The Recognition of Proteins and Peptides by Antibodies

References

• Al Moudallal , Z. , Briand , J. P. and Van Regenmortel , M. H. V. 1982 . Monoclonal antibodies as probes of the antigenic structure of tobacco mosaic virus . EMBO J. , 1 : 1005 – 1010 .
   PubMed Web of Science ®Google Scholar
• Al Moudallal , Z. , Briand , J. F. and Van Regenmortel , M. H. V. 1985 . A major part of the polypeptide chain of tobacco mosaic virus protein is antigenic . EMBO J. , 4 : 1231 – 1235 .
   PubMed Web of Science ®Google Scholar
• Alexander , H. , Alexander , S. , Getzoff , E. D. , Tainer , J. A. , Geysen , H. M. and Lerner , R. A. 1992 . Altering the antigenicity of proteins . Proc. Natl. Acad. Sci. USA , 89 : 3352 – 3356 .
   PubMed Web of Science ®Google Scholar
• Altschuh , D. and Van Regenmortel , M. H. V. 1982 . Localization of antigenic determinants of a viral protein by inhibition of enzyme-linked immunosorbent assay (ELISA) with tryptic peptides . J. Immunol. Methods , 50 : 99 – 108 .
   PubMed Web of Science ®Google Scholar
• Amit , A. G. , Mariuzza , R. A. , Phillips , S. E. V. and Poljak , R. J. 1986 . Three-dimensional structure of an antigen-antibody complex at 2.8 Å resolution . Science , 233 : 747 – 753 .
   PubMed Web of Science ®Google Scholar
• Anderer , F. A. and Schlumberger , H. D. 1965 . Properties of different artificial antigens immunologically related to tobacco mosaic virus . Biochim. Biophys. Acta , 97 : 503 – 509 .
   PubMed Web of Science ®Google Scholar
• Anderer , F. A. and Schlumberger , H. D. 1966 . Cross-reactions of antisera against the terminal amino acid and dipeptide of tobacco mosaic virus . Biochim. Biophys. Acta , 115 : 222 – 224 .
   PubMed Web of Science ®Google Scholar
• Arnon , R. and Van Regenmortel , M. H. V. 1992 . Structural basis of antigenic specificity and design of new vaccines . FASEB J. , 6 : 3265 – 3274 .
   PubMed Web of Science ®Google Scholar
• Arnon , R. , Maron , E. , Sela , M. and Anfinsen , C. B. 1971 . Antibodies reactive with native lysozyme elicited by a completely synthetic antigen . Proc. Natl. Acad. Sci. USA , 68 : 1450 – 1455 .
   PubMed Web of Science ®Google Scholar
• Atassi , M. Z. 1975 . Antigenic structure of myoglobin: The complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins . Immunochemistry , 12 : 423 – 438 .
   PubMedGoogle Scholar
• Atassi , M. Z. 1977 . Immunochemistry of Proteins , Edited by: Atassi , M. Z. 1 – 161 . New York : Plenum Press .
   Google Scholar
• Atassi , M. Z. 1984 . Antigenic structures of proteins. Their determination has revealed important aspects of immune recognition and generated strategies for synthetic mimicking of protein binding sites . Eur. J. Biochem. , 145 : 1 – 20 .
   PubMedGoogle Scholar
• Atassi , M. Z. and Lee , C. 1978 . The precise and entire antigenic structure of native lysozyme . Biochem. J. , 171 : 429 – 434 .
   PubMed Web of Science ®Google Scholar
• Atassi , M. Z. and Smith , J. A. 1978 . A proposal for the nomenclature of antigenic sites in peptides and proteins . Immunochemistry , 15 : 609 – 610 .
   PubMedGoogle Scholar
• Atherton , E. and Sheppard , R. C. 1989 . Solid Phase Peptide Synthesis. A Practical Approach , 203 Oxford : IRL Press .
   Google Scholar
• Bahraoui , E. , El Ayeb , M. , Granier , C. and Rochat , H. 1987 . Immunochemistry of scorpion toxins. Immunogenicity of peptide 19–28 a model of an accessible and relatively rigid region . Eur. J. Biochem. , 167 : 371 – 375 .
   PubMedGoogle Scholar
• Benjamin , D. C. , Berzofsky , J. A. , East , I. J. , Gurd , F. R. N. , Hannum , C. , Leach , S. J. , Margoliash , E. , Michael , J. G. , Miller , A. , Prager , E. M. , Reichlin , M. , Sercaz , E. E. , Smith-Gill , S. J. , Todd , P. E. and Wilson , A. C. 1984 . The antigenic structure of proteins: A reappraisal . Annu. Rev. Immunol. , 2 : 67 – 101 .
   PubMed Web of Science ®Google Scholar
• Benjamin , D. C. , Williams , D. C. , Smith-Gill , S. J. and Rule , G. S. 1992 . Long-range changes in a protein antigen due to antigen-antibody interaction . Biochemistry , 31 : 9539 – 9545 .
   PubMed Web of Science ®Google Scholar
• Benjamini , E. 1977 . Immunochemistry of Proteins , Edited by: Atassi , M. Z. 265 – 310 . New York : Plenum Press .
   Google Scholar
• Bentley , G. A. , Boulot , G. , Riottot , M. M. and Poljak , R. J. 1990 . Three-dimensional structure of an idiotope-anti-idiotope complex . Nature , 348 : 254 – 257 .
   PubMed Web of Science ®Google Scholar
• Berzofsky , J. A. 1984 . Monoclonal and Anti-ldiotypic Antibodies: Probes for Receptor Structure and Function , Edited by: Venter , J. C. , Fraser , C. M. and Lindstrom , J. 1 – 19 . New York : Alan R. Liss .
   Google Scholar
• Berzofsky , J. A. 1985 . Intrinsic and extrinsic factors in protein antigenic structure . Science , 229 : 932 – 940 .
   PubMed Web of Science ®Google Scholar
• Berzofsky , J. A. , Buckenmeyer , G. K. , Hicks , G. , Gurd , F. R. N. , Feldmann , R. J. and Minna , J. 1982 . Topographic antigenic determinants recognized by monoclonal antibodies to sperm whale myoglobin . J. Biol. Chem. , 257 : 3189 – 3198 .
