Effects of running a marathon on sclerostin and parathyroid hormone concentration in males aged over 50

References

• Amrein, K., Amrein, S., Drexler, C., Dimai, H. P., Dobnig, H., Pfeifer, K., Tomaschitz, A., Pieber, T. R., & Fahrleitner-Pammer, A. (2012). Sclerostin and its association with physical activity, age, sex, body composition, and bone mineral content in healthy adults. Journal of Clinical Endocrinology & Metabolism, 97(1), 148–154. https://doi.org/10.1210/jc.2011-2152
   PubMed Web of Science ®Google Scholar
• Anastasilakis, A. D., Polyzos, S. A., Saridakis, Z. G., Kynigopoulos, G., Skouvaklidou, E. C., Molyvas, D., Vasiloglou, M. F., Apostolou, A., Karagiozoglou-Lampoudi, T., Siopi, A., Mougios, V., Chatzistavridis, P., Panagiotou, G., Filippaios, A., Delaroudis, S., & Mantzoros, C. S. (2014). Circulating irisin in healthy young individuals: Day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition. The Journal of Clinical Endocrinology and Metabolism, 99(9), 3247–3255. https://doi.org/10.1210/jc.2014-1367
   PubMed Web of Science ®Google Scholar
• Ardawi, M. S., Rouzi, A. A., & Qari, M. H. (2012). Physical activity in relation to serum sclerostin, insulin-like growth factor-1, and bone turnover markers in healthy premenopausal women: A cross-sectional and a longitudinal study. The Journal of Clinical Endocrinology and Metabolism, 97(10), 3691–3699. https://doi.org/10.1210/jc.2011-3361
   PubMed Web of Science ®Google Scholar
• Armamento-Villareal, R., Sadler, C., Napoli, N., Shah, K., Chode, S., Sinacore, D. R., Qualls, C., & Villareal, D. T. (2012). Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 27(5), 1215–1221. https://doi.org/10.1002/jbmr.1560
   PubMed Web of Science ®Google Scholar
• Ashizawa, N., Fujimura, R., Tokuyama, K., & Suzuki, M. (1997). A bout of resistance exercise increases urinary calcium independently of osteoclastic activation in men. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology, 83(4), 1159–1163. https://doi.org/10.1152/jappl.1997.83.4.1159
   Web of Science ®Google Scholar
• Banfi, G., Lombardi, G., Colombini, A., & Lippi, G. (2010). Bone metabolism markers in sports medicine. Sports Medicine, 40(8), 697–714. https://doi.org/10.2165/11533090-000000000-00000
   PubMed Web of Science ®Google Scholar
• Bonnet, N., & Ferrari, S. L. (2010). Exercise and the skeleton: How it works and what it really does. IBMS BoneKey, 7(7), 235–248. https://doi.org/10.1138/20100454
   Google Scholar
• Brahm, H., Ström, H., Piehl-Aulin, K., Mallmin, H., & Ljunghall, S. (1997). Bone metabolism in endurance trained athletes: A comparison to population-based controls based on DXA, SXA, quantitative ultrasound, and biochemical markers. Calcified Tissue International, 61(6), 448–454. https://doi.org/10.1007/s002239900366
   PubMed Web of Science ®Google Scholar
• Brown, E. M. (1991). Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers. Physiological Reviews, 71(2), 371–411. https://doi.org/10.1152/physrev.1991.71.2.371
   PubMed Web of Science ®Google Scholar
• Bruce, R. (1971). Exercise testing of patients with coronary heart disease. Principles and normal standards for evaluation. Annals of Clinical Research, 3(6), 323–332.
