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Original Articles

Mechanistic aspects the dioxin (aryl hydrocarbon) receptor

Pages 261-266 | Published online: 06 Dec 2010

References

  • Andersen , M. E. , Mills , J.-J. , Gorges , M. L. , Keddens , L. , Birnbaum , L. S. , Neubert , D. and Greenleaf , W. F. 1993 . Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment . Risk Analyses , 13 : 25 – 36 .
  • Andersen , M. E. , Birnbaum , L. S. , Barton , H.-A. and Ekland , L. R. 1997 . Regional hepatic CYP1A1 and CYP1A2 induction with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation . Toxicology and Applied Pharmacology , 144 : 145 – 155 .
  • Andreola , F. , Fernandez-Salguero , P. M. , Chiantore , M. V. , Petkovich , M. P. , Gonzalez , F. J. and De Luca , L. M. 1997 . Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism . Cancer Research , 57 : 2835 – 2838 .
  • Antoch , M. P. , Song , E. J. , Chang , A. M. , Vitaterna , M. H. , Zhao , Y. , Wilsbacher , L. D. , Sangoram , A. M. , King , D. P. , Pinto , L. H. and Takahashi , J. S. 1997 . Functional identification of the mouse circadian Clock gene by transgenic BAC rescue . Cell , 89 : 655 – 667 .
  • Ashok , M. , Turner , C. and Wilson , T. G. 1998 . Insect juvenile hormone resistance gene homology with the bHLH-PAS family of transcription factors . Proceedings of the National Academy of Sciences of the United States of America , 95 : 2761 – 2766 .
  • Ballario , P. and Macino , G. 1997 . White collar proteins: Passing the light signal in Neurospora crassa . Trends in Microbiology , 5 : 458 – 462 .
  • Bjeldames , L. F. , Kim , J. Y. , Grose , K. R. , Bartholomew , J. C. and Bradfield , C. A. 1991 . Aromatic hydrocarbon reponsiveness receptor agouits generated from indole-3-carbinol in vitro and in vivo: comparison with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin . Proceedings of the Natural Academy of Science USA , 88 : 9543 – 9547 .
  • Carver , L. A. , Jackiw , V. and Bradfield , C. A. 1994 . The 90-kDa heat shock protein is essential for Ah receptor signaling in a yeast expression system . Journal of Biological Chemistry , 269 : 30 109 – 30 112 .
  • Carver , L. A. and Bradfield , C. A. 1997 . Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo . Journal of Biological Chemistry , 272 : 11 452 – 11 456 .
  • Chang , C. Y. and Puga , A. 1998 . Constitutive activation of the aromatic hydrocarbon receptor . Molecular and Cellular Biology , 18 : 525 – 535 .
  • Chen , Y. H. , Riby , J. , Srivastava , P. , Bartholomew , J. , Denison , M. and Bjeldames , L. 1995 . Regulation of CYPIAI by indolo [3-2-6] carbazole in marine hepatomia cells . Journal of Biological Chemistry , 270 : 22548 – 22555 .
  • Crosthwaite , S. K. , Dunlap , J. C. and Loros , J. J. 1997 . Neurospora wc-1 and wc-2: transcription, photoresponses, and the origins of circadian rhythmicity . Sciences , 276 : 763 – 769 .
  • Dahmane , N. , Charron , G. , Lopes , C. , Yaspo , M.-L. , Manoury , C. , Decorte , L. , Sinet , P.-M. , Bloch , M. and Delabar , J.-M. 1995 . Down syndrome critical region contains a gene homologous to drosophila sim expressed during rat and human central nervous system development . Proceedings of the National Academy of Sciences of the United States of America , 92 : 9191 – 9195 .
  • Dong , L. , Ma , Q. and Whitlock , J. P. Jr . 1997 . Down-regulation of major histocompatibility complex Q1b gene expression by 2, 3, 7, 8- tetrachlorodibenzo-p-dioxin . Journal of Biological Chemistry , 272 : 29 614 – 29 619 .
  • Duncan , D. M. , Burgess , E. A. and Duncan , I. 1998 . Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor . Genes and Development , 12 : 1290 – 1303 .
  • Ema , M. , Matsushita , N. , Sogawa , K. , Ariyama , T. , Inazawa , J. , Nemoto , T. , Ota , M. , Oshimura , M. and Fujii-Kuriyama , Y. 1994a . Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21 . Journal of Biochemistry , 116 : 845 – 851 .
