A NEW CONCEPT IN THE STABILIZATION OF INJECTABLE FLUOROCARBON EMULSIONS: THE USE OF MIXED FLUOROCARBON-HYDROCARBON DOWELS.

REFERENCES

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• The RFRH dowels used in this study are easily prepared by classical procedures by addition of a perfluoroalkylated iodide to a terminal olefine, followed by dehydroiodation, according to a ) Tiers G.V.D., J. Org. Chem ., 27 , 2261 ( 1962 ); b) Brace N.O., J. Org. Chem., 37. 2429 (1972). Their structures both in the solid state and in binary mixtures with hydrocarbon liquids have been studied mainly by the group of Rabolt J.F., see for example Russell T.P., Rabolt J.F., Twieg R.J., Siemens R.L., Farmer B.L., Macromolecules, 19,1135–1143 (1986) and references herein .
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• Perfluorodecalin (Flutec PP5, FDC), was purchased from Imperial Smelting Chemicals Ltd ( Avonmouth , Bristol UK ). Perfluorooctylbromide was a gift from Atochem (Pierre-Bënite France) .
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• Egg yolk phospholipids were from Lipoïd KG (Ludwigshafen FRG) .
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• The emulsion's average particle sizes (± 10%) and size distributions were measured on a Horiba Capa 700 particle size analyzer based on light absorption during centrifugal sedimentation .
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• The composition for the PFOB reference emulsion (% w/v) was. PFOB, 90;EYP, 4; NaCl, 0.3; EDTACaNa2, 0.02; NaHP04-Na2P04, 35 mM; a-tocopherol, 0.002; H2O for injection, 47. The composition for the FDC reference emulsion (% w/v) was FDC, 100; EYP, 4.5; NaCl, 0.3; EDTACaNa2, 0.02; NaHPO4-Na2P04, 35 mM; a-tocopherol, 0.002; H2O for injection, 47. These formulation are typical for concentrated injectable fluorocarbon emulsions .
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• Tests performed at the Centre de Transfusion Sanguine des Alpes Maritimes .
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