Mechanisms of deoxynivalenol-induced gene expression and apoptosis

References

• Abbas , HK , Mirocha , CJ and Tuite , J . 1986 . Natural occurrence of deoxynivalenol, 15-acetyl-deoxynivalenol, and zearalenone in refusal factor corn stored since 1972 . Appl Environ Microbiol , 51 : 841 – 843 .
   PubMed Web of Science ®Google Scholar
• Abouzied , MM , Azcona , JI , Braselton , WE and Pestka , JJ . 1991 . Immunochemical assessment of mycotoxins in 1989 grain foods: evidence for deoxynivalenol (vomitoxin) contamination . Appl Environ Microbiol , 57 : 672 – 677 .
   PubMed Web of Science ®Google Scholar
• Arnold , DL , McGuire , PF , Nera , EA , Karpinski , KF , Bickis , MG , Zawidzka , ZZ , Fernie , S and Vesonder , RF . 1986 . The toxicity of orally administered deoxynivalenol (vomitoxin) in rats and mice . Food Chem Toxicol , 24 : 935 – 941 .
   PubMed Web of Science ®Google Scholar
• Atkinson , HA and Miller , K . 1984 . Inhibitory effect of deoxynivalenol, 3-acetyldeoxynivalenol and zearalenone on induction of rat and human lymphocyte proliferation . Toxicol Lett , 23 : 215 – 221 .
   PubMed Web of Science ®Google Scholar
• Azcona-Olivera , JI , Ouyang , YL , Warner , RL , Linz , JE and Pestka , JJ . 1995c . Effects of vomitoxin (deoxynivalenol) and cycloheximide on IL-2, 4, 5 and 6 secretion and mRNA levels in murine CD4+ cells . Food Chem Toxicol , 33 : 433 – 441 .
   PubMed Web of Science ®Google Scholar
• Azcona-Olivera , JI , Ouyang , Y , Murtha , J , Chu , FS and Pestka , JJ . 1995a . Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition . Toxicol Appl Pharmacol , 133 : 109 – 120 .
   PubMed Web of Science ®Google Scholar
• Azcona-Olivera , JI , Ouyang , Y , Murtha , J , Chu , FS and Pestka , JJ . 1995b . Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition . Toxicol Appl Pharmacol , 133 : 109 – 120 .
   PubMed Web of Science ®Google Scholar
• Bae , HK and Pestka , JJ . 2006 . Protein kinases associate ribosomes during the deoxynivalenol-induced ribotoxic stress response in the macrophage . Toxicologist , 90 : 206
   Google Scholar
• Bergsjo , B , Matre , T and Nafstad , I . 1992 . Effects of diets with graded levels of deoxynivalenol on performance in growing pigs . Zentralbl Veterinarmed. [A] , 39 : 752 – 758 .
   PubMedGoogle Scholar
• Bhat , RV , Beedu , SR , Ramakrishna , Y and Munshi , KL . 1989 . Outbreak of trichothecene mycotoxicosis associated with consumption of mould-damaged wheat production in Kashmir Valley , 35 – 37 . India : Lancet i(8628) .
   Google Scholar
• Bondy , GS and Pestka , JJ . 1991 . Dietary exposure to the trichothecene vomitoxin (deoxynivalenol) stimulates terminal differentiation of Peyer's patch B cells to IgA secreting plasma cells . Toxicol Appl Pharmacol , 108 : 520 – 530 .
   PubMed Web of Science ®Google Scholar
• Bondy , GS , McCormick , SP , Beremand , MN and Pestka , JJ . 1991 . Murine lymphocyte proliferation impaired by substituted neosolaniols and calonectrins–Fusarium metabolites associated with trichothecene biosynthesis . Toxicon , 29 : 1107 – 1113 .
   PubMed Web of Science ®Google Scholar
• Carter , CJ and Cannon , M . 1977 . Structural requirements for the inhibitory action of 12,13-epoxytrichothecenes on protein synthesis in eukaryotes . Biochem J , 166 : 399 – 409 .
   PubMed Web of Science ®Google Scholar
• Chung , YJ , Yang , GH , Islam , Z and Pestka , JJ . 2003 . Up-regulation of macrophage inflammatory protein-2 and complement 3A receptor by the trichothecenes deoxynivalenol and satratoxin G . Toxicology , 186 : 51 – 65 .
   PubMed Web of Science ®Google Scholar
• Chung , YJ , Zhou , HR and Pestka , JJ . 2003 . Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin) . Toxicol Appl Pharmacol , 193 : 188 – 201 .