   PubMedGoogle Scholar
• Crespo, R., Revilla, M., Villa, L., Usabiaga, J., Leibar, X., & Rico, H. (1999). Transient dissociation of bone metabolism induced by high performance exercise: A study in elite marathon runners. Calcified Tissue International, 64(4), 287–290. https://doi.org/10.1007/s002239900620
   PubMed Web of Science ®Google Scholar
• Dawson-Hughes, B. (1991). Calcium supplementation and bone loss: A review of controlled clinical trials. The American Journal of Clinical Nutrition, 54(1 Suppl), 274s–280s. https://doi.org/10.1093/ajcn/54.1.274S
   PubMed Web of Science ®Google Scholar
• Dekker, J., Nelson, K., Kurgan, N., Falk, B., Josse, A., & Klentrou, P. (2017). Wnt signaling–related osteokines and transforming growth factors before and after a single bout of plyometric exercise in child and adolescent females. Pediatric Exercise Science, 29(4), 504–512. https://doi.org/10.1123/pes.2017-0042
   PubMed Web of Science ®Google Scholar
• Dill, D. B., & Costill, D. L. (1974). Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology, 37(2), 247–248. https://doi.org/10.1152/jappl.1974.37.2.247
   PubMed Web of Science ®Google Scholar
• Duncan, R. L., & Turner, C. H. (1995). Mechanotransduction and the functional response of bone to mechanical strain. Calcified Tissue International, 57(5), 344–358. https://doi.org/10.1007/BF00302070
   PubMed Web of Science ®Google Scholar
• Eliakim, A., Raisz, L. G., Brasel, J. A., & Cooper, D. M. (1997). Evidence for increased bone formation following a brief endurance-type training intervention in adolescent males. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 12(10), 1708–1713. https://doi.org/10.1359/jbmr.1997.12.10.1708
   PubMed Web of Science ®Google Scholar
• Erickson, C. R., & Vukovich, M. D. (2010). Osteogenic index and changes in bone markers during a jump training program: A pilot study. Medicine & Science in Sports & Exercise, 42(8), 1485–1492. https://doi.org/10.1249/MSS.0b013e3181d0fa7a
   PubMed Web of Science ®Google Scholar
• Fairfield, H., Rosen, C. J., & Reagan, M. R. (2017). Connecting bone and fat: The potential role for sclerostin. Current Molecular Biology Reports, 3(2), 114–121. https://doi.org/10.1007/s40610-017-0057-7
   PubMedGoogle Scholar
• Falk, B., Haddad, F., Klentrou, P., Ward, W., Kish, K., Mezil, Y., & Radom-Aizik, S. (2016). Differential sclerostin and parathyroid hormone response to exercise in boys and men. Osteoporosis International, 27(3), 1245–1249. https://doi.org/10.1007/s00198-015-3310-z
   PubMed Web of Science ®Google Scholar
• Franck, H., Beuker, F., & Gurk, S. (1991). The effect of physical activity on bone turnover in young adults. Experimental and Clinical Endocrinology, 98(1), 42–46. https://doi.org/10.1055/s-0029-1211099
   PubMedGoogle Scholar
• Gardinier, J. D., Mohamed, F., & Kohn, D. H. (2015). PTH signaling during exercise contributes to bone adaptation. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 30(6), 1053–1063. https://doi.org/10.1002/jbmr.2432
   PubMed Web of Science ®Google Scholar
• Gaudio, A., Pennisi, P., Bratengeier, C., Torrisi, V., Lindner, B., Mangiafico, R. A., Pulvirenti, I., Hawa, G., Tringali, G., & Fiore, C. E. (2010). Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss. The Journal of Clinical Endocrinology and Metabolism, 95(5), 2248–2253. https://doi.org/10.1210/jc.2010-0067
   PubMed Web of Science ®Google Scholar
• Gerosa, L., & Lombardi, G. (2021). Bone-to-brain: A round trip in the adaptation to mechanical stimuli. Frontiers in Physiology, 12, 623893. https://doi.org/10.3389/fphys.2021.623893
   PubMed Web of Science ®Google Scholar
• Gombos, G. C., Bajsz, V., Pék, E., Schmidt, B., Sió, E., Molics, B., & Betlehem, J. (2016). Direct effects of physical training on markers of bone metabolism and serum sclerostin concentrations in older adults with low bone mass. BMC Musculoskeletal Disorders, 17(1), 1–8. https://doi.org/10.1186/s12891-016-1109-5
   PubMedGoogle Scholar
