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Original Articles

Evaluation of the genotoxic and antioxidant effects of two novel feed additives (ethoxyquin complexes with flavonoids) by the comet assay and micronucleus test

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Pages 553-560 | Received 22 Jun 2006, Accepted 05 Nov 2006, Published online: 08 May 2007

References

  • Błaszczyk , A . 2006 . DNA damage induced by ethoxyquin in human peripheral lymphocytes . Toxicology Letters , 163 : 77 – 83 .
  • Błaszczyk , A and Skolimowski , J . 2005a . Apoptosis and cytotoxicity caused by ethoxyquin and two of its salts . Cellular and Molecular Biology Letters , 10 : 15 – 21 .
  • Błaszczyk , A and Skolimowski , J . 2005b . Synthesis and studies on antioxidants: Ethoxyquin and its derivatives . Acta Poloniae Pharmaceutica — Drug Research , 62 : 111 – 115 .
  • Błaszczyk , A and Skolimowski , J . 2006 . Comparative analysis of cytotoxic, genotoxic and antioxidant effects of 2,2,4,7-tetramethyl-1,2,3,4-tetrahydroquinoline and ethoxyquin on human lymphocytes . Chemico-Biological Interactions , 162 : 70 – 80 .
  • De Koning , AJ . 2002 . The antioxidant ethoxyquin and its analogues: A review . International Journal of Food Properties , 5 : 451 – 461 .
  • Dorey , G , Lockhart , B , Lestage , P and Casara , P . 2000 . New quinolinic derivatives as centrally active antioxidants . Bioorganic and Medicinal Chemistry Letters , 10 : 935 – 939 .
  • Drewhurst , I . 1998 . Ethoxyquin. JMPR Evaluations Available: http://www.inchem.org/documents/jmpr/jmpmono/v098pr09.htm
  • Dzanis , DA . 1991 . Safety of ethoxyquin in dog foods . Journal of Nutrition , 121 : S163
  • Fenech , M . 1993 . The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations . Mutation Research , 285 : 35 – 44 .
  • He , JL , Chen , WL , Jin , LF and Jin , HY . 2000 . Comparative evaluation of the in vitro micronucleus test and the comet assay for the detection of genotoxic effects of X-ray radiation . Mutation Research , 469 : 223 – 231 .
  • Kalweit , S , Vasudey , V and Obe , G . 1988 . Liquid-holding experiments with human lymphocytes; III experiment with G0 and G1 cells . Mutation Research , 207 : 41 – 44 .
  • Kirsch-Voldres , M , Sofuni , T , Aardema , M , Albertini , M , Eastmond , D , Fenech , M , Ishidate , M , Kirchner , S , Lorge , E Morita , T . 2003 . Report from the in vitro micronucleus assay working group . Mutation Research , 540 : 153 – 163 .
  • Końca , K , Lankoff , A , Banasik , A , Lisowska , H , Kuszewski , T , Góźdź , S , Koza , Z and Wójcik , A . 2003 . A cross-platform public domain PC image-analysis program for the comet assay . Mutation Research , 534 : 15 – 20 .
  • Little , AD . 1990 . “ Chemical Committee Draft Report, Ethoxyquin ” . In CAS Number 91-53-2, Submitted to National Toxicology Program, Executive Summary of Safety and Toxicity Information Available: http://ntp-server.niehs.nih.gov/htdocs/Chem Background/execSumm.Ethoxyquin.html
  • Manson , MM , Green , JA and Driver , HE . 1987 . Ethoxyquin alone induces preneoplastic changes in rat kidney whilst preventing induction of such lesions in liver by aflatoxin B1 . Carcinogenesis , 8 : 723 – 728 .
  • Metodieva , D , Skolimowski , J , Kochman , A and Karolczak , S . 1997 . Rutoxyl(rutin/4-acetamide-1-hydroxy-2,2,6,6-tetramethylpiperidinium) is a new member of the class of semi-natural products of high pharmacological potency . Biochemistry and Molecular Biology International , 42 : 1261 – 1270 .
  • Miyata , Y , Fukushima , S , Hirose , M , Masui , T and Ito , N . 1985 . Short-term screening of promoters of bladder carcinogenesis in N-butyl-N-(4hydroxylbutyl) nitrosamine-initiated, unilaterally ureter-ligated rats . Japanese Journal of Cancer Research , 76 : 828 – 834 .
  • Rubel , DM and Freeman , S . 1998 . Allergic contact dermatitis to ethoxyquin in a farmer handling chicken feeds . Australasian Journal of Dermatology , 39 : 89 – 91 .
  • Singh , NP , McCoy , MT , Tice , RR and Schneider , EL . 1988 . A simple technique for quantification of low levels of DNA damage in individual cells . Experimental Cell Research , 175 : 184 – 191 .
  • Skolimowska , U and Wędzisz , A . 2004 . Effect of rutin and complex ethoxyquin-rutin on the stability of Oenothera paradoxa oil . Bromatologia i Chemia Toksykologiczna , 37 : 225 – 230 .

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