  • Ema , M. , Ohe , N. , Suzuki , M. , Mimura , J. , Sogawa , K. , Ikawa , S. and Fujii-Kuriyama , Y. 1994b . Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors . Journal of Biological Chemistry , 269 : 27 337 – 27 343 .
  • Ema , M. , Tanya , S. , Yohatami , N. , Sogawa , K. , Matsuda , Y. and Fujii-Kuriyama , Y. 1997 . A novel factor with close sequence similarity to hypoxia-inducible factor GHLH-PAS regulates VEGI expression and is potentially involved in lung and vascular development . Proceedings of the Natural Academy of Science USA , 94 : 4273 – 4278 .
  • Fan , C. M. , Kuwana , E. , Bulfone , A. , Flet cher , C. F. , Copeland , N. G. , Jenkins , N. A. , Crews , S. , Martinez , S. , Puelles , L. , Rubenstein , J. L. and Tessier-Lavigne , M. 1996 . Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome . Molecular and Cellular Neuroscience , 7 : 1 – 16 .
  • Fernandez-Salguero , P. , Pineau , T. , Hilbert , D. M. , McPhail , T. , Lee , S. S. , Kimura , S. , Nebert , D. W. , Rudikoff , S. , Ward , J. M. and Gonzalez , F. J. 1995 . Immune system impairment and hepatic fibrosis in mice lacking the dioxinbinding Ah receptor . Sciences , 268 : 722 – 726 .
  • Fernandez-Salguero , P. M. , Hilbert , D. M. , Rudikoff , S. , Ward , J. M. and Gonzalez , F. J. 1996 . Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity . Toxicology and Applied Pharmacology , 140 : 173 – 179 .
  • Fernandez-Salguero , P. M. , Ward , J. M. , Sundberg , J. P. and Gonzalez , F. J. 1997 . Lesions of aryl-hydrocarbon receptor-deficient mice . Veterinary Pathology , 34 : 605 – 614 .
  • Fujii-Kuriyama , Y. , Ema , M. , Mimura , J. , Matsushita , N. and Sogawa , K. 1995 . Polymorphic forms of the Ah receptor and induction of the CYP1A1 gene . Pharmacogenetics , 15 : 149 – 153 .
  • Gillner , M. , Bergman , J. , Ambilleau , C. , Feruström , B. and Gustafsson , J.-Đ. 1985 . Interactions of indoles with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver . Molecular Pharmacology , 28 : 357 – 363 .
  • Gillner , M. , Bergman , J. , Ambilleau , C. , Alexandersson , M. , Feruström , B. and Gustafsson , J.-Đ. 1993 . Interactions of indolo [3-2-6]carbazoles and related polycyclic aroma hydrocarbons with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver . Molecular Pharmacology , 44 : 336 – 345 .
  • Gonzalez , F. J. , Fernandez-Salguero , P. and Ward , J. M. 1996 . The role of the aryl hydrocarbon receptor in animal development, physiological homeostasis and toxicity of TCDD . Journal of Toxicological Sciences , 21 : 273 – 277 .
  • Gradin , K. , McGuire , J. , Wenger , R. H. , Kvietikova , I. , Whitelaw , M. L. , Toftgđrd , R. , Tora , L. , Gassmann , M. and Poellinger , L. 1996 . Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arut transcription factor . Molecular Cellular Biology , 16 : 5221 – 5231 .
  • Hahn , M. , Karchner , S. I. , Shapiro , M. A. and Perera , S. A. 1997 . Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family . Proceedings of the National Academy of Sciences of the United States of America , 94 : 13 743 – 13 748 .
  • Hankinson , O. 1995 . The aryl hydrocarbon receptor complex . Annual Review of Pharmacology and Toxicology , 35 : 307 – 340 .
  • Hoffman , E. C. , Reyes , H. , Chu , F. F. , Saunder , F. , Conley , L. H. , Brooks , B. A. and Hambiusan , O. 1991 . Cloning of a factor required for activity of the Ah (dioxin) receptor . Science , 252 : 954 – 958 .
  • IARC . 1997 . “ Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans ” . In IARC Monographs on the evaluation of carcinogenic risk to humans , Vol. 69 , Lyon : WHO, International Agency for Research on Cancer .
