2017;9(12):e2000.doi:10.7759/cureus.2000.
   PubMed Web of Science ®Google Scholar
• Levine JP, Stelnicki E, Weiner HL, Bradley JP, McCarthy JG. Hyponatremia in the postoperative craniofacial pediatric patient population: a connection to cerebral salt wasting syndrome and management of the disorder. Plast Reconstr Surg. 2001;108(6):1501–1508. doi:10.1097/00006534-200111000-00009.
   PubMed Web of Science ®Google Scholar
• Coleman M. Axon degeneration mechanisms: commonality amid diversity. Nat Rev Neurosci. 2005;6(11):889–898. doi:10.1038/nrn1788.
   PubMed Web of Science ®Google Scholar
• Pandit L. Differential diagnosis of white matter diseases in the tropics: an overview. Ann Indian Acad Neurol. 2009;12:12–21.
   PubMed Web of Science ®Google Scholar
• Lawson B, Silva J. Central pontine myelinolysis and hyponatremia. Clinical case. [ Article in Spanish]. Rev Med Chil. 2001;129(4):427–432. doi:10.4067/S0034-98872001000400012
   PubMed Web of Science ®Google Scholar
• Burneo J, Vizcarra D, Miranda H. Central pontine myelinolysis and pregnancy: a case report and review of literature. Rev Neurol. 2000: 30(11): 1036–1040. [in Spanish]
   PubMed Web of Science ®Google Scholar
• Corona G, Simonetti L, Giuliani C, Sforza A, Peri A. A case of osmotic demyelination syndrome occurred after the correction of severe hyponatraemia in hyperemesis gravidarum. BMC Endocr Disord. 2014;14(1):34. doi:10.1186/1472-6823-14-34.
   PubMedGoogle Scholar
• Baldrighi M, Sainaghi PP, Bellan M, Bartoli E, Castello LM. Hyperosmolar state: a pragmatic approach to properly manage sodium derangements. Curr Diabetes Rev. 2018;14(6):534–541. doi:10.2174/1573399814666180320091451.
   PubMed Web of Science ®Google Scholar
• Bonkowsky JL, Filloux FM. Extrapontine myelinolysis in a pediatric case of diabetic ketoacidosis and cerebral edema. J Child Neurol. 2003;18(2):144–147. doi:10.1177/08830738030180021201.
   PubMed Web of Science ®Google Scholar
• Sharma C, Kumawat BL, Panchal M, Shah M. Osmotic demyelination syndrome in type 1 diabetes in the absence of dyselectrolytaemia: an overlooked complication?. BMJ Case Rep. 2017; 2017:bcr2016219148. doi:10.1136/bcr-2016-219148
   Google Scholar
• Stavroulopoulos A, Nakopoulou L, Xydakis AM, et al. Interstitial nephritis and nephrogenic diabetes insipidus in a patient treated with pemetrexed. Ren Fail. 2010;32(8):1000–1004. doi:10.3109/0886022X.2010.501930.
   PubMed Web of Science ®Google Scholar
• Tajitsu M, Yamada T, Cao X, et al. Osmotic demyelination syndrome complicating diabetes with anti-glutamic acid decarboxylase antibodies, diabetes and Graves’ disease: a case report. J Diabetes Investig. 2016;7(1):130–131. doi:10.1111/jdi.12377.
   PubMed Web of Science ®Google Scholar
• Arao K, Fujiwara T, Sakakura K, et al. Hyponatremia as a predictor for worsening heart failure in patients receiving cardiac resynchronization therapy. Circ J. 2013;77(1):116–122. doi:10.1253/circj.CJ-12-0672.
   PubMed Web of Science ®Google Scholar
• Jha AA, Behera V, Jairam A, Baliga KV. Osmotic demyelination syndrome in a normonatremic patient of chronic kidney disease. Indian J Crit Care Med. 2014;18(9):609–611. doi:10.4103/0972-5229.140153.
   PubMedGoogle Scholar
• Sharma HS, Kiyatkin EA. Rapid morphological brain abnormalities during acute methamphetamine intoxication in the rat: an experimental study using light and electron microscopy. Journal of Chemical Neuroanatomy. 2009;37(1):18–32. doi:10.1016/j.jchemneu.2008.08.002.
   PubMed Web of Science ®Google Scholar
• Guha K, Spießhöfer J, Hartley A, Pearse S, Xiu PY, Sharma R. The prognostic significance of serum sodium in a population undergoing cardiac resynchronisation therapy. Indian Heart J. 2017;69(5):613–618. doi:10.1016/j.ihj.2017.01.019.
   PubMedGoogle Scholar
• Martinez-Cano JP, Cortes-Castillo V, Martinez-Villa J, et al. Dysnatremia among runners in a half marathon performed under warm and humid conditions. BMJ Open Sport Exerc Med. 2018;4(1):e000351. eCollection. doi:10.1136/bmjsem-2018-000351.
   PubMedGoogle Scholar
• Meinders AJ, Meinders AE. Hyponatremia during a long-distance run: due to excessive fluid intake. Ned Tijdschr Geneeskd. 2007;151:581–587.
   PubMedGoogle Scholar
• Orakzai RH, Orakzai SH, Hasley PB. Treating hyponatremia: how slow is safe? Central pontine myelinolysis despite appropriate correction of hyponatremia. Eur J Intern Med. 2008;19(6):29–31. doi:10.1016/j.ejim.2007.08.009.
   Google Scholar
• Facciorusso A, Amoruso A, Neve V, et al. Role of vaptans in the management of hydroelectrolytic imbalance in liver cirrhosis. World J Hepatol. 2014;6(11):793–799. doi:10.4254/wjh.v6.i11.793.
   PubMedGoogle Scholar
• Yu C, Sharma N, Saab S. Hyponatremia: clinical associations, prognosis, and treatment in cirrhosis. Exp Clin Transplant. 2013;11(1):3–11. doi:10.6002/ect.2012.0147.
   PubMed Web of Science ®Google Scholar
• Park M, Son HJ, Kim GS. Osmotic demyelination syndrome following hyponatremia-oriented management in liver transplant: a single center 20-year experience. Exp Clin Transplant. 2019;17(4):540–545. doi:10.6002/ect.2018.0216.
   PubMed Web of Science ®Google Scholar
• Guillaumin J, DiBartola SP. Disorders of sodium and water homeostasis. Vet Clin North Am Small Anim Pract. 2017;47(2):293–312. doi:10.1016/j.cvsm.2016.10.015.
   PubMed Web of Science ®Google Scholar
• Burton AG, Hopper K. Hyponatremia in dogs and cats. J Vet Emerg Crit Care (San Antonio). 2019;29(5):461–471. doi:10.1111/vec.12881.
   PubMed Web of Science ®Google Scholar
• Kleinschmidt-DeMasters BK, Norenberg MD. Rapid correction of hyponatremia causes demyelination: relation to central pontine myelinolysis. Science. 1981;211(4486):1068–1070. doi:10.1126/science.7466381.
   PubMed Web of Science ®Google Scholar
• Illowsky BP, Laureno R. Encephalopathy and myelinolysis after rapid correction of hyponatraemia. Brain. 1987;110(4):855–867. doi:10.1093/brain/110.4.855.
   PubMed Web of Science ®Google Scholar
• Laureno R. Central pontine myelinolysis following rapid correction of hyponatremia. Ann Neurol. 1983;13(3):232–242. doi:10.1002/ana.410130303.
   PubMed Web of Science ®Google Scholar
• Verbalis JG, Drutarosky MD. Adaptation to chronic hypoosmolality in rats. Kidney Int. 1988;34(3):351–360. doi:10.1038/ki.1988.188.
   PubMed Web of Science ®Google Scholar
• Thurston JH, Hauhart RE. Brain amino acids decrease in chronic hyponatremia and rapid correction causes brain dehydration: possible clinical significance. Life Sci. 1987;40(26):2539–2542. doi:10.1016/0024-3205(87)90076-2.