   PubMed Web of Science ®Google Scholar
• Bhat , T. N. , Bentley , G. A. , Fischmann , T. O. , Boulot , G. and Poljak , R. J. 1990 . Small rearrangements in structures of Fv and Fab fragments of antibody D1.3 on antigen binding . Nature , 347 : 483 – 485 .
   PubMed Web of Science ®Google Scholar
• Bittle , J. L. , Houghten , R. A. , Alexander , H. , Shinnick , T. , Sutcliffe , J. G. , Lerner , R. A. , Rowlands , D. J. and Brown , F. 1982 . Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence . Nature , 298 : 30 – 33 .
   PubMed Web of Science ®Google Scholar
• Blondel , B. , Crainic , R. , Fichot , O. , Dufraisse , G. , Candrea , A. , Diamond , D. , Girard , M. and Horaud , F. 1986 . Mutations conferring resistance to neutralization with monoclonal antibodies in type 1 poliovirus can be located outside or inside the antibody-binding site . J. Virol. , 57 : 81 – 90 .
   PubMed Web of Science ®Google Scholar
• Boersma , W. J. A. , Haaijman , J. J. and Claassen , E. 1993 . Immunohislochemistry , Edited by: Cuello , A. C. 1 – 77 . Chichester, , UK : Wiley & Sons . II
   Google Scholar
• Boulain , J.-C. , Menez , A. , Couderc , J. , Faure , G. , Liacopoulos , P. and Fromageot , P. 1982 . Neutralizing monoclonal antibody specific for Naja nigricollis toxin a: Preparation, characterization, and localization of the antigenic binding site . Biochemistry , 21 : 2910 – 2915 .
   PubMed Web of Science ®Google Scholar
• Briand , J. P. , Muller , S. and Van Regenmortel , M. H. V. 1985 . Synthetic peptides as antigens: Pitfalls of conjugation methods . J. Immunol. Methods , 78 : 59 – 69 .
   PubMed Web of Science ®Google Scholar
• Briand , J. P. , Barin , C. , Van Regenmortel , M. H. V. and Muller , S. 1992 . Application and limitations of the multiple antigen peptide (MAP) system in the production and evaluation of antipeptide and antiprotein antibodies . J. Immunol. Methods , 156 : 255 – 265 .
   PubMed Web of Science ®Google Scholar
• Broekhuijsen , M. P. , Van Rijn , J. N. M. , Blom , A. J. M. , Pouwels , P. H. , Enger-Valk , B. E. , Brown , F. and Francis , M. J. 1987 . Fusion proteins with multiple copies of the antigenic determinant of foot-and-mouth disease virus protect both the natural host and laboratory animals . J. Gen. Virol. , 68 : 3137 – 3143 .
   PubMed Web of Science ®Google Scholar
• Burke , K. L. , Evans , D. J. , Jenkins , O. , Meredith , J. , D'Souza , E. D. A. and Almond , J. W. 1989 . A cassette vector for the construction of antigen chimaeras of poliovirus . J. Gen. Virol. , 70 : 2475 – 2479 .
   PubMed Web of Science ®Google Scholar
• Burnens , A. , Demotz , S. , Corradin , G. , Binz , H. and Bosshard , H. R. 1987 . Epitope mapping by chemical modification of free and antibody-bound protein antigen . Science , 235 : 780 – 783 .
   PubMed Web of Science ®Google Scholar
• Cesareni , G. 1992 . Peptide display on filamentous phage capsids. A new powerful tool to study proteinligand interaction . FEBS Lett. , 307 : 66 – 70 .
   PubMed Web of Science ®Google Scholar
• Charbit , A. , Sobczak , E. , Michel , M. L. , Molla , A. , Tiollais , P. and Hofnung , M. 1987 . Presentation of two epitopes of the preS2 region of hepatitis B virus on live recombinant bacteria . J. Immunol. , 139 : 1658 – 1664 .
   PubMed Web of Science ®Google Scholar
• Chien , N. C. , Roberts , V. A. , Giusti , A. M. , Scharff , M. D. and Getzoff , E. D. 1989 . Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: Proposal of a structural mechanism . Proc. Natl. Acad. Sci. USA , 86 : 5532 – 5536 .
   PubMed Web of Science ®Google Scholar
• Chong , P. , Sydor , M. , Wu , E. and Klein , M. 1992 . Resin-bound synthetic peptides: Use as antigens and immunogens . Mol. Immunol. , 29 : 443 – 446 .
   PubMed Web of Science ®Google Scholar
• Christian , R. B. , Zuckermann , R. N. , Kerr , J. M. , Wang , L. and Malcolm , B. A. 1992 . Simplified methods for construction, assessment and rapid screening of peptide libraries in bacteriophage . J. Mol. Biol. , 227 : 711 – 718 .
   PubMed Web of Science ®Google Scholar
• Collawn , J. F. , Wallace , C. J. A. , Proudfoot , A. E. I. and Paterson , Y. 1988 . Monoclonal antibodies as probes of conformational changes in protein-engineered cytochrome c . J. Biol. Chem. , 263 : 8625 – 8634 .
   PubMed Web of Science ®Google Scholar
• Colman , P. M. 1988 . Structure of antibody-antigen complexes: Implications for immune recognition . Adv. Immunol. , 43 : 99 – 132 .
   PubMed Web of Science ®Google Scholar
• Colman , P. M. , Laver , W. G. , Varghese , J. N. , Baker , A. T. , Tulloch , P. A. , Air , G. M. and Webster , R. G. 1987 . Three-dimensional structure of a complex of antibody with influenza virus neuraminidase . Nature , 326 : 358 – 363 .
   PubMed Web of Science ®Google Scholar
• Cooper , H. M. , Jemmerson , R. , Hunt , D. F. , Griffin , R. , Yates , J. R. , Shabanowitz , J. , Zhu , N. Z. and Paterson , Y. 1987 . Site-directed chemical modification of horse cytochrome c results in changes in antigenicity due to local and long-range conformational perturbations . J. Biol. Chem. , 262 : 11591 – 11597 .
   PubMed Web of Science ®Google Scholar
• Crumpton , M. J. 1986 . Synthetic peptides as antigens . Ciba Found. Symp. , 119 : 93 – 106 .
   PubMedGoogle Scholar
• Cunningham , B. C. and Wells , J. A. 1989 . High resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis . Science , 244 : 1081 – 1085 .
