126
Views
10
CrossRef citations to date
0
Altmetric
Original Articles

Analysis of aflatoxin regulatory factors in serial transfer-induced non-aflatoxigenic Aspergillus parasiticus

, , , , , , & show all
Pages 1061-1069 | Received 17 May 2007, Accepted 10 Jul 2007, Published online: 24 Sep 2007

References

  • Adams , TH , Boylan , MT and Timberlake , WE . 1988 . brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans . Cell , 54 : 353 – 362 .
  • Adye , J and Mateles , RI . 1964 . Incorporation of labelled compounds into aflatoxins . Biochimica et Biophysica Acta , 86 : 418 – 420 .
  • Bhatnagar , D , Ehrlich , KC and Cleveland , TE . 2003 . Molecular genetic analysis and regulation of aflatoxin biosynthesis . Applied Microbiology and Biotechnology , 61 : 83 – 93 .
  • Bok , JW , Hoffmeister , D , Maggio-Hall , LA , Murillo , R , Glasner , JD and Keller , NP . 2006 . Genomic mining for Aspergillus natural products . Chemistry and Biology , 13 : 31 – 37 .
  • Bok , JW and Keller , NP . 2004 . LaeA, a regulator of secondary metabolism in Aspergillus spp . Eukaryotic Cell , 3 : 527 – 535 .
  • Brown , DW , Yu , JH , Kelkar , HS , Fernandes , M , Nesbitt , TC , Keller , NP , Adams , TH and Leonard , TJ . 1996 . Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans . Proceedings of the National Academy of Sciences, USA , 93 : 1418 – 1422 .
  • Calvo , AM , Bok , JW , Brooks , W and Keller , NP . 2004 . veA is required for toxin and sclerotial production in Aspergillus parasiticus . Applied and Environmental Microbiology , 70 : 4733 – 4739 .
  • Cary , JW , Dyer , JM , Ehrlich , KC , Wright , MS , Liang , SH and Linz , JE . 2002 . Molecular and functional characterization of a second copy of the aflatoxin regulatory gene, aflR-2, from Aspergillus parasiticus . Biochimica et Biophysica Acta , 1576 : 316 – 323 .
  • Cary , JW , Ehrlich , KC , Kale , SP , Calvo , AM , Bhatnagar , D and Cleveland , TE . 2006 . Regulatory elements in aflatoxin biosynthesis . Mycotoxin Research , 22 : 105 – 109 .
  • Cary , JW , Linz , JE and Bhatnagar , D . 2000 . “ Aflatoxins: Biological significance and regulation of biosynthesis ” . In Microbial foodborne diseases: Mechanisms of pathogenesis and toxin synthesis , Edited by: Cary , JW , Cary , Linz , JE and Bhatnagar , D . 317 – 361 . Lancaster, Pennsylvania : Technomic .
  • Chang , PK . 2003 . Aspergillus parasiticus AFLJ interacts with the aflatoxin pathway specific regulator AFLR . Molecular Genetics and Genomics , 268 : 711 – 719 .
  • Chang , PK . 2004 . Lack of interaction between AFLR and AFLJ contributes to nonaflatoxigenicity of Aspergillus sojae . Journal of Biotechnology , 197 : 245 – 253 .
  • Chang , PK , Cary , JW , Bhatnagar , D , Cleveland , TE and Bennett , JW . 1993 . Cloning of the Aspergillus parasiticus apa-2 gene associated with the regulation of aflatoxin biosynthesis . Applied and Environmental Microbiology , 59 : 3273 – 3279 .
  • Chang , P-K , Ehrlich , KC , Linz , JE , Bhatnagar , D , Cleveland , TE and Benentt , JW . 1996 . Characterization of the Aspergillus parasiticus niaD and niiA gene cluster . Current Genetics , 30 : 68 – 75 .
  • Chang , PK , Ehrlich , KC , Yu , J , Bhatnagar , D and Cleveland , TE . 1995 . Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein, relieves nitrate inhibition of aflatoxin biosynthesis . Applied and Environmental Microbiology , 61 : 2372 – 2377 .
  • Chang , P-K , Yu , J , Bhatnagar , D and Cleveland , TE . 1999 . The carboxy-terminal portion of the aflatoxin pathway regulatory protein AFLR of Aspergillus parasiticus activates GAL1::lacZ gene expression in Saccharomyces cerevisiae . Applied and Environmental Microbiology , 65 : 2508 – 2516 .
