Evaluating the histomorphological and biochemical changes induced by Tributyltin Chloride on pituitary-testicular axis of adult albino rats and the possible ameliorative role of hesperidin

References

• Fink G. 60 Years of neuroendocrinology: memoir: harris’ neuroendocrine revolution: of portal vessels and self-priming. J Endocrinol. 2015 Aug 1;226(2):T13–24. doi:10.1530/JOE-15-0130.
   PubMed Web of Science ®Google Scholar
• Kaprara A, Huhtaniemi IT. The hypothalamus-pituitary-gonad axis: tales of mice and men. Metabolism. 2018 Sep 1;86:3–17. doi:10.1016/j.metabol.2017.11.018.
   PubMed Web of Science ®Google Scholar
• Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, et al. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev. 2009 Jun 1;30(4):293–342. doi:10.1210/er.2009-0002.
   PubMed Web of Science ®Google Scholar
• Sharan S, Nikhil K, Roy P. Effects of low dose treatment of tributyltin on the regulation of estrogen receptor functions in MCF-7 cells. Toxicol Appl Pharmacol. 2013 Jun;269(2):176–186. doi:10.1016/j.taap.2013.03.009.
   PubMed Web of Science ®Google Scholar
• Batista-Andrade JA, Caldas SS, Batista RM, Castro IB, Fillmann G, Primel EG. From TBT to booster biocides levels and impacts of antifouling along coastal areas of Panama. Environmental Pollution. 2018 Mar 1;234:243–252. doi:10.1016/j.envpol.2017.11.063.
   PubMed Web of Science ®Google Scholar
• Finnegan C, Ryan D, Enright AM, Garcia-Cabellos G. A review of strategies for the detection and remediation of organotin pollution. Crit Rev Environ Sci Technol. 2018 Jan 2;48(1):77–118. doi:10.1080/10643389.2018.1443669.
   Web of Science ®Google Scholar
• Anastasiou TI, Chatzinikolaou E, Mandalakis M, Arvanitidis C. Imposex and organotn compounds in ports of the Mediterranean and the Atlantic: is the story over? Sci Total Environ. 2016 Nov 1;569:1315–1329. doi:10.1016/j.scitotenv.2016.06.209.
   PubMed Web of Science ®Google Scholar
• Chen C, Chen L, Huang Q, Chen Z, Zhang W. Organotin contamination in commercial and wild oysters from China: increasing occurrence of triphenyltin. Sci Total Environ. 2019 Feb 10;650:2527–2534. doi:10.1016/j.scitotenv.2018.09.310.
   PubMed Web of Science ®Google Scholar
• Gao JM, Fu PT, Chen XL, et al. Fate simulation and risk assessment of TBT and TPhT considering water level fluctuations in the TGR before and after AFS Convention implementation in China. Environmental Sciences Europe. 2020 Dec;32(1):1–4. doi:10.1186/s12302-020-0298-6.
   Web of Science ®Google Scholar
• Younis AM. Accumulation and rate of degradation of organotin compounds in coastal sediments along the Red Sea, Egypt. Egypt J Aquat Biol Fish. 2020 Aug 21;24(5):413–436. doi:10.21608/ejabf.2020.108918.
   Google Scholar
• Merlo E, Silva IV, Cardoso RC, Graceli JB. The obesogen tributyltin induces features of polycystic ovary syndrome (PCOS): a review. J Tox Env Health Part B. 2018 Apr 3;21(3):181–206. doi:10.1080/10937404.2018.1496214.
   PubMed Web of Science ®Google Scholar
• Barbosa CM, Ferrão FM, Graceli JB. Organotin compounds toxicity: focus on kidney. Front Endocrinol (Lausanne). 2018 May 22;9:256. doi:10.3389/fendo.2018.00256.
   PubMed Web of Science ®Google Scholar
• Jaiswal AK, Kumar R, Thakur A, Puri P, Kumar R, Kanojia R. Cobalt toxicity/poisoning with analytical aspects and its management. Int J Med Lab Res. 2019;4(3):29–36. doi:10.35503/IJMLR.2019.4305.
   Google Scholar
• Lawrence S, Ismail F, Jamal SZ, Whalen MM. Tributyltin stimulates synthesis of interferon gamma and tumor necrosis factor alpha in human lymphocytes. Journal of Applied Toxicology. 2018 Aug;38(8):1081–1090. doi:10.1002/jat.3617.