   PubMed Web of Science ®Google Scholar
• Cobb , MH . 1999 . MAP kinase pathways . Prog Biophys Mol Biol , 71 : 479 – 500 .
   PubMed Web of Science ®Google Scholar
• Cooray , R . 1984 . Effects of some mycotoxins on mitogen-induced blastogenesis and SCE frequency in human lymphocytes . Food Chem Toxicol , 22 : 529 – 534 .
   PubMed Web of Science ®Google Scholar
• Der , SD , Yang , YL , Weissmann , C and Williams , BR . 1997 . A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis . Proc Natl Acad Sci USA , 94 : 3279 – 3283 .
   PubMed Web of Science ®Google Scholar
• Dixon , DA , Kaplan , CD , McIntyre , TM , Zimmerman , GA and Prescott , SM . 2000 . Post-transcriptional control of cyclooxygenase-2 gene expression. The role of the 3′-untranslated region . J Biol Chem , 275 : 11750 – 11757 .
   PubMed Web of Science ®Google Scholar
• Dong , C , Davis , RJ and Flavell , RA . 2002 . MAP kinases in the immune response . Annu Rev Immunol. , 20 : 55 – 72 .
   PubMed Web of Science ®Google Scholar
• Dong , W and Pestka , JJ . 1993 . Persistent dysregulation of IgA production and IgA nephropathy in the B6C3F1 mouse following withdrawal of dietary vomitoxin (deoxynivalenol) . Fundam Appl Toxicol , 20 : 38 – 47 .
   PubMedGoogle Scholar
• Dong , W , Sell , JE and Pestka , JJ . 1991 . Quantitative assessment of mesangial immunoglobulin A (IgA) accumulation, elevated circulating IgA immune complexes, and hematuria during vomitoxin-induced IgA nephropathy . Fundam Appl Toxic Off J Soc Toxicol , 17 : 197 – 207 .
   PubMedGoogle Scholar
• Ernst , M , Inglese , M , Scholz , GM , Harder , KW , Clay , FJ , Bozinovski , S , Waring , P , Darwiche , R , Kay , T Sly , P . 2002 . Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response . J Exp Med , 196 : 589 – 604 .
   PubMed Web of Science ®Google Scholar
• Forsell , JH , Kateley , JR , Yoshizawa , T and Pestka , JJ . 1985 . Inhibition of mitogen-induced blastogenesis in human lymphocytes by T-2 toxin and its metabolites . Appl Environ Microbial. , 49 : 1523 – 1526 .
   PubMed Web of Science ®Google Scholar
• Forsell , JH , Jensen , R , Tai , JH , Witt , M , Lin , WS and Pestka , JJ . 1987 . Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse . Food Chem Toxicol , 25 : 155 – 162 .
   PubMed Web of Science ®Google Scholar
• Forsell , JH and Pestka , JJ . 1985 . Relation of 8-ketotrichothecene and zearalenone analog structure to inhibition of mitogen-induced human lymphocyte blastogenesis . Appl Environ Microbiol , 50 : 1304 – 1307 .
   PubMed Web of Science ®Google Scholar
• Forsell , JH , Witt , MF , Tai , JH , Jensen , R and Pestka , JJ . 1986 . Effects of 8-week exposure of the B6C3F1 mouse to dietary deoxynivalenol (vomitoxin) and zearalenone . Food Chem Toxicol , 24 : 213 – 219 .
   PubMed Web of Science ®Google Scholar
• Forsyth , DM , Yoshizawa , T , Morooka , N and Tuite , J . 1977 . Emetic and refusal activity of deoxynivalenol to swine . Appl Environ Microbiol , 34 : 547 – 552 .
   PubMed Web of Science ®Google Scholar
• Friend , DW , Trenholm , HL , Elliot , JI , Thompson , BK and Hartin , KE . 1982 . Effect of feeding vomitoxin-contaminated wheat to pigs . Can J Anim Sci , 62 : 1211 – 1222 .
   Web of Science ®Google Scholar
• Friend , SC , Babiuk , LA and Schiefer , HB . 1983 . The effects of dietary T-2 toxin on the immunological function and herpes simplex reactivation in Swiss mice . Toxicol Appl Pharmacol , 69 : 234 – 244 .
   PubMed Web of Science ®Google Scholar
• Goh , KC , deVeer , MJ and Williams , BR . 2000 . The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin . EMBO J , 19 : 4292 – 4297 .
   PubMed Web of Science ®Google Scholar
• Gray , JS and Pestka , JJ . 2007 . Transcriptional regulation of deoxynivalenol-induced IL-8 expression in human monocytes . Toxicol Sci. , 99 : 502 – 511 .
