Methylotrophs for Biotechnology; Methanol as a Raw Material for Fermentative Production

References

• Anthony , C. 1982 . The Biochemistry of Methylotrophs , London : Academic Press .
   Google Scholar
• Aston , W. J. and Turner , A. P. F. 1984 . “ Biosensors and biofuel cells ” . In Biotechnology and Genetic Engineering Reviews , Edited by: Russell , G. E. Vol. 1 , 89 – 120 . Ponteland. Newcastle upon Tyne. : Intercept. .
   Google Scholar
• Baratti , J. , Couderc , R. , Cooney , C. L. and Wang , D. I. C. 1978 . Preparation and properties of immobilized methanol oxidase . Biotechnology and Bioengineering , 20 : 333 – 348 .
   Web of Science ®Google Scholar
• Chida , K. , Shen , G.-J. , Kodama , T. and Minoda , Y. 1983 . Acidic polysaccharide production from methane by a new methane-oxidizing bacterium H-2 . Agricultural and Biological Chemistry , 47 : 275 – 280 .
   Web of Science ®Google Scholar
• Colby , J. , Dalton , H. and Whittenbury , R. 1979 . Biological and biochemical aspects of microbial growth on C1 compounds . Annual Review of Microbiology , 33 : 481 – 517 .
   PubMed Web of Science ®Google Scholar
• Colby , J. , Stirling , D. I. and Walton , H. 1977 . The soluble methane mono-oxygenase of Methylococcus capsulatus (Bath). Its ability to oxygenate n-alkanes, n-alkenes, ethers, and alicyclic. aromatic and heterocyclic compounds . Biochemical Journal , 165 : 395 – 402 .
   PubMed Web of Science ®Google Scholar
• Cooney , C. L. and Levine , D. W. 1975 . “ SCP production from methanol by yeast ” . In Single Cell Protein , Edited by: Tannenbaum , S. R. and Wang , D. I. C. Vol. 2 , 402 – 423 . Cambridge : MIT Press. .
   Google Scholar
• Couderc , R. and Baratti , J. 1980 . Immobilized yeast cells with methanol oxidase activity: Preparation and enzymatic properties . Biotechnology and Bioengineering , 22 : 1155 – 1173 .
   Web of Science ®Google Scholar
• Crawford , R. L. and Hanson , R. S. , eds. 1984 . Microbial growth on C₁ compounds: Proceeding of the Fourth International Symposium , DC : American Society for Microbiology. Washington .
   Google Scholar
• Dalton , H. 1980 . Oxidation of hydrocarbons by methane mono-oxygenases from a variety of microbes . Advances in Applied Microbiology , 26 : 71 – 87 .
   Google Scholar
• Davis , G. , Hill , H. A.O. , Aston , W. J. , Higgins , I. J. and Turner , A. P. F. 1983 . Bioelectrochemicai fuel cell and sensor based on a quinoprotein methanol dehydrogenase . Enzyme and Microbial Technology , 5 : 383 – 388 .
   Web of Science ®Google Scholar
• Denenu , E. O. and Demain , A. L. 1981 . Derivation of aromatic amino acid mutants from a methanol-utilizing yeast . Hansenula polymorpha. Applied and Environmental Microbiology , 41 : 1088 – 1096 .
   PubMed Web of Science ®Google Scholar
• Dumenil , G. , Crémieux , A. , Couderc , R. , Chevalier , J. , Guiraud , H. and Ballerini , D. 1979 . Production of vitamin B12 by Gram-variable methanol-utilizing bacteria . Biotechnology Letters , 1 : 371 – 376 .
   Web of Science ®Google Scholar
• Dworkin , M. and Foster , J. W. 1957 . Studies on Pseudomonas methanica (Söhngen) nov. comb . Journal of Bacteriology , 72 : 646 – 659 .
   Web of Science ®Google Scholar
• Eggeling, L., Sahm, H. and Wagner, F. (1977). Induction of FMN adenylyltrans-ferase in the methanol utilizing yeast Candida biodinii. FEMS Microbiology Letters 1, 205–210.
