Reviews of Science for Science Librarians: Alpha-Gal: The Curious Case of Ticks Whose Bite Induces Red Meat Allergies in Humans

References

• Abdallah, M. A., and E. A. Larson. 2018. Delayed anaphylaxis to mammalian meat: A fascinating disease and captivating story. South Dakota Medicine 71 (10):463–65.
   PubMedGoogle Scholar
• Anemüller, W., M. Mohr, R. Brans, A. Homann, and U. Jappe. 2018. Alpha-Gal-associated delayed red meat anaphylaxis as an occupational disease. Der Hautarzt 69 (10):848–52. doi:10.1007/s00105-018-4224-4.
   PubMed Web of Science ®Google Scholar
• Apostolovic, D., T. A. Tran, M. Starkhammar, S. Sanchez-Viddaurre, C. Hamsten, and M. Van Hage. 2016. The red meat allergy in Sweden. Allergology Journal International 25 (2):49–54. doi:10.1007/s40629-016-0098-0.
   PubMedGoogle Scholar
• Barbarroja-Escudero, J., M. J. Sanchez-Gonzalez, M. Rodriguez-Rodriguez, M. Castillo, and M. Alvarez-Mon. 2019. Role of creatine kinase as an allergen in immediate selective allergy to pork meat. Journal of Investigational Allergology and Clinical Immunology 29 (1):64. doi:10.18176/jiaci.0333.
   PubMed Web of Science ®Google Scholar
• Berg, E. A., T. A. Platts-Mills, and S. P. Commins. 2013. Drug allergens and food—The Cetuximab and galactose-α-1,3-galactose story. Annals of Allergy, Asthma & Immunology 112 (2):97–101. doi:10.1016/j.anai.2013.11.014.
   PubMed Web of Science ®Google Scholar
• Boese, J. L. 1972. Tissue reactions at site of attachment of chiggers. Journal of Medical Entomology 9 (6):59.
   Web of Science ®Google Scholar
• Bourne, H. C., P. Restani, M. Moutzouris, and C. H. Katelaris. 2005. An unusual pattern of meat allergy. Allergy 60 (5):706–07. doi:10.1111/all.2005.60.issue-5.
   PubMed Web of Science ®Google Scholar
• Brestoff, J. R., M. A. Zaydman, M. G. Scott, and A. M. Gronowski. 2017. Diagnosis of red meat allergy with antigen-specific IgE tests in serum. Journal of Allergy and Clinical Immunology 140 (2):608. doi:10.1016/j.jaci.2017.01.032.
   PubMed Web of Science ®Google Scholar
• Burgdorfer, W., A. G. Barbour, S. F. Hayes, J. L. Benach, E. Grunwaldt, and J. P. Davis. 1982. Lyme-disease - A tick-borne spirochetosis. Science 216 (4552):1317–19. doi:10.1126/science.7043737.
   PubMed Web of Science ®Google Scholar
• Burridge, M. J. 2011. Non-native and invasive ticks: Threats to human and animal health in the United States. Gainsville: University of Florida Press.
   Google Scholar
• Carter, M. C., K. N. Ruiz-Esteves, L. Workman, P. Lieberman, T. A. E. Platts-Mills, and D. D. Metcalfe. 2018. Identification of alpha-Gal sensitivity in patients with a diagnosis of idiopathic anaphylaxis. Allergy 73 (5):1131–34. doi:10.1111/all.13366.
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. 2018. Vaccine information statements. Chicken Pox. Varicella. Accessed February 12, 2018. https://www.cdc.gov/vaccines/hcp/vis/vis-statements/varicella.html.
   Google Scholar
• Chao, L. L., C. W. Lin, Y. F. Lin, and C. M. Shin. 2017. Molecular and morphological identification of a human biting tick. Amblyomma testudinarium (Acari: Ixodidae), in Taiwan. Experimental and Applied Acarology 71 (4):401–14. doi:10.1007/s10493-017-0119-9.