   PubMed Web of Science ®Google Scholar
• Greene , DM , Azcona Olivera , JI and Pestka , JJ . 1994 . Vomitoxin (deoxynivalenol)-induced IgA nephropathy in the B6C3F1 mouse: dose response and male predilection . Toxicology , 92 : 245 – 260 .
   PubMed Web of Science ®Google Scholar
• Greene , DM , Azcona Olivera , JI , Murtha , JM and Pestka , JJ . 1995 . Effects of dihydrotestosterone and estradiol on experimental IgA nephropathy induced by vomitoxin . Fundam Appl Toxicol , 26 : 107 – 116 .
   PubMedGoogle Scholar
• Greene , DM , Bondy , GS , Azcona Olivera , JI and Pestka , JJ . 1994 . Role of gender and strain in vomitoxin-induced dysregulation of IgA production and IgA nephropathy in the mouse . J Toxicol Environ Health , 43 : 37 – 50 .
   PubMed Web of Science ®Google Scholar
• Groopman , JD , Johnson , D and Kensler , TW . 2005 . Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk . Cancer Biomark , 1 : 5 – 14 .
   PubMedGoogle Scholar
• Grove , JF . 1988 . Non-macrocyclic trichothecenes . Nat Prod Rep , 5 : 187 – 209 .
   PubMed Web of Science ®Google Scholar
• Grove , JF . 1993 . Macrocyclic trichothecenes . Nat Prod Rep , 10 : 429 – 448 .
   Web of Science ®Google Scholar
• Grove , JF . 2000 . Non-macrocyclic trichothecenes Part 2 . Prog Chem Org Nat Prod , 69 : 1 – 70 .
   Google Scholar
• Hughes , BJ , Hsieh , GC , Jarvis , BB and Sharma , RP . 1989 . Effects of macrocyclic trichothecene mycotoxins on the murine immune system . Arch Environ Contam Toxicol , 18 : 388 – 395 .
   PubMed Web of Science ®Google Scholar
• Hughes , BJ , Jarvis , BB and Sharma , RP . 1990 . Effects of macrocyclic trichothecene congeners on the viability and mitogenesis of murine splenic lymphocytes . Toxicol Lett , 50 : 57 – 67 .
   PubMed Web of Science ®Google Scholar
• Hughes , BJ , Taylor , MJ and Sharma , RP . 1988 . Effects of verrucarin A and roridin A, macrocyclic trichothecene mycotoxins, on the murine immune system . Immunopharmacology , 16 : 79 – 87 .
   PubMed Web of Science ®Google Scholar
• Hughes , DM , Gahl , MJ , Graham , CH and Grieb , SL . 1999 . Overt signs of toxicity to dogs and cats of dietary deoxynivalenol . J Anim Sci , 77 : 693 – 700 .
   PubMed Web of Science ®Google Scholar
• Hunder , G , Schumann , K , Strugala , G , Gropp , J , Fichtl , B and Forth , W . 1991 . Influence of subchronic exposure to low dietary deoxynivalenol, a trichothecene mycotoxin, on intestinal absorption of nutrients in mice . Food Chem Toxicol , 29 : 809 – 814 .
   PubMed Web of Science ®Google Scholar
• Ihara , T , Sugamata , M , Sekijima , M , Okumura , H , Yoshino , N and Ueno , Y . 1997 . Apoptotic cellular damage in mice after T-2 toxin-induced acute toxicosis . Nat Toxins , 5 : 141 – 145 .
   PubMedGoogle Scholar
• Ihara , T , Yamamoto , T , Sugamata , M , Okumura , H and Ueno , Y . 1998 . The process of ultrastructural changes from nuclei to apoptotic body . Virchows Arch , 433 : 443 – 447 .
   PubMed Web of Science ®Google Scholar
• Iordanov , MS , Pribnow , D , Magun , JL , Dinh , TH , Pearson , JA , Chen , SL and Magun , BE . 1997 . Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA . Mol Cell Biol , 17 : 3373 – 3381 .
   PubMed Web of Science ®Google Scholar
• Islam , Z , Gray , JS and Pestka , JJ . 2006 . p38 Mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes . Toxicol Appl Pharmacol , 213 : 235 – 244 .
   PubMed Web of Science ®Google Scholar
• Islam , Z , Nagase , M , Yoshizawa , T , Yamauchi , K and Sakato , N . 1998a . T-2 toxin induces thymic apoptosis in vivo in mice . Toxicol Appl Pharmacol , 148 : 205 – 214 .