   PubMed Web of Science ®Google Scholar
• Cwirla , S. E. , Peters , E. A. , Barrett , R. W. and Dower , W. J. 1990 . Peptides on phage: A vast library of peptides for identifying ligands . Proc. Natl. Acad. Sci. USA , 87 : 6378 – 6382 .
   PubMed Web of Science ®Google Scholar
• Darst , S. A. , Robertson , C. R. and Berzofsky , J. A. 1988 . Adsorption of the protein antigen myoglobin affects the binding of conformation-specific monoclonal antibodies . Biophys. J. , 53 : 533 – 539 .
   PubMed Web of Science ®Google Scholar
• Davies , D. R. , Padlan , E. A. and Sheriff , S. 1990 . Antibody-antigen complexes . Annu. Rev. Biochem. , 59 : 439 – 473 .
   PubMed Web of Science ®Google Scholar
• Delpeyroux , F. , Van Wezel , E. , Blondel , B. and Crainic , R. 1990 . Structural factors modulate the activity of antigenic poliovirus sequences expressed on hybrid hepatitis B surface antigen particles . J. Virol. , 64 : 6090 – 6100 .
   PubMed Web of Science ®Google Scholar
• Devlin , J. J. , Panganiban , L. C. and Devlin , P. E. 1990 . Random peptide libraries: A source of specific protein binding molecules . Science , 249 : 404 – 406 .
   PubMed Web of Science ®Google Scholar
• Dubs , M. C. , Altschuh , D. and Van Regenmortel , M. H. V. 1992 . Mapping of viral epitopes with conformationally specific monoclonal antibodies using biosensor technology . J. Chromatogr. , 597 : 127 – 148 .
   Web of Science ®Google Scholar
• Dyrberg , T. and Oldstone , M. B. A. 1986 . Peptides as antigens. Importance of orientation . J. Exp. Med. , 164 : 1344 – 1349 .
   PubMed Web of Science ®Google Scholar
• Dyson , H. J. , Lerner , R. A. and Wright , P. E. 1988 . The physical basis for induction of protein-reactive antipeptide antibodies . Annu. Rev. Biophys. Biophys. Chem. , 17 : 305 – 324 .
   PubMedGoogle Scholar
• Emini , E. A. , Hughes , J. V. , Perlow , D. S. and Boger , J. 1985 . Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide . J. Virol. , 55 : 836 – 839 .
   PubMed Web of Science ®Google Scholar
• Fagerstam , L. G. , Frostell , A. , Karlsson , R. , Kullman , M. , Larsson , A. , Malmqvist , M. and Butt , H. 1990 . Detection of antigen-antibody interactions by surface plasmon resonance. Application to epitope mapping . J. Mol. Recognition , 3 : 208 – 214 .
   PubMedGoogle Scholar
• Fersht , A. R. , Shi , J.-P. , Knill-Jones , J. , Lowe , D. M. , Wilkinson , A. J. , Blow , D. M. , Brick , P. , Carter , P. , Waye , M. M. Y. and Winter , G. 1985 . Hydrogen bonding and biological specificity analysed by protein engineering . Nature , 314 : 235 – 238 .
   PubMed Web of Science ®Google Scholar
• Fieser , T. M. , Tainer , J. A. , Geysen. , H. M. and Houghten , R. A. 1987 . Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein alpha-helix . Proc. Natl. Acad. Sci. USA , 84 : 8568 – 8572 .
   PubMed Web of Science ®Google Scholar
• Fischmann , T. O. , Bentley , G. A. , Bhat , T. N. , Boulot , G. , Mariuzza , R. A. , Phillips , S. E. V. , Tello , D. and Poljak , R. J. 1991 . Crystallographic refinement of the three-dimensional structure of the FabD1.3-lysozyme complex at 2.5-Å resolution . J. Biol. Chem. , 266 : 12915 – 12920 .
   PubMed Web of Science ®Google Scholar
• Fourquet , P. , Bahraoui , E. , Fontecilla-Camps , J. C. , Van Rietschoten , J. , Rochat , H. and Granier , C. 1988 . Immunochemistry of scorpion toxins. Synthesis and antigenic properties of a model of a loop region specific to alpha-toxins . Int. J. Peptide Protein Res. , 32 : 81 – 88 .
   PubMedGoogle Scholar
• Francis , M. J. , Clarke , B. E. , Hastings , G. Z. , Brown , A. L. , Rowlands , D. J. and Brown , F. 1990 . Vaccines 90. Modern Approaches to New Vaccines Including Prevention of AIDS , Edited by: Brown , F. , Chanock , R. M. , Ginsberg , H. S. and Lerner , R. A. 179 – 185 . Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press .
   Google Scholar
• Friguet , B. , Djavadi-Ohaniance , L. and Goldberg , M. E. 1984 . Some monoclonal antibodies raised with a native protein bind preferentially to the denatured antigen . Mol. Immunol. , 21 : 673 – 677 .
   PubMed Web of Science ®Google Scholar
• Frison , E. A. and Stace-Smith , R. 1992 . Cross-reacting and heterospecific monoclonal antibodies produced against Arabis mosaic nepovirus . J. Gen. Virol. , 73 : 2525 – 2530 .
   PubMed Web of Science ®Google Scholar
• Geerligs , H. J. , Weijer , W. J. , Bloemhoff , W. , Welling , G. W. and Welling-Wester , S. 1988 . The influence of pH and ionic strength on the coating of peptides of herpes simplex virus type 1 in an enzyme-linked immunosorbent assay . J. Immunol. Methods , 106 : 239 – 244 .
   PubMed Web of Science ®Google Scholar
• Getzoff , E. D. , Geysen , H. M. , Rodda , S. J. , Alexander , H. , Tainer , J. A. and Lerner , R. A. 1987 . Mechanisms of antibody binding to a protein . Science , 235 : 1191 – 1196 .
   PubMed Web of Science ®Google Scholar
• Geysen , H. M. 1985 . Antigen-antibody interactions at the molecular level: Adventures in peptide synthesis . Immunol. Today , 6 : 364 – 369 .
   PubMedGoogle Scholar
• Geysen , H. M. , Meloen , R. H. and Barteling , S. J. 1984 . Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid . Proc. Natl. Acad. Sci. USA , 81 : 3998 – 4002 .
