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Research Article

In vitro and in vivo properties of usnic acid encapsulated into PLGA-microspheres

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Pages 371-384 | Received 16 Jun 2003, Accepted 20 Nov 2003, Published online: 03 Oct 2008

References

  • ALLEY, M. C., SCUDIERO, D. A., MONKS, A., HURSEY, M. L., CZERWINSKI, M. J., FINE, D. L., ABBOTT, B. J., MAYO, J. G., SHOEMAKER, R. H. and BODY, M. R., 1988, Feasibility of drug screening with panels of human tumour cell lines using a microculture tetrazolium assay. Cancer Research, 48, 589–601.
  • BARRIO, G. G., Novo, F. L. and IRACHE, J. M., 2003, Loading of plasmid DNA into PLGA microparticles using TROMS (total recirculation one-machine system): evaluation of its integrity and controlled release properties. Journal of Controlled Release, 86, 123–130.
  • BLANCO-PIETRO, M. J., FATTAL, E., PUISIETJX, F. and COUVREUR, P., 1998, Nouvelles approches pour encapsulation de peptides au sein de microspheres de PLG. Annales Pharmaceutiques Franfaises, 56, 256–263.
  • CAMPANELLA, L., DELFINI, M., ERCOLE, P., IACOANGELI, A. and RISULEO, G., 2002, Molecular characterization and action of usnic acid: a drug that inhibits proliferation of mouse polyomavirus in vitro and whose main target is RNA transcription. Biochimie, 84, 329–334.
  • CLEEK, R. L., TING, K. C., ESKIN, S. G. and MIKOS, A. G., 1997, Microparticles of poly(DL-lactic-co-glycolic acid)/poly(ethylene glycol) blends for controlled drug delivery. Journal of Controlled Release, 48, 259–268.
  • COCCHIETTO, M., SKERT, N., Nimis, P. L. and SAVA, G., 2002, A review on usnic acid, an interesting natural compound. Naturwissenschaften, 89, 137–149.
  • GERAN, R. I., GREENBERG, N. H., MACDONALD, M. M., SCHUMACHER, A. M. and ABBOTT, B. J., 1972, Protocols for screening chemical agents and natural products against animal and other biological systems, 3'd edn. Cancer Chemotherapy Reports, Part III, 3 (2).
  • INGOLFSDOTTIR, K., 2002, Molecules of interest usnic acid. Phytochemistry, 61, 729–736.
  • JAIN, R. A., RHODES, C. T., RAILKAR, A. M., MALICK, A. W. and SHAH, N. H., 2000, Controlled release of drugs from injectable in situ formed biodegradable, PLGA microspheres: effect of various formulation variables. European Journal of Pharmaceutics and Biopharmaceutics, 50, 257–262.
  • KUMAR, N., RAVIKUMAR, M. N. V. and Doms, A. J., 2001, Biodegradable block copolymers. Advanced Drug Delivery Reviews, 53, 23–44.
  • LAMPRECHT, A., SCHAFER, U. F. and LEHR, C. M., 2000, Visualization and quantification of polymer distribution in microcapsules by confocal laser scanning microscopy (CLSM). International of Journal Pharmaceutics, 196, 223–226.
  • LE RAY, A. M., CHIFFOLEAU, S., IOOSS, P., GRIMANDI, G., GOUYETTE, A., DACULSI, G. and MERLE, C., 2003, Vancomycin encapsulation in biodegradable poly(caprolactone) microparticles for bone implantation. Influence of the formulation process on size, drug loading, in vitro release and cytocompatibility. Biomaterials, 24, 443–449.
  • LEWIS, D. H., 1990, Controlled release of bioactive agents from lactide/glycolide polymers. In Biodegradable polymers as drug delivery systems, edited by M. Chasin and R. Langer (Marcel Dekker: New York).
  • MOSMANN, T., 1983, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal Immunology Methods, 65, 55–63.
  • MULLER, K., 2001, Pharmaceutically relevant metabolites from lichens. Applied Microbiological Biotechnology, 56, 9–16.
  • RAFATI, H., COOMBES, A. G. A., ADLER, J., HOLLAND, J. and DAVIS, S. S., 1997, Protein-loaded poly(DL-lactide-co-glycolide) microparticles for oral administration: formulation, structural and release characteristics. Journal of Controlled Release, 43, 89–102.
  • ROULLIN, V. G., DEVERRE, J. R., LAURENT, L., HINDRE F., JULIENNE, M. C. V., VIENET, R. and BENOIT, J. P., 2002, Anti-cancer drug diffusion within living rat brain tissue: an experimental study using [3H] (6)-5-fluorouracil-loaded PLGA microspheres. European Journal of Pharmaceutics and Biopharmaceutics, 53, 293–299.
  • SINGH, U. V. and UDUPA, N., 1997, In vitro characterization of methotrexate loaded poly(lactic-co-glycolic) acid microspheres and antitumour efficay in Sarcoma-180 mice bearing tumour. Pharmaceutica Acta Helvetiae, 72, 165–173.
  • TAKAI, M., UEHARA, Y. and BEISLER, J. A., 1979, Usnic acid derivatives as potential antineoplasic agents. Journal of Medicinal Chemistry, 22, 1380.
  • VENKATARAMANA, D. and KRISHNA, D. R., 1992, High-performance liquid chromatographic determination of usnic acid in plasma. Journal of Chromatography, 575, 167-170. VERMA, R. K. and GARG, S., 2001, Drug delivery technologies and future directions. Pharmaceutics Technology, 25, 1–14.
  • WANG, Y. M., SATO, H. and HORIKOSHI, I., 1997, In vitro in vivo evaluation of taxol release from poly(lactic-co-glucolic acid) microspheres containing isopropyl myristate and degradation of the microspheres. Journal of Controlled Release, 49, 157–166.

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