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Research Article

Formulation and process parameters affecting protein encapsulation into PLGA microspheres during ethyl acetate-based microencapsulation process

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Pages 1-12 | Received 06 Jan 2004, Accepted 10 May 2004, Published online: 03 Oct 2008

References

  • Arica B, Kas HS, Orman MN, Hincal AA. 2002. Biodegradable bromocryptine mesylate microspheres prepared by a solvent evaporation technique. I: Evaluation of formulation variables on microspheres characteristics for brain delivery. Journal of Microencapsulation 19:473–484.
  • Bahl Y, Sah H. 2000. Dynamic changes in size distribution of emulsion droplets during ethyl acetate-based microencapsulation process. AAPS PharmSciTech 1:article 5.
  • Benoit JP, Marchais H, Rolland H, Velde VV. 1996. Biodegradable microspheres: advances in production technology. In: Benita S, editor. Microencapsulation: Methods and industrial applications. New York: Marcel Dekker Inc.
  • Birnbaum DT, Kosmala JD, Henthom DB, Brannon-Peppas L. 2000. Controlled release of /3-estradiol from PLGA microparticles: the effect of organic phase solvent on encapsulation and release. Journal of Controlled Release 65:375–387.
  • Cho SW, Song SH, Choi YW. 2000. Effects of solvent selection and fabrication method on the characteristics of biodegradable poly(lactide-co-glycolide) microspheres containing ovalbumin. Archives of Pharmaceutical Research 23:385–390.
  • Chung TW, Huang YY, Tsai YL, Liu YZ. 2002. Effects of solvent evaporation rate on the properties of protein-loaded PLLA and PDLLA microspheres fabricated by emulsion-solvent evaporation process. Journal of Microencapsulation 19:463–471.
  • Freytag T, Dashevsky A, Tillman L, Hardee GE, Bodmeier R. 2000. Improvement of the encapsulation efficiency of oligonucleotide-containing biodegradable microspheres. Journal of Controlled Release 69:197–207.
  • Gander B, Wehrli E, Alder R, Merkle HP. 1995. Quality improvement of spray-dried, protein-loaded D,L-PLA microspheres by appropriate polymer solvent selection. Journal of Microencapsulation 12:83–97.
  • Jiang G, Thanoo BC, DeLuca PP. 2002. Effect of osmotic pressure in the solvent extraction phase on BSA release profile from PLGA microspheres. Pharmaceutical Developments in Technology 7:391–399.
  • Mandal TK. 1999. Effect of solvent on the characteristics of pentamidine loaded microcapsules. Journal of Biomaterials Science, Polymer Edition 10:1–17.
  • Sah H. 1997a. A new strategy to determine the actual protein content of PLGA microspheres. Journal of Pharmaceutical Science 86:1315–1318.
  • Sah H. 1997b. Microencapsulation techniques using ethyl acetate as dispersed solvent: effects of extraction rate on characteristics of PLGA microspheres. Journal of Controlled Release 47:233–245.
  • Soppimath KS, Aminabhavi TM. 2002. Ethyl acetate as a dispersing solvent in the production of poly(D,L-lactide-co-glycolide) microspheres: effect of process parameters and polymer type. Journal of Microencapsulation 19:281–292.
  • Wang J, Schwendeman SP. 1999. Mechanisms of solvent evaporation encapsulation processes: prediction of solvent evaporation rate. Journal of Pharmaceutical Science 88:1090–1099.
  • Watts PJ, Davies MC, Melia CD. 1990. Microencapsulation using emulsification/solvent evaporation: an overview of techniques and applications. Critical Reviews in Thermal Drug Carrier Systems 7:235–259.
  • Yan CH, Resau JH, Hewetson J, West M, Rill WL, Kende M. 1994. Characterization and morphological analysis of protein-loaded poly(lactide-co-glycolide) microparticles prepared by water-in-oil-in-water emulsion technique. Journal of Controlled Release 32:231–241.
  • Yang YY, Chia HH, Chung TS. 2000. Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. Journal of Controlled Release 69:81–96.
  • Yang YY, Chung TS, Ng NP. 2001. Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. Biomaterials 22:231–241.

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