   PubMed Web of Science ®Google Scholar
• Thurston JH, Hauhart RE, Nelson JS. Adaptive decreases in amino acids (taurine in particular), creatine, and electrolytes prevent cerebral edema in chronically hyponatremic mice: rapid correction (experimental model of central pontine myelinolysis) causes dehydration and shrinkage of brain. Metab Brain Di. 1987;2(4):223–241. doi:10.1007/BF00999694.
   PubMed Web of Science ®Google Scholar
• Sugimura Y, Takagi H, Murase T, et al. Prevention of demyelination induced by rapid correction of hyponatremia in mice. Environmental Med. 2002;46(2):58–61.
   Google Scholar
• Iwama S, Sugimura Y, Suzuki H, et al. Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome. Glia. 2011;59(3):452–462. doi:10.1002/glia.21114.
   PubMed Web of Science ®Google Scholar
• Bouchat J, Couturier B, Marneffe C, et al. Regional oligodendrocytopathy and astrocytopathy precede myelin loss and blood-brain barrier disruption in a murine model of osmotic demyelination syndrome. Glia. 2018;66(3):606–622. doi:10.1002/glia.23268.
   PubMed Web of Science ®Google Scholar
• Bouchat J, Gilloteaux J, Suain V, et al. Ultrastructural analysis of thalamus damages in a mouse model of osmotic-induced demyelination. Neurotox Res. 2019;36(1):144–162. doi:10.1007/s12640-019-00041-x.
   PubMed Web of Science ®Google Scholar
• Nicaise C, Marneffe C, Bouchat J, Gilloteaux J. Osmotic demyelination: from oligodendrocyte to astrocyte perspective. Int J Med Sci. 2019;20(5): pii: E1124 doi:10.3390/ijms20051124.
   Google Scholar
• Yuridullah R, Kumar V, Nanavati S, Singhal M, Chandran C. Clinical resolution of osmotic demyelination syndrome following overcorrection of severe hyponatremia. Case Rep Nephrol. 2019;2019:1757656. doi:10.1155/2019/1757656.
   PubMedGoogle Scholar
• Menger H, Jarg T. Outcome of central pontine and extrapontine myelinolysis. J Neurol. 1999;246(8):700–705. doi:10.1007/s004150050435.
   PubMed Web of Science ®Google Scholar
• Lambeck J, Hieber M, Dreßing A, Niesen WD. Central pontine myelinosis and osmotic demyelination syndrome. Dtsch Arztebl Int. 2019;116:600–606.
   PubMed Web of Science ®Google Scholar
• Tandukar S, Rondon-Berrios H. Treatment of severe symptomatic hyponatremia. Physiol Rep. 2019;7(21):e14265. doi:10.14814/phy2.14265.
   PubMed Web of Science ®Google Scholar
• Kiernan JA. Chromoxane cyanine R. II. Staining of animal tissues by the dye and its iron complexes. J Microsc. 1984;134(1):25–39. doi:10.1111/j.1365-2818.1984.tb00501.x.
   PubMedGoogle Scholar
• Stefanović D. Use of eriochrome cyanine R for routine histology and histopathology: an improved dichromatic staining procedure. Biotechnic Histochem. 2015;90(6):470–474. doi:10.3109/10520295.2015.1058420.
   PubMed Web of Science ®Google Scholar
• Sternberger LA. Immunochemistry. New York: J Wiley & Sons; 1979.
   Google Scholar
• Franklin K, Paxinos G. The Mouse Brain in Stereotaxic Coordinates. San Diego: Academic Press; 1997.
   Google Scholar
• Bauer KF. Elektronenmikroskopische Beobachtungen an der menschlichen Himrinde. Fortsch Neurol Psych Grenzgebiete. 1968;36:274–309.
   PubMedGoogle Scholar
• Vaughn JE, Skoff RP. Neuroglia in experimentally altered central nervous system. In: Bourne GH, ed. The Structure and Function of Nervous Tissue. Vol. V. New York: Academic Press. 1972; 39–72.
   Google Scholar
• Peters A, Palay SL, Webster H de F. The fine structure of the nervous system. 3rd edition. Alan Peters (ed.)  New York: Oxford University Press. 1991.
   Google Scholar
• Peters A, Palay SL, Webster HDF. The Fine Structure of the Nervous System. Peters A, ed. 3rd. New York: Oxford University Press; 1991.
   Google Scholar
• Karasek M, Swiltosławski J, Zielińiska A. Ultrastructure of the central nervous system: the basics. Folia Neuropathol. 2004;42:1–9.
   PubMedGoogle Scholar
• Brodal P. The Central Nervous System. 5th. New York: Oxford University Press; 2010.
   Google Scholar
• Morell P. Myelin. 2nd edn. New York: Plenum Publishing Co.; 1984.
   Google Scholar
• Jones EG. Thalamic circuitry and thalamocortical synchrony. Phil Trans R Soc Lond B Biol Sci. 2002; 357(1428): 1659-1673.
   Google Scholar
• Jones EG. Thalamic circuitry and thalamocortical synchrony. Phil Trans R Soc Lond B Biol Sci. 2002;357(1428):1659–1673. doi:10.1098/rstb.2002.1168.
   PubMed Web of Science ®Google Scholar
• Jones EG. Thalamic organization and function after Cajal. Prog Brain Res. 2002;136:333–357.
   PubMed Web of Science ®Google Scholar
• Bokor H, Frère SG, Eyre MD, et al. Selective GABAergic control of higher-order thalamic relays. Neuron. 2005;45(6):929–940. doi:10.1016/j.neuron.2005.01.048.
   PubMed Web of Science ®Google Scholar
• Hammer S, Carrillo GL, Govindaiah G, et al. Nuclei-specific differences in nerve terminal distribution, morphology, and development in mouse visual thalamus. Neural Dev. 2014;16:1–20.
   Google Scholar
• Liu XB, Warren RA, Jones EG. Synaptic distribution of afferents from reticular nucleus in ventroposterior nucleus of cat thalamus. J Comp Neurol. 1995;352:187–202.
   PubMed Web of Science ®Google Scholar
• Simpson K, Wang Y, Lin RC. Patterns of convergence in rat zona incerta from the trigeminal nuclear complex: light and electron microscopic study. J Comp Neurol. 2008;507(4):1341–1521. doi:10.1002/cne.21624.
   Web of Science ®Google Scholar
• Yeterian EH, Pandya DN. Corticothalamic connections of the posterior parietal cortex in the rhesus monkey. J Comp Neurol. 1985;237(3):408–426. doi:10.1002/cne.902370309.
   PubMed Web of Science ®Google Scholar
• Carpenter MB. Connectivity patterns of thalamic nuclei implicated in dyskinesia. Stereotact Funct Neurosurg. 1989;52(2–4):79–119. doi:10.1159/000099491.
   PubMed Web of Science ®Google Scholar
• Lopez C, Blanke O. The thalamocortical vestibular system in animals and humans. Brain Res Rev. 2011;67(1–2):119–146. doi:10.1016/j.brainresrev.2010.12.002.
   PubMedGoogle Scholar
• Olsen GM, Witter MP. Posterior parietal cortex of the rat: architectural delineation and thalamic differentiation. J Comp Neurol. 2016;524(18):3774–3809. doi:10.1002/cne.24032.
   PubMed Web of Science ®Google Scholar
• Gankam-Kengne F, Nicaise C, Soupart A, et al. Astrocytes are an early target in osmotic demyelination syndrome. J Am Soc Nephrol. 2011;22(10):1834–1845. doi:10.1681/ASN.2010111127.
   PubMed Web of Science ®Google Scholar
• Gankam-Kengne F, Couturier BS, Soupart A, Brion JP, Decaux G. Osmotic stress-induced defective glial proteostasis contributes to brain demyelination after hyponatremia treatment. J Am Soc Nephrol. 2017;28(6):1802–1813. doi:10.1681/ASN.2016050509.