   Google Scholar
• Eguchi, S. Y., Nishio, N. and Nagai, S. (1983). NADPH production from NADP+ by a formate-utilizine methanogenic bacterium. Agricultural and Biological Chemistry 47, 2941–2943.
   Google Scholar
• Furuhashi, K., Taoka, A., Uchida, S., Karube, I. and Suzuki, S. (1981). Production of 1,2-epoxyalkanes from 1-alkenes by Nocardia corallina B-276. European Journal of Applied Microbiology and Biotechnology 12, 39–45.
   Google Scholar
• Geigert, J., Neidleman, S. L., Liu, T.-N. E., DeWitt, S. K., Panschar, B. M., Dalietos, D. J. and Siegel, E. R. (1983). Production of epoxides from a, ß-halohvdrins by Flavobacterium sp. Applied and Environmental Microbiology 45, 1148–1149.
   Google Scholar
• Häggström, L. (1977). Mutant of Methylomonas methanolica and its characterization with respect to biomass production from methanol. Applied and Environmental Microbiology 33, 567–576.
   Google Scholar
• Hennam, J. F., Cunningham, A. E., Sharpe, G. S. and Atherton, K. T. (1982). Expression of eukarvotic coding sequences in Methvlophilus methylotrophus. Nature 297, 80–82.
   Google Scholar
• Higgins, I. J., Hammond, R. C, Sariaslani, F. S., Best, D., Davies, M. M., Tryhorn, S. E. and Taylor, F. (1979). Biotransformation of hydrocarbons and related compounds by whole organism suspensions of methane-grown Methylosinus trichosporium OB 3b. Biochemical and Biophysical Research Communications 89, 671–677.
   Google Scholar
• Higgins, I J., Aston, W. J., Best, D. J., Turner, A. P. F., Jezequel, S. G. and Hill, H. A. O. (1984). Applied aspects of methylotrophy: Bioelectrochemicai applications, purification of methanol dehydrogenase, and mechanism of methane monooxygenase. In Microbial Growth on C1 Compounds (R. L. Crawford and R. S. Hanson, Eds), pp. 297–305. American Society for Microbiology, Washington, DC.
   Google Scholar
• Hou, C. T. (Ed.) (1984). Methylotrophs: Microbiology, Biochemistry and Genetics. CRC Press. Florida.
   Google Scholar
• Hou, C. T., Laskin, A. I. and Patel, R. N. (1978). Growth and polysaccharide production by Methylocystis parvus OBBP on methanol. Applied and Environmental Microbiology 37, 800–804.
   Google Scholar
• Hou, C. T., Patel, R. N. and Laskin, A. I. (1980). Epoxidation and ketone formation by C1-utilizing microbes. Advances in Applied Microbiology 26, 41–69.
   Google Scholar
• Hou, C. T., Patel, R., Laskin, A. I. and Barnabe, N. (1979a). Microbial oxidation of gaseous hydrocarbons: Epoxidation of C2 to C4 n-alkenes by methylotrophic bacteria. Applied and Environmental Microbiology 38, 127–134.
   Google Scholar
• Hou, C. T., Patel, R., Laskin, A. I., Barnabe, N. and Marczak. 1. (1979b). Microbial oxidation of gaseous hydrocarbons: Production of methyl ketones from their corresponding secondary alcohols by methane- and methanol-grown microbes. Applied and Environmental Microbiology 38, 135–142.
   Google Scholar
• Hou, C. T., Patel, R. N., Laskin, A. I. Barnaul, N. and Marczak, I. (1979c). Identification and purification of a nicotinamide adenine dinucleotide-dependent secondary alcohol dehydrogenase from C1-utilizing microbes. FEBS Letters 101, 179–183.
   Google Scholar
• Hou, C. T., Patel, R., Barnabe, N. and Marczak, I. (1981). Stereospecificity and other properties of a novel secondary-alcohol-specific alcohol dehydrogenase. European Journal of Biochemistry 119, 359–364.