   PubMed Web of Science ®Google Scholar
• Geysen , H. M. , Rodda , S. J. and Mason , T. J. 1986 . A priori delineation of a peptide which mimics a discontinuous antigenic determinant . Mol. Immunol. , 23 : 709 – 715 .
   PubMedGoogle Scholar
• Geysen , H. M. , Rodda , S. J. , Mason , T. J. , Tainer , J. A. , Alexander , H. , Getzoff , E. D. and Lerner , R. A. 1987a . Antigenicity of myohemerythrin . Science , 238 : 1584 – 1586 .
   PubMed Web of Science ®Google Scholar
• Geysen , H. M. , Rodda , S. J. , Mason , T. J. , Tribbick , G. and Schoofs , P. G. 1987b . Strategies for epitope analysis using peptide synthesis . J. Immunol. Methods , 102 : 259 – 274 .
   PubMed Web of Science ®Google Scholar
• Geysen , H. M. , Mason , T. J. and Rodda , S. J. 1988 . Cognitive features of continuous antigenic determinants . J. Mol. Recognition , 1 : 32 – 41 .
   PubMedGoogle Scholar
• Gras-Masse , H. , Jolivet , M. , Drobecq , H. , Aubert , J. P. , Beachey , E. H. , Audibert , F. , Chedid , L. and Tartar , A. 1988 . Influence of helical organization on immunogenicity and antigenicity of synthetic peptides . Mol. Immunol. , 25 : 673 – 678 .
   PubMed Web of Science ®Google Scholar
• Greenspan , N. S. 1992 . Epitopes, paratopes and other topes: Do immunologists know what they are talking about? . Bull. Inst. Pasteur , 90 : 267 – 279 .
   Google Scholar
• Greenwood , J. , Willis , A. E. and Perham , R. N. 1991 . Multiple display of foreign peptides on a filamentous bacteriophage. Peptides from Plasmodium falciparum circumsporozoite protein as antigens . J. Mol. Biol. , 220 : 821 – 827 .
   PubMed Web of Science ®Google Scholar
• Harper , M. , Lema , F. , Boulot , G. and Poljak , R. J. 1987 . Antigen specificity and cross-reactivity of monoclonal anti-lysozyme antibodies . Mol. Immunol. , 24 : 97 – 108 .
   PubMed Web of Science ®Google Scholar
• Hodges , R. S. , Heaton , R. J. and Parker , J. M. 1988 . Antigen—antibody interaction. Synthetic peptides define linear antigenic determinants recognized by monoclonal antibodies directed to the cytoplasmic carboxyl terminus of rhodopsin . J. Biol. Chem. , 263 : 11768 – 11775 .
   PubMed Web of Science ®Google Scholar
• Hofnung , M. 1991 . Methods in Cell Biology , Edited by: Tartakoff , A. M. 77 – 105 . New York : Academic Press .
   Google Scholar
• Hofnung , M. and Charbit , A. 1993 . Structure of Antigens , Edited by: V , M. H. and Van Regenmortel . Vol. 2 , 79 – 128 . Boca Raton : CRC Press .
   Google Scholar
• Hopp , T. P. 1986 . Protein surface analysis. Methods for identifying antigenic determinants and other interaction sites . J. Immunol. Methods , 88 : 1 – 18 .
   PubMed Web of Science ®Google Scholar
• Hopp , T. P. , Prickett , K. S. , Price , V. L. , Libby , R. T. , March , C. J. , Cerretti , D. P. , Urdal , D. L. and Conlon , P. J. 1988 . A short polypeptide marker sequence useful for recombinant protein identification and purification . Biotechnology , 6 : 1204 – 1210 .
   Web of Science ®Google Scholar
• Hornbeck , P. V. and Wilson , A. C. 1984 . Local effects of amino acid substitutions on the active site region of lysozyme: A comparison of physical and immunological results . Biochemistry , 23 : 998 – 1002 .
   PubMed Web of Science ®Google Scholar
• Houghten , R. A. 1985 . General method for the rapid solid-phase synthesis of large numbers of peptides; Specificity of antigen-antibody interaction at the level of individual amino acids . Proc. Natl. Acad. Sci. USA , 82 : 5131 – 5135 .
   PubMed Web of Science ®Google Scholar
• Houghten , R. A. , Pinilla , C. , Blondelle , S. E. , Appel , J. R. , Dooley , C. T. and Cuervo , J. H. 1991 . Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery . Nature , 354 : 84 – 86 .
   PubMed Web of Science ®Google Scholar
• Houghten , R. A. , Appel , J. R. , Blondelle , S. E. , Cuervo , J. H. , Dooley , C. T. and Pinilla , C. 1992 . The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides . Peptide Res. , 5 : 351 – 358 .
   Google Scholar
• Jemmerson , R. 1987 . Antigenicity and native structure of globular proteins: Low frequency of peptide reactive antibodies . Proc. Natl. Acad. Sci. USA , 84 : 9180 – 9184 .
   PubMed Web of Science ®Google Scholar
• Jemmerson , R. and Blankenfeld , R. 1989 . Affinity consideration in the design of synthetic vaccines intended to elicit antibodies . Mol. Immunol. , 26 : 301 – 307 .
   PubMed Web of Science ®Google Scholar
• Jemmerson , R. and Hutchinson , R. M. 1990 . Fine manipulation of antibody affinity for synthetic epitopes by altering peptide structure: Antibody binding to looped peptides . Eur. J. Immunol. , 20 : 579 – 585 .
   PubMed Web of Science ®Google Scholar
• Jemmerson , R. and Paterson , Y. 1986 . Mapping epitopes on a protein antigen by the proteolysis of antigen-antibody complexes . Science , 232 : 1001 – 1004 .
   PubMed Web of Science ®Google Scholar
• Jin , L. , Fendly , B. M. and Wells , J. A. 1992 . High resolution functional analysis of antibody-antigen interactions . J. Mol. Biol. , 226 : 851 – 865 .
   PubMed Web of Science ®Google Scholar
• Joisson , C. , Dubs , M. C. , Briand , J. P. and Van Regenmortel , M. H. V. 1992 . Detection of potyviruses with antisera to synthetic peptides . Res. Virol. , 143 : 167 – 178 .
   PubMedGoogle Scholar
• Joisson , C. , Kuster , F. , Plaué , S. and Van Regenmortel , M. H. V. 1993 . Antigenic analysis of bean pod mottle virus using linear and cyclized synthetic peptides . Arch. Virol. , 128 : 299 – 317 .