• Grasso, D., Corsetti, R., Lanteri, P., DiBernardo, C., Colombini, A., Graziani, R., Banfi, G., & Lombardi, G. (2015). Bone-muscle unit activity, salivary steroid hormones profile, and physical effort over a 3-week stage race. Scandinavian Journal of Medicine & Science in Sports, 25(1), 70–80. https://doi.org/10.1111/sms.12147
   PubMed Web of Science ®Google Scholar
• Guerriere, K. I., Hughes, J. M., Gaffney-Stomberg, E., Staab, J. S., & Matheny, R. W., Jr. (2018). Circulating sclerostin is not suppressed following a single bout of exercise in young men. Physiological Reports, 6(10), e13695. https://doi.org/10.14814/phy2.13695
   PubMed Web of Science ®Google Scholar
• Heinonen, I., Kemppainen, J., Kaskinoro, K., Langberg, H., Knuuti, J., Boushel, R., Kjaer, M., & Kalliokoski, K. K. (2013). Bone blood flow and metabolism in humans: Effect of muscular exercise and other physiological perturbations. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 28(5), 1068–1074. https://doi.org/10.1002/jbmr.1833
   PubMed Web of Science ®Google Scholar
• Holguin, N., Brodt, M. D., & Silva, M. J. (2016). Activation of Wnt signaling by mechanical loading is impaired in the bone of old mice. Journal of Bone and Mineral Research, 31(12), 2215–2226. https://doi.org/10.1002/jbmr.2900
   PubMed Web of Science ®Google Scholar
• Jürimäe, J., Purge, P., Jürimäe, T., & von Duvillard, S. P. (2006). Bone metabolism in elite male rowers: Adaptation to volume-extended training. European Journal of Applied Physiology, 97(1), 127–132. https://doi.org/10.1007/s00421-006-0158-0
   PubMed Web of Science ®Google Scholar
• Keller, H., & Kneissel, M. (2005). SOST is a target gene for PTH in bone. Bone, 37(2), 148–158. https://doi.org/10.1016/j.bone.2005.03.018
   PubMed Web of Science ®Google Scholar
• Khosla, S., Westendorf, J. J., & Oursler, M. J. (2008). Building bone to reverse osteoporosis and repair fractures. Journal of Clinical Investigation, 118(2), 421–428. https://doi.org/10.1172/jci33612
   PubMed Web of Science ®Google Scholar
• Kirmani, S., Amin, S., McCready, L. K., Atkinson, E. J., Melton, L. J., 3rd, Müller, R., & Khosla, S. (2012). Sclerostin levels during growth in children. Osteoporosis International: A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 23(3), 1123–1130. https://doi.org/10.1007/s00198-011-1669-z
   PubMed Web of Science ®Google Scholar
• Klentrou, P., Angrish, K., Awadia, N., Kurgan, N., Kouvelioti, R., & Falk, B. (2018). Wnt Signaling-related osteokines at rest and following plyometric exercise in prepubertal and early pubertal boys and girls. Pediatric Exercise Science, 30(4), 457–465. https://doi.org/10.1123/pes.2017-0259
   PubMed Web of Science ®Google Scholar
• Kouvelioti, R., Kurgan, N., Falk, B., Ward, W. E., Josse, A. R., & Klentrou, P. (2018). Response of sclerostin and bone turnover markers to high intensity interval exercise in young women: does impact matter? BioMed Research International, 2018, 1–8. https://doi.org/10.1155/2018/4864952
   Web of Science ®Google Scholar
• Kramer, I., Halleux, C., Keller, H., Pegurri, M., Gooi, J. H., Weber, P. B., Feng, J. Q., Bonewald, L. F., & Kneissel, M. (2010). Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis. Molecular and Cellular Biology, 30(12), 3071–3085. https://doi.org/10.1128/mcb.01428-09
   PubMed Web of Science ®Google Scholar
• Krishnan, V., Bryant, H. U., & Macdougald, O. A. (2006). Regulation of bone mass by Wnt signaling. Journal of Clinical Investigation, 116(5), 1202–1209. https://doi.org/10.1172/jci28551
   PubMed Web of Science ®Google Scholar
• Lepers, R., & Cattagni, T. (2012). Do older athletes reach limits in their performance during marathon running? Age, 34(3), 773–781. https://doi.org/10.1007/s11357-011-9271-z
   PubMedGoogle Scholar
• Lombardi, G., Lanteri, P., Colombini, A., Mariotti, M., & Banfi, G. (2012). Sclerostin concentrations in athletes: Role of load and gender. Journal of Biological Regulators and Homeostatic Agents, 26(1), 157–163.