   Google Scholar
• Izumi, Y., Asano, Y., Tani, Y. and Ogata, K. (1977). Mutants of an obligate methyiotroph, formation of valine and leucine by analog-resistant Methylomonas aminofaciens. Journal of Fermentation Technology 55, 452–458.
   Google Scholar
• Izumi, Y., Takizawa, M., Tani, Y. and Yamada, H. (1982). L-Serine production by resting cells of a methanol-utilizing bacterium. Journal of Fermentation Technology 60, 269–276.
   Google Scholar
• Izumi, Y., Mishra, S. K., Ghosh, B. S., Tani Y. and Yamada, H. (1983). NADH production from NAD+ using a formate dehydrogenase system with cells of a methanol-utilizing bacterium. Journal of Fermentation Technology 61, 135–142.
   Google Scholar
• Jigami, Y., Suzuki, O. and Nakasato, S (1979). Comparison of lipid composition of Candida guilliermondii grown on glucose, ethanol and methanol as the sole carbon source. Lipids 14, 937–942.
   Google Scholar
• Kanamaru, K., Hieda, T., Iwamuro, Y., Mikami, Y., Obi, Y. and Kisaki, T. (1982a). Isolation and characterization of a Hyphomicrobium species and its polysaccharide formation from methanol. Agricultural and Biological Chemistry 46, 2411–2417. Kanamaru, K.,, Iwamuro, Y., Mikami, Y., Obi, Y. and Kisaki, T. (1982b). 2-O-methyl-D-mannose in an extracellular polysaccharide from Hyphomicrobium sp, Agricultural and Biological Chemistry 46, 2419–2424.
   Google Scholar
• Karube, I. (1984). Possible developments in microbial and other sensors for fermentation control. In Biotechnology and Genetic Engineering Reviews (G. E. Russell, Ed.), volume 2, pp. 313–339. Intercept, Ponteland, Newcastle upon Tyne.
   Google Scholar
• Karube, I., Okada, T. and Suzuki, S. (1982). A methane gas sensor based on methane-oxidizing bacteria. Analytica chimica acta 135, 61–67.
   Google Scholar
• Kato, N., Kano, M, Tani, Y. and Ogata, K. (1974). Purification and characterization of formate dehydrogenase in a methanol-utilizing yeast, Kloeckera sp. No. 2201. Agricultural and Biological Chemistry 38, 111–116.
   Google Scholar
• Kato, N., Tani, Y. and Yamada, H. (1983). Microbial utilization of methanol: Production of useful metabolites. Advances in Biotechnological Processes 1, 171–202.
   Google Scholar
• Keune, H., Sahm, H. and Wagner, F. (1976). Production of L-serine by the methanol utilizing bacterium. Pseudomonas 3ab. European Journal of Applied Microbiology 2, 175–184.
   Google Scholar
• KierStan, M. (1982). The enzymatic conversion of ethanol to acetaldehyde as a model recovery system. Biotechnology and Bioengineering 24, 2275–2277’.
   Google Scholar
• KierStan , M. 1982 . The enzymatic conversion of ethanol to acetaldehyde as a model recovery system . Biotechnology and Bioengineering , 24 : 2275 – 2277 .
   PubMed Web of Science ®Google Scholar
• King , P. P. 1982 . Biotechnology. An industrial view . Journal of Chemical Technology and Biotechnology , 32 : 2 – 8 .
   Web of Science ®Google Scholar
• Kuraishi, M., Ohkouchi, H., Matsuda, N. and Terao, I. (1977). A study on the performance of air-lift fermentors in the production of methanol single cell protein. In Microbial Growth on C1-Compounds, (G. K. Skryabin, M. V. Ivanov, E. N. Kondratjeva, G. A. Zavarzin, Yu, A. Trotsenko and A. I. Nesterov, Eds), pp. 180–181. Scientific Centre for Biological Research, USSR Academy of Sciences. Puschino.
   Google Scholar
• Longin, R., Cooney, C. L. and Demain, A. L. (1982). Studies on the overproduction of indole-containing metabolites by a methanol-utilizing yeast, Hansenula polymorpha. Applied Biochemistry and Biotechnology 7, 281–293.