   PubMed Web of Science ®Google Scholar
• Islam , Z , Nagase , M , Yoshizawa , T , Yamauchi , K and Sakato , N . 1998b . T-2 toxin induces thymic apoptosis in vivo in mice . Toxicol Appl Pharmacol , 148 : 205 – 214 .
   PubMed Web of Science ®Google Scholar
• Iverson , F , Armstrong , C , Nera , E , Truelove , J , Fernie , S , Scott , P , Stapley , R , Hayward , S and Gunner , S . 1995 . Chronic feeding study of deoxynivalenol in B6C3F1 male and female mice . Teratog Carcinog Mutagen , 15 : 283 – 306 .
   PubMedGoogle Scholar
• Jia , Q , Zhou , HR , Shi , Y and Pestka , JJ . 2006 . Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages . J Nutr , 136 : 366 – 372 .
   PubMed Web of Science ®Google Scholar
• Joffe , AZ . 1978 . “ Fusarium poae and F. sporotichiodes as principal causal agents of alimentary toxic aleukia ” . In Mycotoxic fungi, mycotoxins, mycotoxicoses: an encylcopedic handbook , Edited by: Wyllie , TD and Morehouse , LG . 21 – 86 . New York, NY : Dekker .
   Google Scholar
• Kanra , GY , Ozen , H and Kara , A . 2006 . Infection and anorexia . Turk J Pediatr , 48 : 279 – 287 .
   PubMed Web of Science ®Google Scholar
• Kinser , S , Jia , Q , Li , M , Laughter , A , Cornwell , P , Corton , JC and Pestka , J . 2004 . Gene expression profiling in spleens of deoxynivalenol-exposed mice: immediate early genes as primary targets . J Toxicol Environ Health A , 67 : 1423 – 1441 .
   PubMed Web of Science ®Google Scholar
• Laskin , JD , Heck , DE and Laskin , DL . 2002 . The ribotoxic stress response as a potential mechanism for MAP kinase activation in xenobiotic toxicity . Toxicol Sci , 69 : 289 – 291 .
   PubMed Web of Science ®Google Scholar
• Le , DG , Auffret , M , Batina , P , Arnold , F , Sibiril , Y , Arzur , D and Parent-Massin , D . 2005 . Myelotoxicity of trichothecenes and apoptosis: an in vitro study on human cord blood CD34+ hematopoietic progenitor . Toxicol In Vitro , 19 : 1015 – 1024 .
   PubMed Web of Science ®Google Scholar
• Lee , US , Jang , HS , Tanaka , T , Hasegawa , A , Oh , YJ and Ueno , Y . 1985 . The coexistence of the Fusarium mycotoxins nivalenol, deoxynivalenol and zearalenone in Korean cereals harvested in 1983 . Food Addit Contam , 2 : 185 – 192 .
   PubMed Web of Science ®Google Scholar
• Li , G , Shinozuka , J , Uetsuka , K , Nakayama , H and Doi , K . 1997 . T-2 toxin-induced apoptosis in intestinal crypt epithelial cells of mice . Exp Toxicol Pathol , 49 : 447 – 450 .
   PubMedGoogle Scholar
• Li , J , Shimizu , T , Miyoshi , N and Yasuda , N . 1997 . Rapid apoptotic changes in the gastric glandular epithelium of rats administered intraperitoneally with fusarenon-X . J Vet Med Sci , 59 : 17 – 22 .
   PubMed Web of Science ®Google Scholar
• Li , S , Ouyang , YL , Dong , W and Pestka , JJ . 1997 . Superinduction of IL-2 gene expression by vomitoxin (deoxynivalenol) involves increased mRNA stability . Toxicol Appl Pharmacol , 147 : 331 – 342 .
   PubMed Web of Science ®Google Scholar
• Li , S , Ouyang , Y , Yang , GH and Pestka , JJ . 2000 . Modulation of transcription factor AP-1 activity in murine EL-4 thymoma cells by vomitoxin (deoxynivalenol) . Toxicol Appl Pharmacol , 163 : 17 – 25 .
   PubMed Web of Science ®Google Scholar
• Luo , X . 1994 . “ Food poisoning caused by Fusarium toxins. ” . In Proceedings of the Second Asian Conference on Food Safety. , 129 – 136 . Thailand : ILSI .
   Google Scholar
• McMullen , M , Jones , R and Gallenberg , D . 1997 . Scab of wheat and barley: a re-emerging disease of devasting impact . Plant Dis , 81 : 1340 – 1348 .
   PubMed Web of Science ®Google Scholar
• Meusel , TR , Kehoe , KE and Imani , F . 2002 . Protein kinase R regulates double-stranded RNA induction of TNF-alpha but not IL-1 beta mRNA in human epithelial cells . J Immunol , 168 : 6429 – 6435 .