   PubMed Web of Science ®Google Scholar
• Gocht A, Lohler J. Changes in glial cell markers in recent and old demyelinated lesions in central pontine myelinolysis. Acta Neuropathol. 1990;80(1):46–58. doi:10.1007/BF00294221.
   PubMed Web of Science ®Google Scholar
• McCormick DA. Neurotransmitter actions in the thalamus and cerebral cortex. J Clin Neurophysiol. 1992;9(2):212–223. doi:10.1097/00004691-199204010-00004.
   PubMed Web of Science ®Google Scholar
• Soupart A, Decaux G. Therapeutic recommendations for management of severe hyponatremia: current concepts on pathogenesis and prevention of neurologic complications. Clin Nephrol. 1996;46:149–169.
   PubMed Web of Science ®Google Scholar
• Sood L, Sterns RH, Hix JK, Silver SM, Chen L. Hypertonic saline and desmopressin: a simple strategy for safe correction of severe hyponatremia. Am J Kidney Dis. 2013;61(4):571–578. doi:10.1053/j.ajkd.2012.11.032.
   PubMed Web of Science ®Google Scholar
• Giuliani C, Peri A. Effects of hyponatremia on the brain. J Clin Med. 2014;3(4):1163–1177. doi:10.3390/jcm3041163.
   PubMedGoogle Scholar
• Baker EA, Tian Y, Adler S, Verbalis JG. Blood-brain barrier disruption and complement activation in the brain following rapid correction of chronic hyponatremia. Exp Neurol. 2000;165(2):221–230. doi:10.1006/exnr.2000.7474.
   PubMed Web of Science ®Google Scholar
• Rojiani AM, Prineas JW, Cho E-S. Electrolyte-induced demyelination in rats. 1. Role of the blood-brain barrier and edema. Acta Neuropathol. 1994;88(4):287–292. doi:10.1007/BF00310371.
   PubMed Web of Science ®Google Scholar
• Rojiani AM, Cho E-S, Sharer L, Prineas JW. Electrolyte-induced demyelination in rats. 2. Ultrastructural evolution. Acta Neuropathol. 1994;88(4):293–299. doi:10.1007/BF00310372.
   PubMed Web of Science ®Google Scholar
• Hochstrasser T, Rühling S, Hecher K, et al. Stereological investigation of regional brain volumes after acute and chronic cuprizone-induced demyelination. Cells. 2019;8(9):1024.doi:10.3390/cells8091024.
   Web of Science ®Google Scholar
• Chow BW, Gu C. Gradual suppression of transcytosis governs functional blood-retinal barrier formation. Neuron. 2017;93(6):1325–1333.e3. doi:10.1016/j.neuron.2017.02.043.
   PubMed Web of Science ®Google Scholar
• Chow BW, Nuñez V, Kaplan L, et al. Caveolae in CNS arterioles mediate neurovascular coupling. Nature. 2020;579(7797):106–110. doi:10.1038/s41586-020-2026-1.
   PubMed Web of Science ®Google Scholar
• Ono S, Inoue K, Mannen T, et al. Intracytoplasmic inclusion bodies of the thalamus and the substantia nigra, and Marinesco bodies in myotonic dystrophy: a quantitative morphological study. Acta Neuropathol. 1989;77(4):350–356.
   PubMed Web of Science ®Google Scholar
• Sato H, Sato M. Ultrastructural morphology of thalamic cytoplasmic inclusion bodies in El mouse. Exp Neurol. 1986;93(1):160–167. doi:10.1016/0014-4886(86)90155-X.
   PubMed Web of Science ®Google Scholar
• Arcelli P, Rassoni C, Regondi MC, De Biasi S, Spreafico R. GABAergic neurons in mammalian thalamus: a marker of thalamic complexity? Brain Res Bull. 1997;42(1):27–37. doi:10.1016/S0361-9230(96)00107-4.
   PubMed Web of Science ®Google Scholar
• Sherman SM, Guillery RW. On the actions that one nerve cell can have on another: distinguishing “drivers” from “modulators”. Proc Natl Acad Sci USA. 1998;95(12):7121–7126. doi:10.1073/pnas.95.12.7121.
   PubMed Web of Science ®Google Scholar
• Sherman SM. Thalamic relay functions. Prog Brain Res. 2001;134:51–69.
   PubMed Web of Science ®Google Scholar
• Sherman SM, Guillery RW. The role of the thalamus in the flow of information to the cortex. Philos Trans R Soc Lond B Biol Sci. 2002;357(1428):1695–1708. doi:10.1098/rstb.2002.1161.
   PubMed Web of Science ®Google Scholar
• MÁ G-C, John YJ, Barbas H, Zikopoulos B. Distinction of neurons, glia and endothelial cells in the cerebral cortex: an algorithm based on cytological features. Front Neuroanat. 2016;10:107. doi:10.3389/fnana.2016.00107.
   PubMed Web of Science ®Google Scholar
• Bopp R, Holler-Rickauer S, Martin KAC, Schuhknecht GFP. An ultrastructural study of the thalamic input to layer 4 of primary motor and primary somatosensory cortex in the mouse. J Neurosci. 2017;37(9):2435–2448. doi:10.1523/JNEUROSCI.2557-16.2017.
   PubMed Web of Science ®Google Scholar
• Mullen RJ, Buck CR, Smith AM. NeuN, a neuronal specific nuclear protein in vertebrates. Development. 1992;116:201–211.
   PubMed Web of Science ®Google Scholar
• Alekseeva OS, Gusel’nikova VV, Beznin GV, Korzhevskii DE. Prospects of the nuclear protein NeuN application as an index of functional state of the vertebrate nerve cells. Zh Evol Biokhim Fiziol. 2015;51:313–323.
   PubMedGoogle Scholar
• Gusel’nikova VV, Korzhevskiy DE. NeuN as a neuronal nuclear antigen and neuron differentiation marker. Acta Naturae. 2015;7(2):42–47. doi:10.32607/20758251-2015-7-2-42-47.
   PubMed Web of Science ®Google Scholar
• Duan W, Zhang Y-P, Hou Z, et al. Novel insights into NeuN: from neuronal marker to splicing regulator. Mol Neurobiol. 2016;53(3):1637–1647. doi:10.1007/s12035-015-9122-5.
   PubMed Web of Science ®Google Scholar
• You H, Kim YI, Im SY, et al. Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma. J Neurooncol. 2005;74(1):1–8. doi:10.1007/s11060-004-2354-2.
   PubMed Web of Science ®Google Scholar
• Wolf HK, Buslei R, Schmidt-Kastner R, et al. NeuN: a useful neuronal marker for diagnostic histopathology. J Histochem Cytochem. 1996;44(10):1167–1171. doi:10.1177/44.10.8813082.
   PubMed Web of Science ®Google Scholar
• Darlington PJ, Goldman JS, Cui Q-L, Antel JP, Kennedy TE. Widespread immunoreactivity for neuronal nuclei in cultured human and rodent astrocytes. J Neurochem. 2008;104(5):1201–1209. doi:10.1111/j.1471-4159.2007.05043.x.
   PubMed Web of Science ®Google Scholar
• Kim KK, Adelstein RS, Kawamoto S. Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors. J Biol Chem. 2009;284(45):31052–31061. doi:10.1074/jbc.M109.052969.
   PubMed Web of Science ®Google Scholar
• Kim KK, Kim YC, Adelstein RS, Kawamoto S. Fox-3 and PSF interact to activate neural cell-specific alternative splicing. Nucleic Acids Res. 2011;39(8):3064–3078. doi:10.1093/nar/gkq1221.
   PubMed Web of Science ®Google Scholar
• Maxeiner S, Glassmann A, Kao H-T, Schilling K. The molecular basis of the specificity and cross-reactivity of the NeuN epitope of the neuron-specific splicing regulator, Rbfox3. Histochem Cell Biol. 2014;141(1):43–55. doi:10.1007/s00418-013-1159-9.