   Google Scholar
• Misaki, A., Tsumuraya, Y. and Kakuta, M. (1979). D-Allose-containing polysaccharide synthesized from methanol by Pseudomonas sp. Carbohydrate Research 75, C8.
   Google Scholar
• Morinaga, Y., Tani, Y. and Yamada, H. (1982a). Regulatory properties of L-metbionine biosynthesis in obligate methylotroph OM 33: Role of homoserine-O-transsuccinylase. Agricultural and Biological Chemistry 46, 57–63.
   Google Scholar
• Morinaga, Y., Tani, Y. and Yamada, H. (1982b). L-Metnionine production by ethionine-resistant mutants of a facultative methylotroph, Pseudomonas FM 518. Agricultural and Biological Chemistry 46, 473–480.
   Google Scholar
• Morinaga, Y., Tani, Y. and Yamada, H. (1983). Biosynthesis of homocysteine in a facultative methylotroph, Pseudomonas FM 518. Agricultural and Biological Chemistry 47, 2855–2860.
   Google Scholar
• Morinaga, Y., Tani, Y. and Yamada, H. (1984). Homocysteine transmethylation in methanol-utilizing bacteria and its application to L-methionine production. Agricultural and Biological Chemistry 48, 143–148.
   Google Scholar
• Morinaga, Y., Yamanaka, S. and Takinami, K. (1981a). L-Serine production by methanol-utilizing bacterium Pseudomonas MS31. Agricultural and Biological Chemistry 45, 1419–1424.
   Google Scholar
• Morinaga, Y., Yamanaka, S. and Takinami, K. (1981b). L-Serine production by temperature-sensitive mutants of methanol-utilizing bacterium Pseudomonas MS31. Agricultural and Biological Chemistry 45, 1425–1430.
   Google Scholar
• Morinaga, Y., Yamanaka, S. and Takinami, K. (1983). L-Serine production improved by analogue-resistant mutants of a methanol-utilizing bacterium. Agricultural and Biological Chemistry 47, 2113–2114.
   Google Scholar
• Natori, Y. and Nagasaki, T. (1979). Formation of coenzyme Q11 by Pseudomonas M16. a mutant. Agricultural and Biological Chemistry 43, 797–801.
   Google Scholar
• Natori, Y. and Nagasaki, T. (1980). Occurrence of coenzyme Q12 and coenzyme Q13 in facultative methanol-oxidizing bacteria. Agricultural and Biological Chemistry 4, 2105–2110.
   Google Scholar
• Natori, Y. and Nagasaki, T. (1981). Enhancement of coenzyme Q10 accumulation by mutation and effects of medium components on the formation of coenzyme Q homologs by Pseudomonas N842 and mutants. Agricultural unci Biological Chemistry 45, 2175–2182.
   Google Scholar
• Natori, Y., Nagasaki, T., Kobayashi, A. and Fukawa, H. (1978). Production of coenzyme Q10 by Pseudomonas N842. Agricultural and Biological Chemistry 42, 1799–1800.
   Google Scholar
• Nishio, N., Yano, T. and Kamikubo, T. (1975a). Isolation of methanol-utilizing bacteria and its vitamin B12 production. Agricultural and Biological Chemistry 39, 21–27.
   Google Scholar
• Nishio, N., Yano, T. and Kamikubo, T. (1975b). Further studies of vitamin B12 production by methanol utilizing bacterium, Klebsiella sp. No. 101. Agricultural and Biological Chemistry 39, 207–213.
   Google Scholar
• Nishio, N., Tanaka, M., Matsuno, R. and Kamikubo, T. (1977a). Production of vitamin B12 by methanol-utilizing bacteria, Pseudomonas AM-1 and Microcyclus eburneus. Journal of Fermentation Technology 55, 200–203.
   Google Scholar
• Nishio, N., Tsuchiya, Y., Hayashi, M. and Nagai, S. (1977b). A fed-batch culture of methanol-utilizing bacteria with pH stat. Journal of Fermentation Technology 55, 151–155.
