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Original Articles

A binary screening assay for pro-oestrogens in food: metabolic activation using hepatic microsomes and detection with oestrogen sensitive recombinant yeast cells

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Pages 1138-1147 | Published online: 10 Nov 2010

References

  • ABDEL Aziz , M. T. and WILLIAMS , K. I. 1969 . Metabolism of 17-alpha ethynylestradiol and it 3-methyl ether by the rabbit, an in vivo D-homoannulation . Steroids , 13 : 809 – 820 .
  • BLIZARD , D. , SUEYOSHI , T. , NEGISHI , M. , DEHAL , S. S. and KUPFER , D. 2001 . Mechanism of induction of cytochrome P450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlon Interactions of methoxychlor metabolites with the constitutive androstane receptor system . Drug Metabolism and Disposition , 29 : 781 – 785 .
  • BULGER , W. H. , FEIL , V. J. and KUPFER , D. 1985 . Role of hepatic monoxygenase in generating estrogenic metabolites from methoxychlor and from its identified contaminants . Molecular Pharmacology , 27 : 115 – 124 .
  • CARGILL , D. I. , STEINETZ , B. G. , GOSNELL , E. , BEACH , V. L. , MELI , A. , FUJIMOTO , G. I and RAYNOLDS , B. M. 1969 . Fate of ingested radio labelled ethynylestradiol and its 3-cyclopentyl ether in patients with tile fistulas . Journal of Clinical Endocrinology/metabolism , 29 : 1051 – 1061 .
  • COLDHAM , N. G. and JAMES , V. H. T. 1990 . A possible mechanism for increased breast cell proliferation by progestins through increase reductive 17β-hydroxysteroid oxidoreductase activity . International Journal of Cancer , 45 : 174 – 178 .
  • COLDHAM , N. G and SAUER , M. J. 2001 . Identification, quantitation and biological activity of phytoestrogens in a dietary supplement for breast enhancement . Food Chemical Toxicology , 39 : 1211 – 1224 .
  • COLDHAM , N. G. , DARBY , C. , Hows , M. , KING , L. J. , ZHANG , A.-Q. and SAUER , M. J. 2002 . Comparative metabolism of genistin by human and rat gut micro-flora; detection and identification of end products of metabolism . Xenobiotica , 32 : 45 – 62 .
  • COLDHAM , N. G. , DAVE , M. , SIVAPATHASUNDARAM , S. , MCDONALD , D. , CONNELLY , C. and SAUER , M. J. 1997 . Evaluation of a recombinant yeast cell estrogen screening assay . Environmental Health Perspectives , 105 : 734 – 742 .
  • COLDHAM , N. G. , MOORE , A. S. , DAVE , M. , GRAHAM , P. J. , SIVAPATHASUNDARAM , S. , LAKE , B. G. and SAUER , M. J. 1995 . Imizol™ residues in edible bovine tissues and in vitro assessment of imidocarb metabolism and cytotoxicity . Drug Metabolism and Disposition , 23 : 501 – 505 .
  • ELSBY , R. , MAGGS , J. L. , ASHBY , J. , PATON , D. , SUMPTER , J. P. and PARK , B. K. 2001 . Assessment of the effects of metabolism on the estrogenic activity of xenoestrogens: a two stage approach coupling human liver microsomes and a yeast estrogenicity assay . Journal of Pharmacology and Experimental Therapeutics , 296 : 329 – 337 .
  • FANG , H. , TONG , W. , PERKINS , R. , SOTO , A. , PRECHTL , N. V. t and SHEEHAN , D. M. 2000 . Quantitative comparisons of in vitro assays for estrogenic activities . Environmental Health Perspectives , 108 : 723 – 729 .
  • FANG , H. , TONG , W. , SHI , L. M. , BLAIR , R. , PERKINS , R. , BRANHAM , W. , HASS , B. S. , XIE , Q. , DIAL , S. L. , MORLAND , C. L. and SHEEHAN , D. M. 2001 . Structure-activity relationships for a large diverse set of natural, synthetic and environmental estrogens . Chemical Research Toxicology , 1 : 280 – 294 .
  • GUENGERICH , F. P. 1997 . Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species . Chemico-Biological Interactions , 106 : 161 – 182 .