   PubMed Web of Science ®Google Scholar
• Chen, Y. J. M., S. M. Gunthart, W. J. Hawthorne, E. J. Salvaris, P. J. O’Connell, M. B. Nottle, A. J. d’Apice, P. J. Cowan, and M. Kearns-Jonker. 2014. Xenoantibody response to porcine islet cell transplantation using GTKO, CD55, CD59, and fucosyltransferase multiple transgenic donors. Xenotransplantation 21 (3):244–53. doi:10.1111/xen.12091.
   PubMed Web of Science ®Google Scholar
• Childs, J. E., and C. D. Paddock. 2003. The ascendancy of Amblyomma americanum as a vector of pathogens affecting humans in the United States. Annual Review of Entomology 48:307–37. doi:10.1146/annurev.ento.48.091801.112728.
   PubMed Web of Science ®Google Scholar
• Choudhary, S., O. I. Iweala, C. T. Addison, and S. P. Commins. 2019. Tick salivary extract induces alpha-Gal allergy in alpha-Gal deficient mice. Journal of Allergy and Clinical Immunology 143 (2 Supplement, Meeting Abstract 766):AB252–AB252. doi:10.1016/j.jaci.2018.12.771.
   Web of Science ®Google Scholar
• Chung, C. H., B. Mirakhur, E. Chan, Q. T. Le, J. Berlin, M. Morse, B. A. Murphy, A. Barbara, S. M. Satinover, J. Hosen, et al. 2008. Cetuximab-induced anaphylaxis and IgE specific for galactose-α-1,3-galactose. The New England Journal of Medicine 358 (11):1109–17. doi:10.1056/NEJMoa074943.
   PubMed Web of Science ®Google Scholar
• Commins, S. P., S. M. Satinover, J. Hoser, J. Mozena, L. Borish, B. D. Lewis, J. A. Woodfolk, and T. A. Platts-Mills. 2009. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. Journal of Allergy and Clinical Immunology 123 (2):426–33. doi:10.1016/j.jaci.2008.10.052.
   PubMed Web of Science ®Google Scholar
• Dumler, J. S., and J. S. Bakken. 1998. Human Ehrlichioses: Newly recognized infections transmitted by ticks. Annual Review of Medicine 49:201–13. doi:10.1146/annurev.med.49.1.201.
   PubMed Web of Science ®Google Scholar
• Dunkman, W. J., W. Rycek, and M. W. Manning. 2018. What does a red meat allergy have to do with anesthesia? Perioperative management of alpha-Gal syndrome. Anesthesia and Analgesia. doi:10.1213/ANE.0000000000003460.
   PubMedGoogle Scholar
• Edlow, J. A. 2003. Bull’s-eye: Unraveling the medical mystery of Lyme disease. New Haven: Yale University Press.
   Google Scholar
• Fischer, J., B. Eberlein, C. Hilger, F. Eyer, S. Eyerich, M. Ollert, and T. Biedermann. 2017. Alpha-Gal is a possible target of IgE-mediated reactivity to antivenom. Allergy 72 (5):764–71. doi:10.1111/all.13073.
   PubMed Web of Science ®Google Scholar
• Flaherty, M. G., S. J. Kaplan, and M. R. Jerath. 2017. Diagnosis of life-threatening alpha-Gal food allergy appears to be patient driven. Journal of Primary Care and Community Health 8 (4):345–48. doi:10.1177/2150131917705714.
   PubMed Web of Science ®Google Scholar
• Garcia-Menaya, J. M., C. Cordobes-Duran, J. Gomex-Ulla, M. A. Zambonino, A. C. Mahecha, G. M. Chiarella, N. Giangrande, and P. Bobadilla-Gonzales. 2016. Successful desensitization to cetuximab in a patient with a positive skin test to Cetuximab and specific IgE to alpha-Gal. Journal of Investigative Allergology and Clinical Immunology 26 (2):132–34. doi:10.18176/jiaci.0031.
   PubMed Web of Science ®Google Scholar
• Gray, J. S., A. Estrada-Peña, and A. Zintl. 2019. Vectors of Babesiosis. Annual Review of Entomology 64:149–65. doi:10.1146/annurev-ento-011118-111932.