   Google Scholar
• Nishio , N. , Tsuchiya , Y. , Hayashi , M. and Nagai , S. 1977b . A fed-batch culture of methanol-utilizing bacteria with pH stat . Journal of Fermentation Technology , 55 : 151 – 155 .
   Google Scholar
• Ogata , K. , Izumi , Y. , Kawamori , M. , Asano , Y. and Tank , Y. 1977 . Amino acid formation by methanol-utilizing bacteria . Journal of Fermentation Technology , 55 : 444 – 451 .
   Google Scholar
• Ohsugi , M. , Yamada , M. , Yoshida , Y. , Ishibashi , F. and Inoue , Y. 1983 . Isolation of a formate-assimilating bacterium and its vitamin B12 formation . Agricultural and Biological Chemistry , 47 : 1127 – 1128 .
   Web of Science ®Google Scholar
• Okada , T. , Karube , I. and Suzuki , S. 1981 . Microbial sensor system which uses Methylomonas sp. for the determination of methane . European Journal of Applied Microbiology and Biotechnology , 12 : 102 – 106 .
   Web of Science ®Google Scholar
• Oki , T. , Kitai , A. , Kouno , K. and Ozaki , A. 1973 . Production of L-glutamic acid by methanol-utilizing bacteria . Journal of General and Applied Microbiology , 19 : 79 – 83 .
   Web of Science ®Google Scholar
• Patel , R. N. 1984 . “ Methane monooxygenase from Methylobacterium sp. strain CRL-26 ” . In Microbial Growth on C₁ Compounds , Edited by: Crawford , R. L. and Hanson , R. S. 83 – 90 . Washington, DC : American Society for Microbiology .
   Google Scholar
• Patel , R. N. , Hou , C. T. , Laskin , A. I. , Felix , A. and Derelanko , P. 1979a . Microbial oxidation of gaseous hydrocarbons. II. Hydroxylation of alkenes and epoxidation of alkenes by cell-free particulate fractions of methane-utilizing bacteria . Journal of Bacteriology , 139 : 675 – 679 .
   PubMed Web of Science ®Google Scholar
• Patel , R. N. , Hou , C. T. , Laskin , A. I. , Derelanko , P. and Felix , A. 1979b . Oxidation of secondary alcohols to methyl ketones by yeast . Applied and Environmental Microbiology , 38 : 219 – 223 .
   PubMed Web of Science ®Google Scholar
• Patel , R. N. , Hou , C. T. , Laskin , A. I. , Derelanko , P. and Felix , A. 1979c . Microbial production of methyl ketones. Purification and properties of a secondary alcohol dehydrogenase from yeast . European Journal of Biochemistry , 101 : 401 – 406 .
   PubMedGoogle Scholar
• PloTkin , E. V. , Higgins , I. J. and Hill , H. A. O. 1981 . Methanol dehydrogenase bioeiectrochemicai cell and alcohol detector . Biotechnology Letters , 3 : 187 – 192 .
   Web of Science ®Google Scholar
• Reuss , M. , Gnieser , J. , Reng , H. G. and Wagner , F. 1975 . Extended culture of Candida boidinii on methanol . European Journal of Applied Microbiology , 1 : 295 – 305 .
   Web of Science ®Google Scholar
• Sahm , H. 1977 . Metabolism of methanol by yeasts . Advances in Biochemical Engineering , 6 : 77 – 103 .
   Google Scholar
• Salisbury , S. A. , Forrest , H. S. , Cruse , W. B. T. and Kennard , O. 1979 . A novel coenzyme from bacterial primary alcohol dehydrogenases . Nature , 280 : 844 – 845 .
   Web of Science ®Google Scholar
• Sanchez , S. and Demain , A. L. 1978 . Tryptophan excretion by a bradytroph of Hansenula polymorpha growing in methanol . Applied and Environmental Microbiology , 35 : 459 – 461 .