  • ISHII , Y. , MIYOSHI , A. , WATANABE , R. , TSURUDA , K. , TSUDA , M. , YAMAGUCHI-NAGAMATSU , Y. , YOSHISUE , K. , TANAKA , M. , MAJI , D. , OHGIYA , S. and OGURI , K. 2001 . Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation . Molecular Pharmacology , 60 : 1040 – 1048 .
  • KORACH , K. , SARVER , P. , CHAE , K. , MCLACHLAN , J. and McKINNEY , J. 1988 . Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: conformationally restricted structural probes . Molecular Pharmacology , 33 : 120 – 126 .
  • KUPFER , D. 1988 . Critical evaluation of methods for detection and assessment of estrogenic compounds in mammals: strengths and limitations for application to risk assessment . Reproductive Toxicology , 2 : 147 – 153 .
  • KUPFER , D. and BULGER , W. H. 1979 . A novel in vitro method for demonstrating proestrogens. Metabolism of methoxychlor and o,p'DDT by liver microsomes in the presence of uteri and effects on intracellular distribution of estrogen receptors . Life Sciences , 25 : 975 – 984 .
  • KUPFER , D. and BULGER , W. H. 1987 . Metabolic activation of pesticides with proestrogenic activity . Federation Proceedings , 46 : 1864 – 1869 .
  • LEWIS , D. 1997 . Sex and drugs and P450 . Chemistry and Industry , : 831 – 834 .
  • LOGANATHAN , B. G. and KANNAN , K. 1994 . Global organochlorine contamination trends: an overview . Ambio , 23 : 187 – 191 .
  • MILLIGAN , S. R. , KALITA , J. C. , HEYERICK , A. , RONG , H. , DE COOMAN , L. and DEKEUKELEIRE , D. 1999 . Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer . Journal of Clinical Endocrinology and Metabolism , 83 : 2249 – 2252 .
  • NEBERT , D. W. , PUGA , A. and VASILIOU , V. 1993 . Role of the Ah receptor and the dioxin inducible [Ah] gene battery in toxicity, cancer, and signal transduction . Annals of the New York Academy of Science , 685 : 624 – 640 .
  • NESARETNAM , K. , CORCORAN , D. , DILS , R. R. and DABRE , P. 1996 . 3,4,3'4'-Tetrachlorobiphenyl acts as an estrogen in vitro and in vivo . Molecular Endocrinology , 10 : 923 – 936 .
  • SCHMIDER , J. , GREENBLATT , D. J. , VON MOLTKE , L. L. , KARSOV , D. , VENA , R. , FRIEDMAN , H. L. and SHADER , R. 1997 . Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors . Journal of Clinical Pharmacology , 37 : 193 – 200 .
  • SETCHELL , K. D. R. and ADLERCREUTZ , H. 1988 . “ Mammalian lignans and phyto-oestrogens. Recent studies on their formation, metabolism and biological role in health and disease ” . In Role of the Gut Flora in Toxicity and Cancer , Edited by: Rowland , I. A. 315 – 345 . New York : Academic Press .
  • SOTO , A. M. , SONNENSCHEIN , C. , CHUNG , L. K. , FERNANDEZ , M. F. , OLEA , N. and OLEA-SERRANO , M. F. 1995 . The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants . Environmental Health Perspectives , 103S : 113 – 122 .
  • SUMIDA , K. , OOE , N. , NAGAHORI , H. , SAITO , K. , ISOBE , N. , KANEKO , H. and NAKATSUKA , I. 2001 . An in vitro reporter gene assay method incorporating metabolic activation with human and rat 59 or liver microsomes . Biochemical Biophysical Research Communications , 280 : 85 – 91 .
  • WALTER , L. M. , ROURKE , A. W. and EROSCHENKO , V. P. 1993 . Purified methoxychlor stimulates the reproductive tract in immature female mice . Reproductive Toxicology , 7 : 599 – 606 .
  • YOSHIHARA , S. , MAKISHIMA , M. , SUZUKI , N. and OHTA , S. 2001 . Metabolic activation of bisphenol A by rat liver S9 fraction . Toxicology Science , 62 : 221 – 227 .
  • ZACHAREWSKI , T. 1993 . Identification and assessment of endocrine disrupters: limitations of in vivo and in vitro assays . Environmental Health Perspecnves , 106s : 577 – 582 .

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