References
- Balducci, S., Zanuso, S., Nicolucci, A., Fernando, F., Cavallo, S., Cardelli, P., Fallucca, S., Alessi, E., Letizia, C., Jimenez, A., Fallucca, F., & Pugliese, G. (2010). Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutrition, Metabolism and Cardiovascular Diseases, 20(8), 608–617. https://doi.org/https://doi.org/10.1016/j.numecd.2009.04.015
- Burghardt, R. D., Kazim, M. A., Ruther, W., Niemeier, A., & Strahl, A. (2019). The impact of physical activity on serum levels of inflammatory markers in rheumatoid arthritis: A systematic literature review. Rheumatology International, 39(5), 793–804. https://doi.org/https://doi.org/10.1007/s00296-019-04284-x
- Butts, B., Butler, J., Dunbar, S. B., Corwin, E., & Gary, R. A. (2018). Effects of exercise on ASC methylation and IL-1 cytokines in heart failure. Medicine & Science in Sports & Exercise, 50(9), 1757–1766. https://doi.org/https://doi.org/10.1249/MSS.0000000000001641
- Butts, B., Gary, R. A., Dunbar, S. B., & Butler, J. (2016). Methylation of apoptosis-associated speck-like protein with a caspase recruitment domain and outcomes in heart failure. Journal of Cardiac Failure, 22(5), 340–346. https://doi.org/https://doi.org/10.1016/j.cardfail.2015.12.004
- Cahu Rodrigues, S. L., Farah, B. Q., Silva, G., Correia, M., Pedrosa, R., Vianna, L., & Ritti-Dias, R. M. (2020). Vascular effects of isometric handgrip training in hypertensives. Clinical and Experimental Hypertension, 42(1), 24–30. https://doi.org/https://doi.org/10.1080/10641963.2018.1557683
- Calder, P. C., Bosco, N., Bourdet-Sicard, R., Capuron, L., Delzenne, N., Dore, J., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S., & Visioli, F. (2017). Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing Research Reviews, 40, 95–119. https://doi.org/https://doi.org/10.1016/j.arr.2017.09.001
- Cassidy, S., Thoma, C., Houghton, D., & Trenell, M. I. (2017). High-intensity interval training: A review of its impact on glucose control and cardiometabolic health. Diabetologia, 60(1), 7–23. https://doi.org/https://doi.org/10.1007/s00125-016-4106-1
- Cheema, B. S., Abas, H., Smith, B. C., O’Sullivan, A. J., Chan, M., Patwardhan, A., Kelly, J., Gillin, A., Pang, G., Lloyd, B., Berger, K., Baune, B. T., & Fiatarone Singh, M. A. (2011). Effect of resistance training during hemodialysis on circulating cytokines: A randomized controlled trial. European Journal of Applied Physiology, 111(7), 1437–1445. https://doi.org/https://doi.org/10.1007/s00421-010-1763-5
- Christgen, S., & Kanneganti, T. D. (2020). Inflammasomes and the fine line between defense and disease. Current Opinion in Immunology, 62, 39–44. https://doi.org/https://doi.org/10.1016/j.coi.2019.11.007
- Cordero, M. D., Williams, M. R., & Ryffel, B. (2018). AMP-activated protein kinase regulation of the NLRP3 inflammasome during aging. Trends in Endocrinology & Metabolism, 29(1), 8–17. https://doi.org/https://doi.org/10.1016/j.tem.2017.10.009
- Cronin, O., Keohane, D. M., Molloy, M. G., & Shanahan, F. (2017). The effect of exercise interventions on inflammatory biomarkers in healthy, physically inactive subjects: A systematic review. QJM : Monthly Journal of the Association of Physicians, 110(10), 629–637. https://doi.org/https://doi.org/10.1093/qjmed/hcx091
- Dinarello, C. A. (2006). Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process. The American Journal of Clinical Nutrition, 83(2), 447S–455S. https://doi.org/https://doi.org/10.1093/ajcn/83.2.447S
