Unkind cytokines: Current evidence for the potential role of cytokines in immune-mediated depression

References

• Anisman H, Kokkinidis L, Borowski T, Merali Z. Differential effects of interleukin (IL)-1beta, IL-2 and IL-6 on responding for rewarding lateral hypothalamic stimulation. Brain Research 1998; 779(1–2)177–187
   Google Scholar
• Anisman H, Merali Z, Poulter MO, Hayley S. Cytokines as a precipitant of depressive illness: Animal and human studies. Current Pharmaceutical Design 2005; 11(8)963–972
   PubMed Web of Science ®Google Scholar
• Anisman H, Ravindran AV, Griffiths J, Merali Z. Interleukin-1 beta production in dysthymia before and after pharmacotherapy. Biological Psychiatry 1999; 46(12)1649–1655
   Google Scholar
• Bell C, Abrams J, Nutt D. Tryptophan depletion and its implications for psychiatry. British Journal of Psychiatry 2001; 178: 399–405
   PubMed Web of Science ®Google Scholar
• Besedovsky H, Del Rey A, Sorkin E, Dinarello CA. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 1986; 233(4764)652–654
   PubMed Web of Science ®Google Scholar
• Bluthe RM, Dantzer R, Kelley KW. Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat. Brain Research 1992; 573(2)318–320
   Google Scholar
• Bonaccorso S, Marino V, Puzella A, Pasquini M, Biondi M, Artini M. Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system. Journal of Clinical Psychopharmacology 2002; 22(1)86–90
   PubMed Web of Science ®Google Scholar
• Capuron L, Gumnick JF, Musselman DL, Lawson DH, Reemsnyder A, Nemeroff CB. Neurobehavioral effects of interferon-alpha in cancer patients: Phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology 2002a; 26(5)643–652
   PubMed Web of Science ®Google Scholar
• Capuron L, Raison CL, Musselman DL, Lawson DH, Nemeroff CB, Miller AH. Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy. American Journal of Psychiatry 2003; 160(7)1342–1345
   PubMed Web of Science ®Google Scholar
• Capuron L, Ravaud A, Neveu PJ, Miller AH, Maes M, Dantzer R. Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Molecular Psychiatry 2002b; 7(5)468–473
   PubMed Web of Science ®Google Scholar
• Chrousos GP. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. New England Journal of Medicine 1995; 332(20)1351–1362
   PubMed Web of Science ®Google Scholar
• Czeh B, Michaelis T, Watanabe T, Frahm J, De Biurrun G, Van Kampen M. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proceedings of the National Academy of Science USA 2001; 98(22)12796–12801
   PubMed Web of Science ®Google Scholar
• Dunn AJ. The role of interleukin-1 and tumor necrosis factor alpha in the neurochemical and neuroendocrine responses to endotoxin. Brain Research Bulletin 1992; 29(6)807–812
   Google Scholar
• Dunn AJ, Swiergiel AH, De Beaurepaire R. Cytokines as mediators of depression: What can we learn from animal studies?. Neuroscience & Biobehavioural Reviews 2005; 29(4–5)891–909
   PubMed Web of Science ®Google Scholar
• Foley FW, Traugott U, Larocca NG, Smith CR, Perlman KR, Caruso LS. A prospective study of depression and immune dysregulation in multiple sclerosis. Archives of Neurology 1992; 49(3)238–244
   PubMed Web of Science ®Google Scholar
• Frommberger UH, Bauer J, Haselbauer P, Fraulin A, Riemann D, Berger M. Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: Comparison between the acute state and after remission. European Archives in Psychiatry & Clinical Neuroscience 1997; 247(4)228–233
   PubMed Web of Science ®Google Scholar
• Goshen I, Yirmiya R, Iverfeldt K, Weidenfeld J. The role of endogenous interleukin-1 in stress-induced adrenal activation and adrenalectomy-induced adrenocorticotropic hormone hypersecretion. Endocrinology 2003; 144(10)4453–4458
   PubMed Web of Science ®Google Scholar