  • Eaton , DL and Gallagher , EP . 1994 . Mechanisms of aflatoxin carcinogenesis . Annual Review of Pharmacology and Toxicology , 34 : 135 – 172 .
  • Ehrlich , KC , Chang , PK , Yu , J and Cotty , PJ . 2004 . Aflatoxin biosynthesis cluster gene cypA is required for G aflatoxin formation . Applied and Environmental Microbiology , 70 : 6518 – 6524 .
  • Ehrlich , KC , Montalbano , BG , Bhatnagar , D and Cleveland , TE . 1998 . Alteration of different domains in AFLR affects aflatoxin pathway metabolism in Aspergillus parasiticus transformants . Fungal Genetics and Biology , 23 : 279 – 287 .
  • Ehrlich , KC , Montalbano , BG and Cotty , PJ . 2003 . Sequence comparison of aflR from different Aspergillus species provides evidence for variability in regulation of aflatoxin production . Fungal Genetics and Biology , 38 : 63 – 74 .
  • Glassbrook , NJ , Kale , SP , Bhatnagar , D , Bennett , JW , Wilkinson , JR , Yu , JJ , Cary , JW , Cleveland , TE and Payne , GA . 2006 . “ The sec–mutant of Aspergillus parasiticus has pronounced alterations in its biochemical profile ” . In Abstract presented at the General Meeting of the American Society for Microbiology (ASM) Orlando, FL, , USA abst. O-040
  • Guzman-de-Pena , D , Aguirre , J and Ruiz-Herrera , J . 1998 . Correlation between the regulation of sterigmatocystin biosynthesis and sporulation in Emericella nidulans . Antonie van Leeuwenhoek , 73 : 199 – 205 .
  • Hicks , JK , Shimizu , K and Keller , NP . 2002 . “ Genetics and biosynthesis of aflatoxins and sterigmatocystin ” . In Mycota XI agricultural applications , Edited by: Kempken , F . 55 – 69 . Berlin : Springer .
  • Hicks , JK , Yu , JH , Keller , NP and Adams , TH . 1997 . Aspergillus sporulation and mycotoxin production both require inactivation of the FadA Gα protein-dependent signalling pathway . EMBO Journal , 16 : 4916 – 4923 .
  • Kale , SP , Cary , JW , Baker , C , Walker , D , Bhatnagar , D and Bennett , JW . 2003 . Genetic analysis of morphological variants of Aspergillus parasiticus deficient in secondary metabolite production . Mycological Research , 107 : 831 – 840 .
  • Kale , SP , Cary , JW , Bhatnagar , D and Bennett , JW . 1994 . Isolation and characterization of morphological variants of Aspergillus parasiticus deficient in secondary metabolite production . Mycological Research , 98 : 645 – 652 .
  • Kale , SP , Cary , JW , Bhatnagar , D and Bennett , JW . 1996 . Characterization of experimentally induced nonaflatoxigenic variant strains of Aspergillus parasiticus . Applied and Environmental Microbiology , 62 : 3399 – 3404 .
  • Kato , N , Brooks , W and Calvo , AM . 2003 . The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans is controlled by veA, a gene required for sexual development . Eukaryotic Cell , 2 : 1178 – 1186 .
  • Meyers , DM , OBrian , G , Du , WL , Bhatnagar , D and Payne , GA . 1998 . Characterization of aflJ, a gene required for conversion of pathway intermediates to aflatoxin . Applied and Environmental Microbiology , 64 : 3713 – 3717 .
  • O’Brian , GR , Georgianna , DR , Wilkinson , JR , Yu , J , Abbas , HK , Bhatnagar , D , Cleveland , TE , Nierman , W and Payne , GA . 2007 . The effect of elevated temperature on gene transcription and aflatoxin biosynthesis . Mycologia , 99 : 232 – 239 .
  • Otim , MO , Mukiibi-Muka , G , Christensen , H and Bisgaard , M . 2005 . Aflatoxicosis, infectious bursal disease and immune response to Newcastle disease vaccination in rural chickens . Avian Pathology , 34 : 319 – 323 .
  • Payne , GA and Brown , MP . 1998 . Genetics and physiology of aflatoxin biosynthesis . Annual Review of Phytopathology , 36 : 329 – 362 .
