167
Views
59
CrossRef citations to date
0
Altmetric
Research Article

Nasal delivery of insulin using chitosan microspheres

, &
Pages 761-774 | Received 20 Sep 2003, Accepted 03 Feb 2004, Published online: 03 Oct 2008

References

  • ACIKGOZ, M., KAs, H. S., ORMAN, M. and HINCAL, A. A., 1996, Chitosan microspheres of diclofenac sodium: I. application of factorial design and evaluation of release kinetics. Journal of Microencapsulation, 13, 141–160.
  • AIEDEH, K., GIANASI, E., ORIENTI, I. and ZECCHI, V., 1997, Chitosan microcapsules as controlled release systems for insulin. Journal of Microencapsulation, 14, 567–576.
  • AKBUGA, J. and BERGISADI, N., 1997, Effect of drug properties on physical and release characteristics of eudragit microspheres prepared by spherical crystallization techniques. Drug Development and Industrial Pharmacy, 23, 407–411.
  • AL-HELw, A. A., AL-ANGARY, A. A., MAHROUS, G. M. and AL-DARDARI, M. M., 1998, Preparation and evaluation of sustained release cross-linked chitosan microspheres containing phenobarbitone. Journal of Microencapsulation, 15, 373–382.
  • ALMEIDA, A. J., ALPAR, H. 0. and BROWN, M. R. W., 1993, Immune response to nasal delivery of antigenisity intact tetanus toxoid associated with poly (L-lactic acid) microspheres in rats, rabbits and guinea-pigs. International Journal of Pharmaceutics, 45, 198–203.
  • ALPAT, H. 0. and ALMEIDA, A. J., 1994, Identification of some of the physico-chemical characteristics of microspheres which influence the induction of the immune response following mucosal delivery. European Journal of Pharmaceutics and Biopharmaceutics, 40, 198–202.
  • BANAKAR, U. V., 1992, Pharmaceutical dissolution testing (New York: Marcel Dekker), pp. 192–193.
  • BJORK, E. and EDMAN, P., 1988, Degradable starch microspheres as a nasal delivery system for insulin. International Journal of Pharmaceutics, 47, 233–238.
  • CAHILL, E. S., CPHAGAN, D. T., ILLUM, L., BARNARD, A., MILLS, K. H. G. and REDHEAD, K., 1995, Immune responses and protection against Bordetella pertussis infection after intranasal immunization of mice with filamentous haemagglutinin in solution or incorporated in biodegradable microparticles. Vaccine, 13, 455–462.
  • CRITCHLEY, H. S. S. D., FARRAJ, D. and ILLum, L., 1994, Nasal absorption of desmopressin in rats and in sheep. Effect of bioadhesive microsphere delivery system. Journal of Pharmaceutics and Pharmacology, 46, 651–656.
  • DENKBAS, E. B., SEVYAL, M. and PISKIN, E., 1999, 5-fluorouracil loaded chitosan microspheres for chemoembolization. Journal of Microencapsulation, 16, 741–749.
  • ELDRIDGE, J. H., STAAS, J. K., MEULBROEK, J. A., MCGHEE, J. R., TICE, T. R. and GILLEY, R. M., 1991, Biodegradable microspheres as a vaccine delivery system. Molecular Immunology, 28, 287–294.
  • FARRAJ, N. F., JOHANSON, B. R., DAVIS, S. S. and ILLum, L., 1990, Nasal administration of insulin using bioadhesive microspheres as a delivery system. Journal of Controlled Release, 13, 253–261.
  • HINCHCLIFFE, M. and ILLum, L., 1999, Intranasal insulin delivery and therapy. Advanced Drug Delivery Review, 35, 199–234.
  • ILLum, L., 1998, Chitosan and its use as a pharmaceutical excipient. Pharmaceutical Research, 15, 1326–1331.
  • ILLum, L., FARRAJ, N. F., CRITCHLEY, H. and DAVIS, S. S., 1988, Nasal administration of gentamycin using a novel microsphere delivey system. International Journal of Pharmaceutics, 46, 261–265.
  • ILLum, L., FARRAJ, N. F. and DAVIS, S. S., 1994b, Chitosan as a novel nasal delivery system for peptide drugs. Pharmaceutical Research, 11, 1186–1189.