   PubMed Web of Science ®Google Scholar
• Karlsen , A. , Lernmark , A. , Kofod , H. and Dyrberg , T. 1990 . A novel affinity purification method to isolate peptide specific antibodies . J. Immunol. Methods , 128 : 151 – 157 .
   PubMed Web of Science ®Google Scholar
• Kennel , S. J. 1982 . Binding of monoclonal antibody to protein antigen in fluid phase or bound to solid supports . J. Immunol. Methods , 55 : 1 – 12 .
   PubMed Web of Science ®Google Scholar
• Kent , S. and Clark-Lewis , I. 1985 . Synthetic Peptides in Biology and Medicine , Edited by: Alitalo , K. , Partanen , P. and Vaheri , A. 29 – 57 . Amsterdam : Elsevier Science .
   Google Scholar
• Lando , G. and Reichlin , M. 1982 . Antigenic structure of sperm whale myoglobin. II. Characterization of antibodies preferentially reactive with peptides arising in response to immunization with the native protein . J. Immunol. , 129 : 212 – 216 .
   PubMed Web of Science ®Google Scholar
• Lando , G. , Berzofsky , J. A. and Reichlin , M. 1982 . Antigenic structure of sperm whale myoglobin. I. Partition of specificities between antibodies reactive with peptides and native protein . J. Immunol. , 129 : 206 – 211 .
   PubMed Web of Science ®Google Scholar
• Laver , W. G. , Air , G. M. , Webster , R. G. and Smith-Gill , S. J. 1990 . Epitopes on protein antigens: Misconceptions and realities . Cell , 61 : 553 – 556 .
   PubMed Web of Science ®Google Scholar
• Lavoie , T. B. , Drohan , W. N. and Smith-Gill , S. J. 1992 . Experimental analysis by site-directed mutagenesis of somatic mutation effects on affinity and fine specificity in antibodies specific for lysozyme . J. Immunol. , 148 : 503 – 513 .
   PubMed Web of Science ®Google Scholar
• Lenstra , J. A. , Kusters , J. G. and Van der Zeijst , B. A. M. 1990 . Mapping of viral epitopes with prokaryotic expression products . Arch. Virol. , 110 : 1 – 24 .
   PubMed Web of Science ®Google Scholar
• Lerner , R. A. 1984 . Antibodies of predetermined specificity in biology and medicine . Adv. Immunol. , 36 : 1 – 44 .
   PubMed Web of Science ®Google Scholar
• Maeji , N. J. , Bray , A. M. , Valerio , R. M. , Seldon , M. A. , Wang , J. X. and Geysen , H. M. 1991 . Systematic screening for bioactive peptides . Peptide Res. , 4 : 142 – 146 .
   PubMedGoogle Scholar
• Mariani , M. , Bracci , L. , Presentini , R. , Nucci , D. , Neri , P. and Antoni , G. 1987 . Immunogenicity of a free synthetic peptide: Carrier-conjugation enhances antibody affinity for the native protein . Mol. Immunol. , 24 : 297 – 303 .
   PubMed Web of Science ®Google Scholar
• Mariuzza , R. A. , Phillips , S. E. V. and Poljak , R. J. 1987 . The structural basis of antigen-antibody recognition . Annu. Rev. Biophys. Biophys. Chem. , 16 : 139 – 159 .
   PubMedGoogle Scholar
• Marsden , H. S. , Owsianka , A. M. , Graham , S. , McLean , G. W. , Robertson , C. A. and Subak-Sharpe , J. H. 1992 . Advantages of branched peptides in serodiagnosis. Detection of HIV-specific antibodies and the use of glycine spacers to increase sensitivity . J. Immunol. Methods , 147 : 65 – 72 .
   PubMed Web of Science ®Google Scholar
• Maruyama , T. , Thornton , G. B. , Iino , S. , Kurokawa , K. and Milich , D. R. 1992 . Use of antipeptide antibodies for the design of antigen-specific immune complex assays . J. Immunol. Methods , 155 : 65 – 75 .
   PubMed Web of Science ®Google Scholar
• Mazza , M. M. and Retegui , L. A. 1989 . The antigenic topography of human growth hormone . Mol. Immunol. , 26 : 231 – 240 .
   PubMed Web of Science ®Google Scholar
• McLean , G. W. , Owsianka , A. M. , Subak-Sharpe , J. H. and Marsden , H. S. 1991 . Generation of antipeptide and anti-protein sera. Effect of peptide presentation on immunogenicity . J. Immunol. Methods , 137 : 149 – 157 .
   PubMed Web of Science ®Google Scholar
• Mehra , V. , Sweetser , D. and Young , R. A. 1986 . Efficient mapping of protein antigenic determinants . Proc. Natl. Acad. Sci. USA. , 83 : 7013 – 7017 .
   PubMed Web of Science ®Google Scholar
• Minez , A. , Pillet , L. , Léonetti , M. , Bontems , F. and Maillère , B. 1992 . Structure of Antigens , Edited by: V , M. H. and Van Regenmortel . Vol. 1 , 293 – 320 . Boca Raton : CRC Press .
   Google Scholar
• Mian , I. S. , Bradwell , A. R. and Olson , A. J. 1991 . Structure, function and properties of antibody binding sites . J. Mol. Biol. , 217 : 133 – 151 .
   PubMed Web of Science ®Google Scholar
• Muller , S. 1988 . Synthetic Polypeptides as Antigens , Edited by: V , M. H. , Van Regenmortel , J. P. , Briand , S. , Muller , S. and Plaué . Vol. 19 , 95 – 130 . Amsterdam : Elsevier Scientific .
   Google Scholar
• Muller , S. , Plaué , S. , Couppez , M. and Van Regenmortel , M. H. V. 1986 . Comparison of different methods for localizing antigenic regions in histone H2A . Mol. Immunol. , 23 : 593 – 601 .
   PubMed Web of Science ®Google Scholar
• Muller , S. , Plaué , S. , Samama , J. P. , Valette , M. , Briand , J. P. and Van Regenmortel , M. H. V. 1990 . Antigenic properties and protective capacity of a cyclic peptide corresponding to site A of influenza virus haemagglutinin . Vaccine , 8 : 308 – 314 .