   PubMed Web of Science ®Google Scholar
• Nickerson JA, Krochmalnic G, Wan KM, Penman S. Chromatin architecture and nuclear RNA. Proc Natl Acad Sci USA. 1989;86(1):177–181. doi:10.1073/pnas.86.1.177.
   PubMed Web of Science ®Google Scholar
• Ma B, JP D, Phillips H, et al. Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage. J Neuroinflammation. 2016;13:26. doi:10.1186/s12974-016-0490-1.
   PubMed Web of Science ®Google Scholar
• Hakim NH, Kounishi T, Alam AH, Tsukahara T, Suzuki H. Alternative splicing of Mef2c promoted by Fox-1 during neural differentiation in P19 cells. Genes Cells. 2010;15(3):255–267. doi:10.1111/j.1365-2443.2009.01378.x.
   PubMed Web of Science ®Google Scholar
• Dent MA, Segura-Anaya E, Alva-Medina J, Aranda-Anzaldo A. NeuN/Fox-3 is an intrinsic component of the neuronal nuclear matrix. FEBS Lett. 2010;584(13):2767–2771. doi:10.1016/j.febslet.2010.04.073.
   PubMed Web of Science ®Google Scholar
• Dredge BK, Jensen KB. NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsense-mediated decay of Rbfox2. PLoS One. 2011;6(6):e21585. doi:10.1371/journal.pone.0021585.
   PubMed Web of Science ®Google Scholar
• Thiry M, Lepoint A, Goessens G. Re-evaluation of the site of transcription in Ehrlich tumour cell nucleoli. Biol Cell. 1985;54(1):57–64. doi:10.1111/j.1768-322X.1985.tb00380.x.
   PubMed Web of Science ®Google Scholar
• Thiry M, Goessens G. Distinguishing the sites of pre-rRNA synthesis and accumulation in Ehrlich tumor cell nucleoli. J Cell Sci. 1991;99:759–767.
   PubMed Web of Science ®Google Scholar
• Schwarzacher HG, Wachtler F. The functional significance of nucleolar structures. Ann Genet. 1991;34:151–160.
   PubMedGoogle Scholar
• Schwarzacher HG, Wachtler F. The nucleolus. Anat Embryol (Berl). 1993;188(6):515–536. doi:10.1007/BF00187008.
   PubMedGoogle Scholar
• Thiry M, Cheutin T, O’Donohue M-F, Kaplan H, Ploton D. Dynamics and three- dimensional localization of ribosomal RNA within the nucleolus. RNA. 2000;6(12):1750–1761. doi:10.1017/S1355838200001564.
   PubMed Web of Science ®Google Scholar
• Fakan S, Hernandez-Verdun D. The nucleolus and the nucleolar organizer regions. Biol Cell. 1986;56(3):189–205. doi:10.1111/j.1768-322X.1986.tb00452.x.
   PubMed Web of Science ®Google Scholar
• Thiry M, Thiry-Blaise L. In situ hybridization at the electron microscope level: an improved method for precise localization of ribosomal DNA and RNA. Eur J Cell Biol. 1989;50:235–243.
   PubMed Web of Science ®Google Scholar
• Derenzini M, Thiry M, Goessens G. Ultrastructural cytochemistry of the mammalian cell nucleolus. J Histochem Cytochem. 1990;38(9):1237–1256. doi:10.1177/38.9.2201735.
   PubMed Web of Science ®Google Scholar
• Biggiogera M, Malatesta M, Abolhassani-Dadras, et al. Revealing the unseen: the organizer region of the nucleolus. J Cell Sci. 2001;114:3199–3205.
   PubMed Web of Science ®Google Scholar
• Thiry M, Goessens G. Where, within the nucleolus, are the rRNA genes located? Exp Cell Res. 1992;200(1):1–4. doi:10.1016/S0014-4827(05)80064-3.
   PubMed Web of Science ®Google Scholar
• Angelier N, Tramier M, Louvet E, et al. Tracking the interactions of rRNA processing proteins during nucleolar assembly in living cells. Mol Biol Cell. 2005;16(6):2862–2871. doi:10.1091/mbc.e05-01-0041.
   PubMed Web of Science ®Google Scholar
• Raska I, Shaw PJ, Cmarko D. New insights into nucleolar architecture and activity. Int Rev Cytol. 2006;255:177–234.
   PubMed Web of Science ®Google Scholar
• Gitler D, Xu Y, Kao HT, et al. Molecular determinants of synapsin targeting to presynaptic terminals. J Neurosci. 2004;24(14):3711–3720. doi:10.1523/JNEUROSCI.5225-03.2004.
   PubMed Web of Science ®Google Scholar
• Buratti E. Baralle FE Influence of RNA secondary structure on the pre-mRNA splicing process. Mol Cell Biol. 2004;24(24):10505–10514. doi:10.1128/MCB.24.24.10505-10514.2004.
   PubMed Web of Science ®Google Scholar
• Li Q, Lee J-A, Black DL. Neuronal regulation of alternative pre-mRNA splicing. Nature Rev Neurosci. 2007;8(11):819–831. doi:10.1038/nrn2237.
   PubMed Web of Science ®Google Scholar
• Gu J, Chen F, Chu D, et al. Rbfox3/NeuN regulates alternative splicing of tau exon 10. J Alzheimers Dis. 2018;66(4):1695–1704. doi:10.3233/JAD-180882.
   PubMed Web of Science ®Google Scholar
• Burns ER, Soloff BL, Hanna C, Buxton DF. Nuclear pocket associated with the nucleolus in normal and neoplastic cells. Cancer Res. 1971;31:159–165.
   PubMed Web of Science ®Google Scholar
• Buxton DF. Nuclear pocket associated with the nucleolus in normal and neoplastic cells. Cancer Res. 1971;31:159–165.
   PubMed Web of Science ®Google Scholar
• Dupuy-Coin AM, Moens P, Bouteille M. Three-dimensional analysis of given cell structures: nucleolus, nucleoskeleton, and nuclear inclusions. Methods Achiev Exp Pathol. 1986;12:1–25.
   PubMedGoogle Scholar
• Bourgeois CA, Hubert J. Spatial relationship between the nucleolus and the nuclear envelope: structural aspects and functional significance. Int Rev Cytol. 1988;111:1–52.
   PubMed Web of Science ®Google Scholar
• Wang N, Butler JP, Ingber DE. Mechanotransduction across the cell surface and through the cytoskeleton. Science. 1993;260(5111):1124–1127. doi:10.1126/science.7684161.
   PubMed Web of Science ®Google Scholar
• Coene ED, Van Oostveldt P, Willems K, van Emmelo J, De Potter CR. BRCA1 is localized in cytoplasmic tube-like invaginations in the nucleus. Nature Genet. 1997;16(2):122–124. doi:10.1038/ng0697-122.
   PubMed Web of Science ®Google Scholar
• Fricker M, Hollinshead M, White N, Vaux D. Interphase nuclei of many mammalian cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope. J Cell Biol. 1997;136(3):531–544. doi:10.1083/jcb.136.3.531.
   PubMed Web of Science ®Google Scholar
• Maniotis AJ, Chen CS, Ingber DE. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc Natl Acad Sci USA. 1997;94(3):849–854. doi:10.1073/pnas.94.3.849.
   PubMed Web of Science ®Google Scholar
• Pederson T. The plurifunctional nucleolus. Nucleic Acids Res. 1998;26(17):3871–3876. doi:10.1093/nar/26.17.3871.
   PubMed Web of Science ®Google Scholar
• Pederson T. The nucleolus. Cold Spring Harb Perspect Biol. 2011;3(3): pii: a000638. doi:10.1101/cshperspect.a000638.
   Web of Science ®Google Scholar
• Johnson N, Krebs M, Boudreau R, et al. Actin-filled nuclear invaginations indicate degree of cell de-differentiation. Differentiation. 2003;71(7):414–424. doi:10.1046/j.1432-0436.2003.7107003.x.
   PubMed Web of Science ®Google Scholar
• Lammerding J, Lee RT. Mechanical properties of interphase nuclei probed by cellular strain application. Methods Mol Biol. 2009;464:13–26.