  • Ikuta , T. , Eguchi , H. , Tachibana , T. , Yoneda , Y. and Kawajiri , K. 1998 . Nuclear localization and export signals of the human aryl hydrocarbon receptor . Journal of Biological Chemistry , 273 : 2895 – 2904 .
  • Jan , Y. N. and Jan , L. Y. 1993 . HLH proteins, fly neurogenesis, and vertebrate myogenesis . Cell , 75 : 827 – 830 .
  • Kedderis , L. B. 1993 . A physiologically based pharmacokinetic model for 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in the rat: tissue distribution and CYP1A induction . Toxicology and Applied Pharmacology , 121 ( 1 ) : 87 – 98 .
  • King , D. P. , Zhao , Y. , Sangoram , A. M. , Wilsbacher , L. D. , Tanaka , M. , Antoch , M. P. , Steeves , T. D. , Vitaterna , M. H. , Kornhauser , J. M. , Lowrey , P. L. , Turek , F. W. and Takahashi , J. S. 1997 . Positional cloning of the mouse circadian clock gene . Cell , 89 : 641 – 653 .
  • Kleman , M. , Poellinger , L. and Gustafsson , J.-Đ. 1994 . Regulation of human dioxin receptor function by indolocarbazoles, receptor ligands of dietary origin . Journal of Biological Chemistry , 269 : 5137 – 5144 .
  • Kohn , M. C. 1993 . A mechanistic model of effects of dioxin on gene expression in the rat liver . Toxicology and Applied Pharmacology , 120 ( 1 ) : 138 – 154 .
  • Kohn , M. C. 1996 . A mechanistic model of effects of dioxin on thyroid hormones in the rat . Toxicology and Applied Pharmacology , 136 ( 1 ) : 29 – 48 .
  • Kozak , K. R. , Abbott , B. and Hankinson , O. 1997 . ARNT-deficient mice and placental differentiation . Developments in Biology , 191 : 297 – 305 .
  • Leung , H. W. 1990 . Pharmacokinetics of [125I]-2-iodo-3, 7, 8-trichlorodibenzo-p-dioxin in mice: analysis with a physiological modeling approach . Toxicology and Applied Pharmacology , 103 ( 3 ) : 411 – 419 .
  • Linden , H. and Macino , G. 1997 . White collar 2, a partner in bluelight signal transduction, controlling expression of light-regulated genes in Neurospora crassa . Journal of the European Molecular Biology Organization , 16 : 98 – 109 .
  • Ma , Q. and Whitlock , J. P. Jr . 1997 . A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2, 3, 7, 8- tetrachlorodibenzo-p-dioxin . Journal of Biological Chemistry , 272 : 8878 – 8884 .
  • Maltepe , E. , Schmidt , J. V. , Baunoch , D. , Bradfield , C. A. and Simon , M. C. 1997 . Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT . Nature , 386 : 403 – 407 .
  • Mimura , J. , Yamashita , K. , Nakamura , K. , Morita , M. , Takagi , T. N. , Nakao , K. , Ema , M. , Sogawa , K. , Yasuda , M. , Katsuki , M. and Fujii-Kuriyama , Y. 1997 . Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor . Genes To Cells , 2 : 645 – 654 .
  • Nambu , J. R. , Chen , W. , Hu , S. and Crews , S. T. 1996 . The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1 alpha and Drosophila single-minded . Gene , 172 : 249 – 254 .
  • Poellinger , L. 1995 . “ Mechanism of signal transduction by the basic helix-loop-helix dioxin receptor ” . In Inducible Gene Expression , Edited by: Baeuerle , P. A. Vol. 1 , 177 – 205 . Boston : Birkhäuser .
  • Poljamuista , R. , Wong , J. M. Y. , Li , W. , Harper , P. A. , Tuomisto , J. and Obey , A. B. 1998 . Point mutation in intron sequence causes altered carboxy terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin resistant rat strain . Molecular Pharmacolog y , 554 : 86 – 93 .
  • Portier , C. J. , Sharman , C. D. , Kohn , M. , Eddar , L. , Kopp Schneider , A. , Maronpot , R. M. and Lucier , G. 1996 . Modeling the number and size of hepatic focal lesions following exposure to 2,3,7,8-TCDD . Toxicology and Applied Pharmacology , 138 ( 1 ) : 20 – 30 .
