Advanced search
Publication Cover
Journal of Microencapsulation
Micro and Nano Carriers
Volume 21, 2004 - Issue 7
Submit an article Journal homepage
92
Views
13
CrossRef citations to date
0
Altmetric
Research Article

In vivo and in vitro characteristics for insulin-loaded PLA microparticles prepared by w/o/w solvent evaporation method with electrolytes in the continuous phase

M.-K. Yeh Department of Clinical Pharmacy, Tri-service General Hospital, National Defence Medical Center, 325, Sec 2 Chen-kung R.D, Neihu, Taipei (114), TaiwanCorrespondence[email protected]
,
J.-L. Chen School of Pharmacy, National Defence Medical Center, Taipei, Taiwan
&
C.-H. Chiang School of Pharmacy, National Defence Medical Center, Taipei, Taiwan
Pages 719-728 | Received 15 Dec 2003, Accepted 10 May 2004, Published online: 03 Oct 2008

References

  • CHEN, J. L., YEH, M. K. and CHIANG, C. H., 2002, The mechanism of PLA microparticle formation by water-in-oil-in-water solvent evaporation method. Journal of Microencapsulation, 19, 333–346.
  • CHEN, J. L., YEH, M. K. and CHIANG, C. H., 2003, The mechamism of surface-idented protein-loaded PLGA microparticle formulation: the effect of salt (NaC1) on the solidification process. Journal of Microencapsulation, in press.
  • COOMBES, A. G. A., YEH, M. K., EAVELLE, E. C. and DAVIS, S. S., 1998, The control of protein release from poly(DL lactide co-glycolide) microparticles by variation of the external aqueous phase surfactant in the water-in oil-in water method. Journal of Controlled Release, 52, 311–320.
  • CROTTS, G. and PARK, T. G., 1997, Stability and release of bovine serum albumin encapsulated within poly(DL-lactide-co-glycolide) microparticles. Journal of Controlled Release, 44, 123–134.
  • EAVELLE, E. C., YEH, M. K., COOMBES, A. G. A. and DAVIS, S. S., 1999, The stability and immunogenicity of a protein antigen encapsulated in biodegradable microparticles based on blends of lactide polymers and polyethylene glycol. Vaccine, 17, 512–529.
  • GOMBOTZ, W. R. and PETTIT, D. K., 1995, Biodegradable polymers for protein and peptide drug delivery. Bioconjugate Chemistry, 6, 332–351.
  • HOME, P., 1999, Insulin glargine: the first clinically useful extended acting insulin in half a century? Expert Opinions in Investigative Drugs, 8, 307–314.
  • JENKINS, P. G., COOMBES, A. G. A., YEH, M. K., THOMAS, N. W. and DAVIS, S. S., 1995, Aspects of the design and delivery of microparticles for vaccine application. Journal of Drug Targeting, 3, 79–81.
  • KIM, H. K. and PARK, T. G., 1999, Microencapsulation of human growth hormone within biodegradable polyester microspheres: protein aggregation, stability and incomplete release mechanism. Biotechnology and Bioengineering, 65, 659–667.
  • UCHIDA, T., YOSHIDA, K. and GOTO, S., 1996, Preparation and characterization of polyactic acid microsphere containing water-soluble dyes using a novel w/o/w emulsion solvent evaporation method. Journal of Microencapsulation, 13, 219–228.
  • WEERT, M., HENNINK, W. E. and jisKoorr, W., 2000, Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharmaceutical Research, 17, 1159–1167.
  • YEH, M. K., 2000, The stability of insulin in biodegradable microparticles based on blends of lactide polymers and polyethylene glycol. Journal of Microencapsulation, 17, 743–756.
  • YEH, M. K, CHEN, J. L. and CHIANG, C. H., 2002a, Vibrio cholerae-loaded poly(DL lactide co-glycolide) microparticles. Journal of Microencapsulation, 19, 203–212.
  • YEH, M. K., CHEN, J. L. and CHIANG, C. H., 2002b, Oral immunogenicity of the inactived Vibrio cholerae whole-cell vaccine encapsulated in biodegradable microparticles. Journal of Controlled Release, 82, 237–247.
  • YEH, M. K., COOMBES, A. G. A., CHEN, J. L. and CHIANG, C. H., 2002c, Japanese encephalitis virus vaccine formulations using PLA lamellar and PLG microparticles adjuvant. Journal of Microencapsulation, 19, 671–682.
  • YEH, M. K., COOMBES, A. G. A., JENKINS, P. G. and DAVIS, S. S., 1995a, A novel emulsification-solvent extraction technique for production of protein loaded biodegradable microparticles for vaccine and drug delivery. Journal of Controlled Release, 33, 437–445.
  • YEH, M. K., JENKINS, P. G., DAVIS, S. S. and COOMBES, A. G. A., 1995b, Improving the delivery capacity of microparticle systems using blends of poly(DL lactide co-glycolide) and poly(ethylene glycol). Journal of Controlled Release, 37, 1–9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.