  • ILLum, L., FARRAJ, N. F., DAVIS, S. S., JOHANSEN, B. R. and CPHAGAN, D. T., 1990, Investigation of the nasal absorption of biosynthetic human growth hormone in sheep-use of a bioadhesive microsphere delivery system. International Journal of Pharmaceutics, 63, 207–211.
  • ILLum, L., FARRAJ, N. F., FISHER, A. N., GILL, I., MIGLIETTA, M. and BENEDETTI, L. M., 1994a, Hyaluronic acid ester microspheres as a nasal delivery system for insulin. Journal of Controlled Release, 29, 133–141.
  • JAMEELA, S. R., KUMARY, T. V., LAL, A. V. and JAYAKRISHNAN, A., 1998, Progestrone-loaded chitosan microspheres: a long acting biodegradable controlled delivery system. Journal of Controlled Release, 52, 17–24.
  • KHAN, K. A., 1975, The concept of dissolution efficiency. Journal of Pharmaceutics and Pharmacology, 27, 48–49.
  • KIANG, S. W., KUAN, S. S. and GUILBAULUT, G. G., 1976, Measurement of glucose in plasma, with use of immobilized glucose oxidase. Clinical Chemistry, 22, 1374–1382.
  • KRIWET, B. and KISSEL, T., 1996, Poly (acrylic acid) microspheres widen intercellular spaces of Caco-2 cell monolayers: an examination by confocal laser scanning microscopy. European Journal of Pharmaceutics and Biopharmaceutics, 42, 233–240.
  • LACHMAN, L., LIBERMAN, H. A. and KANIG, J. L., 1986, The theory and practice of industrial pharmacy (Philadelphia: Lea and Febiger), p. 67.
  • LEHR, C. M., BOUWSTRA, J. A., SCHACHT, E. H. and JUNGINGER, H. E., 1992, In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. International Journal of Pharmaceutics, 76, 43–49.
  • LI, Y. P., MACHIDA, T. Y., SANNAN, T. and NAGAI, T., 1991, Preparation of chitosan microspheres containing fluorouracil using the dry-in-oil method and its release characteristics. STP Pharmaceutical Science, 1, 363–368.
  • LIME, L. Y., WAN, L. S. C. and Ti, P. Y., 1997, Chitosan microspheres prepared by emulsification and ionotropic gelation. Drug Development and Industrial Pharmacy, 23, 981–985.
  • MACHERAS, P., REPPAS, C. and DRESSMAN, B., 1995, Biopharmaceutics of orally administered drugs (London: Ellis Horwood), pp. 49–77.
  • NAGAI, T., NISHIMOTO, Y., NAMBU, N. SuzuKI, Y. and SERKINE, K., 1984, Powder dosage form of insulin for nasal administration. Journal of Controlled Release, 1, 15–22. PERESWETOFF-MORATH, L., 1998, Microspheres as nasal drug delivery systems. Advanced
  • Drug Delivery Review, 29, 185–194.
  • PERESWETOFF-MORATH, L. and EDMAN, P., 1996, Immunological consequences of nasal drug delivery in dextran microspheres and ethyl (hydroxyethyl) cellulose in rats. International Journal of Pharmaceutics, 128, 23–28.
  • SWITZER, R. L. and GARRITY, L. F., 1999, Experimental biochemistry (New York: W.H. Freeman and company), pp. 22–24.
  • TING, T. Y., GONDA, I. and GIPPS, E. M., 1992, Microparticles of pplyvinyl alcohol for nasal delivery. I. Generation by spray-drying and spray-desolvation. Pharmaceutical Research, 9, 1330–1335.
  • UGWOKE, M. I., VERBEKE, N. and KINGET, R., 2001, The biopharmaceutical aspects of nasal mucoadhesive drug delivery. Journal of Pharmaceutics and Pharmacology, 53, 3–22.
  • VIDGREN, P., VIDGREN, M., ARPPE, J., HAKULI, T., LAINE, E. and PARONEN, P., 1992, In vitro evaluation of spray-dried mucoadhesive microspheres for nasal administration. Drug Development and Industrial Pharmacy, 18, 581–597.
  • VIVIEN, N., BURI, P., BALANT, L. and LACROIX, S., 1994, Nasal absorption of metoclopramide administered to man. European Journal of Pharmaceutics and Biopharmaceutics, 40, 228–231.
  • VYAS, S. P. BHATNAGAR, S., GOGOI, P. J. and JAIN, N. K., 1991, Preparation and characterization of HAS -propranolol microspheres for nasal administration. International Journal of Pharmaceutics, 69, 5–12.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.