   PubMedGoogle Scholar
• Mirre C, Lammerding J. Mechanics of the nucleus. Compr Physiol. 2011;1:783–807.
   PubMed Web of Science ®Google Scholar
• Mukherjee RN, Chen P, Levy DL. Recent advances in understanding nuclear size and shape. Nucleus. 2016;7(2):167–186. doi:10.1080/19491034.2016.1162933.
   PubMed Web of Science ®Google Scholar
• Drozdz MM, Vaux DJ. Shared mechanisms in physiological and pathological nucleoplasmic reticulum formation. Nucleus. 2017;8(1):34–45. doi:10.1080/19491034.2016.1252893.
   PubMed Web of Science ®Google Scholar
• Delpire E, Duchêne C, Goessens G, Gilles R. Effects of osmotic shocks on the ultrastructure of different tissues and cell types. Exp Cell Res. 1985;160(1):106–116. doi:10.1016/0014-4827(85)90240-X.
   PubMed Web of Science ®Google Scholar
• Bourgeois CA, Hernandez-Verdun D, Hubert J, Bouteille M. Silver staining of NORs in electron microscopy. Exp Cell Res. 1979;123(2):449–452. doi:10.1016/0014-4827(79)90498-1.
   PubMed Web of Science ®Google Scholar
• Clubb BH, Locke M. 3T3 cells have nuclear invaginations containing F-actin. Tissue Cell. 1998;30(6):684–691. doi:10.1016/S0040-8166(98)80087-6.
   PubMed Web of Science ®Google Scholar
• Alam SG, Lovett D, Kim DI, Roux KJ, Dickinson RB, Lele TP. The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts. J Cell Sci. 2015;128(10):1901–1911. doi:10.1242/jcs.161703.
   PubMed Web of Science ®Google Scholar
• Poplawski GHD, Kawaguchi R, Van Niekerk E, et al. Injured adult neurons regress to an embryonic transcriptional growth state. Nature. 2020;581(7806):77–82. doi:10.1038/s41586-020-2200-5.
   PubMed Web of Science ®Google Scholar
• Valentin G. Repertorium für Anatomie und Physiologie, Vol. 1. Berlin:Verlag von Veit und Comp; 1836:1–293.
   Google Scholar
• Schwann T. Mikroskopische Untersuchungen über die Übereinstimmung in der Struktur und dem Wachsthum der Theiren und Pflanze. Berlin: Verlag der Sander’schen Buchhandlung; 1839:1–270.
   Google Scholar
• Montgomery TH. Comparative cytological studies, with especial regard to the morphology of the nucleolus. J Morph. 1898;15:265–582. doi:10.1002/jmor.1050150204.
   Google Scholar
• Goessens G. The nucleolar fibrillar centres in various cell types in vivo or in vitro. Cell Tissue Res. 1976;173(3):315–324. doi:10.1007/BF00220319.
   PubMed Web of Science ®Google Scholar
• Goessens G. Nucleolar ultrastructure during reversible inhibition of RNA synthesis in chick fibroblasts cultivated in vitro. J Ultrastruct Res. 1978;65(1):83–89. doi:10.1016/S0022-5320(78)90024-2.
   PubMedGoogle Scholar
• Goessens G. Relations between fibrillar centres and nucleolus-associated chromatin in Ehrlich tumour cells. Cell Biol Int Rep. 1979;3(4):337–343. doi:10.1016/S0309-1651(79)80004-1.
   PubMedGoogle Scholar
• Goessens G. Localisation of nucleolus-organizing regions in interphase cells. Cell Tissue Res. 1979;200(1):159–161. doi:10.1007/BF00236896.
   PubMed Web of Science ®Google Scholar
• Bouteille M, Hernandez-Verdun D. Localization of a gene: the nucleolar organizer. Biomedicine (Taipei). 1979;30:282–287.
   PubMedGoogle Scholar
• Goessens G. Nucleolar structure. Int Rev Cytol. 1984;87:107–158.
   PubMed Web of Science ®Google Scholar
• Radoux D, Lepoint A, Goessens G. Cytological study of nucleoli and nucleolar organizers during inhibition of RNA synthesis. Bull Assoc Anat (Nancy). 1980;64(185):259–266. [In French].
   PubMedGoogle Scholar
• Mirre C, Knibiehler B. A re-evaluation of the relationships between the fibrillar centres and the nucleolus-organizing regions in reticulated nucleoli: ultrastructural organization, number and distribution of the fibrillar centres in the nucleolus of the mouse Sertoli cell. J Cell Sci. 1982;55:247–259.
   PubMed Web of Science ®Google Scholar
• Mirre C, Stahl A. Ultrastructural organization, sites of transcription and distribution of fibrillar centres in the nucleolus of the mouse oocyte. J Cell Sci. 1981;48:139–148.
   Web of Science ®Google Scholar
• Ploton D, Thiry M, Menager M, et al. Behaviour of nucleolus during mitosis. A comparative ultrastructural study of various cancerous cell lines using the Ag-NOR staining procedure. Chromosoma. 1987;95(2):95–107. doi:10.1007/BF00332182.
   PubMed Web of Science ®Google Scholar
• Chelidze PV, Mdivani TV, Dzidziguri DV. et al., The 3-dimensional organization of the nucleolus and the nucleolus organizer regions in differentiated cells. II. The reticular, vacuolized and nucleolonemal nucleoli of hepatocytes from the intact mouse liver and of hepatocytes stimulated to proliferation as a result of partial hepatectomy. Tsitologiia. 1992; 34(9): 17–25. Article in Russian
   PubMed Web of Science ®Google Scholar
• Chelidze PV, Dzidziguri DV, Zarandiia MA. et al., The 3-dimensional organization of the nucleolus and nucleolus-organizer regions of differentiated cells. IV. The structural and functional heterogeneity of the nucleoli in the epithelium of the proximal nephron in the mouse. Tsitologiia. 1993; 35(10): 3–12. Article in Russian
   PubMedGoogle Scholar
• Chelidze PV, Dzidziguri DV, Kintsurashvili LN. et al., The dependence of the 3-dimensional organization and length of the nucleolonema in the hepatocyte nucleoli of normal and regenerating rat livers on the nucleosome structure of the intranucleolar chromatin. Tsitologiia. 1995; 37(9–10): 859–871. Article in Russian
   PubMedGoogle Scholar
• Jamison JM. Effect of enthidium on the morphology, antiviral activity and subcellular distribution of Poly r(A-U). Cell Biol Int. 1993;17(12):1091–1106. doi:10.1006/cbir.1993.1042.
   PubMed Web of Science ®Google Scholar
• Krabill K, Jamison JM, Gilloteaux J, Summers JL. Subcellular localization and antiviral activity of carminic acid/poly r(A-U) combinations. Cell Biol Int. 1993;17(10):919–934. doi:10.1006/cbir.1993.1014.
   PubMed Web of Science ®Google Scholar
• Thiry M, Jamison JM, Gilloteaux J, et al. Ultrastructural nucleolar alterations induced by an ametantrone/polyr(A-U) complex. Exp Cell Res. 1997;236(1):275–284. doi:10.1006/excr.1997.3743.
   PubMed Web of Science ®Google Scholar
• Thiry M, Ploton D, Menager M, Goessens G. Ultrastructural distribution of DNA within the nucleolus of various animal cell lines or tissues revealed by terminal deoxynucleotidyl transferase. Cell Tissue Res. 1993;271(1):33–45. doi:10.1007/BF00297539.
   PubMed Web of Science ®Google Scholar
• Thiry M, Scheer U, Goessens G. Localization of DNA within Ehrlich tumour cell nucleoli by immunoelectron microscopy. Biol Cell. 1988;63(1):27–34. doi:10.1111/j.1768-322X.1988.tb00738.x.