   PubMed Web of Science ®Google Scholar
• Miller , K and Atkinson , HA . 1986 . The in vitro effects of trichothecenes on the immune system . Food Chem Toxicol , 24 : 545 – 549 .
   PubMed Web of Science ®Google Scholar
• Miller , K and Atkinson , HA . 1987 . The in vitro effects of trichothecenes on the immune system . Arch Toxicol. Suppl , 11 : 321 – 324 .
   PubMedGoogle Scholar
• Miura , K , Nakajima , Y , Yamanaka , N , Terao , K , Shibato , T and Ishino , S . 1998 . Induction of apoptosis with fusarenon-X in mouse thymocytes . Toxicology , 127 : 195 – 206 .
   PubMed Web of Science ®Google Scholar
• Moon , Y and Pestka , JJ . 2002 . Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases . Toxicol Sci , 69 : 373 – 382 .
   PubMed Web of Science ®Google Scholar
• Moon , Y and Pestka , JJ . 2003a . Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin (deoxynivalenol) in vitro and in vivo . Toxicol Appl Pharmacol , 187 : 80 – 88 .
   PubMed Web of Science ®Google Scholar
• Moon , Y and Pestka , JJ . 2003b . Deoxynivalenol-induced mitogen-activated protein kinase phosphorylation and IL-6 expression in mice suppressed by fish oil . J Nutr Biochem , 14 : 717 – 726 .
   PubMed Web of Science ®Google Scholar
• Moon , Y , Uzarski , R and Pestka , JJ . 2003 . Relationship of trichothecene structure to COX-2 induction in the macrophage: selective action of type B (8-keto) trichothecenes . J Toxicol Environ Health A , 66 : 1967 – 1983 .
   PubMed Web of Science ®Google Scholar
• Ouyang , YL , Azcona Olivera , JI , Murtha , J and Pestka , JJ . 1996 . Vomitoxin-mediated IL-2, IL-4, and IL-5 superinduction in murine CD4+ T cells stimulated with phorbol ester calcium ionophore: relation to kinetics of proliferation . Toxicol Appl Pharmacol , 138 : 324 – 334 .
   PubMed Web of Science ®Google Scholar
• Ouyang , YL , Li , S and Pestka , JJ . 1996 . Effects of vomitoxin (deoxynivalenol) on transcription factor NF-kappa B/Rel binding activity in murine EL-4 thymoma and primary CD4+ T cells . Toxicol Appl Pharmacol , 140 : 328 – 336 .
   PubMed Web of Science ®Google Scholar
• Parent-Massin , D . 2004 . Haematotoxicity of trichothecenes . Toxicol Lett , 153 : 75 – 81 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ . 2003 . Deoxynivalenol-induced IgA production and IgA nephropathy-aberrant mucosal immune response with systemic repercussions. . Toxicol Lett. , 140–141 : 287 – 295 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ , Azcona Olivera , JI , Plattner , RD , Minervini , F , Doko , MB and Visconti , A . 1994 . Comparative assessment of fumonisin in grain-based foods by ELISA, GC-MS, and HPLC . J Food Prot , 57 : 169 – 172 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ , Dong , W , Warner , RL , Rasooly , L , Bondy , GS and Brooks , KH . 1990 . Elevated membrane IgA+ and CD4+ (T helper) populations in murine Peyer's patch and splenic lymphocytes during dietary administration of the trichothecene vomitoxin (deoxynivalenol) . Food Chem Toxicol , 28 : 409 – 420 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ , Dong , W , Warner , RL , Rasooly , L and Bondy , GS . 1990 . Effect of dietary administration of the trichothecene vomitoxin (deoxynivalenol) on IgA and IgG secretion by Peyer's patch and splenic lymphocytes . Food Chem Toxicol , 28 : 693 – 699 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ and Forsell , JH . 1988 . Inhibition of human lymphocyte transformation by the macrocyclic trichothecenes roridin A and verrucarin A . Toxicol Lett , 41 : 215 – 222 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ , Lin , WS and Miller , ER . 1987 . Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swine . Food Chem Toxicol , 25 : 855 – 858 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ , Moorman , MA and Warner , RL . 1989 . Dysregulation of IgA production and IgA nephropathy induced by the trichothecene vomitoxin . Food Chem Toxicol , 27 : 361 – 368 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ , Moorman , MA and Warner , RL . 1990 . Altered serum immunoglobulin response to model intestinal antigens during dietary exposure to vomitoxin (deoxynivalenol) . Toxicol Lett , 50 : 75 – 84 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ and Smolinski , AT . 2005 . Deoxynivalenol: toxicology and potential effects on humans . J Toxicol Environ Health B Crit Rev , 8 : 39 – 69 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ , Tai , JH , Witt , MF , Dixon , DE and Forsell , JH . 1987 . Suppression of immune response in the B6C3F1 mouse after dietary exposure to the Fusarium mycotoxins deoxynivalenol (vomitoxin) and zearalenone . Food Chem Toxicol , 25 : 297 – 304 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ , Yan , D and King , LE . 1994 . Flow cytometric analysis of the effects of in vitro exposure to vomitoxin (deoxynivalenol) on apoptosis in murine T, B and IgA+ cells . Food Chem Toxicol , 32 : 1125 – 1136 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ , Zhou , HR , Moon , Y and Chung , YJ . 2004 . Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox . Toxicol Lett , 153 : 61 – 73 .