   PubMed Web of Science ®Google Scholar
• Hamden, I., K. Kiernan, and M. Kearns-Jonker. 2010. The anti-nonGal xenoantibody response to alpha1,3-galactosyltransferase gene knockout pigxenografts. Current Opinion in Organ Transplanation 15 (2):207–11. doi:10.1097/MOT.0b013e328336b854.
   PubMed Web of Science ®Google Scholar
• Hamsten, C., M. Starkhammar, T. A. T. Tran, M. Johansson, U. Bengston, G. Ahlen, M. Sallberg, H. Gronlund, and M. van Hage. 2013. Identification of galactose‐α‐1,3‐galactose in the gastrointestinal tract of the tick Ixodes ricinus: Possible relationship with red meat allergy. Allergy 68:549–52. doi:10.1111/all.12128.
   PubMed Web of Science ®Google Scholar
• Han, G. D., M. Matsuno, G. Ito, Y. Ikeucht, and A. Suzuki. 2000. Meat allergy: Investigation of potential allergenic proteins in beef. Bioscience, Biotechnology, and Biochemistry 64 (9):1887–95. doi:10.1271/bbb.64.1887.
   PubMed Web of Science ®Google Scholar
• Harris, W. G., and E. C. Burns. 1972. Predation on the Lone Star Tick by the imported fire ant. Environmental Entomology 1 (3):362–65. doi:10.1093/ee/1.3.362.
   Google Scholar
• Hashizume, H., T. Fujiyama, T. Umayahara, R. Kageyama, A. F. Walls, and T. Satoh. 2018. Repeated Amblyomma testudinarium tick bites are associated with increased galactose-α-1,3-galactose carbohydrate Ige antibody levels: A retrospective cohort study in a single institution. Journal of the American Academy of Dermatology 78 (6):1135–1141.e3. doi:10.1016/j.jaad.2017.12.028.
   PubMed Web of Science ®Google Scholar
• Hilger, C., J. Fischer, F. Wölbing, and T. Biedermann. 2019. Role and mechanism of galactose-alpha-1,3-galactose in the elicitation of delayed anaphylactic reactions to red meat. Current Allergy and Asthma Reports 19 (1):3. doi:10.1007/s11882-019-0835-9.
   PubMed Web of Science ®Google Scholar
• Hoogstraal, H. 1981. Changing patterns of tickborne diseases in modern society. Annual Review of Entomology 26:75–99. doi:10.1146/annurev.en.26.010181.000451.
   PubMed Web of Science ®Google Scholar
• Iglesia, E. G. A., C. Stone, and S. P. Commins. 2019. Regional and temporal patterns of alpha-Gal allergy using google trends. Journal of Allergy and Clinical Immunology 143 (2 Supplement):AB161–AB161. Meeting Abstract 487. doi:10.1016/j.jaci.2018.12.490.
   Web of Science ®Google Scholar
• Jackson, W. L. 2018. Mammalian meat allergy following a tick bite: A case report. Oxford Medical Case Reports 2018 (2):omx098. doi:10.1093/omcr/omx098.
   PubMedGoogle Scholar
• Jappe, U., S. Minge, B. Kreft, A. Ludwig, B. Przybilla, A. Walker, R. Varga, P. Seidel, T. Biedrmann, W. Annemuller, et al. 2018. Meat allergy associated with galactosyl-α-(1,3)-galactose (α-Gal)-closing diagnostic gaps by anti-α-Gal Ige immune profiling. Allergy 73 (1):93–105. doi:10.1111/all.13238.
   PubMed Web of Science ®Google Scholar
• Jenkins, D. W. 1947. A laboratory method of rearing chiggers affecting man (Acarina: Trombiculidae). Annals of the Entomological Society of America 40 (1):56–68. doi:10.1093/aesa/40.1.56.
   Google Scholar
• Jongejan, F., and G. Uilenberg. 2004. The global importance of ticks. Parasitology 129 (Supplement):S3–S14. doi:10.1017/S0031182004005967.
   PubMedGoogle Scholar
• Kageyama, R., T. Fujiyama, T. Satoh, Y. Keneko, S. Kitano, Y. Tokura, and H. Hashizume. 2019 March. The contribution made by skin-infiltrating basophils to the development of alpha Gal Syndrome. Allergy. doi:10.1111/all.13794.