• Gould E, Tanapat P, McEwen BS, Flugge G, Fuchs E. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proceedings of the National Academy of Science USA 1998; 95(6)3168–3171
   PubMed Web of Science ®Google Scholar
• Hagan P, Poole S, Bristow AF. Endotoxin-stimulated production of rat hypothalamic interleukin-1 beta in vivo and in vitro, measured by specific immunoradiometric assay. Journal of Molecular Endocrinology 1993; 11(1)31–36
   Google Scholar
• Johnson JD, O'Connor KA, Deak T, Stark M, Watkins LR, Maier SF. Prior stressor exposure sensitizes LPS-induced cytokine production. Brain, Behaviour & Immunity 2002; 16(4)461–476
   PubMed Web of Science ®Google Scholar
• Kent S, Bluthe RM, Kelley KW, Dantzer R. Sickness behavior as a new target for drug development. Trends in Pharmacological Science 1992; 13(1)24–28
   Google Scholar
• Lanquillon S, Krieg JC, Bening-Abu-Shach U, Vedder H. Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology 2000; 22(4)370–379
   PubMed Web of Science ®Google Scholar
• Levine J, Barak Y, Chengappa KN, Rapoport A, Rebey M, Barak V. Cerebrospinal cytokine levels in patients with acute depression. Neuropsychobiology 1999; 40(4)171–176
   PubMed Web of Science ®Google Scholar
• Madsen TM, Treschow A, Bengzon J, Bolwig TG, Lindvall O, Tingstrom A. Increased neurogenesis in a model of electroconvulsive therapy. Biological Psychiatry 2000; 47(12)1043–1049
   PubMed Web of Science ®Google Scholar
• Maes M. The immunoregulatory effects of antidepressants. Human Psychopharmacology 2001; 16(1)95–103
   Google Scholar
• Maes M, Bosmans E, Meltzer HY. Immunoendocrine aspects of major depression. Relationships between plasma interleukin-6 and soluble interleukin-2 receptor, prolactin and cortisol. European Archives in Psychiatry & Clinical Neuroscience 1995; 245(3)172–178
   Google Scholar
• Maes M, Lin AH, Delmeire L, Van Gastel A, Kenis G, De Jongh R. Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in post-traumatic stress disorder following accidental man-made traumatic events. Biological Psychiatry 1999; 45(7)833–839
   PubMed Web of Science ®Google Scholar
• Maes M, Meltzer HY, Scharpe S, Bosmans E, Suy E, De Meester I. Relationships between lower plasma L-tryptophan levels and immune-inflammatory variables in depression. Psychiatry Research 1993a; 49(2)151–165
   PubMed Web of Science ®Google Scholar
• Maes M, Scharpe S, Meltzer HY, Bosmans E, Suy E, Calabrese J. Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression. Psychiatry Research 1993b; 49(1)11–27
   PubMed Web of Science ®Google Scholar
• Maes M, Song C, Lin A, De Jongh R, Van Gastel A, Kenis G. The effects of psychological stress on humans: Increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine 1998; 10(4)313–318
   PubMed Web of Science ®Google Scholar
• Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. Journal of Neuroscience 2000; 20(24)9104–9110
   PubMed Web of Science ®Google Scholar
• Mohr DC, Goodkin DE, Islar J, Hauser SL, Genain CP. Treatment of depression is associated with suppression of nonspecific and antigen-specific T(H)1 responses in multiple sclerosis. Archives in Neurology 2001; 58(7)1081–1086
   PubMed Web of Science ®Google Scholar
• Mohr DC, Hart SL, Julian L, Cox D, Pelletier D. Association between stressful life events and exacerbation in multiple sclerosis: A meta-analysis. British Medical Journal 2004; 328(7442)731
   PubMed Web of Science ®Google Scholar
• Monje ML, Toda H, Palmer TD. Inflammatory blockade restores adult hippocampal neurogenesis. Science 2003; 302(5651)1760–1765
   PubMed Web of Science ®Google Scholar
• Patten SB, Metz LM. Depression in multiple sclerosis. Psychotherapy & Psychosomatics 1997; 66(6)286–292
   PubMed Web of Science ®Google Scholar
• Perlstein RS, Whitnall MH, Abrams JS, Mougey EH, Neta R. Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo. Endocrinology 1993; 132(3)946–952