   PubMed Web of Science ®Google Scholar
• Harer C. Toxicological profile for tin and tin compounds. Agency Toxic Subs Dis Reg. 2005.
   Google Scholar
• Langston WJ, Pope ND, Davey M, et al. Recovery from TBT pollution in English Channel environments: a problem solved? Marine pollution bulletin. 2015 Jun 30. 95(2):551–564. doi:10.1016/j.marpolbul.2014.12.011
   Google Scholar
• Champ MA, Seligman PF. Organotin: Environmental Fate and Effects. Springer Science & Business Media; Dec 6, 2012.
   Google Scholar
• Antizar-Ladislao B. Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. A review. Environ Int. 2008 Feb 1;34(2):292–308. doi:10.1016/j.envint.2007.09.005.
   PubMed Web of Science ®Google Scholar
• Heroult J, Nia Y, Denaix L, Bueno M, Lespes G. Kinetic degradation processes of butyl-and phenyltins in soils. Chemosphere. 2008 Jun 1;72(6):940–946. doi:10.1016/j.chemosphere.2008.03.027.
   PubMed Web of Science ®Google Scholar
• Badr El Dine FM, Nabil IM, Dwedar FI. The effect of tributyltin on thyroid follicular cells of adult male albino rats and the possible protective role of green tea: a toxicological, histological and biochemical study. Egyp J Forensic Sci. 2017 Dec;7(1):1–3. doi:10.1186/s41935-017-0012-z.
   PubMedGoogle Scholar
• Roohbakhsh A, Parhiz H, Soltani F, Rezaee R, Iranshahi M. Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin—a mini-review. Life Sci. 2014 Sep 15;113(1–2):1–6. doi:10.1016/j.lfs.2014.07.029.
   PubMed Web of Science ®Google Scholar
• Shaban NZ, Ahmed Zahran AM, El-Rashidy FH, Abdo Kodous AS. Protective role of hesperidin against γ-radiation-induced oxidative stress and apoptosis in rat testis. J Biol Res (Thessalon). 2017 Dec;24(1):1. doi:10.1186/s40709-017-0059-x.
   PubMedGoogle Scholar
• Shokoohi M, Khaki A, Shoorei H, Khaki AA, Moghimian M, Abtahi‐eivary SH. Hesperidin attenuated apoptotic‐related genes in testicle of a male rat model of varicocoele. Andrology. 2020 Jan;8(1):249–258. doi:10.1111/andr.12681.
   PubMed Web of Science ®Google Scholar
• Barreca D, Gattuso G, Bellocco E, et al. Flavanones: citrus phytochemical with health‐promoting properties. Biofactors. 2017 Jul 8;43(4):495–506. doi:10.1002/biof.1363.
   PubMed Web of Science ®Google Scholar
• Meneguzzo F, Ciriminna R, Zabini F, Pagliaro M. Review of evidence available on hesperidin-rich products as potential tools against COVID-19 and hydrodynamic cavitation-based extraction as a method of increasing their production. Processes. 2020 May;8(5):549. doi:10.3390/pr8050549.
   Web of Science ®Google Scholar
• Pari L, Karthikeyan A, Karthika P, Rathinam A. Protective effects of hesperidin on oxidative stress, dyslipidaemia and histological changes in iron-induced hepatic and renal toxicity in rats. Toxicol Rep. 2015 Jan 1;2:46–55. doi:10.1016/j.toxrep.2014.11.003.
   PubMed Web of Science ®Google Scholar
• Yu WJ, Lee BJ, Nam SY, Kim YC, Lee YS, Yun YW. Spermatogenetic disorders in adult rats exposed to tributyltin chloride during puberty. J Vet Med. 2003;65(12):1331–1335. doi:10.1292/jvms.65.1331.
   Google Scholar
• Mitra S, Gera R, Singh V, Khandelwal S. Comparative toxicity of low dose tributyltin chloride on serum, liver, lung and kidney following subchronic exposure. Food Chem Toxicol. 2014 Feb 1;64:335–343. doi:10.1016/j.fct.2013.11.031.
   PubMed Web of Science ®Google Scholar
• Teilmann AC, Nygaard Madsen A, Holst B, et al. Physiological and pathological impact of blood sampling by retro-bulbar sinus puncture and facial vein phlebotomy in laboratory mice. PLoS One. 2014 Nov 26;9(11):e113225. doi:10.1371/journal.pone.0113225.