   PubMed Web of Science ®Google Scholar
• Nicosia , A. , Bartoloni , A. , Perugini , M. and Rappuoli , R. 1987 . Expression and immunological properties on the five subunits of pertussis toxin . Infect. Immun. , 55 : 963 – 967 .
   PubMed Web of Science ®Google Scholar
• Norrby , E. , Mufson , M. A. , Alexander , H. , Houghten , R. A. and Lerner , R. A. 1987 . Site-directed serology with synthetic peptides representing the large glycoprotein G of respiratory syncytial virus . Proc. Natl. Acad. Set. USA , 84 : 6572 – 6576 .
   PubMed Web of Science ®Google Scholar
• Novotny , J. , Bruccoleri , R. E. , Carlson , W. D. , Handschumacher , M. and Haber , E. 1987 . Antigenicity of myohemerythrin . Science , 238 : 1584 – 1586 .
   PubMed Web of Science ®Google Scholar
• Novotny , J. , Bruccoleri , E. and Saul , F. A. 1989 . On the attribution of binding energy in antigen-antibody complexes McPC 603, D1.3, and HyHEL-5 . Biochemistry , 28 : 4735 – 4749 .
   PubMed Web of Science ®Google Scholar
• Oertle , M. , Immergluck , K. , Paterson , Y. and Bosshard , H. R. 1989 . Mapping of four discontiguous antigenic determinants on horse cytochrome . c, Eur. J. Biochem. , 182 : 699 – 704 .
   PubMed Web of Science ®Google Scholar
• Padlan , E. A. 1990 . On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligands . Proteins Struct. Funct. Genet. , 7 : 112 – 124 .
   PubMed Web of Science ®Google Scholar
• Padlan , E. A. 1992 . Structure of Antigens , Edited by: Van Regenmortel , M. H. V. Vol. 1 , 29 – 42 . Boca Raton : CRC Press .
   Google Scholar
• Padlan , E. A. , Silverton , E. W. , Sheriff , S. and Cohen , G. H. 1989 . Structure of an antibody-antigen complex: Crystal structure of the HyHEL-10 Fab-lysozyme complex . Proc. Natl. Acad. Sci. USA , 86 : 5938 – 5942 .
   PubMed Web of Science ®Google Scholar
• Parker , J. M. R. , Guo , D. and Hodges , R. S. 1986 . New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: Correlation of predicted surface residues with antigenicity and x-ray-derived accessible sites . Biochemistry , 25 : 5425 – 5432 .
   PubMed Web of Science ®Google Scholar
• Paterson , Y. 1992 . Mapping antibody binding sites on protein antigens . Nature , 356 : 456 – 457 .
   PubMed Web of Science ®Google Scholar
• Paterson , Y. , Englander , S. W. and Roder , H. 1990 . An antibody binding site on cytochrome c defined by hydrogen exchange and two-dimensional NMR . Science , 249 : 755 – 759 .
   PubMed Web of Science ®Google Scholar
• Pellequer , J. L. , Westhof , E. and Van Regenmortel , M. H. V. 1991 . Predicting the location of continuous epitopes in proteins from their primary structures . Methods Enzymol. , 203 : 176 – 201 .
   PubMed Web of Science ®Google Scholar
• Pellequer , J. L. , Westhof , E. and Van Regenmortel , M. H. V. 1994 . Peptide Antigens: A Practical Approach , Edited by: Wisdom , G. B. Oxford : IRL Press . in press
   Google Scholar
• Plaue , S. 1990 . Synthesis of cyclic peptides on solid support. Application to analogs of hemagglutinin of influenza virus . Int. J. Peptide Protein Res. , 35 : 510 – 517 .
   PubMedGoogle Scholar
• Plaue , S. and Briand , J. P. 1988 . Synthetic Polypeptides as Antigens , Edited by: Van Regenmortel , M. H. V. , Briand , J. P. , Muller , S. and Plaue , S. Vol. 19 , 41 – 94 . Amsterdam : Elsevier Scientific .
   Google Scholar
• Plaue , S. , Muller , S. , Briand , J. P. and Van Regenmortel , M. H. V. 1990 . Recent advances in solid-phase peptide synthesis and preparation of antibodies to synthetic peptides . Biologicals , 18 : 147 – 157 .
   PubMed Web of Science ®Google Scholar
• Quesniaux , V. F. J. , Schmitter , D. , Schreier , M. H. and Van Regenmortel , M. H. V. 1990 . Monoclonal antibodies to cyclosporine are representative of the major antibody populations present in antisera of immunized mice . Mol. Immunol. , 27 : 227 – 236 .
   PubMed Web of Science ®Google Scholar
• Rini , J. M. , Schulze-Gahmen , U. and Wilson , I. A. 1992 . Structural evidence for induced fit as a mechanism for antibody-antigen recognition . Science , 255 : 959 – 965 .
   PubMed Web of Science ®Google Scholar
• Roberts , V. A. , Getzoff , E. D. and Tainer , J. A. 1993 . Structure of Antigens , Edited by: Van Regenmortel , M. H. V. Vol. 2 , 31 – 53 . Boca Raton : CRC Press .
   Google Scholar
• Satterthwait , A. C. , Arrhenius , T. , Hagopian , R. A. , Zavala , F. , Nussenzweig , V. and Lerner , R. A. 1989 . The conformational restriction of synthetic peptides, including a malaria peptide, for use as immuno-gens . Philos. Trans. R. Soc. Lond. B. , 323 : 565 – 572 .
   PubMed Web of Science ®Google Scholar
• Savoca , R. , Schwab , C. and Bosshard , H. R. 1991 . Epitope mapping employing immobilized synthetic peptides . J. Immunol. Methods , 141 : 245 – 252 .
   PubMed Web of Science ®Google Scholar
• Schaaper , M. M. , Lankhof , H. , Puijk , W. C. and Meloen , R. H. 1989 . Manipulation of antipeptide immune response by varying the coupling of the peptide with the carrier protein . Mol. Immunol. , 26 : 81 – 85 .
   PubMed Web of Science ®Google Scholar
• Scherf , T. , Hiller , R. , Naider , F. , Levitt , M. and Anglister , J. 1992 . Induced peptide conformations in different antibody complexes: Molecular modeling of the three-dimensional structure of peptide-antibody complexes using NMR-derived distance restraints . Biochemistry , 31 : 6884 – 6897 .