   PubMed Web of Science ®Google Scholar
• Thiry M, Scheer U, Goessens G. Localization of nucleolar chromatin by immunocytochemistry and in situ hybridization at the electron microscopy level. Electron Microsc Rev. 1991;4(1):85–110.doi:10.1016/0892-0354(91)90017-7.
   PubMedGoogle Scholar
• Schwarzacher HG, Mosgoeller W. Ribosome biogenesis in man: current views on nucleolar structures and function. Cytogenet Cell Genet. 2000;91(1–4):243–252. doi:10.1159/000056853.
   PubMedGoogle Scholar
• Boisvert F-M, van Kőningsbruggen S, Navascués J, Lamond AI. The multifunctional nucleolus. Nat Rev Mol Cell Biol. 2007;8(7):574–585. doi:10.1038/nrm2184.
   PubMed Web of Science ®Google Scholar
• Mattaj IW, Tollervey D, Séraphin B. Small nuclear RNAs in messenger RNA and ribosomal RNA processing. Faseb J. 1993;7(1):47–53. doi:10.1096/fasebj.7.1.8422974.
   PubMed Web of Science ®Google Scholar
• Scheer U, Thiry M, Goessens G. Structure, function and assembly of the nucleolus. Trends Cell Biol. 1993;3(7):236–241. doi:10.1016/0962-8924(93)90123-I.
   PubMedGoogle Scholar
• Trendelenburg MF, Zatsepina OV, Waschek T, et al. Multiparameter microscopic analysis of nucleolar structure and ribosomal gene transcription. Histochem Cell Biol. 1996;106(2):167–192.
   PubMed Web of Science ®Google Scholar
• Vandelaer M, Thiry M, Goessens G. AgNOR proteins from morphologically intact isolated nucleoli. Life Sci. 1999;64(22):2039–2047. doi:10.1016/S0024-3205(99)00151-4.
   PubMed Web of Science ®Google Scholar
• Savino TM, Gébrane-Younès J, De Mey J, Sibarita J-B, Hernandez-Verdun D. Nucleolar assembly of the rRNA processing machinery in living cells. J Cell Biol. 2001;153(5):1097–1110. doi:10.1083/jcb.153.5.1097.
   PubMed Web of Science ®Google Scholar
• Hernandez-Verdun D, Roussel P, Thiry M, Sirri V, Lafontaine DL. The nucleolus: structure/function relationship in RNA metabolism. Wiley Interdiscip Rev RNA. 2010;1(3):415–431. doi:10.1002/wrna.39.
   PubMed Web of Science ®Google Scholar
• Jamison JM, Gilloteaux J, Perlaky L, et al. Nucleolar changes and fibrillarin redistribution following apatone treatment of human bladder carcinoma cells. J Histochem Cytochem. 2010;58(7):635–651. doi:10.1369/jhc.2010.956284.
   PubMed Web of Science ®Google Scholar
• Gilloteaux J, Jamison JM, Neal D, Summers JL. Synergistic antitumor cytotoxic actions of ascorbate and menadione on human prostate (DU145) cancer cells in vitro: nucleus and other injuries preceding cell death by autoschizis. Ultrastruct Pathol. 2014;38(2):116–140. doi:10.3109/01913123.2013.852645.
   PubMed Web of Science ®Google Scholar
• Gilloteaux J, Jamison JM, Arnold D, Summers JL. Autoschizis: a mode of cell death of cancer cells induced by a prooxidant treatment in vitro and in vivo. In: Radosevich JA, ed. Apoptosis and Beyond. Ch 28. New York: Wiley-Blackwell; 2018:583–694. doi:10.1002/9781119432463.
   Google Scholar
• Hadjiolov AA. The Nucleolus and Ribosome Biogenesis. Vienna: Springer Verlag; 1985.
   Google Scholar
• Grummt I. The nucleolus—guardian of cellular homeostasis and genome integrity. Chromosoma. 2013;122(6):487–497. doi:10.1007/s00412-013-0430-0.
   PubMed Web of Science ®Google Scholar
• Day RN, Periasamy A, Schaufele F. Fluorescence resonance energy transfer microscopy of localized protein interactions in the living cell nucleus. Methods. 2001;25(1):4–18. doi:10.1006/meth.2001.1211.
   PubMed Web of Science ®Google Scholar
• Fatica A, Tollervey D. Making ribosomes. Curr Opin Cell Biol. 14(3):313–318. doi:10.1016/S0955-0674(02)00336-8.
   PubMed Web of Science ®Google Scholar
• Lagace TA, Ridgway ND. The rate-limiting enzyme in phosphatidylcholine synthesis regulates proliferation of the nucleoplasmic reticulum. Mol Biol Cell. 2005;16(3):1120–1130. doi:10.1091/mbc.e04-10-0874.
   PubMed Web of Science ®Google Scholar
• Russell J, Zomerdijk JC. RNA-polymerase-I-directed rDNA transcription, life and works. Trends Biochem Sci. 2005;30(2):87–96. doi:10.1016/j.tibs.2004.12.008.
   PubMed Web of Science ®Google Scholar
• Louvet E, Tramier M, Angelier N, Hernandez-Verdun D. Time-lapse microscopy and fluorescence resonance energy transfer to analyze the dynamics and interactions of nucleolar proteins in living cells. Methods Mol Biol. 2008;463:123–135.
   PubMedGoogle Scholar
• Szczepanowska K, Senft K, Heidler J, et al. A salvage pathway maintains highly functional respiratory complex I. Nature Commun. 2020;11(1):1643.doi:10.1038/s41467-020-15467-7.
   PubMed Web of Science ®Google Scholar
• Barron KD, Means ED, Larsen E. Ultrastructure of retrograde degeneration in thalamus of rat: 1. Neuronal somata dendrites. J Neuropathol Exp Neurol. 1973;32:218–244.
   PubMed Web of Science ®Google Scholar
• Brooks GA, Dubouchaud H, Brown M, Sicurello JP, Butz CE. Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle. Proc Natl Acad Sci USA. 1999;96(3):1129–1134. doi:10.1073/pnas.96.3.1129.
   PubMed Web of Science ®Google Scholar
• Pérez-Escuredo J, Van Hée VF, Sboarina M, et al. Monocarboxylate transporters in the brain and in cancer. Biochim Biophys Acta. 2016;1863(10):2481–2497. doi:10.1016/j.bbamcr.2016.03.013.
   PubMed Web of Science ®Google Scholar
• Bak LK, Walls AB, Schousboe A, Waagepetersen HS. Astrocytic glycogen metabolism in the healthy and diseased brain. J Biol Chem. 2018;293(19):7108–7116. doi:10.1074/jbc.R117.803239.
   PubMed Web of Science ®Google Scholar
• Díaz-García CM, Mongeon R, Lahmann C, Koveal D, Zucker H, Yellen G. Neuronal stimulation triggers neuronal glycolysis and not lactate uptake. Cell Metab. 2017;26(2):361–374.e4. doi:10.1016/j.cmet.2017.06.021.
   PubMed Web of Science ®Google Scholar
• Yellen G. Fueling thought: management of glycolysis and oxidative phosphorylation in neuronal metabolism. J Cell Biol. 2018;217(7):2235–2246. doi:10.1083/jcb.201803152.
   PubMed Web of Science ®Google Scholar
• Zhu J, Li P, Zhou Y-G, Ye J. Altered energy metabolism during early optic nerve crush injury: implications of Warburg-like aerobic glycolysis in facilitating retinal ganglion cell survival. Neurosci Bull. 2020;36(7):761–777. doi:10.1007/s12264-020-00490-x.
   PubMed Web of Science ®Google Scholar
• Lui L, Lowe T. Small nucleolar RNAs and RNA-guided post-transcriptional modification. Essays Biochem. 2013;54:53–77. doi:10.1042/bse0540053.
   PubMed Web of Science ®Google Scholar
• Vincent WS. Structure and chemistry of nucleoli. Int Rev Cytol. 1955;4:269–298.
   Web of Science ®Google Scholar
• Porter KR. Observations on a submicroscopic basophilic component of cytoplasm. J Exp Med. 1953;97:727–750.