  • Payne , GA , Nierman , WC , Wortman , JR , Pritchard , BL , Brown , D , Dean , RA , Bhatnagar , D , Cleveland , TE , Machida , M and Yu , J . 2006 . Whole genome comparison of Aspergillus flavus and A. oryzae . Medical Mycology , 44 : 9 – 11 .
  • Payne , GA , Nystrom , GJ , Bhatnagar , D , Cleveland , TE and Woloshuk , CP . 1993 . Cloning of the afl-2 gene involved in aflatoxin biosynthesis from Aspergillus flavus . Applied and Environmental Microbiology , 59 : 156 – 162 .
  • Richard , JL and Payne , GA . 2003 . Mycotoxins: risks in plant, animal, and human systems . Task Force Report No. 139. Ames, IA: Council for Agricultural Science and Technology (CAST) ,
  • Roze , LV , Miller , MJ , Rarick , M , Mahanti , N and Linz , JE . 2004 . A novel cAMP-responsive element CRE1, modulates expression of nor-1 in Aspergillus parasiticus . Journal of Biological Chemistry , 279 : 27428 – 27439 .
  • Shimizu , K , Hicks , JK , Huang , TP and Keller , NP . 2003 . Pka, Ras and RGS protein interactions regulate activity of AflR, a Zn(II)2Cys6 transcription factor in Aspergillus nidulans . Genetics , 165 : 1095 – 1104 .
  • Shimizu , K and Keller , NP . 2001 . Genetic involvement of a cAMP-dependent protein kinase in a G protein signalling pathway regulating morphological and chemical transitions in Aspergillus nidulans . Genetics , 157 : 591 – 600 .
  • Tilburn , J , Sarkar , S , Widdick , DA , Espeso , EA , Orejas , M , Mungroo , J , Penalva , Ma and Arst , HN Jr . 1995 . The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed gences by ambient PH. EMBO J 14:779–90 ,
  • Turner , PC , Moore , SE , Hall , AJ , Prentice , AM and Wild , CP . 2003 . Modification of immune function through exposure to dietary aflatoxin in Gambian children . Environmental Health Perspectives , 111 : 217 – 220 .
  • Validivia , AG , Martinez , A , Damian , FJ , Quezada , T , Ortiz , R , Maryinez , C , Llamas , J , Rodriguez , ML , Yamamoto , L Jaramillo , F . 2001 . Efficacy of N-acetylcysteine to reduce the effects of aflatoxin B1 intoxication in broiler chickens . Poultry Science , 80 : 727 – 734 .
  • Vardon , P , McLaughlin , C and Nardinelli , C . 2003 . Mycotoxins: Risks in plant, animal, and human systems . Task Force Report No. 139. Ames, IA: Council for Agricultural Science and Technology (CAST) ,
  • Wilkinson , JR , Yu , J , Bland , JM , Nierman , WC , Bhatnagar , D and Cleveland , TE . 2007 . Amino acid supplementation reveals differential regulation of aflatoxin biosynthesis in Aspergillus flavus NRRL 3357 and Aspergillus parasiticus SRRC 143 . Applied Microbiology and Biotechnology , 74 : 1308 – 1319 .
  • Woloshuk , CP , Foutz , KR , Brewer , JF , Bhatnagar , D , Cleveland , TE and Payne , GA . 1994 . Molecular characterization of aflR, a regulatory locus for aflatoxin biosynthesis . Applied and Environmental Microbiology , 60 : 2408 – 2414 .
  • Woloshuk , CP , Yousibova , GL , Rollins , JA , Bhatnagar , D and Payne , GA . 1995 . Molecular characterization of the afl-1 locus in Aspergillus flavus . Applied Environmental Microbiology , 61 : 3019 – 3023 .
  • Yu , J , Chang , P-K , Ehrlich , KC , Cary , JW , Bhatnagar , D , Cleveland , TE , Payne , GA , Linz , JE , Woloshuk , CP and Bennett , JW . 2004a . Clustered pathway genes in aflatoxin biosynthesis . Applied and Environmental Microbiology , 70 : 1253 – 1262 .
  • Yu , J , Whitelaw , CA , Nierman , WC , Bhatnagar , D and Cleveland , TE . 2004b . Aspergillus flavus expressed sequence tags for identification of genes with putative roles in aflatoxin contamination of crops . FEMS Microbiology Letters , 237 : 333 – 340 .
  • Yu , JH and Keller , NP . 2005 . Regulation of secondary metabolism in filamentous fungi . Annual Review of Phytopathology , 43 : 437 – 458 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.