   PubMed Web of Science ®Google Scholar
• Pestka , JJ and Zhou , HR . 2000 . Interleukin-6-deficient mice refractory to IgA dysregulation but not anorexia induction by vomitoxin (deoxynivalenol) ingestion . Food Chem Toxicol , 38 : 565 – 575 .
   PubMed Web of Science ®Google Scholar
• Pestka , J and Zhou , HR . 2003 . Hck- and PKR-dependent mitogen-activated protein kinase phosphorylation and AP-1, C/EBP and NF-kB activation precendes deoxynivalenol-induced TNF-α and MIP-2 expression . Toxicologist , 72 : 121
   Google Scholar
• Prelusky , DB and Trenholm , HL . 1993 . The efficacy of various classes of anti-emetics in preventing deoxynivalenol-induced vomiting in swine . Nat Toxins , 1 : 296 – 302 .
   PubMedGoogle Scholar
• Prelusky , DB , Gerdes , RG , Underhill , KL , Rotter , BA , Jui , PY and Trenholm , HL . 1994 . Effects of low-level dietary deoxynivalenol on haematological and clinical parameters of the pig . Nat Toxins , 2 : 97 – 104 .
   PubMedGoogle Scholar
• Rasooly , L , Abouzied , MM , Brooks , KH and Pestka , JJ . 1994 . Polyspecific and autoreactive IgA secreted by hybridomas derived from Peyer's patches of vomitoxin-fed mice: characterization and possible pathogenic role in IgA nephropathy . Food Chem Toxicol , 32 : 337 – 348 .
   PubMed Web of Science ®Google Scholar
• Rasooly , L and Pestka , JJ . 1992 . Vomitoxin-induced dysregulation of serum IgA, IgM and IgG reactive with gut bacterial and self antigens . Food Chem Toxicol , 30 : 499 – 504 .
   PubMed Web of Science ®Google Scholar
• Rasooly , L and Pestka , JJ . 1994 . Polyclonal autoreactive IgA increase and mesangial deposition during vomitoxin-induced IgA nephropahty in the BALB/c mouse . Food Chem Toxicol , 32 : 329 – 336 .
   PubMed Web of Science ®Google Scholar
• Robbana-Barnat , S , Loridon-Rosa , B , Cohen , H , Lafarge-Frayssinet , C , Neish , GA and Frayssinet , C . 1987 . Protein synthesis inhibition and cardiac lesions associated with deoxynivalenol ingestion in mice . Food Addit Contam , 4 : 49 – 56 .
   PubMed Web of Science ®Google Scholar
• Rotter , BA , Prelusky , DB and Pestka , JJ . 1996 . Toxicology of deoxynivalenol (vomitoxin) . J Toxicol Environ Health , 48 : 1 – 34 .
   PubMed Web of Science ®Google Scholar
• Rotter , BA , Thompson , BK , Lessard , M , Trenholm , HL and Tryphonas , H . 1994 . Influence of low-level exposure to Fusarium mycotoxins on selected immunological and hematological parameters in young swine . Fundam Appl Toxicol , 23 : 117 – 124 .
   PubMedGoogle Scholar
• Schaeffer , HJ and Weber , MJ . 1999 . Mitogen-activated protein kinases: specific messages from ubiquitous messengers . Mol Cell Biol , 19 : 2435 – 2444 .
   PubMed Web of Science ®Google Scholar
• Schwartz , GJ . 2002 . Neural-immune gut–brain communication in the anorexia of disease . Nutrition , 18 : 528 – 533 .
   PubMed Web of Science ®Google Scholar
• Shifrin , VI and Anderson , P . 1999 . Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis . J Biol Chem , 274 : 13985 – 13992 .