- Duval, S., & Tweedie, R. (2000). Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics, 56(2), 455–463. https://doi.org/https://doi.org/10.1111/j.0006-341X.2000.00455.x
- Farah, B. Q., Rodrigues, S. L. C., Silva, G. O., Pedrosa, R. P., Correia, M. A., Barros, M. V. G., Deminice, R., Marinello, P. C., Smart, N. A., Vianna, L. C., & Ritti-Dias, R. M. (2018). Supervised, but not home-based, isometric training improves brachial and central blood pressure in medicated hypertensive patients: A randomized controlled trial. Frontiers in Physiology, 9, 961. https://doi.org/https://doi.org/10.3389/fphys.2018.00961
- Ferrucci, L., & Fabbri, E. (2018). Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty. Nature Reviews. Cardiology, 15(9), 505–522. https://doi.org/https://doi.org/10.1038/s41569-018-0064-2
- Franceschi, C., Bonafe, M., Valensin, S., Olivieri, F., De Luca, M., Ottaviani, E., & De Benedictis, G. (2000). Inflamm-aging. An evolutionary perspective on immunosenescence. Annals of the New York Academy of Sciences, 908(1), 244–254. https://doi.org/https://doi.org/10.1111/j.1749-6632.2000.tb06651.x
- Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018). Inflammaging: A new immune-metabolic viewpoint for age-related diseases. Nature Reviews Endocrinology, 14(10), 576–590. https://doi.org/https://doi.org/10.1038/s41574-018-0059-4
- Garber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I. M., Nieman, D. C., & Swain, D. P. (2011). American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: Guidance for prescribing exercise. Medicine and Science in Sports and Exercise, 43(7), 1334–1359. https://doi.org/https://doi.org/10.1249/MSS.0b013e318213fefb
- Guo, H., Callaway, J. B., & Ting, J. P. (2015). Inflammasomes: Mechanism of action, role in disease, and therapeutics. Nature Medicine, 21(7), 677–687. https://doi.org/https://doi.org/10.1038/nm.3893
- Hammonds, T. L., Gathright, E. C., Goldstein, C. M., Penn, M. S., & Hughes, J. W. (2016). Effects of exercise on c-reactive protein in healthy patients and in patients with heart disease: A meta-analysis. Heart & Lung, 45(3), 273–282. https://doi.org/https://doi.org/10.1016/j.hrtlng.2016.01.009
- Han, Y., Liu, Y., Zhao, Z., Zhen, S., Chen, J., Ding, N., Ma, Y., & Wen, D. (2019). Does physical activity-based intervention improve systemic proinflammatory cytokine levels in overweight or obese children and adolescents? Insights from a meta-analysis of randomized control trials. Obesity Facts, 12(6), 653–668. https://doi.org/https://doi.org/10.1159/000501970
- Hayashino, Y., Jackson, J. L., Hirata, T., Fukumori, N., Nakamura, F., Fukuhara, S., Tsujii, S., & Ishii, H. (2014). Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes: A meta-analysis of randomized controlled trials. Metabolism, 63(3), 431–440. https://doi.org/https://doi.org/10.1016/j.metabol.2013.08.018
- Higgins, J. P., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. BMJ, 327(7414), 557–560. https://doi.org/https://doi.org/10.1136/bmj.327.7414.557
- Higgins, J. P. T., & Green, S. E. (2011). Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration.
- Hojan, K., Kwiatkowska-Borowczyk, E., Leporowska, E., Gorecki, M., Ozga-Majchrzak, O., Milecki, T., & Milecki, P. (2016). Physical exercise for functional capacity, blood immune function, fatigue, and quality of life in high-risk prostate cancer patients during radiotherapy: A prospective, randomized clinical study. European Journal of Physical and Rehabilitation Medicine, 52(4), 489–501.