   PubMed Web of Science ®Google Scholar
• Gomaa AM, Abou Khalil NS, Abdel-Ghani MA. The protective role of folic acid against testicular dysfunction in lead-intoxicated rat model. Gen Physiol Biophys. 2017 Jul 1;36(3):297–308. doi:10.4149/gpb_2016048.
   PubMed Web of Science ®Google Scholar
• Wen Q, Wang Y, Tang J, Cheng CY, Liu YX, Ramchandran R. Sertoli cell Wt1 regulates peritubular myoid cell and fetal Leydig cell differentiation during fetal testis development. PLoS One. 2016 Dec 30;11(12):e0167920. doi:10.1371/journal.pone.0167920.
   PubMed Web of Science ®Google Scholar
• Suvarna KS, Layton C, Bancroft JD. Bancroft’s theory and practice of histological techniques E-Book. Elsevier Health Sci. 2018 Feb 27.
   Google Scholar
• Magaki S, Hojat SA, Wei B, So A, Yong WH. An introduction to the performance of immunohistochemistry. Biobanking. 2019;289–298.
   Google Scholar
• Sobecki M, Mrouj K, Colinge J, et al. Cell-cycle regulation accounts for variability in Ki-67 expression LevelsKi-67 expression and the cell cycle. Cancer Res. 2017 May 15;77(10):2722–2734. doi:10.1158/0008-5472.CAN-16-0707.
   PubMed Web of Science ®Google Scholar
• El‐wakf AM, El‐habibi ES, Ali DA, Abd El‐ghany E, Elmougy R. Marjoram and sage oils protect against testicular apoptosis, suppressed Ki‐67 expression and cell cycle arrest as a therapy for male infertility in the obese rats. J Food Biochem. 2020 Jan;44(1):e13080. doi:10.1111/jfbc.13080.
   PubMed Web of Science ®Google Scholar
• Huhtaniemi I. A short evolutionary history of FSH-stimulated spermatogenesis. Hormones. 2015 Oct;14(4):468–478. doi:10.14310/horm.2002.1632.
   PubMedGoogle Scholar
• Tizro P, Choi C, Khanlou N. Sample preparation for transmission electron microscopy. Biobanking. 2019;417–424.
   Google Scholar
• Johnsen SG. The stage of spermatogenesis involved in the testicular-hypophyseal feed-back mechanism in man. Acta Endocrinol (Copenh). 1970;64(2):193–210. doi:10.1530/acta.0.0640193.
   PubMedGoogle Scholar
• Podratz PL, Merlo E, de Araújo Jf, et al. Disruption of fertility, placenta, pregnancy outcome, and multigenerational inheritance of hepatic steatosis by organotin exposure from contaminated seafood in rats. Sci Total Environ. 2020 Jun 25;723:138000. doi:10.1016/j.scitotenv.2020.138000.
   PubMed Web of Science ®Google Scholar
• Moreira S, Pereira SC, Seco-Rovira V, Oliveira PF, Alves MG, Pereira MD. Pesticides and male fertility: a dangerous crosstalk. Metabolites. 2021 Nov 25;11(12):7994. doi:10.3390/metabo11120799.
   Web of Science ®Google Scholar
• Graceli JB, Dettogni RS, Merlo E, et al. The impact of endocrine-disrupting chemical exposure in the mammalian hypothalamic-pituitary axis. Mol Cell Endocrinol. 2020 Dec 1;518:110997. doi:10.1016/j.mce.2020.110997.
   PubMed Web of Science ®Google Scholar
• He S, Li P, Li ZH. Review on endocrine disrupting toxicity of triphenyltin from the perspective of species evolution: aquatic, amphibious and mammalian. Chemosphere. 2021 Apr 1;269:128711. doi:10.1016/j.chemosphere.2020.128711.
   PubMed Web of Science ®Google Scholar
• Kanimozhi V, Palanivel K, Kadalmani B, Krikun G, Taylor HS. Apolipoprotein E induction in Syrian hamster testis following tributyltin exposure: a potential mechanism of male infertility. Reproductive Sciences. 2014 Aug;21(8):1006–1014. doi:10.1177/1933719114522519.