   PubMed Web of Science ®Google Scholar
• Khoury, J. K., N. C. Khoury, D. Schaefer, A. Chitnis, and G. W. Hassen. 2018. A tick-acquired red meat allergy. The American Journal of Emergency Medicine 36 (2):341.e1–341.e3. doi:10.1016/j.ajem.2017.10.044.
   PubMed Web of Science ®Google Scholar
• Kim, S. R., K. H. Park, J. H. Lee, B. J. Kim, J. H. Wang, K. J. Lim, and J. W. Park. 2019. Validation of Protia ™ Allergy-Q 64 Atopy ® as a specific IgE measurement assay for 10 major allergen components. Allergy, Asthma & Immunology Research 11 (3):422–32. doi:10.4168/aair.2019.11.3.422.
   PubMed Web of Science ®Google Scholar
• Kwak, M., C. Somerville, and S. van Nunen. 2018. A novel Australian tick Ixodes (Endopalpiger) australiensis inducing mammalian meat allergy after tick bite. Asia Pacific Allergy 8 (3):e31. doi:10.5415/apallergy.2018.8.e31.
   PubMed Web of Science ®Google Scholar
• Levin, M., D. Apostolovic, T. Biedermann, S. P. Commins, O. I. Iweala, T. A. E. Platts-Mills, E. Savi, M. van Hage, and J. M. Wilson. 2019 March. Alpha-Gal phenotypes- lessons from various patient populations. Annals of Allergy, Asthma & Immunology. doi:10.1016/j.anai.2019.03.021.
   Web of Science ®Google Scholar
• Lu, Y., A. Shao, Y. Shan, H. Zhao, M. Leiguo, Y. Zhang, Y. Tang, W. Zhang, Y. Jin, and L. Xu. 2018. A standardized quantitative method for detecting remnant alpha-Gal antigen in animal tissues or animal tissue-derived biomaterials and its application. Scientific Reports 8 (1):15424. doi:10.1038/s41598-018-32959-1.
   PubMedGoogle Scholar
• Mabelane, T., W. Basera, M. Botha, H. F. Thomas, J. Ramjith, and M. E. Levin. 2018. Predictive values of alpha-Gal IgE levels and alpha-Gal IgE: Total IgE ratio and oral food challenge-proven meat allergy in a population with a high prevalence of reported red meat allergy. Pediatric Allergy and Immunology 29 (8):841–49. doi:10.1111/pai.12969.
   PubMed Web of Science ®Google Scholar
• Mateo-Borrega, M. B., B. Garcia, C. Hernando Larramendi, J. Azofra, E. González-Mancebo, M. I. Alvarado, M. D. Alonso Díaz de Durana, R. Núñez-Orjales, M. C. Diéguez, M. Guilarte, et al. 2019, January. IgE-mediated sensitization to galactose-alpha-1,3-galactose (α-Gal) in urticaria and anaphylaxis in Spain: geographical variations and risk factors. Journal of Investigational Allergology and Clinical Immunology. 29. doi:10.18176/jiaci.0373.
   Google Scholar
• Mehlich, J., J. Fischer, C. Hilger, K. Swiontek, M. Morisset, F. Codreanu-Morel, M. Schiener, S. Blank, M. Ollert, U. Darsow, et al. 2019. The basophil activation test differentiates between patients with alpha-Gal syndrome and asymptomatic alpha-Gal sensitization. The Journal of Allergy and Clinical Immunology 143 (1):182–89. doi:10.1016/j.jaci.2018.06.049.
   PubMed Web of Science ®Google Scholar
• Melvin, R. 1946. A note on the culturing of chiggers (Trombiculidae). Annals of the Entomological Society of America 39 (1):143–44. doi:10.1093/aesa/39.1.143.
   Google Scholar
• Nuttall, P. A., and M. Labuda. 2008. Saliva-assisted transmission of tick-borne pathogens. In Ticks: Biology, disease, and control, ed. A. S. Bowman and P. A. Nuttall, 205–52. Cambridge, UK: Cambridge University Press, UK.