  • Pougrate , I. , Mason , G. F. and Poellinger , L. 1992 . Dual roles of the 90 k-Da heat shick protein hsp 90 in modulating functional activities of the dioxin receptor . Journal of Biological Chemistry , 267 : 13728 – 13734 .
  • Powell-Coffman , J. A. , Bradfield , C. A. and Wood , W. B. 1998 . Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator . Proceedings of the National Academy of Sciences of the United States of America , 95 : 2844 – 2849 .
  • Pratt , W. B. and Toft , D. O. 1997 . Steroid receptor interactions with heat shock protein and immunophiliu chaperones . Endocriue Reviews , 18 : 306 – 360 .
  • Rannug , U. , Rannug , A. , Sjöberg , U. , Li , H. , Westerholm , R. and Bergman , J. 1995 . Structure elucidation of two tryptophan-derived high affinity Au receptor ligands . Chemistry & Biology , 2 : 841 – 845 .
  • Sassone-Corsi , P. 1998 . Molecular clocks: mastering time by gene regulation . Nature , 392 : 871 – 874 .
  • Schmidt , J. V. and Bradfield , C. A. 1996 . Ah receptor signaling pathways . Annual Review of Cell and Developmental Biology , 12 : 55 – 89 .
  • Schmidt , J. V. , Su , G. H. , Reddy , J. K. , Simon , M. C. and Bradfield , C. A. 1996 . Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development . Proceedings of the National Academy of Sciences of the United States of America , 93 : 6731 – 6736 .
  • Shigeyoshi , Y. , Taguchi , K. , Yamamoto , S. , Takekida , S. , Yan , L. , Tei , H. , Moriya , T. , Shibata , S. , Loros , J. J. , Dunlap , J. C. and Okamura , H. 1997 . Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript . Cell , 91 : 1043 – 1053 .
  • Sogawa , K. and Fujii-Kuriyama , Y. 1997 . Ah receptor, a novel ligand-activated transcription factor . Journal of Biochemistry , 122 : 1075 – 1079 .
  • Sonnenfeld , M. , Ward , M. , Nystrom , G. , Mosher , J. , Stahl , S. and Crews , S. 1997 . The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development . Development , 124 : 4571 – 4582 .
  • Sun , Z.-S. , Albrecht , U. , Zhuchenko , O. , Bailey , J. , Eichele , G. and Lee , C.-C. 1997 . RIGUI, a putative mammalian ortholog of the drosophila period gene . Cell , 90 : 1003 – 1011 .
  • Tei , H. , Okamura , H. , Shigeyoshi , Y. , Fuhuhara , C. , Ozawa , R. , Hirose , M. and Sakaki . 1997 . Circadian oscillation of a mammalian homologue of the drosphila period gene . Nature , 389 : 512 – 516 .
  • Tian , H. , McKnight , S. L. and Russell , D. W. 1997 . Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells . Genes and Development , 11 : 72 – 82 .
  • Wang , G. L. , Jiang , B. H. , Rue , E. A. and Semenza , G. L. 1995 . Hypoxia-inducible factor 1 is a basic-helix-loop-helix-pas heterodimer regulated by cellular O-2 tension . Proceedings of the National Academy of Sciences of the United States of America , 92 : 5510 – 5514 .
  • Whitelaw , M. L. , McGuire , J. , Picard , D. , Gustafsson , J.-Đ. and Poellinger , L. 1995 . Heat shock protein hsp 90 regulates dioxin receptor function in vivo . Proceedings of the Natural Academy of Science USA , 92 : 4437 – 4441 .
  • Whitlock , J. P. Jr , Chichester , C. H. , Bedgood , R. M. , Okino , S. T. , Ko , H. P. , Ma , Q. , Dong , L. , Li , H. and Clarke-Katzenberg , R. 1997 . Induction of drug-metabolizing enzymes by dioxin . Drug Metabolism Reviews , 29 : 1107 – 1127 .
  • Wilhelmsson , A. , Cuthill , S. , Denis , M. , Wikström , A.-C. , Gustafsson , J.-Đ. and Poellinger , L. 1990 . The specific DNA binding activity of the dioxin receptor is modulated by the 90 kD heat shock protein . Journal of the European Molecular Biology Organization , 9 : 69 – 76 .
  • Zelzer , E. , Wappner , P. and Shilo , B.-Z. 1997 . The Pas domain conf ers target gene specificity of Drosophila bHLH/PAS proteins . Genes and Development , 11 : 2079 – 2089 .

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