   PubMed Web of Science ®Google Scholar
• Schroer , J. A. , Bender , T. , Feldmann , R. J. and Kim , K. J. 1983 . Mapping epitopes on the insulin molecule using monoclonal antibodies . Eur. J. Immunol. , 13 : 693 – 700 .
   PubMed Web of Science ®Google Scholar
• Schulze-Gahmen , U. , Rini , J. M. , Arevalo , J. , Stura , E. A. , Kenten , J. H. and Wilson , I. A. 1988 . Preliminary crystallographic data, primary sequence, and binding data for an anti-peptide Fab and its complex with a synthetic peptide from influenza virus hemagglutinin . J. Biol. Chem. , 263 : 17100 – 17105 .
   PubMed Web of Science ®Google Scholar
• Scibienski , R. J. 1973 . Denaturation of lysozyme by Freund's complete adjuvant . J. Immunol. , 111 : 114 – 120 .
   PubMed Web of Science ®Google Scholar
• Scott , J. K. 1992 . Discovering peptide ligands using epitope libraries . TIBS , 17 : 241 – 245 .
   PubMed Web of Science ®Google Scholar
• Scott , J. K. and Smith , G. P. 1990 . Searching for peptide ligands with an epitope library . Science , 249 : 386 – 390 .
   PubMed Web of Science ®Google Scholar
• Sela , M. 1969 . Antigenicity: Some molecular aspects . Science , 166 : 1365 – 1374 .
   PubMed Web of Science ®Google Scholar
• Sheriff , S. , Silverton , E. W. , Padlan , E. A. , Cohen , G. H. , Smith-Gill , S. , Finzel , B. C. and Davies , D. R. 1987 . Three-dimensional structure of an antibody-antigen complex . Proc. Natl. Acad. Sci. USA , 84 : 8075 – 8079 .
   PubMed Web of Science ®Google Scholar
• Shi , P. T. , Riehm , J. P. , Todd , P. E. E. and Leach , S. J. 1984 . The antigenicity of myoglobin-related peptides synthesised on polyacrylamide and polystyrene resin supports . Mol. Immunol. , 21 : 489 – 496 .
   PubMed Web of Science ®Google Scholar
• Smith , A. M. and Benjamin , D. C. 1991 . The antigenic surface of staphylococcal nuclease.II. Analysis of the N-1 epitope by site-directed mutagenesis . J. Immunol. , 146 : 1259 – 1264 .
   PubMed Web of Science ®Google Scholar
• Smith , A. M. , Woodward , M. P. , Hershey , C. W. , Hershey , E. D. and Benjamin , D. C. 1991 . The antigenic surface of staphylococcal nuclease. I. Mapping epitopes by site-directed mutagenesis . J. Immunol. , 146 : 1254 – 1258 .
   PubMed Web of Science ®Google Scholar
• Smith , S. C. , McIntosh , N. and James , K. 1993 . Pitfalls in the use of ELISA to screen for monoclonal antibodies raised against small peptides . J. Immunol. Methods , 158 : 151 – 160 .
   PubMed Web of Science ®Google Scholar
• Smith-Gill , S. J. , Wilson , A. C. , Potter , M. , Prager , E. M. , Feldmann , R. J. and Mainhart , C. R. 1982 . Mapping the antigenic epitope for a monoclonal antibody against lysozyme . J. Immunol. , 128 : 314 – 322 .
   PubMed Web of Science ®Google Scholar
• Smith-Gill , S. J. , Lavoie , T. B. and Mainhart , C. R. 1984 . Antigenic regions defined by monoclonal antibodies correspond to structural domains of avian lysozyme . J. Immunol. , 133 : 384 – 393 .
   PubMed Web of Science ®Google Scholar
• Smyth , M. S. , Hoey , E. M. , Trudgett , A. , Martin , S. J. and Brown , F. 1990 . Chemically synthesized peptides elicit neutralizing antibody to bovine enterovirus . J. Gen. Virol. , 71 : 231 – 234 .
   PubMed Web of Science ®Google Scholar
• Soderquist , M. E. and Walton , A. G. 1980 . Structural changes in proteins adsorbed on polymer surfaces . J. Colloid Interface Sci. , 75 : 386 – 397 .
   Web of Science ®Google Scholar
• Sohma , Y. , Atsushi , M. , Morita , H. , Katoh , S. and Sada , E. 1992 . Recognition of size and charged states of antigens by anti-peptide antibodies . J. Ferment. Bioeng. , 73 : 431 – 434 .
   Google Scholar
• Soutar , A. J. and Palfreyman , J. W. 1986 . Protides of the Biological Fluids , Edited by: Peeters , H. Vol. 34 , 99 – 102 . New York : Pergamon Press .
   Google Scholar
• Spangler , B. D. 1991 . Binding to native proteins by antipeptide monoclonal antibodies . J. Immunol. , 146 : 1591 – 1595 .
   PubMed Web of Science ®Google Scholar
• Stanfield , R. L. , Fieser , T. M. , Learner , R. A. and Wilson , I. A. 1990 . Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A . Science , 248 : 712 – 719 .
   PubMed Web of Science ®Google Scholar
• Stephen , C. W. and Lane , D. P. 1992 . Mutant conformation of p53—precise epitope mapping using a filamentous phage epitope library . J. Mol. Biol. , 225 : 577 – 583 .
   PubMed Web of Science ®Google Scholar
• Tainer , J. A. , Getzoff , E. D. , Paterson , Y. , Olson , A. J. and Lerner , R. A. 1985 . The atomic mobility component of protein antigenicity . Annu. Rev. Immunol. , 3 : 501 – 535 .
   PubMed Web of Science ®Google Scholar
• Tam , J. P. 1988 . Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system . Proc. Natl. Acad. Sci. USA , 85 : 5409 – 5413 .
   PubMed Web of Science ®Google Scholar
• Tanner , J. J. , Nell , L. J. and McCammon , J. A. 1992 . Anti- insulin antibody structure and conformation. II. Molecular dynamics with explicit solvent . Biopolymers , 32 : 23 – 31 .
   PubMed Web of Science ®Google Scholar
• Thornton , J. M. and Sibanda , B. L. 1983 . Amino and carboxy-terminal regions in globular proteins . J. Mol. Biol. , 167 : 443 – 460 .