- Ibeneme, S. C., Omeje, C., Myezwa, H., Ezeofor, S. N., Anieto, E. M., Irem, F., Nnamani, A. O., Ezenwankwo, F. E., & Ibeneme, G. C. (2019). Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: A systematic review with meta-analysis. BMC Infectious Diseases, 19(1), 359. https://doi.org/https://doi.org/10.1186/s12879-019-3960-0
- Irwin, M. R., & Olmstead, R. (2012). Mitigating cellular inflammation in older adults: A randomized controlled trial of Tai Chi Chih. The American Journal of Geriatric Psychiatry, 20(9), 764–772. https://doi.org/https://doi.org/10.1097/JGP.0b013e3182330fd3
- Kadoglou, N. P., Iliadis, F., Angelopoulou, N., Perrea, D., Ampatzidis, G., Liapis, C. D., & Alevizos, M. (2007). The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus. European Journal of Cardiovascular Prevention & Rehabilitation, 14(6), 837–843. https://doi.org/https://doi.org/10.1097/HJR.0b013e3282efaf50
- Kadoglou, N. P., Iliadis, F., Sailer, N., Athanasiadou, Z., Vitta, I., Kapelouzou, A., Karayannacos, P. E., Liapis, C. D., Alevizos, M., Angelopoulou, N., & Vrabas, I. S. (2010). Exercise training ameliorates the effects of rosiglitazone on traditional and novel cardiovascular risk factors in patients with type 2 diabetes mellitus. Metabolism, 59(4), 599–607. https://doi.org/https://doi.org/10.1016/j.metabol.2009.09.002
- Karlsen, T., Aamot, I. L., Haykowsky, M., & Rognmo, O. (2017). High intensity interval training for maximizing health outcomes. Progress in Cardiovascular Diseases, 60(1), 67–77. https://doi.org/https://doi.org/10.1016/j.pcad.2017.03.006
- Karstoft, K., & Pedersen, B. K. (2016). Exercise and type 2 diabetes: Focus on metabolism and inflammation. Immunology & Cell Biology, 94(2), 146–150. https://doi.org/https://doi.org/10.1038/icb.2015.101
- Khakroo Abkenar, I., Rahmani-Nia, F., & Lombardi, G. (2019). The effects of acute and chronic aerobic activity on the signaling pathway of the inflammasome NLRP3 complex in young men. Medicina (Kaunas), 55(4), 105. https://doi.org/https://doi.org/10.3390/medicina55040105
- Khosravi, N., Stoner, L., Farajivafa, V., & Hanson, E. D. (2019). Exercise training, circulating cytokine levels and immune function in cancer survivors: A meta-analysis. Brain, Behavior, and Immunity, 81, 92–104. https://doi.org/https://doi.org/10.1016/j.bbi.2019.08.187
- Kleckner, I. R., Kamen, C., Cole, C., Fung, C., Heckler, C. E., Guido, J. J., Culakova, E., Onitilo, A. A., Conlin, A., Kuebler, J. P., Mohile, S., Janelsins, M., & Mustian, K. M. (2019). Effects of exercise on inflammation in patients receiving chemotherapy: A nationwide NCORP randomized clinical trial. Supportive Care in Cancer, 27(12), 4615–4625. https://doi.org/https://doi.org/10.1007/s00520-019-04772-7
- Kohanpour, M. A., Peeri, M., & Azarbayjani, M. A. (2017). The effects of Glycyrrhiza glabra L. extract use with aerobic training on inflammatory factors and cognitive state in elderly with mild cognitive impairment. Journal of Herbmed Pharmacology, 6(4), 178–184.
- Lin, X., Zhang, X., Guo, J., Roberts, C. K., McKenzie, S., Wu, W. C., Liu, S., & Song, Y. (2015). Effects of exercise training on cardiorespiratory fitness and biomarkers of cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials. Journal of the American Heart Association, 4(7), e002014. https://doi.org/https://doi.org/10.1161/JAHA.115.002014
- Liu, Y., Liu, S. X., Cai, Y., Xie, K. L., Zhang, W. L., & Zheng, F. (2015). Effects of combined aerobic and resistance training on the glycolipid metabolism and inflammation levels in type 2 diabetes mellitus. Journal of Physical Therapy Science, 27(7), 2365–2371. https://doi.org/https://doi.org/10.1589/jpts.27.2365
- Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194–1217. https://doi.org/10.1016/j.cell.2013.05.039
- Man, S. M., & Kanneganti, T. D. (2015). Regulation of inflammasome activation. Immunological Reviews, 265(1), 6–21. https://doi.org/https://doi.org/10.1111/imr.12296
- Marin-Aguilar, F., Lechuga-Vieco, A. V., Alcocer-Gomez, E., Castejon-Vega, B., Lucas, J., Garrido, C., Peralta-Garcia, A., Perez-Pulido, A. J., Varela-Lopez, A., Quiles, J. L., Ryffel, B., Flores, I., Bullon, P., Ruiz-Cabello, J., & Cordero, M. D. (2020). NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice. Aging Cell, 19(1), e13050. https://doi.org/https://doi.org/10.1111/acel.13050
