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Research Article

Microencapsulation of a hydrophilic drug into a hydrophobic matrix using a salting-out procedure. I: Development and optimization of the process using factorial design

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Pages 125-135 | Published online: 16 Oct 2008

References

  • ADEYEYE, C. M. and PRICE, J. C., 1991, Development and evaluation of sustained release ibuprofen wax microspheres. I. Effect of formulation variables on physical characteristics. Pharmaceutical Research, 8, 1377–1383.
  • BLUME, R. W., DAVIS, R. D. and KEYSER, D. J., 2002, Guaifenesin sustained release formulation and tablets. United States Patent Publication No. US 6372252. BODMEIER, R. and WANG, J., 1993, Microencapsulation of drugs with aqueous colloidal polymer dispersions. Journal of Pharmaceutical Sciences, 82, 191–194.
  • BODMEIER, R., WANG, J. and BHAGWATWAR, H., 1992, Process and formulation variables in the preparation of microparticles by a melt dispersion technique. II. w/o/w multiple emulsion technique for water-soluble drugs. Journal of Microencapsulation, 1, 99–107.
  • LEE, J., PARK, T. G. and CHoi, H., 2000, Effect of formulation and processing variables of microspheres for water-soluble drugs prepared by w/o/o double emulsion solvent diffusion method. International Journal of Pharmaceutics, 196, 75–83.
  • MANI, N., JUN, H. W., BEACH, J. W. and NERURKAR, J., 2003, Solubility of guaifenesin in the presence of common pharmaceutical additives. Pharmaceutical Development and Technology, 8, 385–396.
  • MARTIN, A., 1989, Physical Pharmacy, 4th edn (Williams Baltimore and Wilkins: Baltimore).
  • NAKANO, T. and YUASA, H., 2001, Suppression of agglomeration in fluidized bed coating IV. Effects of sodium citrate concentration on the suppression of particle agglomeration and the physical properties of HPMC film. International Journal of Pharmaceutics, 215, 3–12.
  • PHUAPRADIT, W., SHAH, N. H., Lou, Y., KUNDU, S. and INFELD, M. H., 2002, Critical processing factors affecting rheological behavior of a wax based formulation. European Journal of Pharmaceutics and Biopharmaceutics, 53, 175–179.
  • Ruiz, J. M., TISSIOR, B. and BENOIT, J. P., 1989, Microencapsulation of peptides: a study of the phase separation of poly (D,L-lactic acid-co-glycolic acid) copolymer 50/50 by silicon oil. International Journal of Pharmaceutics, 49, 69–77.
  • SHERVINGTON, L. A. and SHERVINGTON, A., 1998, Guaifenesin. Analytical Profiles of Drug Substances and Excipients, 25, 131–164.
  • VILLIVALM, V. D. and ADEYEYE, C. M., 1994, Development and evaluation of controlled-release diclofenac microspheres and tabletted microspheres. Journal of Micro-encapsulation, 11, 455–470.
  • WADA, R., HYON, S. and IKADA, Y., 1990, Lactic acid oligomer microspheres containing hydrophilic drugs. Journal of Pharmaceutical Sciences, 79, 919–924.

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