   Google Scholar
• Parola, P., C. D. Paddock, and D. Raoult. 2005. Tick-borne rickettsioses around the world: Emerging diseases challenging old concepts. Clinical Microbiology Reviews 18 (4):719–56. doi:10.1128/CMR.18.4.719-756.2005.
   PubMed Web of Science ®Google Scholar
• Piesman, J., and L. Eisen. 2008. Prevention of tick-borne diseases. Annual Review of Entomology 53:323–43. doi:10.1146/annurev.ento.53.103106.093429.
   PubMed Web of Science ®Google Scholar
• Pinson, M. L., and K. H. Waibel. 2015. Safe administration of a gelatin-containing vaccine in an adult with Galctose-alpha-1,3 Galactose allergy. Vaccine 33 (10):1231–32. doi:10.1016/j.vaccine.201501.020.
   PubMed Web of Science ®Google Scholar
• Platts-Mills, T. A. E., M. K. C. Retterer, L. Workman, and J. M. Wilson. 2019. A consistent “shortage” of cases of the alpha-Gal syndrome (AS) on the Gulf coast: Possible relevance of fire ants as a predator of lone star ticks. Journal of Allergy and Clinical Immunology 143 (Supplement 2):AB278–AB278. Meeting Abstract: 845. doi:10.1016/j.jaci.2018.12.850.
   Web of Science ®Google Scholar
• Platts-Mills, T. A. E., A. J. Schuyler, S. P. Commins, T. K. Merritt, E. E. McGintee, H. James, L. J. Workman, and J. M. Wilson. 2018. Characterizing the geographic distribution of the alpha-Gal syndrome: Relevance to Lone Star Ticks (Amblyomma americanum) and rickettsia. Journal of Allergy and Clinical Immunology 141 ((2)Supplement):AB147. doi:10.1016/j.jaci.2017.12.470.
   Web of Science ®Google Scholar
• Posthumus, J., H. R. James, C. J. Lane, L. A. Matos, T. A. E. Platts-Mills, and S. P. Commins. 2013. Initial description of pork-cat syndrome in the United States. Journal of Allergy and Clinical Immunology 131 (3):923–25. doi:10.1016/j.jaci.2012.12.665.
   PubMed Web of Science ®Google Scholar
• Sandrin, M. S., and I. F. McKenzie. 1994. Gal alpha-(1,3)Gal, the major xenoantigen(s) recognised in pigs by human natural antibodies. Immunological Reviews 141:169–90.
   PubMed Web of Science ®Google Scholar
• Sauer, J. R., J. L. McSwain, A. S. Bowman, and R. C. Essenberg. 1995. Tick salivary gland physiology. Annual Review of Entomology 40:245–67. doi:10.1146/annurev.en.40.010195.001333.
   PubMed Web of Science ®Google Scholar
• Shatrov, A. B. 1991. Functional-morphology of alveolar salivary-glands of active phases of the life-cycle of trombiculid mites (Acariformes, Trombiculidae). Zoologichesky Zhurnal 70 (2):13–21.
   Web of Science ®Google Scholar
• Shatrov, A. B. M., H. Takahashi, H. Misumi, and Y. Takahashi. 2016. Mouthparts in Leptotrombidium larvae (Acariformes: Trombiculidae). Journal of Morphology 277 (4):424–44. doi:10.1002/jmor.20508.
   PubMed Web of Science ®Google Scholar
• Steinke, J. W., T. A. Platts-Mills, and S. P. Commons. 2015a. The alpha-Gal story: Lessons learned from connecting the dots. Journal of Allergy and Clinical Immunology 135 (3):589–96. doi:10.1016/j.jaci.2014.12.1947.
   PubMed Web of Science ®Google Scholar
• Steinke, J. W., T. A. E. Platts-Mills, A. Schuyler, and S. P. Commins. 2015b. The common food additive carrageenan and the alpha-Gal epitope. Journal of Allergy and Clinical Immunology 136 (6):1709. doi:10.1016/j.jaci.2015.04.010.