- Mattusch, F., Dufaux, B., Heine, O., Mertens, I., & Rost, R. (2000). Reduction of the plasma concentration of C-reactive protein following nine months of endurance training. International Journal of Sports Medicine, 21(1), 21–24. https://doi.org/https://doi.org/10.1055/s-2000-8852
- Mejias-Pena, Y., Estebanez, B., Rodriguez-Miguelez, P., Fernandez-Gonzalo, R., Almar, M., De Paz, J. A., Gonzalez-Gallego, J., & Cuevas, M. J. (2017). Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects. Aging (Albany NY), 9(2), 408–418. https://doi.org/https://doi.org/10.18632/aging.101167
- Metsios, G. S., Moe, R. H., & Kitas, G. D. (2020). Exercise and inflammation. Best Practice & Research Clinical Rheumatology, 34(2), 101504. https://doi.org/https://doi.org/10.1016/j.berh.2020.101504
- Milner, M. T., Maddugoda, M., Gotz, J., Burgener, S. S., & Schroder, K. (2020). The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer’s disease. Current Opinion in Immunology, 68, 116–124. https://doi.org/https://doi.org/10.1016/j.coi.2020.10.011
- Monteiro-Junior, R. S., De Tarso Maciel-pinheiro, P., Da Matta Mello Portugal, E., Da Silva Figueiredo, L. F., Terra, R., Carneiro, L. S. F., Rodrigues, V. D., Nascimento, O. J. M., Deslandes, A. C., & Laks, J. (2018). Effect of exercise on inflammatory profile of older persons: Systematic review and meta-analyses. Journal of Physical Activity and Health, 15(1), 64–71. https://doi.org/https://doi.org/10.1123/jpah.2016-0735
- Munoz-Canoves, P., Scheele, C., Pedersen, B. K., & Serrano, A. L. (2013). Interleukin-6 myokine signaling in skeletal muscle: A double-edged sword? The FEBS Journal, 280(17), 4131–4148. https://doi.org/https://doi.org/10.1111/febs.12338
- Navarro-Pando, J. M., Alcocer-Gomez, E., Castejon-Vega, B., Navarro-Villaran, E., Condes-Hervas, M., Mundi-Roldan, M., Muntane, J., Perez-Pulido, A. J., Bullon, P., Wang, C., Hoffman, H. M., Sanz, A., Mbalaviele, G., Ryffel, B., & Cordero, M. D. (2021). Inhibition of the NLRP3 inflammasome prevents ovarian aging. Science Advances, 7(1), eabc7409. https://doi.org/10.1126/sciadv.abc7409
- Neefkes-Zonneveld, C. R., Bakkum, A. J., Bishop, N. C., Van Tulder, M. W., & Janssen, T. W. (2015). Effect of long-term physical activity and acute exercise on markers of systemic inflammation in persons with chronic spinal cord injury: A systematic review. Archives of Physical Medicine and Rehabilitation, 96(1), 30–42. https://doi.org/https://doi.org/10.1016/j.apmr.2014.07.006
- Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998). Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. The Journal of Physiology, 508(3), 949–953. https://doi.org/https://doi.org/10.1111/j.1469-7793.1998.949bp.x
- Peters, J. L., Sutton, A. J., Jones, D. R., Abrams, K. R., & Rushton, L. (2008). Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry. Journal of Clinical Epidemiology, 61(10), 991–996. https://doi.org/https://doi.org/10.1016/j.jclinepi.2007.11.010
- Petersen, A. M., Mittendorfer, B., Magkos, F., Iversen, M., & Pedersen, B. K. (2008). Physical activity counteracts increased whole-body protein breakdown in chronic obstructive pulmonary disease patients. Scandinavian Journal of Medicine & Science in Sports, 18(5), 557–564. https://doi.org/https://doi.org/10.1111/j.1600-0838.2007.00727.x
- Petersen, A. M., & Pedersen, B. K. (2005). The anti-inflammatory effect of exercise. Journal of Applied Physiology, 98(4), 1154–1162. https://doi.org/https://doi.org/10.1152/japplphysiol.00164.2004
- Prestes, J., Da Cunha Nascimento, D., Tibana, R. A., Teixeira, T. G., Vieira, D. C., Tajra, V., De Farias, D. L., Silva, A. O., Funghetto, S. S., De Souza, V. C., & Navalta, J. W. (2015). Understanding the individual responsiveness to resistance training periodization. Age (Dordr), 37(3), 9793. https://doi.org/https://doi.org/10.1007/s11357-015-9793-x
- Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018). Age and age-related diseases: Role of inflammation triggers and cytokines. Frontiers in Immunology, 9, 586. https://doi.org/10.3389/fimmu.2018.00586
