Advanced search
Publication Cover
Journal of Microencapsulation
Micro and Nano Carriers
Volume 19, 2002 - Issue 6
Submit an article Journal homepage
454
Views
90
CrossRef citations to date
0
Altmetric
Research Article

Preparation and characterization of drug-loaded polymethacrylate microspheres by an emulsion solvent evaporation method

B. K. Kim Graduate School of Biotechnology, Korea University, Seoul 136-701, Korea
,
S. J. Hwang College of Pharmacy, Chungnam National University, Taejon 305-764, Korea
,
J. B. Park Sama Pharm., Co., Ltd, Euwang-Shi, Kyunggi-do 437-821, Korea
&
H. J. Park Department of Packaging Science, Clemson University, Clemson, SC 29634- 0370, USA
Pages 811-822 | Published online: 29 Sep 2008

  • ABRAHAMSSON, B., JAHANSSON D., TORSTENSSON, A. and WINGSTRAND, K., 1994, Evaluation of solubilizer in the drug release testing of hydrophilic matrix extended-release tablets of felodipine. Pharmceutical Research, 11, 1093-1097.
  • ACARTÜRK, F. and SENCAN, A., 1996, Investigation of the effect of different adjuvant on felodipine release kinetics from sustained release monolithic films. International Journal of Pharmaceutics, 131, 183-189.
  • ALEX, R. and BODMEIER, R., 1990, Encapsulation of water-soluble drugs by a modified solvent evaporation method I. Effect of process and formulation variables on drug entrapment. Journal of Microencapsulation, 7, 347-355.
  • AMORIM, M. J. L. G. B. and FERREIRA, J. P. M., 2001, Microparticles for delivering therapeutic peptides and proteins to the lumen of the small intestine. European Journal of Pharmaceutics and Biopharmaceutics, 52, 39-44.
  • BARBATO, F., ROTONDA, M. I. L., MAGLIO, G., PALUMBO, R. and QUAGLIA, F., 2001, Biodegradable microspheres of novel segmented poly(ether-ester-amide)s based on poly(e-caprolactone) for the delivery of bioactive compounds. Biomaterials, 22, 1371-1378.
  • BENOIT, M. A., BARAS, B. and GILLARD, J., 1999, Preparation and characterization of protein-loaded poly(e-caprolactone) microparticles for oral vaccine delivery. International Journal of Pharmaceutics, 184, 73-84.
  • CHEN, D. R., BEI, J. Z. and WANG, S. G., 2000, Polycaprolactone microparticles and their biodegradation. Polymer Degradation and Stability, 66, 455-459.
  • CROTTS, G., SHETH, A., TWIST, J. and SELLASSIE, I. G., 2001, Development of an enteric coating formulation and process for tablets primarily composed of a highly water-soluble, organic acid. European Journal of Pharmaceutics and Biopharmaceutics, 51, 71-76.
  • CUNA, M., JATO, J. L. V. and TORRES, D., 2000, Controlled-release liquid suspensions based on ion-exchange particles entrapped within acrylic microcapsules. International Journal of Pharmaceutics, 199, 151-158.
  • DAS, S. K. and DAS, N. G., 1998, Preparation and in vitro dissolution profile of dual polymer (Eudragit RS 100 and RL 100) microparticles of diltiazem hydrochloride. Journal of Microencapsulation, 15, 445-452.
  • ESPOSITO, E., SEBBEN, S., CORTESI, R., MENEGATTI, E. and NASTRUZZI, C., 1999, Preparation and characterization of catioinic microspheres for gene delivery. International Journal of Pharmaceutics, 189, 29-41.
  • GUPTA, V. K., ASSMUS, M. W., BECKERT, T. E. and PRICE, J. C., 2001b, A novel pH-and time-based multi-unit potential colonie drug delivery system. II. Optimization of multiple response variables. International Journal of Pharmaceutics, 213, 93-102.
  • GUPTA, V. K., BECKERT, T. E. and PRICE, J. C., 2001a, A novel pH-and time-based multi-unit potential colonie drug delivery system. I. Development. International Journal of Pharmaceutics, 213, 83-91.
  • HERRMANN, J. and BODMEIER, R., 1998, Biodegradable, somatostatin acetate containing microspheres prepared by various aqueous and non-aqueous solvent evaporation methods. European Journal of Pharmaceutics and Biopharmaceutics, 45, 75-82.
  • IOOSS, P., RAY, A. M. L., GRIMANDI, G., DACULSI, G. and MERLE, C., 2001, A new injectable bone substitute combining poly(e-caprolactone) microparticles with biphasic calcium phosphate granules. Biomaterials, 22, 2785-2794.