   PubMed Web of Science ®Google Scholar
• Penza M, Jeremic M, Marrazzo E, et al. The environmental chemical tributyltin chloride (TBT) shows both estrogenic and adipogenic activities in mice which might depend on the exposure dose. Toxicol Appl Pharmacol. 2011 Aug 15;255(1):65–75. doi:10.1016/j.taap.2011.05.017.
   PubMed Web of Science ®Google Scholar
• Egusquiza RJ, Blumberg B. Environmental obesogens and their impact on susceptibility to obesity: new mechanisms and chemicals. Endocrinology. 2020 Mar;161(3):bqaa024. doi:10.1210/endocr/bqaa024.
   PubMed Web of Science ®Google Scholar
• Sena GC, Freitas-Lima LC, Merlo E, et al. Environmental obesogen tributyltin chloride leads to abnormal hypothalamic-pituitary-gonadal axis function by disruption in kisspeptin/leptin signaling in female rats. Toxicol Appl Pharmacol. 2017 Mar 15;319:22–38. doi:10.1016/j.taap.2017.01.021.
   PubMed Web of Science ®Google Scholar
• Barbosa KL, Dettogni RS, Da Costa CS, et al. Graceli JB.Tributyltin, and the female hypothalamic-pituitary-gonadal disruption. Toxicol Sci. 2022 Apr;186(2):179–189. doi:10.1093/toxsci/kfab141.
   PubMed Web of Science ®Google Scholar
• Fallara G, Cazzaniga W, Boeri L, et al. Male factor infertility trends throughout the last 10 years: report from a tertiary-referral academic andrology centre. Andrology. 2021 Mar;9(2):610–617. doi:10.1111/andr.12947.
   PubMed Web of Science ®Google Scholar
• Wu X, Liu J, Duan Y, et al. A short-term exposure to tributyltin blocks leydig cell regeneration in the adult rat testis. Front Pharmacol. 2017 Oct 12;8:704. doi:10.3389/fphar.2017.00704.
   PubMed Web of Science ®Google Scholar
• Kanimozhi V, Palanivel K, Akbarsha MA, Kadalmani B. Tributyltin-mediated hepatic, renal and testicular tissue damage in male Syrian hamster (Mesocricetus auratus): a study on impact of oxidative stress. Springerplus. 2016 Dec;5(1):1. doi:10.1186/s40064-016-3186-1.
   PubMedGoogle Scholar
• Rato L, Sousa AC. The impact of endocrine-disrupting chemicals in male fertility: focus on the action of obesogens. J Xenobiot. 2021 Nov 29;11(4):163–196. doi:10.3390/jox11040012.
   PubMed Web of Science ®Google Scholar
• Liu ZJ, Liu YH, Huang SY, Zang ZJ. Insights into the regulation on proliferation and differentiation of stem Leydig cells. Stem Cell Rev. 2021 Oct;17(5):1521–1533. doi:10.1007/s12015-021-10133-x.
   Web of Science ®Google Scholar
• Sakr S, Rashad A, Abaza W. The ameliorative effect of Moringa oleifera oil on tributyltin‐induced brain toxicity in albino rats. Environ Toxicol. 2021 Oct;36(10):2025–2039. doi:10.1002/tox.23320.
   PubMed Web of Science ®Google Scholar
• Rodrigues-Pereira P, Andrade MN, Santos-Silva AP, et al. Subacute and low-dose tributyltin exposure disturbs the mammalian hypothalamus-pituitary-thyroid axis in a sex-dependent manner. Comp Biochem Physiol. 2022 Apr 1;254:109279. doi:10.1016/j.cbpc.2022.109279.
   Google Scholar
• Mendes AB, Motta NA, Lima GF, et al. Evaluation of the effects produced by subacute tributyltin administration on vascular reactivity of male wistar rats. Toxicology. 2022 Jan 15;465:153067. doi:10.1016/j.tox.2021.153067.
   PubMed Web of Science ®Google Scholar
• Gur C, Kandemir FM, Darendelioglu E, et al. Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways. Environ Sci Pollut Res. 2021 Sep;28(36):49808–49819. doi:10.1007/s11356-021-14049-4.
   PubMed Web of Science ®Google Scholar
• Huang X, Ma T, Chen X. Tributyltin inhibits development of pubertal Leydig cells in rats. Reprod Toxicol. 2022 Aug 1;111:49–58. doi:10.1016/j.reprotox.2022.04.004.