   PubMed Web of Science ®Google Scholar
• Shinozuka , J , Guanmin , L , Uetsuka , K , Nakayama , H and Doi , K . 1997 . Process of the development of T-2 toxin-induced apoptosis in the lymphoid organs of mice . Exp Anim , 46 : 117 – 126 .
   PubMed Web of Science ®Google Scholar
• Shinozuka , J , Li , G , Kiatipattanasakul , W , Uetsuka , K , Nakayama , H and Doi , K . 1997 . T-2 toxin-induced apoptosis in lymphoid organs of mice . Exp Toxicol Pathol , 49 : 387 – 392 .
   PubMed Web of Science ®Google Scholar
• Shinozuka , J , Suzuki , M , Noguchi , N , Sugimoto , T , Uetsuka , K , Nakayama , H and Doi , K . 1998 . T-2 toxin-induced apoptosis in hematopoietic tissues of mice . Toxicol Pathol , 26 : 674 – 681 .
   PubMed Web of Science ®Google Scholar
• Smith , WL , DeWitt , DL and Garavito , RM . 2000 . Cyclooxygenases: structural, cellular, and molecular biology . Annu Rev Biochem , 69 : 145 – 182 .
   PubMed Web of Science ®Google Scholar
• Sugiura , Y , Watanabe , Y , Tanaka , T , Yamamoto , S and Ueno , Y . 1990 . Occurrence of Gibberella zeae strains that produce both nivalenol and deoxynivalenol . Appl Environ Microbiol , 56 : 3047 – 3051 .
   PubMed Web of Science ®Google Scholar
• Tanaka , T , Yamamoto , S , Hasegawa , A , Aoki , N , Besling , JR , Sugiura , Y and Ueno , Y . 1990 . A survey of the natural occurrence of Fusarium mycotoxins, deoxynivalenol, nivalenol and zearalenone, in cereals harvested in the Netherlands . Mycopathologia , 110 : 19 – 22 .
   PubMed Web of Science ®Google Scholar
• Tomar , RS , Blakley , BR and DeCoteau , WE . 1987 . Immunological responsiveness of mouse spleen cells after in vivo or in vitro exposure to 3-acetyldeoxynivalenol . Food Chem Toxicol , 25 : 393 – 398 .
   PubMed Web of Science ®Google Scholar
• Tomar , RS , Blakley , BR and De Coteau , WE . 1988 . In vitro effects of T-2 toxin on the mitogen responsiveness and antibody-producing ability of human lymphocytes . Toxicol Lett , 40 : 109 – 117 .
   PubMed Web of Science ®Google Scholar
• Tomar , RS , Blakley , BR , Schiefer , HB and DeCoteau , WE . 1986 . In vitro effects of 3-acetyl-deoxynivalenol on the immune response of human peripheral blood lymphocytes . Int J Immunopharmacol , 8 : 125 – 130 .
   PubMed Web of Science ®Google Scholar
• Trenholm , HL , Hamilton , RM , Friend , DW , Thompson , BK and Hartin , KE . 1984 . Feeding trials with vomitoxin (deoxynivalenol)-contaminated wheat: effects on swine, poultry, and dairy cattle . J Am Vet Med Assoc , 185 : 527 – 531 .
   PubMed Web of Science ®Google Scholar
• Tsygankov , AY . 2003 . Non-receptor protein tyrosine kinases. . Front Biosci. , 8 : s595 – s635 .
   PubMed Web of Science ®Google Scholar
• Ueno , Y . 1984 . Toxicological features of T-2 toxin and related trichothecenes . Fundam Appl Toxicol , 4 : S124 – S132 .
   PubMedGoogle Scholar
• Warner , RL , Brooks , K and Pestka , JJ . 1994 . In vitro effects of vomitoxin (deoxynivalenol) on lymphocyte function: enhanced interleukin production and help for IgA secretion . Food Chem Toxicol , 32 : 617 – 625 .
   PubMed Web of Science ®Google Scholar
• Widmann , C , Gibson , S , Jarpe , MB and Johnson , GL . 1999 . Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human . Physiol Rev , 79 : 143 – 180 .
   PubMed Web of Science ®Google Scholar
• Williams , BR . 2001 . Signal integration via PKR. Sci. STKE 89 . RE2
   Google Scholar
• Wong , SS , Zhou , HR and Pestka , JJ . 2002 . Effects of vomitoxin (deoxynivalenol) on the binding of transcription factors AP-1, NF-kappaB, and NF-IL6 in raw 264.7 macrophage cells . J Toxicol Environ Health A , 65 : 1161 – 1180 .