   PubMed Web of Science ®Google Scholar
• Lombardi, G., Ziemann, E., Banfi, G., & Corbetta, S. (2020). Physical activity-dependent regulation of parathyroid hormone and calcium-phosphorous metabolism. International Journal of Molecular Sciences, 21(15), 5388. https://doi.org/10.3390/ijms21155388
   PubMed Web of Science ®Google Scholar
• Miyamoto-Mikami, E., Sato, K., Kurihara, T., Hasegawa, N., Fujie, S., Fujita, S., Sanada, K., Hamaoka, T., Tabata, I., Iemitsu, M., & Kaser, S. (2015). Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults. PLoS One, 10(3), e0120354. https://doi.org/10.1371/journal.pone.0120354
   PubMed Web of Science ®Google Scholar
• Mödder, U. I., Hoey, K. A., Amin, S., McCready, L. K., Achenbach, S. J., Riggs, B. L., Melton, L. J., 3rd, & Khosla, S. (2011). Relation of age, gender, and bone mass to circulating sclerostin levels in women and men. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 26(2), 373–379. https://doi.org/10.1002/jbmr.217
   PubMed Web of Science ®Google Scholar
• Moustafa, A., Sugiyama, T., Prasad, J., Zaman, G., Gross, T. S., Lanyon, L. E., & Price, J. S. (2012). Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered. Osteoporosis International: A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 23(4), 1225–1234. https://doi.org/10.1007/s00198-011-1656-4
   PubMed Web of Science ®Google Scholar
• Mouzopoulos, G., Stamatakos, M., Tzurbakis, M., Tsembeli, A., Manti, C., Safioleas, M., & Skandalakis, P. (2007). Changes of bone turnover markers after marathon running over 245 km. International Journal of Sports Medicine, 28(7), 576–579. https://doi.org/10.1055/s-2007-964841
   PubMed Web of Science ®Google Scholar
• Pickering, M. E., Simon, M., Sornay-Rendu, E., Chikh, K., Carlier, M. C., Raby, A. L., Szulc, P., & Confavreux, C. B. (2017). Serum sclerostin increases after acute physical activity. Calcified Tissue International, 101(2), 170–173. https://doi.org/10.1007/s00223-017-0272-5
   PubMed Web of Science ®Google Scholar
• Robling, A. G., Burr, D. B., & Turner, C. H. (2000). Partitioning a daily mechanical stimulus into discrete loading bouts improves the osteogenic response to loading. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 15(8), 1596–1602. https://doi.org/10.1359/jbmr.2000.15.8.1596
   PubMed Web of Science ®Google Scholar
• Rogers, R. S., Dawson, A. W., Wang, Z., Thyfault, J. P., & Hinton, P. S. (2011). Acute response of plasma markers of bone turnover to a single bout of resistance training or plyometrics. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology, 111(5), 1353–1360. https://doi.org/10.1152/japplphysiol.00333.2011
   Web of Science ®Google Scholar
• Scofield, K. L., & Hecht, S. (2012). Bone health in endurance athletes: Runners, cyclists, and swimmers. Current Sports Medicine Reports, 11(6), 328–334. https://doi.org/10.1249/JSR.0b013e3182779193
   PubMed Web of Science ®Google Scholar
• Scott, J. P., Sale, C., Greeves, J. P., Casey, A., Dutton, J., & Fraser, W. D. (2010). The effect of training status on the metabolic response of bone to an acute bout of exhaustive treadmill running. The Journal of Clinical Endocrinology and Metabolism, 95(8), 3918–3925. https://doi.org/10.1210/jc.2009-2516
   PubMed Web of Science ®Google Scholar
• Scott, J. P., Sale, C., Greeves, J. P., Casey, A., Dutton, J., & Fraser, W. D. (2011). The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology, 110(2), 423–432. https://doi.org/10.1152/japplphysiol.00764.2010
