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Original Articles

Effect of the dietary exposure of rat to di(2-ethyl hexyl) phthalate on their metabolic efficiency

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Pages 1091-1096 | Published online: 10 Nov 2010

References

  • ATSDR (AGENCY FOR Toxic SUBSTANCES AND DISEASE REGISTRY) . 1993 . Toxicological Profile for Di (2-ethylhexyl) Phthlate (Update) , Atlanta : US Department of Health and Human Services, Public Health Service .
  • BADR , M. Z. 1992 . Induction of peroxisomal enzyme activities by di (2-ethylhexyl) phthalate in thyroidectomized rats with parathyroid replants . Journal of Pharmacology and Experimental Therapeutics , 263 : 1105 – 1110 .
  • CANOLTY , N. L. and KOONG , L. J. 1976 . Utilization of energy for maintenance and for fat and lean gains by mice selected for rapid postweaning growth rate . Journal of Nutrition , 106 : 1202 – 1208 .
  • CEPA(CANADIANENVIRONMENTAL PROTECTIONACT) . 1993 . Priority Substance List. Supporting Documentation: Bis (2-Ethylhexyl) Phthalate , Ottawa, Ontario : Health Canada .
  • CEPA(CANADIANENVIRONMENTAL PROTECTION ACT) . 1994 . Priority Substance List Assessment Report: Bis (2-Ethylhexyl) Phthalate , Ottawa, Ontario : Environment Canada/Health Canada .
  • CUNNIFF , P. , ed. 1999 . Official Methods of Analysis of Association of Official Agricultural Chemists , 16th edn , Maryland, , USA : AOAC International . 5th revn
  • DANIEL , J. W. 1978 . Toxicity and metabolism of phthalate esters . Clinical Toxicology , 13 : 257 – 268 .
  • DAVID , R. M. , MOORE , M. R. , FINNEY , D. C. and GUEST , D. 2000 . Chronic toxicity of di (2 ethyl hexyl) phthalate in rats . Toxicological Sciences , 55 : 433 – 443 .
  • DEGROOT , M. H. , ed. 1975 . Probability and Statistics , Reading : Addison-Wesley .
  • DOSTAL , L. A. , JENKINS , W. L. and SCHWETZ , B. A. 1987 . Hepatic peroxisome proliferation and hypolipidemic effects of di(2ethylhexyl) phthalate in neonatal and adult rats . Toxicology and Applied Pharmacology , 87 : 81 – 90 .
  • DOULL , J. , CATTLEY , R. , ELCOMBE , C. , LAKE , B. G. , SWENBERG , J. , WILKINSON , C. , WILLIAMS , G. and VAN GEMERT , M. 1999 . cancer risk assessment of di 2-ethylhexyl phthalate: application of the new US EPA Risk Assessment Guidelines . Regulatory Toxicology and Pharmacology , 29 : 327 – 357 .
  • DZHEKOVA-STOJKovA , S. , BOGDANSKA , J. and STOJKOVA , Z. 2001 . Peroxisome proliferators: their biological and lexicological effects . Clinical Chemistry and Laboratory Medicine , 39 : 468 – 474 .
  • HASMALL , S. C. , JAMES , N. H. , MACDONALD , N. , SOAMES , A. R. and ROBERTS , R. A. 2000 . Species differences in response to diethylhexylphthalate: suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alpha-mediated gene expression . Archives of Toxicology , 74 : 85 – 91 .
  • KLEIBER , M. 1975 . The Fire of Life , New York : Robert E. Krieger .
  • LATINI , G. 2000 . Potential hazards of exposure to di-(2-ethylhexyl)phthalate in babies . Biology of the Neonate , 78 : 269 – 276 .
  • MANN , A. H. , PRICE , S. C. , MITCHELL , F. E. , GRASSO , P. , HINTON , R. H. and BRIDGES , J. W. 1985 . Comparison of the short-term effects of di(2-ethylhexyl) phthalate, di(n-hexyl) phthalate and di(n-octyl) phthalate in rats . Toxicology and Applied Pharmacology , 77 : 116 – 132 .
  • MEEK , M. E. and CHAN , P. K. 1994 . Bis (2-ethylhexyl)phthalate: evaluation of risk to health from environmental exposure in Canada . Environmental Carcinogenesis and Ecotoxicology Reviews , C12 : 179 – 194 .
