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Research Article

Poly(D,L-lactide-co-glycolide) protein-loaded nanoparticles prepared by the double emulsion method—processing and formulation issues for enhanced entrapment efficiency

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Pages 205-214 | Received 19 May 2004, Accepted 15 Oct 2004, Published online: 03 Oct 2008

References

  • Alex R, Bodmeier R. 1990. Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment. Journal of Microencapsulation 7:347–355.
  • Atkins TW, Peacock J. 1996. The incorporation and release of bovine serum albumin from poly-hydroxybutyrate-hydroxyvalerate microcapsules. Journal of Microencapsulation 13:709–717.
  • Bilati U, Allémann E, Doelker E. 2003. Sonication parameters for the preparation of biodegradable nanocapsules of controlled size by the double emulsion method. Pharmaceutical Development and Technology 8:1–9.
  • Bitz C, Doelker E. 1996. Influence of the preparation method on residual solvents in biodegradable microspheres. International Journal of Pharmaceutics 131:171–181.
  • Blanco D, Alonso MJ. 1997. Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres. European Journal of Pharmaceutics and Biopharmaceutics 43:287–294.
  • Blanco D, Alonso MJ. 1998. Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants. European Journal of Pharmaceutics and Biopharmaceutics 45:285–294.
  • Bodmeier R, McGinity JW. 1987. The preparation and evaluation of drug-containing poly(D,L-lactide) microspheres formed by the solvent evaporation method. Pharmaceutical Research 4:465–471.
  • Conway BR, Alpar HO. 1996. Double emulsion microencapsulation of proteins as model antigens using polylactide polymers: effect of emulsifier on the microsphere characteristics and release kinetics. European Journal of Pharmaceutics and Biopharmaceutics 42:42–48.
  • Gabor F, Ertl B, Wirth M, Mallinger R. 1999. Ketoprofen-poly(D,L-lactic-co-glycolic acid) microspheres: influence of manufacturing parameters and type of polymer on the release characteristics. Journal of Microencapsulation 16:1–12.
  • Gasper MM, Blanco D, Cruz ME, Alonso MJ. 1998. Formulation of L-asparaginase-loaded poly(lactide-co-glycolide) nanoparticles: influence of polymer properties on enzyme loading, activity and in vitro release. Journal of Controlled Release 52:53–62.
  • Jeffery H, Davis SS, O'Hagan DT. 1991. The preparation and characterisation of poly(lactide-co-glycolide) microparticles. I: Oil-in-water emulsion solvent evaporation. International Journal of Pharmaceutics 77:169–175.
  • Jeffery H, Davis SS, O'Hagan DT. 1993. The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique. Pharmaceutical Research 10:362–368.
  • Li X, Deng X, Yuan M, Xiong C, Huang Z, Zhang Y, Jia W. 1999. Investigation on process parameters involved in preparation of poly-D,LL-lactide-poly(ethylene glycol) microspheres containing Leptospira Interrogans antigens. International Journal of Pharmaceutics 178:245–255.
  • Liu Y, Deng X. 2002. Influences of preparation conditions on particle size and DNA-loading efficiency for poly(D,L-lactic acid-polyethylene glycol) microspheres entrapping free DNA. Journal of Controlled Release 83:147–155.
  • Marchais H, Boury F, Damgé C, Proust J-E, Benoit JP. 1996. Formulation of bovine serum albumin loaded PLGA microspheres—Influence of the process variables on the loading and in vitro release. STP Pharma Sciences 6:417–423.
  • Nicoli S, Sand P, Couvreur P, Couarraze G, Colombo P, Fattal E. 2001. Design of triptorelin loaded nanospheres for transdermal iontophoretic administration. International Journal of Pharmaceutics 214:31–35.
  • Okada Y, Yamamoto M, Heya T, Inoue Y, Kamei S, Ogawa Y, Toguchi H. 1994. Drug delivery using biodegradable microspheres. Journal of Controlled Release 28:121–129.
  • Ogawa Y, Yamamoto M, Okada H, Yashiki T, Shimamoto T. 1988. A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid. Chemical and Pharmaceutical Bulletin 36:1095–1103.
  • Pean J-M, Venier-Julienne M-C, Filmon R, Sergent M, Phan-Tan-Luu R, Benoit JP. 1998. Optimization of HSA and NGF encapsulation yields in PLGA microparticles. International Journal of Pharmaceutics 166:105–115.
  • Rafati H, Coombes AGA, Adler J, Holland J, Davis SS. 1997. Protein-loaded poly(d,L-lactide-co-glycolide) microparticles for oral administration: formulation, structural and release characteristics. Journal of Controlled Release 43:89–102.
  • Sah HK, Toddywala R, Chien YW. 1995. Biodegradable microcapsules prepared by a w/o/w technique: effects of shear force to make a primary w/o emulsion on their morphology and protein release. Journal of Microencapsulation 12:59–69.
  • Yan C, Resau JH, Hewetson J, West M, Rill WL, Kende M. 1994. Characterization and morphological analysis of protein-loaded poly(lactide-co-glycolide) microparticles prepared by water-in-oil-in-water emulsion technique. Journal of Controlled Release 32:231–241.
  • Yang YY, Chung TS, Ng NP. 2001. Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. Biomaterials 22:231–241.
  • Zhu KJ, Jiang HL, Du XY, Wang J, Xu WX, Liu SF. 2001. Preparation and characterization of hCG-loaded polylactide or poly(lactide-co-glycolide) microspheres using a modified water-in-oil-in-water (w/o/w) emulsion solvent evaporation technique. Journal of Microencapsulation 18:247–260.

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