Evaluation of the illegal use of clenbuterol in Portuguese cattle farms from drinking water, urine, hair and feed samples

References

• Asato , G , Baker , P , Bass , R , Bentley , T , Chari , S , Dalrymple , R , France , D , Gingher , P , Lences , B Pascavage , J . 1984 . Repartitioning agents: 5-[1-hydroxy-2-(isopropylamino)ethyl]-anthranoline and related phenethanolamines. Agents for promoting growth, increasing muscle acreation and reducing fat deposition in meat-producing animals . Agric Biol Chem , 48 : 2883 – 2888 .
   Web of Science ®Google Scholar
• Barbosa , J , Cruz , C , Martins , J , Silva , JM , Neves , C , Alves , C , Ramos , F and Silveira , MIN . 2005 . Food poisoning by clenbuterol in Portugal . Food Addit Contam , 22 : 563 – 566 .
   PubMed Web of Science ®Google Scholar
• Boyd , D , O’Keeffe , M and Smyth , M . 1996 . Methods for the determination of β-agonists in biological matrices . Analyst , 121 : 1R – 10R .
   PubMed Web of Science ®Google Scholar
• Brambilla , G , Loizzo , A , Fontana , L , Strozzi , M , Guarino , A and Soprano , V . 1997 . Food poisoning following comsuption of clenbuterol-treated veal in Italy . J Am Med Assoc , 278 : 635
   PubMed Web of Science ®Google Scholar
• Brambilla , G , Cenci , T , Franconi , F , Galarini , R , Macri , A , Rondoni , F , Strozzi , M and Loizzo , A . 2000 . Clinical and pharmacological profile in a clenbuterol epidemic poisoning of contaminated beef meat in Italy . Toxicol Lett , 114 : 47 – 53 .
   PubMed Web of Science ®Google Scholar
• Cristino , A , Ramos , F and Silveira , MIN . 2003 . Control of the illegal use of clenbuterol in bovine production . J Pharm Biomed Anal , 32 : 311 – 316 .
   PubMed Web of Science ®Google Scholar
• Decision no. 2002/657/CE . 2002 . Decision no. 2002/657/CE of August 12th . Off J Eur Commun , L221 : 8 – 36 .
   Google Scholar
• Dickson , LC , MacNeil , J , Lee , S and Fesser , CE . 2005 . Determination of β-agonist residues in bovine urine using liquid chromatography-tandem mass spectrometry . J AOAC Int , 88 : 46 – 56 .
   PubMed Web of Science ®Google Scholar
• Directive no. 2003/74/CE . 2003 . Directive no. 2003/74/CE of September 22th . Off J Eur Commun , L262 : 17 – 21 .
   Google Scholar
• Directive no. 96/22/CE . 1996 . Directive no. 96/22/CE of April 29th . Off J Eur Commun , L125 : 3 – 9 .
   Google Scholar
• Directive no. 96/23/CE . 1996 . Directive no. 96/23/CE of April 29th . Off J Eur Commun , L125 : 10 – 32 .
   Google Scholar
• Fente , CA , Vázquez , BI , Franco , C , Cepeda , A and Gigosos , PG . 1999 . Determination of clenbuterol residues in bovine hair using diphasic dialysis and gas chromatography–mass spectrometry . J Chromatogr B , 726 : 133 – 139 .
   PubMed Web of Science ®Google Scholar
• Gallo , P , Brambilla , G , Neri , B , Fiori , M , Testa , C and Serpe , L . 2007 . Purification of clenbuterol-like β2-agonist drugs of new generation from bovine urine and hair by α1-acid glycoprotein affinity chromatography and determination by gas chromatography–mass spectrometry . Anal Chim Acta , 587 : 67 – 74 .
   PubMed Web of Science ®Google Scholar
• Garay , JB , Jiménez , JFH , Jiménez , ML , Sebastian , MV , Matesanz , JP , Moreno , PM and Galiana , JR . 1997 . Intoxicación por clenbuterol: datos clínicos y analíticos de un brote epidémico en Móstoles, Madrid . Revista Clinica Española , 197 : 92 – 95 .
   PubMedGoogle Scholar
• Howells , L , Godfrey , M and Sauer , MJ . 1994 . Melanin as an absorbent for drug residues . Analyst , 119 : 2691 – 2693 .
