757
Views
124
CrossRef citations to date
0
Altmetric
Research Article

Alginate-polylysine-alginate microcapsules: effect of size reduction on capsule properties

, , , &
Pages 615-630 | Published online: 29 Sep 2008

  • AMSDEN, B. G., and GOOSEN, M. F. A., 1997, An examination of factors affecting the size, distribution and release characteristics of polymer microbeads made by using electrostatics. Journal of Controlled Release, 43, 183-196.
  • CHICHEPORTICHE, D., and REACH, G., 1988, In vitro kinetics of insulin release by microencapsulated rat islets: effect of the size of the microcapsules. Diabetologia, 31, 54-57.
  • CLAYTON, H. A., LONDON, N. J. M., BELL, P. R. F., and JAMES, R. F. L., 1992, The transplantation of encapsulated islets of Langerhans into the peritoneal cavity of the BiobBreeding rat. Transplantation, 54, 558-559.
  • DE Vos, P., DE HAAN, B. J., PATER, J., and VAN SCHILFGAARDE, R., 1996a, Association between capsule diameter, adequacy of encapsulation, and survival of microencapsulated rat islet allografts. Transplantation, 62, 893-899.
  • DE Vos, P., DE HAAN, B. J., WOLTERS, G. H. J., and VAN SCHILPGAARDE, R., 1996b, Factors influencing the adequacy of microencapsulation of rat pancreatic islets. Transplantation, 62, 888-893.
  • DULIEU, C., PONCELET, D., and NEUFELD, R., 1998, Encapsulation and immobilization techniques, In Cell encapsulation technology and therapeutics, edited by W. M. Kuhtreiber, R. P. Lanza and W. Chick (Boston: Birkhäuser), pp. 3-17.
  • EIZIRIK, D. L., PIPELEERS, D. G., LING, Z., WELSH, N., HELLERSTROM, C., and ANDERSSON, A., 1994, Major species differences between human and rodents in the susceptibility to pancreatic beta-cell injury. Proceedings of the National Academy of Sciences (USA), 91, 9253-9256.
  • FAN, M.-Y., LUM, Z.-P., Fu, X.-W., LEVESQUE, L., TAI, I., and SUN, A. M., 1990, Reversal of diabetes in BB rats by transplantation of encapsulated pancreatic islets. Diabetes, 39, 519-522.
  • FLORY, P. J. (ed.), 1953, Principles of polymer chemistry (Ithaca: Oxford University).
  • FRITSCHY, W. M., STRUBBE, J. H., WOLTERS, G. H. J., and VAN SCHILFGAARDE, R., 1991a, Glucose tolerance and plasma insulin response to intravenous glucose infusion and test meal in rats with microencapsulated islet allografts. Diabetologia, 34, 542-547.
  • FRITSCHY, W. M., VAN STRAATEN, J. F. M., DE Vos, P., STRUBBE, J. H., WOLTERS, G. H. J., and VAN SCHILFGAARDE, R., 1991b, The efficacy of intraperitoneal pancreatic-islet isografts in the reversal of diabetes in rats. Transplantation, 52, 777-783.
  • GOOSEN, M. F. A., AL-GHAFRI, A. S., EL MARDI, O., AL-BELUSHI, M. I. J., AL-HAJRI, H. A., MAHMOUD, E. S. E., and CONSOLACION, E. C., 1997, Electrostatic droplet generation for encapsulation of somatic tissue: assesment of high-voltage power supply. Biotechnology Progress, 13, 497-502.
  • GRASDALEN, H., 1983, High-field, 1H-NMR spectroscopy of alginate: sequential study and linkage conformations. Carbohydrate Research, 118, 255-260.
  • HALLE, J. P., LEBLOND, F. A., PARISEAU, J. F., JUTRAS, P., BRABANT, M. J., and LEPAGE, Y., 1994, Studies on small (<) microcapsules: II-parameters governing the production of alginate beads by high voltage electrostatic pulses. Cell Transplantation, 3, 365-372.
  • HEDING, L., 1972, Determination of total senim insulin (IRI) in insulin-treated patients. Diabetologica, 17, 1031.
  • HOWELL, S. L., and TAYLOR, K. W., 1968, Potassium ions and the secretion of insulin by islets of Langerhans incubated in vitro. Biochemistry, 17-24.
  • KING, A., SANDLER, S., ANDERSSON, A., HELLERSTROM, C., KULSENG, B., and SKJÅK-BRÆK, G., 1999, Glucose metabolism in vitro of cultured and transplanted mouse pancreatic islets microencapsulated by means of a high-voltage electrostatic field. Diabetes Care, 22, Bl 21-Bl 26.
  • KULSENG, B., THU, B., ESPEVIK, T., and SKJÅK-BRÆK, G., 1997, Alginate polylysine capsules as an immune barrier: permeability of cytokines and immunoglobulins over the capsule membrane. Cell Transplantation, 6, 387-394.