- Saltiel, A. R., & Olefsky, J. M. (2017). Inflammatory mechanisms linking obesity and metabolic disease. Journal of Clinical Investigation, 127(1), 1–4. https://doi.org/https://doi.org/10.1172/JCI92035
- Sardeli, A. V., Tomeleri, C. M., Cyrino, E. S., Fernhall, B., Cavaglieri, C. R., & Chacon-Mikahil, M. P. T. (2018). Effect of resistance training on inflammatory markers of older adults: A meta-analysis. Experimental Gerontology, 111, 188–196. https://doi.org/https://doi.org/10.1016/j.exger.2018.07.021
- So, W. Y., song, M., Park, Y. H., Cho, B. L., Lim, J. Y., Kim, S. H., & Song, W. (2013). Body composition, fitness level, anabolic hormones, and inflammatory cytokines in the elderly: A randomized controlled trial. Aging Clinical and Experimental Research, 25(2), 167–174. https://doi.org/https://doi.org/10.1007/s40520-013-0032-y
- Soares, F. H., & De Sousa, M. B. (2013). Different types of physical activity on inflammatory biomarkers in women with or without metabolic disorders: A systematic review. Women & Health, 53(3), 298–316. https://doi.org/https://doi.org/10.1080/03630242.2013.782940
- Spel, L., & Martinon, F. (2020). Inflammasomes contributing to inflammation in arthritis. Immunological Reviews, 294(1), 48–62. https://doi.org/https://doi.org/10.1111/imr.12839
- Stigger, F. S., Zago Marcolino, M. A., Portela, K. M., & Plentz, R. D. M. (2019). Effects of exercise on inflammatory, oxidative, and neurotrophic biomarkers on cognitively impaired individuals diagnosed with dementia or mild cognitive impairment: A systematic review and meta-analysis. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 74(5), 616–624. https://doi.org/https://doi.org/10.1093/gerona/gly173
- Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012). Inflammasomes in health and disease. Nature, 481(7381), 278–286. https://doi.org/https://doi.org/10.1038/nature10759
- Tartibian, B., FitzGerald, L. Z., Azadpour, N., & Maleki, B. H. (2015). A randomized controlled study examining the effect of exercise on inflammatory cytokine levels in post-menopausal women. Post Reproductive Health, 21(1), 9–15. https://doi.org/https://doi.org/10.1177/2053369114565708
- Thompson, G., Davison, G. W., Crawford, J., & Hughes, C. M. (2020). Exercise and inflammation in coronary artery disease: A systematic review and meta-analysis of randomised trials. Journal of Sports Sciences, 38(7), 814–826. https://doi.org/https://doi.org/10.1080/02640414.2020.1735684
- Tsai, C. L., Pai, M. C., Ukropec, J., & Ukropcova, B. (2019). Distinctive effects of aerobic and resistance exercise modes on neurocognitive and biochemical changes in individuals with mild cognitive impairment. Current Alzheimer Research, 16(4), 316–332. https://doi.org/https://doi.org/10.2174/1567205016666190228125429
- Vandanmagsar, B., Youm, Y. H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011). The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nature Medicine, 17(2), 179–188. https://doi.org/https://doi.org/10.1038/nm.2279
- Wong, V. L., & Holahan, M. R. (2019). A systematic review of aerobic and resistance exercise and inflammatory markers in people with multiple sclerosis. Behavioural Pharmacology, 30(8), 653–660. https://doi.org/https://doi.org/10.1097/FBP.0000000000000514
- Youm, Y.-H., Grant, R. W., McCabe, L. R., Albarado, D. C., Nguyen, K. Y., Ravussin, A., Pistell, P., Newman, S., Carter, R., Laque, A., Munzberg, H., Rosen, C. J., Ingram, D. K., Salbaum, J. M., & Dixit, V. D. (2013). Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metabolism, 30(4), 519–532. https://doi.org/https://doi.org/10.1016/j.cmet.2013.09.010
- Zhao, C., Ma, H., Yang, L., & Xiao, Y. (2017). Long-term bicycle riding ameliorates the depression of the patients undergoing hemodialysis by affecting the levels of interleukin-6 and interleukin-18. Neuropsychiatric Disease and Treatment, 13, 91–100. https://doi.org/https://doi.org/10.2147/NDT.S124630
- Zheng, G., Qiu, P., Xia, R., Lin, H., Ye, B., Tao, J., & Chen, L. (2019). Effect of aerobic exercise on inflammatory markers in healthy middle-aged and older adults: A systematic review and meta-analysis of randomized controlled trials. Frontiers in Aging Neuroscience, 11, 98. https://doi.org/https://doi.org/10.3389/fnagi.2019.00098