   PubMed Web of Science ®Google Scholar
• Wong , SS , Zhou , HR , Marin-Martinez , ML , Brooks , K and Pestka , JJ . 1998 . Modulation of IL-1beta, IL-6 and TNF-alpha secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line . Food Chem Toxicol , 36 : 409 – 419 .
   PubMed Web of Science ®Google Scholar
• Yan , D , Zhou , HR , Brooks , KH and Pestka , JJ . 1997 . Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin . Toxicology , 122 : 145 – 158 .
   PubMed Web of Science ®Google Scholar
• Yan , D , Zhou , HR , Brooks , KH and Pestka , JJ . 1998 . Role of macrophages in elevated IgA and IL-6 production by Peyer's patch cultures following acute oral vomitoxin exposure . Toxicol Appl Pharmacol , 148 : 261 – 273 .
   PubMed Web of Science ®Google Scholar
• Yang , G , Jarvis , BB , Chung , Y and Pestka , JJ . 2000 . Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK and SAPK/JNK Activation . Toxicol Appl Pharmacol , 164 : 149 – 160 .
   PubMed Web of Science ®Google Scholar
• Yeung , MC , Liu , J and Lau , AS . 1996 . An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells . Proc Natl Acad Sci USA , 93 : 12451 – 12455 .
   PubMed Web of Science ®Google Scholar
• Yoshizawa , T . 1983 . “ Red-mold disease and natural occurrence in Japan ” . In Trichothecenes: chemical, biological and toxicological aspects (Developments in Food Science) , Edited by: Ueno , Y . 195 – 209 . New York : Elsevier .
   Google Scholar
• Yoshizawa , T and Morooka , N . 1977 . “ Trichothecenes in mold infested cereals in Japan ” . In Mycotoxins in human and animal health , Edited by: Rodricks , JV , Hesseltine , CW and Mehlman , MA . 309 – 321 . Park Forest South, IL : Pathotox .
   Google Scholar
• Yoshizawa , T , Takeda , H and Ohim , T . 1983 . Structure of a novel metabolite from deoxynivalenol, a trichothecene mycotoxin, in animals . Agric Biol Chem , 47 : 2133 – 2135 .
   Web of Science ®Google Scholar
• Young , LG , McGirr , L , Valli , VE , Lumsden , JH and Lun , A . 1983 . Vomitoxin in corn fed to young pigs . J Anim Sci , 57 : 655 – 664 .
   PubMed Web of Science ®Google Scholar
• Zhou , HR and Pestka , JJ . 2003 . Deoxynivalenol-induced apoptosis mediated by p38 MAPK-dependent p53 gene induction in RAW 264.7 macrophages . Toxicologist , 72 : 330
   Google Scholar
• Zhou , HR and Pestka , JJ . 2005 . Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol . Toxicol Sci. , 87 : 113 – 122 .
   PubMed Web of Science ®Google Scholar
• Zhou , HR , Harkema , JR , Yan , D and Pestka , JJ . 1999 . Amplified proinflammatory cytokine expression and toxicity in mice coexposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) . J Toxicol Environ Health , 57 : 115 – 136 .
   PubMed Web of Science ®Google Scholar
• Zhou , HR , Islam , Z and Pestka , JJ . 2003 . Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin . Toxicol Sci , 72 : 130 – 142 .
   PubMed Web of Science ®Google Scholar
• Zhou , HR , Islam , Z and Pestka , JJ . 2005 . Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol . Toxicol Sci , 87 : 113 – 122 .
   PubMed Web of Science ®Google Scholar
• Zhou , HR , Jia , Q and Pestka , JJ . 2005 . Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck . Toxicol Sci , 85 : 916 – 926 .
   PubMed Web of Science ®Google Scholar
• Zhou , HR , Lau , AS and Pestka , JJ . 2003 . Role of double-stranded RNA-activated protein kinase R (PKR) in deoxynivalenol-induced ribotoxic stress response . Toxicol Sci. , 74 : 61 – 73 .
   Web of Science ®Google Scholar
• Zhou , HR , Yan , D and Pestka , JJ . 1997 . Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): dose response and time course . Toxicol Appl Pharmacol , 144 : 294 – 305 .
   PubMed Web of Science ®Google Scholar
• Zhou , HR , Yan , D and Pestka , JJ . 1998 . Induction of cytokine gene expression in mice after repeated and subchronic oral exposure to vomitoxin (deoxynivalenol): differential toxin-induced hyporesponsiveness and recovery . Toxicol Appl Pharmacol , 151 : 347 – 358 .
   PubMed Web of Science ®Google Scholar