40
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Degradation of multi-phase microspheres fabricated via solvent removal

, , &
Pages 331-352 | Received 05 Aug 2003, Accepted 22 Nov 2003, Published online: 03 Oct 2008

References

  • BINDSCHAEDLER, C., LEONG, K., MATHIOWITZ, E. and LANGER, R., 1988, Polyanhydride microsphere formulation by solvent extraction. Journal of Pharmaceutical Sciences, 77, 696–698.
  • CAM, D., HYON, S. H. and IKADA, Y., 1995, Degradation of high molecular weight poly(L-lactide) in alkaline medium. Biomaterials, 16, 833–843.
  • GOPFERIcH, A., 1999, Biodegradable polymers: polyanhydrides. In Encyclopedia of Controlled Drug Delivery, edited by E. Mathiowitz (New York: John Wiley & Sons, Inc.), 60–71.
  • HANES, J., CHIBA, M. and LANGER, R., 1997, Degradation of porous poly(anhydride-co-imide) microspheres and implications for controlled macromolecule delivery. Biomaterials, 19, 163–172.
  • HOOPER, K. A., MACON, N. D. and KOHN, J., 1998, Comparative histological evaluation of new tyrosine-derived polymers and poly (L-lactic acid) as a function of polymer degradation. Journal of Biomedical Materials Research, 41, 443–454.
  • JIANG, H. L. and ZHu, K. J., 2001, Synthesis, characterization and in vitro degradation of a new family of alternate poly(ester-anhydrides) based on aliphatic and aromatic diacids. Biomaterials, 22, 211–218.
  • KIDCHOB, T., KIMURA, S. and ImANIsm, Y., 1998, Degradation and release profile of microcapsules made of poly[L-lactic acid-co-L-lysine(Z)]. Journal of Controlled Release, 54, 283–292.
  • LANGER, R. and PEPPAS, N., 1983, Chemical and physical structure of polymers as carriers for controlled release of bioactive agents: a review. Journal of Macromolecular Science, Reviews in Macromolecular Chemical Physics, c23, 61–126.
  • LEACH, K. J. and MATHIOWITZ, E., 1998, Degradation of double-walled polymer microspheres of PLLA and P(CPP:SA)20:80. I. In vitro degradation. Biomaterials, 19, 1973–1980.
  • LEACH, K., NoH, K. and MATHIOWITZ, E., 1999, Effect of manufacturing conditions on the formation of double-walled polymer microspheres. Journal of Microencapsulation, 16, 153–167.
  • LEACH, K. J., TAKAHASHI, S. and MATHIOWITZ, E., 1998, Degradation of double-walled polymer microspheres of PLLA and P(CPP:SA)20:80. II. In vivo degradation. Biomaterials, 19, 1981–1988.
  • Li, S. and VERT, M., 1999, Biodegradable polymers: polyesters. In Encyclopedia of Controlled Drug Delivery, edited by E. Mathiowitz (New York: John Wiley & Sons, Inc.), 71–93.
  • MATHIOWITZ, E., RON, E., MATHIOWITZ, G., AMATO, C. and LANGER, R., 1990, Morphological characterization of bioerodible polymers. 1. Crystallinity of polyanhydride copolymers. Macromolecules, 23, 3212–3218.
  • MATHIOWITZ, E., SALTZMAN, W. M., DUMB, A., DOR, PH. and LANGER, R., 1988, Polyanhydride microspheres as drug carriers. II. Microencapsulation by solvent removal. Journal of Applied Polymer Science, 35, 755–774.
  • PEKAREK, K. J., DYRUD, M. J., FERRER, K., JUNG, Y. S. and MATHIOWITZ, E., 1996, In vitro and in vivo degradation of double-walled polymer microspheres. Journal of Controlled Release, 40, 169–178.
  • PEKAREK, K. J., JACOB, J. S. and MATHIOWITZ, E., 1994, Double-walled polymer microspheres for controlled drug release. Nature, 367, 258–260.
  • SANDERS, L. M., McRAE, G. I., VITALE, K. M. and KELL, B. A., 1985, Controlled delivery of an LHRH analogue from biodegradable injectable microspheres. Journal of Controlled Release, 2, 187–195.
  • SANDOR, M., BAILEY, N. A. and MATHIOWITZ, E., 2002a, Characterization of polyanhydride microsphere degradation by DSC. Polymer, 43, 279–288.
  • SANDOR, M., HARRIS, J. and MATHIOWITZ, E., 2002b, A novel polyethylene depot device for the study of PLGA and P(FASA) microspheres in vitro and in vivo. Biomaterials, 23, 4413–4423.
  • SANTOS, C. A., FREEDMAN, B. D., LEACH, K. J., PRESS, D. L., SCARPULLA, M. and MATHIOWITZ, E., 1999, Poly(fumaric-co-sebacic anhydride) a degradation study as evaluated by FTIR, DSC, GPC, and X-ray diffraction. Journal of Controlled Release, 60, 11–22.
  • SUURONEN, R., POHJONEN, T., HIETANEN, J. and LINDQVIST, C., 1998, A 5-year in vitro and in vivo study of the biodegradation of polylactide plates. Journal of Oral Maxillofacacial Surgery, 56, 604–614.
  • TABATA, Y. and LANGER, R., 1993, Controlled delivery systems for proteins using polyanhydride microspheres. Pharmaceutical Research, 10, 391–399.
  • VON RECUM, H. A., CLEEK, R. L., ESKIN, S. G. and Mixos, A. G., 1995, Degradation of polydispersed poly(L-lactic acid) to modulate lactic acid release. Biomaterials, 16, 441–447.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.