   PubMed Web of Science ®Google Scholar
• Sato , K. 1978 . Bacteriochlorophyll formation by facultative methylotrophs Protaminobacter ruber and Pseudomonas AMI . FEBS Letters , 85 : 207 – 210 .
   PubMed Web of Science ®Google Scholar
• Sato , K. and Shimizu , S. 1979 . The conditions for bacteriochlorophyll formation and the ultrastructure of a methanol-utilizing bacterium. Protaminobacter ruber. classified as non-photosynthetic bacteria . Agricultural and Biological Chemistry , 43 : 1669 – 1675 .
   Web of Science ®Google Scholar
• Sato , K. , Ueda , S. and Shimizu , S. 1976 . Methylmalonyl-CoA mutase in a methanol-utilizing bacterium . Protaminobacter ruber. FEBS Letters , 71 : 248 – 250 .
   PubMed Web of Science ®Google Scholar
• Sato , K. , Ueda , S. and Shimizu , S. 1977 . Form of vitamin B12 and its role in a methanol-utilizing bacterium . Protaminobacter ruber. Applied and Environmental Microbiology , 33 : 515 – 521 .
   PubMed Web of Science ®Google Scholar
• Sato , K. , Mizutani , T. , Hiraoka , M. and Shimizu , S. 1982 . Carotenoid containing sugar moiety from a facultative methylotroph . Protaminobacter ruber. Journal of Fermentation Technology , 60 : 111 – 115 .
   Google Scholar
• Shimizu , S. , Ishida , M. , Kano , N. , Tani , Y. and Ogata , K. 1977a . Flavin changes of Kloeckera sp. No. 2201 during adaptation to methanol . Agricultural and Biological Chemistry , 41 : 423 – 424 .
   Web of Science ®Google Scholar
• Shimizu , S. , Ishida , M. , Tani , Y. and Ogata , K. 1977b . Derepression of FAD pyrophosphorylase and flavin changes during growth of Kloeckera sp. No. 2201 on methanol . Agricultural and Biological Chemistry , 41 : 2215 – 2220 .
   Web of Science ®Google Scholar
• Shimizu , S. , Ishida , M. , Tani , Y. and Ogata , K. 1977c . Production of flavin adenine dinucleotide by methanol-utilizing yeasts . Journal of Fermentation Technology , 5 : 630 – 632 .
   Google Scholar
• Shimizu , S. , Sato , K. , Hiraoka , M. , Yamashita , F. and Kobayashi , T. 1982 . Carotenoid formation by a facultative methylotroph . Protaminobacter ruber. Journal of Fermentation Technology , 60 : 163 – 166 .
   Google Scholar
• Suzuki , M. , Kühn , I. , Berglund , Å. , Unden , A. and Heden , C.-G. 1977a . Identification of a new methanol-utilizing bacterium and its characteristic responses to some chemicals . Journal of Fermentation Technology , 5 : 459 – 465 .
   Google Scholar
• Suzuki , M. , Berglund , Å. , Unden , A. and Heden , C.-G. 1977b . Aromatic amino acids production by analogue-resistant mutants of Methylomonas methanolophila Volume 6 R . Journal of Fermentation Technology , 55 : 466 – 475 .
   Google Scholar
• Suzuki , O. , Jigami , Y. and Nakasato , S. 1979 . Changes in lipid composition of methanol-grown Candida guilliermondii . Agricultural and Biological Chemistry , 43 : 1343 – 1345 .
   Web of Science ®Google Scholar
• Tanaka , A. , Ohya , Y. , Shimizu , S. and Fukui , S. 1974 . Production of vitamin B12 by methanol-assimilating bacteria . Journal of Fermentation Technology , 52 : 921 – 924 .
   Google Scholar
• Tanaka , Y. , Araki , K. and Nakayama , K. 1980 . Accumulation of O-methyl-L-homoserine by methanol-utilizing bacteria . Biotechnology Letters , 2 : 67 – 74 .
   Web of Science ®Google Scholar
• Tani , Y. 1984 . “ Microbiology and biochemistry of methylotrophic yeasts ” . In Methylotrophs: Microbiology, Biochemistry and Genetics , Edited by: Hou , C. T. 55 – 85 . Florida : CRC Press .