  • MITCHELL , A. M. , LHUGUENOT , J. C. , BRIDGES , J. W. and ELCOMBE , C. R. 1985a . Identification of the proximate peroxisome proliferater(s) derived from di(2-ethylhexyl) phthalate . Toxicology and Applied Pharmacology , 80 : 23 – 32 .
  • MITCHELL , F. E. , BRIDGES , J. W. and HINTON , R. H. 1986 . Effects of mono (2-ethylhexyl) phthalate and its straight chain analogues mono-n-hexylphthalate and mono-n-octyl phthalate on lipid metabolism in isolated hepatocytes . Biochemical Pharmacology , 35 : 2941 – 2947 .
  • MITCHELL , F. E. , PRICE , S. C. , HINTON , R. H. , GRASSO , P. and BRIDGES , J. W. 1985b . Time and dose-response study of the effects on rats of the plasticizer di(2-ethylhexyl) phthalate . Toxicology and Applied Pharmacology , 81 : 371 – 392 .
  • MOCCHIUTTI , N. O. and BERNAL , C. A. 1997 . Effects of chronic di(2ethyl hexyl) Phthalate intake on the secretion and removal rate of triglyceride-rich lipoproteins in rats . Food and Chemical Toxicology , 35 : 1017 – 1021 .
  • MOORE , N. P. 2000 . The oestrogenic potential of the phthalate esters . Reproductive Toxicology , 14 : 183 – 192 .
  • NAIR , N. and KURUP , C. K. R. 1986 . Investigations on the mechanism of the hypocholesterolemic action of diethylhexyl phthalate in rats . Biochemical Pharmacology , 35 : 3441 – 3447 .
  • OKITA , R. T. and OKITA , J. R. 1992 . Effects of diethyl phthalate and other plasticizers on laurate hydroxylation in rat liver microsomes . Pharmaceutical Research , 9 : 1648 – 1653 .
  • OSUMI , T. and HASHIMOTO , T. 1978 . Enhancement of fatty acyl-CoA oxidizing activity in rat liver peroxisomes by di-(2-ethylhexyl) phthalate . Journal of Biochemistry , 83 : 1361 – 1365 .
  • PETERSEN , J. H. and BREINDAHL , T. 2000 . Plasticizers in total diet samples, baby food and infant formulae . Food Additive and Contaminants , 17 : 133 – 141 .
  • PRICE , S. C. , CHESCOE , D. , GRASSO , P. , WRIGHT , M. and HINTON , R. H. 1988 . Alterations in the thyroids of rats treated for long periods with di-(2-ethylhexyl) phthalate or with hypolipidaemic agents . Toxicology Letters , 40 : 37 – 46 .
  • RAO , K. N. , ELM , M. S. , KELLY , R. H. , CHANDAR , N. , BRADY , E. , RAO , B. , SHINOZUKA , H. and EAGON , P. 1997 . Hepatic hyperplasia and cancer in rats: metabolic alterations associated with cell growth . Gastroenterology , 113 : 238 – 248 .
  • REUBSAET , F. A. , VEERKAMP , J. H. , BRüCKWILDER , M. L. , TRIJBELS , J. M. and MONNENS , L. A. 1991 . Peroxisomal oxidases and catalase in liver and kidney homogenates of normal and di(ethylhexyl) phthalate-fed rats . International Journal of Biochemistry , 23 : 961 – 967 .
  • REUBSAET , F. A. , VEERKAMP , J. H. , DIRVEN , H. A. , BRÜCKWILDER , M. L. , HASHIMOTO , T. , TRIJBELS , J. M. and MONNENS , L. A. 1990 . The effect of di(ethylhexyl) phthalate on fatty acid oxidation and carnitine palmitoyl transferase in various rat tissues . Biochimica et Biophysica Acta , 1047 : 264 – 270 .
  • SHARMA , R. , LAKE , B. G. and GIBSON , G. G. 1988 . Co-induction of microsomal cytochrome P-452 and the peroxisomal fatty acid ß-oxidation pathway in the rat by clofibrate and di-(2-ethylhexyl) phthalate . Biochemical Pharmacology , 37 : 1203 – 1206 .
  • THOMAS , J. A. , DARBY , T. D. , WALLIN , R. F. , GARVIN , P. J. and MARTIS , L. 1978 . A review of the biological effects of di(2ethylhexyl) phthalate . Toxicology and Applied Pharmacology , 45 : 1 – 27 .

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