   PubMed Web of Science ®Google Scholar
• Stoltz, L. P., L. M. Cristiano, A. P. G. Dowling, J. M. Wilson, T. A. E. Platts-Mills, and R. S. Traister. 2019. Could chiggers be contributing to the prevalence of galactose-Alpha-1,3-galactose sensitization and mammalian meat allergy? The Journal of Allergy and Clinical Immunology in Practice 7 (2):664–66. doi:10.1016/j.jaip.2018.07.014.
   PubMed Web of Science ®Google Scholar
• Stone, C. A., S. P. Commins, S. Choudhary, C. Vethody, J. L. Heavrin, J. Wingerter, J. A. Hemler, K. Babe, E. J. Phillips, and A. E. Norton. 2019. Anaphylaxis after vaccination in a pediatric patient: Further implicating alpha-Gal allergy. The Journal of Allergy and Clinical Immunology in Practice 7 (1):322–324.e2. doi:10.1016/j.jaip.2018.06.005.
   PubMed Web of Science ®Google Scholar
• Stone, C. A., J. A. Hemler, S. P. Commins, A. J. Schuyler, E. J. Phillips, R. S. Peebles, and J. M. Fahrenholz. 2017. Anaphylaxis after zoster vaccine: Implicating alpha-Gal allergy as a possible mechanism. The Journal of Allergy and Clinical Immunology 139 (5):1710–1713.e2. doi:10.1016/j.jaci.2016.10.037.
   PubMed Web of Science ®Google Scholar
• Theler, B., K. Brockow, and B. K. Ballmer-Weber. 2009. Clinical presentation and diagnosis of meat allergy in Switzerland and Southern Germany. Swiss Medical Weekly 139 (17–18):264–70. smw-12603.
   PubMed Web of Science ®Google Scholar
• Tobacman, J. K. 2015. The common food additive carrageenan and the alpha-Gal epitope. Journal of Allergy and Clinical Immunology 136 (6):1708–09. doi:10.1016/j.jaci.2015.08.048.
   PubMed Web of Science ®Google Scholar
• Van Nunen, S. A., K. S. O’Connor, L. R. Clarke, R. X. Boyle, and S. L. Fernando. 2009. An association between tick bite reactions and red meat allergy in humans. The Medical Journal of Australia 190 (9):510–11.
   PubMed Web of Science ®Google Scholar
• Weins, A. B., B. Eberlein, and T. Biedermann. 2019. Diagnostics of alpha-Gal syndrome. Current standards, pitfalls and perspectives. Hautarzt 70 (1):36–43. doi:10.1007/s00105-018-4288-1.
   PubMed Web of Science ®Google Scholar
• Whiteley, P. E., and S. A. Dalrymple. 1998. Current protocols in pharmacology. 5.4.1–5.4.3. Hoboken, NJ: John Wiley & Sons, Inc.
   Google Scholar
• Wilson, J. M., and T. A. E. Platts-Mills. 2018. Meat allergy and allergens. Molecular Immunology 100:107–12. doi:10.1016/j.molimm.2018.03.018.
   PubMed Web of Science ®Google Scholar
• Wilson, J. M., A. J. Schuyler, L. Workman, M. Gupta, H. R. James, J. Posthumus, E. C. McGowan, S. P. Commins, and T. A. E. Platts-Mills. 2019 March. Investigation into the α-Gal syndrome: Characteristics of 261 children and adults reporting red meat allergy. The Journal of Allergy and Clinical Immunology in Practice. doi:10.1016/j.jaip.2019.03.031.
   Web of Science ®Google Scholar
• Wong, X. L., and D. F. Sebaratnam. 2018. Mammalian meat allergy. International Journal of Dermatology 57 (12):1433–36. doi:10.1111/ijd.14208.
   PubMed Web of Science ®Google Scholar
• Yoder, J. A., R. J. Pollack, and A. Spielman. 1993. An ant-diversionary secretion of ticks: First demonstration of an acarine allomone. Journal of Insect Physiology 39 (5):429–35. doi:10.1016/0022-1910(93)90031-L.
   Web of Science ®Google Scholar