  • JEFFERY, H., DAVIS, S. S. and O'HAGAN, D. T., 1991, The preparation and characterization of poly(lactide-co-glycolide) microparticles. I. Oil-in-water emulsion solvent evaporation. International Journal of Pharmaceutics, 77, 169-175.
  • KAMEL, A. H. E., SOKAR, M. S., GAMAL, S. S. A. and NAGGAR, V. F., 2001, Preparation and evaluation of ketoprofen floating oral delivery system. International Journal of Pharmaceutics, 220, 13-21.
  • KAWASHIMA, Y., YAMAMOTO, H., TAKEUCHI, H., HINO, T. and NIWA, T., 1998, Properties of a peptide containing dl-lactide/glycolide copolymer nanospheres prepared by novel emulsion solvent diffusion methods. European Journal of Pharmaceutics and Biopharmaceutics, 45, 41-48
  • KIBBE, A. H., 2000. Handbook of pharmaceutical excipients, 3rd edn (Washington, D.C.: USA: American Pharmaceutical Association).
  • KRISTMUNDSDÓTTIR, T., GUDMUNDSOON, O. S. and INGVARSDOTTIR, K., 1996, Release of diltiazem from Eudragit microparticles prepared by spray-drying. International Journal of Pharmaceutics, 137, 159-165.
  • LAMOSA, M. L. L., LÓPEZ, C. R., JATO, J. L. V. and ALONSO, M. J., 1998, Design of microencapsulated chitosan microspheres for colonie drug delivery. Journal of Controlled Release, 52, 109-118.
  • LAMPRECHT, A., UBRICH, N., FEREZ, M. H., LEHR, C. M., HOMAN, M. and MAINCENT, P., 2000. Influence of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique. International Journal of Pharmaceutics, 196, 177-182.
  • LEE, J. H, PARK, T. G. and CHOI, H. K., 2000, Effect of formulation and processing variables on the characteristics of microspheres for water soluble drugs prepared by w/o/o double emulsion solvent diffusion method. International Journal of Pharmaceutics, 196, 75-83.
  • MURAKAMI, H., KOBAYASHI, M., TAKEUCHI, H. and KAWASHIMA, H., 2000, Further application of a modified spontaneous emulsification solvent diffusion method to various types of PLGA and PLA polymers for preparation of nanoparticles. Powder Technology, 107, 137-143.
  • NYKANEN, P., LEMPAA, S., AALTONEN, M. L., JURJENSON, H., VESKI, P. and MARVOLA, M., 2001. Citric acid as excipient in multiple-unit enteric-coated tablets for targeting drugs on the colon. Internatonal Journal of Pharmaceutics, 229, 155-162.
  • PEREZ, M. H., ZINUTTI, C., LAMPRECHT, A., UBRICH, N., ASTIER, A., HOMAN, M., BODMEIER, R. and MAINCENT, P., 2000, The preparation and evaluation of poly (e-caprolactone) microparticles containing both a lipophilic and hydrophobic drug. Journal of Controlled Release, 65, 429-438.
  • PERUMAL, D., 2001, Microencapsulation ibuprofen and Eudragit RS 100 by the emulsion solvent diffusion technique. International Journal of Pharmaceutics, 218, 1-11.
  • RÉ, M. I. and BISCANS, B., 1999, Preparation of microspheres of ketoprofen with acrylic polymers by a quasi-emulsion solvent diffusion method. Powder Technology, 101, 120-133.
  • RODRIGUEZ, M., JOSE, L. VILA-JATO, J. L. and TORRES, D., 1998, Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonie region. Journal of Controlled Release, 55, 67-77.
  • SIEPMANN, J. and PEPPAS, N. A., 2001, Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Advanced Drug Delivery Review, 48, 139-157.
  • TAKKA, S., RAJBHANDARI, S. and SAKR, A., 2001, Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets. European Journal of Pharmaceutics and Biopharmaceutics, 52, 75-82.
  • VISWANATHAN, N. B., THOMAS, P. A., PANDIT, J. K., KULKARNI, M. G. and MASHELKAR, R. A., 1999, Preparation of non-porous microspheres with high entrapment efficiency of proteins by a (water-in-oil)-in-oil emulsion technique. Journal of Controlled Release, 58, 9-20.
  • YANG, Y. Y., CHIA, H. H. and CHUNG, T. S., 2000, Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double emulsion solvent extraction/evaporation method. Journal of Controlled Release, 69, 81-96.
  • YOUAN, B. B. C., JACSON, T. L., DICKENS, L., HERNANDEZ, C. and ABABIO, G. O., 2001, Protein release profiles and morphology of biodegradable microcapsules containing an oily core. Journal of Controlled Release, 76, 313-326.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.