   PubMed Web of Science ®Google Scholar
• Inkster , J , Hovell , F , Kyle , D , Brown , D and Lobley , G . 1989 . The effect of clenbuterol on basal protein turnover and endogenous nitrogen loss of sheep . Br J Nutr , 62 : 285 – 296 .
   PubMed Web of Science ®Google Scholar
• ISO 11843-2 . 2000 . ISO 11843-2 of May 1st. Capability of detection. Part 2: methodology in the linear calibration case , Geneva : ISO .
   Google Scholar
• Kurien , BT , Everds , NE and Scofield , RH . 2004 . Experimental animal urine collection: a review . Lab Anim , 38 : 333 – 361 .
   PubMed Web of Science ®Google Scholar
• Maistro , S , Chiesa , E , Angeletti , R and Brambilla , G . 1995 . Beta blockers to prevent clenbuterol poisoning . Lancet , 346 : 180
   PubMed Web of Science ®Google Scholar
• Martinez-Navarro , JF . 1990 . Food poisoning related to consumption of illicit β-agonist in liver . Lancet , 336 : 1311
   PubMed Web of Science ®Google Scholar
• Mersmann , HJ . 1987 . Acute metabolic effects of adrenergic agents in swine . Am J Physiol , 252 : E85 – E95 .
   PubMed Web of Science ®Google Scholar
• Montrade , M-P , le Bizec , B , Monteau , F , Siliart , B and André , F . 1993 . Multi-residue analysis for β-agonistic drugs in urine of meat-producing animals by gas chromatography–mass spectrometry . Anal Chim Acta , 275 : 253 – 268 .
   Web of Science ®Google Scholar
• Pulce , C , Lamaison , D , Keck , G , Bostvironnois , C , Nicolas , J , Mora , M and Colmant , A . 1991 . Intoxication alimentaire collective due à la présence de residus de clenbutérol dans du foie de veau . Bull Epidemiol Hebdo , 5 : 17 – 18 .
   Google Scholar
• Ramos , F . 2000 . β2-Agonist extraction procedures for chromatographic analysis . J Chromatogr A , 880 : 69 – 83 .
   PubMed Web of Science ®Google Scholar
• Ramos , F , Bañobre , MC , Castilho , MC and Silveira , MIN . 1999a . Solid phase extraction (SPE) for multi-residue analysis of β2-agonists in bovine urine . J Liq Chromatogr Relat Technol , 22 : 2307 – 2320 .
   Web of Science ®Google Scholar
• Ramos , F , Ribeiro , L , Saltão , R , Costa , JM and Silveira , MIN . 1999b . Clembuterol em alimentos compostos para animais por cromatografia gasosa-espectrometria de massa . Revista Portuguesa de Farmácia , XLIX : 37 – 40 .
   Google Scholar
• Ramos , F , González , P , Oliveira , A , Almeida , A , Fente , C , Franco , C , Cepeda , A and Silveira , MIN . 2001 . Optimization of diphasic dialysis procedure for clenbuterol residues extraction in bovine retina and hair . J Liq Chromatogr Relat Technol , 24 : 251 – 263 .
   Web of Science ®Google Scholar
• Ramos , F , Cristino , A , Carrola , P , Eloy , T , Silva , JM , Castilho , MC and Silveira , MIN . 2003 . Clenbuterol food poisoning diagnosis by gas chromatography–mass spectrometric serum analysis . Anal Chim Acta , 483 : 207 – 213 .
   Web of Science ®Google Scholar
• Salquèbre , G , Bresson , M , Villain , M , Cirimele , V and Kintz , P . 2006 . Clenbuterol determination in calves hair by UPLC–MS–MS: Case report of a fraudulent use for cattle growth . J Anal Toxicol , 30 : 1 – 5 .
   PubMedGoogle Scholar
• Sauer , MJ and Anderson , SPL . 1994 . In vitro and in vivo studies of drug residues accumulation in pigmented tissues . Analyst , 119 : 2553 – 2556 .
   PubMed Web of Science ®Google Scholar
• Shiu , TC and Chong , WH . 2001 . A cluster of clenbuterol poisoning associated with pork and pig offal in Hong Kong . Public Health Epidemiol. Bull , 10 : 14 – 17 .
   Google Scholar