   PubMed Web of Science ®Google Scholar
• Trifilieff , E. , Dubs , M. C. and Van Regenmortel , M. H. V. 1991 . Antigenic cross-reactivity potential of synthetic peptides immobilized on polyethylene rods . Mol. Immunol. , 28 : 889 – 896 .
   PubMed Web of Science ®Google Scholar
• Tsang , P. , Ranee , M. , Fieser , T. M. , Ostresh , J. M. , Houghten , R. A. , Lerner , R. A. and Wright , P. E. 1992 . Conformation and dynamics of an Fab'-bound peptide by isotope-edited NMR spectroscopy . Biochemistry , 31 : 3862 – 3871 .
   PubMed Web of Science ®Google Scholar
• Tulip , W. R. , Varghese , J. N. , Webster , R. G. , Air , G. M. , Laver , W. G. and Colman , P. M. 1989 . Crystal structures of neuraminidase-antibody complexes . Cold Spring Harbor Symp. Quant. Bio. , 54 : 257 – 263 .
   PubMedGoogle Scholar
• Underwood , P. A. 1985 . Theoretical considerations of the ability of monoclonal antibodies to detect antigenic differences between closely related variants, with particular reference to heterospecific reactions . J. Immunol. Methods , 85 : 295 – 307 .
   PubMed Web of Science ®Google Scholar
• Van der Werf , S. , Charbit , A. , Leclerc , C. , Mimic , V. , Ronco , J. , Girard , M. and Hofnung , M. 1990 . Critical role of neighboring sequences on the immunogenicity of the C3 poliovirus neutralization epitope expressed at the surface of recombinant bacteria . Vaccine , 8 : 269 – 277 .
   PubMed Web of Science ®Google Scholar
• Van Regenmortel , M. H. V. 1984 . Hybridoma Technology in Agricultural and Veterinary Research , Edited by: Stern , N. J. and Gamble , H. R. 43 – 82 . Totowa, NJ : Rowman & Allanheld .
   Google Scholar
• Van Regenmortel , M. H. V. 1988 . Synthetic Polypeptides as Antigens , Edited by: Van Regenmortel , M. H. V. , Briand , J. P. , Muller , S. and Plaue , S. Vol. 19 , 145 – 158 . Amsterdam : Elsevier Scientific .
   Google Scholar
• Van Regenmortel , M. H. V. 1989 . Structural and functional approaches to the study of protein antigenicity . Immunol. Today , 10 : 266 – 272 .
   PubMedGoogle Scholar
• Van Regenmortel , M. H. V. and Daney de Marcillac , G. 1988 . An assessment of prediction methods for locating continuous epitopes in proteins . Immunol. Lett. , 17 : 95 – 108 .
   PubMed Web of Science ®Google Scholar
• Van Regenmortel , M. H. V. , Brian , J. P. , Muller , S. and Plaue , S. 1988 . Synthetic Polypeptides as Antigens , Vol. 19 , 227 Amsterdam : Elsevier Scientific .
   Google Scholar
• Vuilleumier , S. and Mutter , M. 1992 . Structure of Antigens , Edited by: Van Regenmortel , M. H. V. Vol. 1 , 43 – 54 . Boca Raton : CRC Press .
   Google Scholar
• Walls , P. H. and Sternberg , M. J. E. 1992 . New algorithm to model protein-protein recognition based on surface complementarity—applications to antibody-antigen docking . J. Mol. Biol. , 228 : 277 – 297 .
   PubMed Web of Science ®Google Scholar
• Walter , G. 1986 . Production and use of antibodies against synthetic peptides . J. Immunol. Methods , 88 : 149 – 161 .
   PubMed Web of Science ®Google Scholar
• Wells , J. A. 1991 . Systematic mutational analysis of protein-protein interfaces . Methods Enzymol. , 202 : 390 – 410 .
   PubMed Web of Science ®Google Scholar
• Westhof , E. , Altschuh , D. , Moras , D. , Bloomer , A. C. , Mondragon , A. , Klug , A. and Van Regenmortel , M. H. V. 1984 . Correlation between segmental mobility and the location of antigenic determinants in proteins . Nature , 311 : 123 – 126 .
   PubMed Web of Science ®Google Scholar
• Wetlaufer , D. B. 1990 . Nucleation in protein folding—confusion of structure and process . TIBS , 15 : 414 – 414 .
   PubMed Web of Science ®Google Scholar
• Wilson , I. A. , Skehel , J. J. and Wiley , D. C. 1981 . Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution . Nature , 289 : 366 – 378 .
   PubMed Web of Science ®Google Scholar
• Wilson , I. A. , Niman , H. L. , Houghten , R. A. , Cherenson , A. R. , Connolly , M. L. and Lerner , R. A. 1984 . The structure of an antigenic determinant in a protein . Cell , 37 : 767 – 778 .
   PubMed Web of Science ®Google Scholar
• Wilson , I. A. , Stanfield , R. L. , Rini , J. M. , Arevalo , J. H. , Schulze-Gahmen , U. , Fremont , D. H. and Stura , E. A. 1991 . Catalytic antibodies . Ciba Found. Symp. , 159 : 13 – 39 .
   PubMedGoogle Scholar
• Wilson , J. E. and Smith , A. D. 1984 . A gel electrophoresis method for epitope mapping studies with monoclonal antibodies . Anal. Biochem. , 143 : 179 – 187 .
   PubMed Web of Science ®Google Scholar
• Wojchowski , D. M. , Sue , J. M. and Sytkowski , J. 1987 . Site-specific antibodies to human erythropoietin: Immunoaffinily purification of urinary and recombinant hormone . Biochim. Biophys. Acta , 913 : 170 – 178 .
   PubMed Web of Science ®Google Scholar
• Yarmush , D. M. , Morel , G. and Yarmush , M. L. 1987 . A new technique for mapping epitope specificities of monoclonal antibodies using quasi-elastic light scattering spectroscopy . J. Biochem. Biophys. Methods , 14 : 279 – 289 .
   PubMedGoogle Scholar
• Zrein , M. , Burckard , J. and Van Regenmortel , M. H. V. 1986 . Use of the biotin-avidin system for detecting a broad range of serologically related plant viruses by ELISA . J. Virol. Methods , 13 : 121 – 128 .
   PubMed Web of Science ®Google Scholar