   Google Scholar
• Tani , Y. and Yamada , H. 1980 . Microbial utilization of C1-compounds . Biotechnology and Bioengineering , 1 : 163 – 175 . 22
   Google Scholar
• Tani , Y. and Yonehara , T. 1985 . ATP production from adenosine or adenine by a methanol yeast, Candida boidinii (Kloeckera sp.) No. 2201 . Agricultural and Biological Chemistry , 49 : 637 – 642 .
   Web of Science ®Google Scholar
• Tani , Y. , Kato , N. and Yamada , H. 1978 . Utilization of methanol by yeasts . Advances in Applied Microbiology , 24 : 165 – 186 .
   PubMedGoogle Scholar
• Tani , Y. , Mitani , Y. and Yamada , H. 1982 . Utilization of C1-compounds: Phosphorylation of adenylate by oxidative phosphorylation in Candida boidinii (Kloeckera sp.) No. 2201 . Agricultural and Biological Chemistry , 46 : 1097 – 1099 .
   Web of Science ®Google Scholar
• Tani , Y. , Mitani , Y. and Yamada , H. 1984a . ATP production by protoplasts of a methanol yeast, Candida boidinii (Kloeckera sp.) No. 2201 . Agricultural and Biological Chemistry , 48 : 431 – 437 .
   Web of Science ®Google Scholar
• Tani , Y. , Mstani , Y. and Yamada , H. 1984b . Preparation of ATP-production cells of a methanol yeast, Candida boidinii (Kloeckera sp.) No. 2201 . Journal of Fermentation Technology , 62 : 99 – 101 .
   Google Scholar
• Tani , Y. , Sakai , Y. and Yamada , H. 1985 . “ Isolation and characterization of a mutant of a methanol yeast ” . In Candida boidinii S2 , with higher formaldehyde productivity. Agricultural and Biological Chemistry . in press
   Google Scholar
• Tani , Y. , Yoon , B.-D. and Yamada , H. 1985 . Production of cytochrome c by an obligate methyiotroph Methylomonas sp. YK1 . Agricultural and Biological Chemistry , in press
   Google Scholar
• Tani , Y. , Miya , T. and Ogata , K. 1972 . The microbial metabolism of methanol. Part II. Properties of crystalline alcohol oxidase from Kloeckera sp. No. 2201 . Agricultural and Biological Chemistry , 36 : 76 – 83 .
   Google Scholar
• Tani , Y. , Miya , T. , Nishikawa , H. and Ogata , K. 1972 . The microbial metabolism of methanol. Part 1. Formation and crystallization of methanol-oxidizing enzyme in a methanol-utilizing yeast, Kloeckera sp. No. 2201 . Agricultural and Biological Chemistry , 36 : 68 – 75 .
   Web of Science ®Google Scholar
• Tani , Y. , Kanagawa , T. , Hanpongkittikun , A. , Ogata , K. and Yamada , H. 1978 . Production of L-serine by a methanol-utilizing bacterium, Arthrobacter globifor-mis SK-200 . Agricultural and Biological Chemistry , 42 : 2275 – 2279 .
   Web of Science ®Google Scholar
• Tani , Y. , Yonehara , T. , Mitani , Y. and Yamada , H. 1984 . ATP production by sorbitol-treated cells of a methanol yeast, Candida boidinii (Kloeckera sp.) No. 2201 . Journal of Biotechnology , 1 : 119 – 127 .
   Web of Science ®Google Scholar
• Toraya , T. , Yongsmitm , B. , Tanaka , A. and Fukui , S. 1975 . Vitamin Bl2 production by a methanol-utilizing bacterium . Applied Microbiology , 30 : 477 – 179 .
   PubMedGoogle Scholar
• Toraya , T. , Yongsmith , B. , Honda , S. , Tanaka , A. and Fukui , S. 1976 . Production of vitamin B12 by a methanol-utilizing bacterium . Journal of Fermentation Technology , 54 : 102 – 108 .