   PubMed Web of Science ®Google Scholar
• Andrade MN, Melo-Paiva FD, Teixeira MP, et al. Environmentally relevant dose of the endocrine disruptor tributyltin disturbs redox balance in female thyroid gland. Mol Cell Endocrinol. 2022 Aug 1;553:111689. doi:10.1016/j.mce.2022.111689.
   PubMed Web of Science ®Google Scholar
• Merlo E, Podratz PL, Sena GC, et al. The environmental pollutant tributyltin chloride disrupts the hypothalamic-pituitary-adrenal axis at different levels in female rats. Endocrinology. 2016 Aug 1;157(8):2978–2995. doi:10.1210/en.2015-1896.
   PubMed Web of Science ®Google Scholar
• Ahmed MG, Ibrahim ME, El-Sayed HR, Ahmed SM. Efficacy of green tea extract in tributyltin induced toxicity on the testes of adult albino rats. Adv Anim Vet Sci. 2021;9(1):1–4. doi:10.17582/journal.aavs/2021/9.1.1.14.
   Google Scholar
• Doridot L, Jeljeli M, Chêne C, Batteux F. Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity, and fibrosis. Redox Biol. 2019 Jul 1;25:101122. doi:10.1016/j.redox.2019.101122.
   PubMed Web of Science ®Google Scholar
• Ronconi KD, Stefanon I, Ribeiro Junior RF. Ribeiro Junior RF.Tributyltin, and vascular dysfunction: the role of oxidative stress. Front Endocrinol (Lausanne). 2018 Jul 12;9:354. doi:10.3389/fendo.2018.00354.
   PubMed Web of Science ®Google Scholar
• Ogedengbe OO, Jegede AI, Onanuga IO, et al. Adjuvant potential of virgin coconut oil extract on antiretroviral therapy‐induced testicular toxicity: an ultrastructural study. Andrologia. 2018 Apr;50(3):e12930. doi:10.1111/and.12930.
   Web of Science ®Google Scholar
• Mohamed D, Saber A, Omar A, Soliman A. Effect of cadmium on the testes of adult albino rats and the ameliorating effect of zinc and vitamin E. Br J Sci. 2014;11:72–94.
   Google Scholar
• Ramalingam V, Marcelline SO, Panneerdoss S, Suryavathi V. Influence of mercuric chloride on antioxidant system in the testis and epididymis of albino rats. In J Andrology. 46–47.
   Google Scholar
• Ibrahim WM, Oda SS, Khafaga AF. Pathological evaluation of the effect of zinc oxide nanoparticles on chromium-induced reproductive toxicity in male albino rats. Alex J Vet Sci. 2017 Jul 1;53(2):24. doi:10.5455/ajvs.251315.
   Google Scholar
• Zhang S, Jiang C, Liu H, et al. Fluoride-elicited developmental testicular toxicity in rats: roles of endoplasmic reticulum stress and inflammatory response. Toxicol Appl Pharmacol. 2013 Sep 1;271(2):206–215. doi:10.1016/j.taap.2013.04.033.
   PubMed Web of Science ®Google Scholar
• Karna KK, Shin YS, Choi BR, Kim HK, Park JK. The role of endoplasmic reticulum stress response in male reproductive physiology and pathology: a review. World J Mens Health. 2020 Oct;38(4):484. doi:10.5534/wjmh.190038.
   PubMedGoogle Scholar
• Kandemir FM, Caglayan C, Aksu EH, et al. Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats. Andrologia. 2020 Apr;52(3):e13524. doi:10.1111/and.13524.
   PubMed Web of Science ®Google Scholar
• Yardim A, Kandemir FM, Ozdemir S, et al. Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating Nrf2, Akt pathways. Neurotoxicology. 2020 Dec 1;81:137–146. doi:10.1016/j.neuro.2020.10.001.
   PubMed Web of Science ®Google Scholar
• Aksu EH, Kandemir FM, Küçükler S. The effects of hesperidin on colistin‐induced reproductive damage, autophagy, and apoptosis by reducing oxidative stress. Andrologia. 2021 Mar;53(2):e13900. doi:10.1111/and.13900.