   Google Scholar
• Pollak Y, Ovadia H, Goshen I, Gurevich R, Monsa K, Avitsur R. Behavioral aspects of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 2000; 104(1)31–36
   Google Scholar
• Rabkin JG, Albert SM, Del Bene ML, O'sullivan I, Tider T, Rowland LP. Prevalence of depressive disorders and change over time in late-stage ALS. Neurology 2005; 65(1)62–67
   PubMed Web of Science ®Google Scholar
• Ramamoorthy S, Ramamoorthy JD, Prasad PD, Bhat GK, Mahesh VB, Leibach FH. Regulation of the human serotonin transporter by interleukin-1 beta. Biochemical & Biophysical Research Communications 1995; 216(2)560–567
   Web of Science ®Google Scholar
• Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A. Cytokine-associated emotional and cognitive disturbances in humans. Archives in General Psychiatry 2001; 58(5)445–452
   PubMed Web of Science ®Google Scholar
• Sakic B, Denburg JA, Denburg SD, Szechtman H. Blunted sensitivity to sucrose in autoimmune MRL-lpr mice: A curve-shift study. Brain Research Bulletin 1996; 41(5)305–311
   Google Scholar
• Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003; 301(5634)805–809
   PubMed Web of Science ®Google Scholar
• Sapolsky RM. Is impaired neurogenesis relevant to the affective symptoms of depression?. Biological Psychiatry 2004; 56(3)137–139
   Google Scholar
• Schiepers OJ, Wichers MC, Maes M. Cytokines and major depression. Progress in Neuropsychopharmacology & Biological Psychiatry 2005; 29(2)201–217
   PubMed Web of Science ®Google Scholar
• Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW. Hippocampal atrophy in recurrent major depression. Proceedings of the National Academy of Science USA 1996; 93(9)3908–3913
   PubMed Web of Science ®Google Scholar
• Smith RS. The macrophage theory of depression. Medical Hypotheses 1991; 35: 298–306
   PubMed Web of Science ®Google Scholar
• Song C, Merali Z, Anisman H. Variations of nucleus accumbens dopamine and serotonin following systemic interleukin-1, interleukin-2 or interleukin-6 treatment. Neuroscience 1999; 88(3)823–836
   Google Scholar
• Stone TW, Darlington LG. Endogenous kynurenines as targets for drug discovery and development. Nature Reviews. Drug Discovery 2002; 1(8)609–620
   PubMed Web of Science ®Google Scholar
• Taylor MW, Feng GS. Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. The FASEB journal: official publication of the Federation of American Societies for Experimental Biology 1991; 5(11)2516–2522
   PubMed Web of Science ®Google Scholar
• Tilders FJ, Schmidt ED. Interleukin-1-induced plasticity of hypothalamic CRH neurons and long-term stress hyper-responsiveness. Annals of the New York Academy of Science 1998; 840: 65–73
   PubMed Web of Science ®Google Scholar
• Vallieres L, Campbell IL, Gage FH, Sawchenko PE. Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. Journal of Neuroscience 2002; 22(2)486–492
   PubMed Web of Science ®Google Scholar
• Wichers MC, Maes M. The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression. Journal of Psychiatry & Neuroscience 2004; 29(1)11–17
   Web of Science ®Google Scholar
• Young EA, Haskett RF, Murphy-Weinberg V, Watson SJ, Akil H. Loss of glucocorticoid fast feedback in depression. Archives in General Psychiatry 1991; 48(8)693–699
   PubMed Web of Science ®Google Scholar
• Zhou D, Kusnecov AW, Shurin MR, Depaoli M, Rabin BS. Exposure to physical and psychological stressors elevates plasma interleukin 6: Relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology 1993; 133(6)2523–2530
   PubMed Web of Science ®Google Scholar
• Zhou D, Shanks N, Riechman SE, Liang R, Kusnecov AW, Rabin BS. Interleukin 6 modulates interleukin-1 and stress-induced activation of the hypothalamic-pituitary-adrenal axis in male rats. Neuroendocrinology 1996; 63(3)227–236
   Google Scholar