  • LANZA, R. P., KUHTREIBER, W. M., ECKER, D., STARUK, J. E., and CHICK, W. L., 1995, Xenotransplantation of porcine and bovine islets without immunosupressing using uncoated alginate microspheres. Transplantation, 59, 1377-1384.
  • LEBLOND, F. A., SIMARD, G., HENLEY, N., ROCHELEAU, B., HUET, P. M., and HALLE, J. P., 1999, Studies on smaller (similar to 315µm) microcapsules: IV. Feasibility and safety of intrahepatic implantations of small alginate poly-L-lysine microcapsules. Cell Transplantation, 8, 327-337.
  • LIABAKK, N. B., NUSTAD, K., and ESPEVIK, T., 1990, A rapid and sensitive immunoassay for tumor necrosis factor using monodisperse polymer particles. Journal of Immunology Methods, 134, 253-259.
  • LIM, F., and SUN, A. M., 1980, Microencapsulated islets as a bioartificial endocrine pancreas. Science, 210, 908-910.
  • LONDON, N. J. M., THIRDBOROUGH, S. M., LOFTUS, I. M., LAKE, S. P., BELL, P. R. F., and JAMES, R. F. L., 1991, Renal subcapsular islet transplantation in the rat-a comparison of 3 techniques. Diabetes Research Clinical and Experimental, 16, 81-83.
  • MARTINSEN, A., SKJÅK-BRÆK, G., and SMIDSROD, O., 1989, Alginate as immobilization material: I. Correlation between chemical and physical properties of alginate gel beads. Biotechnology and Bioengineering, 33, 79-89.
  • MOE, S. T., DRAGET, K. L, SKJÅK-BRÆK, G., and SMIDSROD, O., 1995, Alginates. In Food polysaccharides and their applications, edited by A. M. Stephen (New York: Marcel Decker Inc.), pp. 245-286.
  • PJANOVIC, R., GOOSEN, M. F. A., NEDOVIC, V., and BUGARSKI, B., 2000, Immobilization/ encapsulation of cells using electrostatic droplet generator. Minerva Biotechnologica, 12, 241-248.
  • PONCELET, D., and NEUFELD, R. J., 1989, Shear breakage of nylon membrane microcapsules in a turbine reactor. Biotechnology and Bioengineering, 33, 95-103.
  • PRUSSE, U., DALLUHN, J., BREFORD, J., BREFORD, J., and VORLOP, K. D., 2000, Production of spherical beads by JetCutting. Chemical Engineering Technology, 23, 1105-1110.
  • RIHOVA, B., 2000, Immunocompatibility and biocompatibility of cell delivery systems. Advanced Drug Delivery Reviews, 42, 65-80.
  • ROBITAILLE, R., PARISEAU, J. F., LEBLOND, F., LAMOUREUX, M., LEPAGE, Y., and HALLE, J. P., 1999, Studies on small (<350µm) alginate-poly-L-lysine microcapsules. III. Biocompatibility of smaller versus standard microcapsules. Journal of Biomedical Materials Research, 44, 116-120.
  • SERP, D., CANTANA, E., HEINZEN, C., VON STOCKAR, U., and MARISON, I. W., 2000, Characterization of an encapsulation device for the production of monodisperse alginate beads for cell immobilization. Biotechnology and Bioengineering, 70, 41-53.
  • SOON-SHIONG, P., FELDMAN, E., NELSON, R., KOMTEBEDDE, J., SMIDSROD, O., SKJAK-BRAK, G., ESPEVIK, T., HEINTZ, R., and LEE, M., 1992, Successful reversal of spontaneous diabetes in dogs by intraperitoneal microencapsulated islets. Transplantation, 54, 769-774.
  • SooN-SmoNG, P., HEINTZ, R. E., MERIDETH, N., YAO, Q. X., YAO, Z., ZHENG, T., MURPHY, M., MOLONEY, M. K., SCHMEHL, M., HARRIS, M., MENDEZ, R., and SANDFORD, P. A., 1994, Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation. Lancet, 343, 950-951.
  • STRAND, B. L., MORCH, Y. A., and SKJÅK-BRÆK, G., 2000, Alginate as immobilization matrix for cells. Minerva Biotechnologica, 12, 223-233.
  • TANAKA, T., 1979, Phase transitions in gels and a single polymer. Polymer, 20, 1404-1412.
  • THU, B., BRUHEIM, P., ESPEVIK, T., SMIDSROD, O., SKJÅN-BRÆNG, P., and SKJÅK-BRÆK, G., 1996a, Alginate polycation microcapsules. I. Interaction between alginate and polycation. Biomaterials, 17, 1031-1040.
  • THU, B., BRUHEIM, P., ESPEVIK, T., SMIDSROD, O., SOON-SHIONG, P., and SKJÅK-BRÆK, G., 1996b, Alginate polycation microcapsules. II. Some functional properties. Biomaterials, 17, 1069-1079.
  • THU, B., GASEROD, O., PAUS, D., MIKKELSEN, A., SKJÅK-BRÆK, G., TOFFANIN, R., VITTUR, F., and RIZZO, R., 2000, Inhomogenious alginate gel spheres: an assesment of the polymer gradients by synchrotron radiation-induced X-ray emmision, magnetic resonance microimaging, and mathematic modeling. Biopolymers, 53, 60-71.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.