   PubMed Web of Science ®Google Scholar
• Guazelli CFS, Fattori V, Ferraz CR, et al. Antioxidant and anti-inflammatory effects of hesperidin methyl chalcone in experimental ulcerative colitis. Chem Biol Interact. 2021 Jan 5;333:109315. doi:10.1016/j.cbi.2020.109315.
   PubMed Web of Science ®Google Scholar
• Hanchang W, Khamchan A, Wongmanee N, Seedadee C. Hesperidin ameliorates pancreatic β-cell dysfunction and apoptosis in streptozotocin-induced diabetic rat model. Life Sci. 2019 Oct 15;235:116858. doi:10.1016/j.lfs.2019.116858.
   PubMed Web of Science ®Google Scholar
• Parhiz H, Roohbakhsh A, Soltani F, Rezaee R, Iranshahi M. Antioxidant and anti‐inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models. Phytother Res. 2015 Mar;29(3):323–331. doi:10.1002/ptr.5256.
   PubMed Web of Science ®Google Scholar
• Estruel-Amades S, Massot-Cladera M, Garcia-Cerdà P, et al. Protective effect of hesperidin on the oxidative stress induced by an exhausting exercise in intensively trained rats. Nutrients. 2019 Apr 4;11(4):783. doi:10.3390/nu11040783.
   PubMed Web of Science ®Google Scholar
• Zhu C, Dong Y, Liu H, Ren H, Cui Z. Hesperetin protects against H2O2-triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells. Biomed Pharmacother. 2017 Apr 1;88:124–133. doi:10.1016/j.biopha.2016.11.089.
   PubMed Web of Science ®Google Scholar
• Man M-Q, Yang B, Elias PM. Benefits of hesperidin for cutaneous functions. Evid Based Complementary Altern Med. 2019 Apr 2;2019:1–19. doi:10.1155/2019/2676307.
   Web of Science ®Google Scholar
• Liu WY, Liou S-S, Hong T-Y, Liu I-M. Protective effects of hesperidin (citrus flavonone) on high glucose induced oxidative stress and apoptosis in a cellular model for diabetic retinopathy. Nutrients. 2017 Dec 2;9(12):1312. doi:10.3390/nu9121312.
   PubMed Web of Science ®Google Scholar
• Si J, Li P, Xin Q, Li X, An L, Li J. Perinatal exposure to low doses of tributyltin chloride reduces sperm count and quality in mice. Environ Toxicol. 2015 Jan;30(1):44–52. doi:10.1002/tox.21892.
   PubMed Web of Science ®Google Scholar
• Marques VB, Faria RA, Dos Santos L. Overview of the pathophysiological implications of organotins on the endocrine system. Front Endocrinol (Lausanne). 2018 Mar 16;9:101. doi:10.3389/fendo.2018.00101.
   PubMed Web of Science ®Google Scholar
• Mikac N, Turk MF, Petrović D, Bigović M, Krivokapić S. First assessment of butyltins (BuTs) contamination of the Montenegrin coast (Southeast Adriatic): tributyltin (TBT) poses a threat to the marine ecosystem. Mar Pollut Bull. 2022 Dec 1;185:114270. doi:10.1016/j.marpolbul.2022.114270.
   PubMed Web of Science ®Google Scholar
• Warford L, Mason C, Lonsdale J, et al. A reassessment of TBT action levels for determining the fate of dredged sediments in the United Kingdom. Mar Pollut Bull. 2022 Mar 1;176:113439. doi:10.1016/j.marpolbul.2022.113439.
   PubMed Web of Science ®Google Scholar
• Mitra S, Srivastava A, Khandelwal S. Tributyltin chloride induced testicular toxicity by JNK and p38 activation, redox imbalance and cell death in sertoli-germ cell co-culture. Toxicology. 2013;314(1):39–50. doi:10.1016/j.tox.2013.09.003.
   PubMed Web of Science ®Google Scholar
• Kim S-K, Kim J-H, Han JH, Yoon Y-D. Yoon YD.Inhibitory effect of tributyltin on expression of steroidogenic enzymes in mouse testis. Int J Toxicol. 2008;27(2):175–182. doi:10.1080/10915810801977906.
   PubMed Web of Science ®Google Scholar
• Binkowska I. Hesperidin: synthesis and characterization of bioflavonoid complex. SN Applied Sci. 2020 Mar;2(3):445. doi:10.1007/s42452-020-2256-8.
   Web of Science ®Google Scholar