   PubMed Web of Science ®Google Scholar
• Palade GE, Porter KR. Studies on the endoplasmic reticulum. J Exp Med. 1954;100(6):641–656. doi:10.1084/jem.100.6.641.
   PubMed Web of Science ®Google Scholar
• Watson ML. The nuclear envelope; its structure and relation to cytoplasmic membranes. J Biophys Biochem Cytol. 1955;1(3):257–270. doi:10.1083/jcb.1.3.257.
   PubMedGoogle Scholar
• Walter P, Gilmore R, Muller M, Blobel G. The protein translocation machinery of the endoplasmic reticulum. Philos Trans R Soc Lond B Biol Sci. 1982;300:225–228.
   PubMed Web of Science ®Google Scholar
• Franke WW. Nuclear envelopes. Structure and biochemistry of the nuclear envelope. Phil Trans R Soc Lond B. 1974;268:67–93.
   PubMed Web of Science ®Google Scholar
• Franke WW. Structure, biochemistry, and functions of the nuclear envelope. Int Rev Cytol. 1974268:67–93.
   PubMedGoogle Scholar
• Gilloteaux J, Kashouty R, Yono N. The perinuclear space of pancreatic acinar cells and the synthetic pathway of zymogen in Scorpaena scrofa L.: ultrastructural aspects. Tissue Cell. 2008;40(1):7–20. doi:10.1016/j.tice.2007.08.004.
   PubMed Web of Science ®Google Scholar
• Goler-Baron V, Selitrennik M, Barkai O, et al. Transcription in the nucleus and mRNA decay in the cytoplasm are coupled processes. Genes Dev. 2008;22(15):2022–2027. doi:10.1101/gad.473608.
   PubMed Web of Science ®Google Scholar
• Hartenian E, Glaunsinger BA. Feedback to the central dogma: cytoplasmic mRNA decay and transcription are interdependent processes. Crit Rev Biochem Mol Biol. 2019;54(4):385–398. doi:10.1080/10409238.2019.1679083.
   PubMed Web of Science ®Google Scholar
• George R, Griffin JW. The proximo-distal spread of axonal degeneration in the dorsal columns of the rat. J Neurocytol. 1994;23(11):657–667. doi:10.1007/BF01181641.
   PubMedGoogle Scholar
• Koshinaga M, Whittemore SR. The temporal and spatial activation of microglia in fiber tracts undergoing anterograde and retrograde degeneration following spinal cord lesion. J Neurotrauma. 1995;12(2):209–222. doi:10.1089/neu.1995.12.209.
   PubMed Web of Science ®Google Scholar
• Freeman MR. Signaling mechanisms regulating Wallerian degeneration. Curr Opin Neurobiol. 2014;27:224–231. doi:10.1016/j.conb.2014.05.001.
   PubMed Web of Science ®Google Scholar
• Geden MJ, Deshmukh M. Axon degeneration: context defines distinct pathways. Curr Opin Neurobiol. 2016;39:108–115. doi:10.1016/j.conb.2016.05.002.
   PubMed Web of Science ®Google Scholar
• Buss A, Schwab ME. Sequential loss of myelin proteins during Wallerian degeneration in the rat spinal cord. Glia. 2003;42(4):424–432. doi:10.1002/glia.10220.
   PubMed Web of Science ®Google Scholar
• Adalbert R, Nógrádi A, Szabó A, Coleman MP. The slow Wallerian degeneration gene in vivo protects motor axons but not their cell bodies after avulsion and neonatal axotomy. Eur J Neurosci. 2006;24(8):2163–2168. doi:10.1111/j.1460-9568.2006.05103.x.
   PubMed Web of Science ®Google Scholar
• Guo S, Tjärnlund-Wolf A, Deng W, et al. Comparative transcriptome of neurons after oxygen-glucose deprivation: potential differences in neuroprotection versus reperfusion. J Cereb Blood Flow Metab. 2018;38(12):2236–2250. doi:10.1177/0271678X18795986.
   PubMed Web of Science ®Google Scholar
• Sanders P, De Keyser J. Janus faces of microglia in multiple sclerosis. Brain Res Rev. 2007;54(2):274–285. doi:10.1016/j.brainresrev.2007.03.001.
   PubMedGoogle Scholar
• Takefuji S, Murase T, Sugimura Y, et al. Role of microglia in the pathogenesis of osmotic-induced demyelination. Exp Neurol. 2007;204(1):88–94. doi:10.1016/j.expneurol.2006.09.025.
   PubMed Web of Science ®Google Scholar
• Ghosh N, DeLuca GC, Esiri MM. Evidence of axonal damage in human acute demyelinating diseases. J Neurol Sci. 2004;222(1–2):29–34. doi:10.1016/j.jns.2004.03.032.
   PubMed Web of Science ®Google Scholar
• Kumar V, Abbas A, Aster J. Cellular responses to stress and toxic insults: adaptation, injury, and death. In: Robbins Basic Pathology. 10th ed. Chapter 2. Philadelphia: Elsevier; 2017:3–23.
   Google Scholar
• Kumar V, Abbas A, Fausto N, Aster J. Robbins and Cotran: Pathologic Basis of Disease. 8th ed. Philadelphia: Elsevier-Saunders; 2010:5–16.
   Google Scholar
• Peña CE. Intracytoplasmic neuronal inclusions in the human thalamus. Light-microscopic, histochemical, and ultrastructural observations. Acta Neuropathol. 1980;52(2):157–159. doi:10.1007/BF00688015.
   PubMed Web of Science ®Google Scholar
• Aikawa H, Suzuki K, Iwasaki Y. Ultrastructural observation on the thalamic neuronal inclusion in young mice. Acta Neuropathol. 1983;59(4):316–318. doi:10.1007/BF00691499.
   PubMed Web of Science ®Google Scholar
• Ono S, Inoue K, Mannen T, et al. Intracytoplasmic inclusion bodies of the thalamus and the substantia nigra, and Marinesco bodies in myotonic dystrophy: a quantitative morphological study. Acta Neuropathol. 1989;77(4):350–356. doi:10.1007/BF00687369.
   PubMed Web of Science ®Google Scholar
• Takahashi H, Ohama E, Ikuta F. Are bunina bodies of endoplasmic reticulum origin? An ultrastructural study of subthalamic eosinophilic inclusions in a case of atypical motor neuron disease. Acta Pathol Jpn. 1991;41:889–894.
   PubMedGoogle Scholar
• Cummings JF, de Lahunta A, Summers BA, et al. Eosinophilic cytoplasmic inclusions in sporadic equine motor neuron disease: an electron microscopic study. Acta Neuropathol. 1993;85(3):291–297. doi:10.1007/BF00227725.
   PubMed Web of Science ®Google Scholar
• Brabec V, Kleinwächter V, Vetterl V. Bioelectrochemistry of biomacromolecules. In: Lenaz G, Milazzo G, eds. Bioelectrochemistry of Biomacromolecules. Basel: Birkhäuser Verlag; 1997:1–104. doi:10.1007/978-3-0348-9179-0.
   Google Scholar
• Brengues M. Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies. Science. 2005;310(5747):486–489. doi:10.1126/science.1115791.
   PubMed Web of Science ®Google Scholar
• Bhattacharyya SN, Habermacher R, Martine U, Closs EI, Filipowicz W. Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells. Cold Spring Harb Symp Quant Biol. 2006;71:513–521. doi:10.1101/sqb.2006.71.038.
   PubMedGoogle Scholar
• Pillai RS, Bhattacharyya SN, Filipowicz W. Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol. 2007;17(3):118–126. doi:10.1016/j.tcb.2006.12.007.
   PubMed Web of Science ®Google Scholar
• Parker R, Sheth U. P bodies and the control of mRNA translation and degradation. Mol Cell. 2007;25(5):635–646. doi:10.1016/j.molcel.2007.02.011.