   PubMed Web of Science ®Google Scholar
• Scott, J. P., Sale, C., Greeves, J. P., Casey, A., Dutton, J., & Fraser, W. D. (2014). Treadmill running reduces parathyroid hormone concentrations during recovery compared with a nonexercising control group. The Journal of Clinical Endocrinology and Metabolism, 99(5), 1774–1782. https://doi.org/10.1210/jc.2013-3027
   PubMed Web of Science ®Google Scholar
• Shea, K. L., Barry, D. W., Sherk, V. D., Hansen, K. C., Wolfe, P., & Kohrt, W. M. (2014). Calcium supplementation and parathyroid hormone response to vigorous walking in postmenopausal women. Medicine & Science in Sports & Exercise, 46(10), 2007–2013. https://doi.org/10.1249/mss.0000000000000320
   PubMed Web of Science ®Google Scholar
• Sims, N. A., & Chia, L. Y. (2012). Regulation of sclerostin expression by paracrine and endocrine factors. Clinical Reviews in Bone and Mineral Metabolism, 10(2), 98–107. https://doi.org/10.1007/s12018-011-9121-7
   Google Scholar
• Smith, J. E., Garbutt, G., Lopes, P., & Tunstall Pedoe, D. (2004). Effects of prolonged strenuous exercise (marathon running) on biochemical and haematological markers used in the investigation of patients in the emergency department. British Journal of Sports Medicine, 38(3), 292–294. https://doi.org/10.1136/bjsm.2002.002873
   PubMed Web of Science ®Google Scholar
• Tanda, G., & Knechtle, B. (2013). Marathon performance in relation to body fat percentage and training indices in recreational male runners. Open Access Journal of Sports Medicine, 4, 141. https://doi.org/10.2147/OAJSM.S44945
   PubMedGoogle Scholar
• Thompson, W. R., Rubin, C. T., & Rubin, J. (2012). Mechanical regulation of signaling pathways in bone. Gene, 503(2), 179–193. https://doi.org/10.1016/j.gene.2012.04.076
   PubMed Web of Science ®Google Scholar
• Woitge, H. W., Friedmann, B., Suttner, S., Farahmand, I., Müller, M., Schmidt-Gayk, H., Baertsch, P., Ziegler, R., & Seibel, M. J. (1998). Changes in bone turnover induced by aerobic and anaerobic exercise in young males. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 13(12), 1797–1804. https://doi.org/10.1359/jbmr.1998.13.12.1797
   PubMed Web of Science ®Google Scholar
• Xiao, Z., & Quarles, L. D. (2015). Physiological mechanisms and therapeutic potential of bone mechanosensing. Reviews in Endocrine & Metabolic Disorders, 16(2), 115–129. https://doi.org/10.1007/s11154-015-9313-4
   PubMed Web of Science ®Google Scholar
• Xu, J., Lombardi, G., Jiao, W., & Banfi, G. (2016). Effects of exercise on bone status in female subjects, from young girls to postmenopausal women: an overview of systematic reviews and meta-analyses. Sports Medicine, 46(8), 1165–1182. https://doi.org/10.1007/s40279-016-0494-0
   PubMed Web of Science ®Google Scholar
• Yavropoulou, M. P., & Yovos, J. G. (2007). The role of the Wnt signaling pathway in osteoblast commitment and differentiation. Hormones (Athens), 6(4), 279–294. https://doi.org/10.14310/horm.2002.1111024
   PubMedGoogle Scholar
• Yu, E. W., Kumbhani, R., Siwila-Sackman, E., & Leder, B. Z. (2011). Acute decline in serum sclerostin in response to PTH infusion in healthy men. The Journal of Clinical Endocrinology & Metabolism, 96(11), E1848–E1851. https://doi.org/10.1210/jc.2011-1534
   PubMed Web of Science ®Google Scholar