   Google Scholar
• Tsuchiya , Y. , Nishio , N. and Nagai , S. 1980 . Vitamin B12 production from methanol by continuous culture of Pseudomonas AM-1 . Journal of Fermentation Technology , 58 : 485 – 487 .
   Google Scholar
• Ueda , S. , Sato , K. and Shimizu , S. 1981 . Glyoxylate formation from mesaconyl-CoA and its related reactions in a methanol-utilizing bacterium . Protaminobacter ruber. Agricultural and Biological Chemistry , 45 : 823 – 830 .
   Web of Science ®Google Scholar
• Urakami , T. and Komagata , K. 1979 . Cellular fatty acid composition and coenzyme Q system in gram-negative methanol-utilizing bacteria . Journal of General and Applied Microbiology , 25 : 343 – 360 .
   Web of Science ®Google Scholar
• Urakami , T. and Komagata , K. 1981 . Electrophoretic comparison of enzymes in the gram negative methanol-utilizin bacteria . Journal of General and Applied Microbiology , 27 : 381 – 403 .
   Web of Science ®Google Scholar
• Urakami , T. , Terao , I. and Nagai , I. 1981 . “ Process for producing bacterial single cell protein from methanol ” . In Microbial Growth on C ₁-Compounds , Edited by: Dalton , H. 349 – 359 . London : Heyden & Son Ltd .
   Google Scholar
• Van Dijken , J. P. and Harder , W. 1975 . Growth yields of microorganisms on methanol and methane. A theoretical studv . Biotechnology and Bioengineering , 17 : 15 – 30 .
   Web of Science ®Google Scholar
• Van Dijken , H. P. , Harder , W. and Quayle , J. R. 1981 . “ Energy transduction and carbon assimilation in methylotrophic yeasts ” . In Microbial Growth on C₁ Compounds , Edited by: Dalton , H. 191 – 201 . London : Heyden & Sons Ltd .
   Google Scholar
• Van Dijken , J. P. , Otto , R. and Harder , W. 1976 . Growth of Hansenuia polymorpha in a methanol-limited chemostat. Physiological responses due to the involvement of methanol oxidase as a key enzyme in methanol metabolism . Archives of Microbiology , 111 : 137 – 144 .
   PubMed Web of Science ®Google Scholar
• Vasey , R. B. and Powell , K. A. 1984 . “ Single-cell protein ” . In Biotechnology and Genetic Engineering Reviews , Edited by: Russell , G. E. Vol. 2 , 285 – 311 . Ponteland, Newcastle upon Tyne : Intercept .
   Google Scholar
• Windass , J. D. , Worsey , M. J. , Pioli , E. M. , Pioli , D. , Barth , P. T. , Atherton , K. T. , Dart , E. C. , Byrom , D. , Powell , K. and Senior , P. J. 1980 . Improved conversion of methanol to single-cell protein by Methylophilus methyiotrophus . Nature , 287 : 396 – 401 .
   PubMed Web of Science ®Google Scholar
• Yamada , H. , Morinaga , Y. and Tani , Y. 1982 . L-Methionine overproduction by ethionine-resistant mutants of obligate methylotroph strain OM33 . Agricultural and Biological Chemistry , 46 : 47 – 55 .
   Web of Science ®Google Scholar
• Yamamoto , M. , Okamoto , R. and Inui , T. 1979 . Application of a marine methanol-utilizing bacterium for bioassay of vitamin B12 in sea water . Journal of Fermentation Technology , 57 : 400 – 407 .
   Google Scholar
• Yamane,T., Kishimoto.M. and Yoshida, F. (1976) Semi-batch culture of methanol-assimilating bacteria with exponentially increased methanol feed. Journal of Fermentation Technology, 54, 229–240.
   Google Scholar
• Yano , T. , Kobayashi , T. and Shimizu , S. 1978 . Fed batch culture of methanol-utilizing bacterium with DO stat . Journal of Fermentation Technology , 56 : 416 – 420 .
   Google Scholar