   PubMed Web of Science ®Google Scholar
• Balagopal V, Polysomes PR. P bodies and stress granules: states and fates of eukaryotic mRNAs. Curr Opin Cell Biol. 2009;21(3):403–408. doi:10.1016/j.ceb.2009.03.005.
   PubMed Web of Science ®Google Scholar
• Von Roretz C, Di Marco S, Mazroui R, Gallouzi I-E. Turnover of AU-rich-containing mRNAs during stress: a matter of survival. Wiley Interdiscip Rev RNA. 2011;2(3):336–347. doi:10.1002/wrna.55.
   PubMed Web of Science ®Google Scholar
• Decker CJ, Parker R. P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. Cold Spring Harb Perspect Biol. 2012;4(9):a012286. doi:10.1101/cshperspecta012286.
   PubMed Web of Science ®Google Scholar
• Anderson KI, Wang YL, Small JV. Coordination of protrusion and translocation of the keratocyte involves rolling of the cell body. J Cell Biol. 1996;134(5):1209–1218. doi:10.1083/jcb.134.5.1209.
   PubMed Web of Science ®Google Scholar
• Kumar A, Maitra A, Sumit M, Ramaswamy S, Shivashankar GV. Actomyosin contractility rotates the cell nucleus. Sci Rep. 2015;4(1):3781. doi:10.1038/srep03781.
   Google Scholar
• Bhattacharyya A, Oppenheim RW, Prevette D, et al. S100 is present in developing chicken neurons and Schwann cell and promotes motor neuron survival in vivo. J Neurol. 1992;23(4):451–466.
   Google Scholar
• Bard F, Bourgeois CA, Costagliola D, Bouteille M. Rotation of the cell nucleus in living cells: a quantitative analysis. Biol Cell. 1985;54(2):135–142. doi:10.1111/j.1768-322X.1985.tb00388.x.
   PubMed Web of Science ®Google Scholar
• Fung LC, De Boni U. Modulation of nuclear rotation in neuronal interphase nuclei by nerve growth factor, by gamma-aminobutyric acid, and by changes in intracellular calcium. Cell Motil Cytoskeleton. 1988;10(3):363–373. doi:10.1002/cm.970100303.
   PubMed Web of Science ®Google Scholar
• Paddock SW. Rigidity of the nucleus during nuclear rotation in 3T3 cells. Exp Cell Res. 1988;175(2):409–413. doi:10.1016/0014-4827(88)90205-4.
   PubMed Web of Science ®Google Scholar
• Park PC, De Boni U. Dynamics of nucleolar fusion in neuronal interphase nuclei in vitro: association with nuclear rotation. Exp Cell Res. 1991;197(2):213–221. doi:10.1016/0014-4827(91)90425-T.
   PubMed Web of Science ®Google Scholar
• Gundersen GG, Worman HJ. Nuclear positioning. Cell. 2013;152(6):1376–1389. doi:10.1016/j.cell.2013.02.031.
   PubMed Web of Science ®Google Scholar
• Yang Z, Voke PR. Large-eddy simulation of boundary-layer separation and transition at a change of surface curvature. J Fluid Mech. 2001;439:305–333. doi:10.1017/S0022112001004633.
   Web of Science ®Google Scholar
• Garrett SJ, Peake N. The stability and transition of the boundary layer on a rotating sphere. J Fluid Mech. 2002;456:199–218. doi:10.1017/S0022112001007571.
   Web of Science ®Google Scholar
• Wu M-H, Wen C-Y, Yen R-H, et al. Experimental and numerical study of the separation angle for flow around a circular cylinder at low reynolds number. J Fluid Mech. 2004;515:233–260. doi:10.1017/S0022112004000436.
   Web of Science ®Google Scholar
• Kundu PK, Cohen IM, Dowling DR.  Fluid Mechanics.  (eds), Sixth Edition, Amsterdam: Elsevier/ Academic Press. 2016; p 171-196; 473-540 and 541-620.  https://doi.org/10.1016/C2009-0-63410-3
   Google Scholar
• Salehi  MA, Mazaheri S,  Kazeminezhad MH.  Study of flow characteristics around a near-wall circular cylinder subjected to a steady cross-flow. Int J COE. 2018 : 1 (4): 45-55. http://ijcoe.org/browse.php?a_code=A-10-183-1&sid=1&slc_lang=en
   Google Scholar
• Wiggins A. Fluid flow about immersed bodies flow stream U drag = pressure + friction. Part B. In: White F, ed. Fluid Mechanics, 7th. Ch 9. New York: McGrawHill Co; 2016:609–700.
   Google Scholar
• Riback JA, Zhu L, Ferrolino MC, et al. Composition-dependent thermodynamics of intracellular phase separation. Nature. 2020;581(7807):209–214. doi:10.1038/s41586-020-2256-2.
   PubMed Web of Science ®Google Scholar
• Sanders DW, Kedersha N, Lee DSW, et al. Competing protein-RNA interaction networks control multiphase intracellular organization. Cell. 2020;181(2):306–324.doi:10.1016/j.cell.2020.03.050.
   PubMed Web of Science ®Google Scholar
• Wicke F, Moreitz S, Weidauer S. Osmotic demyelination syndrome due to severe hyponatremia mimicking hypoxic encephalopathy. Fortschr Neurol Psychiatr. 2017;85(4):212–215. doi:10.1055/s-0043-100460.
   PubMed Web of Science ®Google Scholar
• Li Q, Weiland A, Chen X. et al. Ultrastructural characteristics of neuronal death and white matter injury in mouse brain tissues after intracerebral hemorrhage: coexistence of ferroptosis, autophagy, and necrosis. Front Neurol. 2018;9:581. doi:10.3389/fneur.2018.00581.
   PubMed Web of Science ®Google Scholar
• Sterns RH, Silver SM. Complications and management of hyponatremia. Curr Opin Nephrol Hypertens. 2016;25(2):114–119. doi:10.1097/MNH.0000000000000200.
   PubMed Web of Science ®Google Scholar
• Vogel FS, Bouldin TW. The nervous system. In: Rubin E, Farber JL, eds. Pathology, 2nd ed. Chapter 28. Philadelphia: J.B. Lippincott; 1994:1373–1455.
   Google Scholar
• Zhan J, Mann T, Joost S, Behrangi N, Frank M, Kipp M. The cuprizone model: dos and do nots. Cells. 2020;9(4):843. pii: E843. doi:10.3390/cells9040843.
   PubMed Web of Science ®Google Scholar
• Powers JM, McKeever PE. Central pontine myelinolysis. An ultrastructural and elemental study. J Neurol Sci. 1976;29(1):65–81. doi:10.1016/0022-510X(76)90081-2.
   PubMed Web of Science ®Google Scholar
• Adler S, Verbalis JG, Meyers S, Simplaceanu E, Williams DS. Changes in cerebral blood flow and distribution associated with acute increases in plasma sodium and osmolality of chronic hyponatremic rats. Exp Neurol. 2000;163(1):63–71. doi:10.1006/exnr.2000.7376.
   PubMed Web of Science ®Google Scholar
• Norenberg MD, Leslie KO, Robertson AS. Association between rise in serum sodium and central pontine myelinolysis. Ann Neurol. 1982;11(2):128–135. doi:10.1002/ana.410110204.
   PubMed Web of Science ®Google Scholar
• Popescu BFG, Bunyan RF, Guo Y, et al. Evidence of aquaporin involvement in human central pontine myelinolysis. Acta Neuropathol Commun. 2013;1(1):40.doi:10.1186/2051-5960-1-40.
   PubMedGoogle Scholar
• Ghadially FN. Ultrastructural Pathology of the Cell and Matrix. 4th ed. Boston: Butterworth-Heinemann; 1997:30–31.
   Google Scholar
• Sullivan AA, Chervin RD, Albin RL. Parkinsonism after correction of hyponatremia with radiological central pontine myelinolysis and changes in the basal ganglia. J Clin Neurosci. 2000;7(3):256–259. doi:10.1054/jocn.1999.0192.
   PubMed Web of Science ®Google Scholar