Sodium fusidate-poly(D,L-lactide-co-glycolide) microspheres: Preparation, characterisation and in vivo evaluation of their effectiveness in the treatment of chronic osteomyelitis

References

• Adams K, Couch L, Cierny G, Calhoun J, Mader JT. In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads. Clinical Orthopaedics and Related Research 1992; 278: 244–252
   PubMed Web of Science ®Google Scholar
• Ambrose CG, Clyburn TA, Louden K, Joseph J, Wright J, Gulati P, Gogola GR, Mikos AG. Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model. Clinical Orthopaedics and Related Research 2004; 421: 293–299
   Web of Science ®Google Scholar
• Atkins B, Gottlieb T. Fusidic acid in bone and joint infections. International Journal of Antimicrobial Agents 1999; 12: S79–S93
   PubMed Web of Science ®Google Scholar
• Barrow EL, Winchester GA, Staas JK, Quenelle DC, Barrow WW. Use of microsphere technology for targeted delivery of rifampicin to Mycobacterium tuberculosis-infected macrophages. Antimicrobial Agents and Chemotherapy 1998; 42: 2682–2689
   PubMed Web of Science ®Google Scholar
• Benita S, Benoit JP, Puisieux F, Thies C. Characterisation of drug loaded poly (D,L-lactide) microspheres. Journal of Pharmaceutical Sciences 1984; 73: 1721–1724
   PubMed Web of Science ®Google Scholar
• Billon A, Chabaud L, Gouyette A, Bouler J-M, Merle C. Vancomycin biodegradable poly(lactide-co-glycolide) microparticles for bone implantation. Influence of the formulation parameters on the size, morphology, drug loading and in vitro release. Journal of Microencapsulation 2005; 22: 841–852
   PubMed Web of Science ®Google Scholar
• Calhoun JH, Mader JT. Treatment of osteomyelitis with a biodegradable antibiotic implant. Clinical Orthopaedics and Related Research 1997; 341: 206–214
   Google Scholar
• Carek PJ, Dickerson LM, Sack JL. Diagnosis and management of osteomyelitis. American Family Physician 2001; 63: 2413–2420
   PubMed Web of Science ®Google Scholar
• Castro C, Evora C, Baro M, Soriano I, Sanchez E. Two-month ciprofloxacin implants for multibacterial bone infections. European Journal of Pharmaceutics and Biopharmaceutics 2005; 60: 401–406
   PubMed Web of Science ®Google Scholar
• Castro C, Sanchez E, Delgado A, Soriano I, Nunez P, Baro M, Perera A, Evora C. Ciprofloxacin implants for bone infection. In vitro–in vivo characterization. Journal of Controlled Release 2003; 93: 341–354
   PubMed Web of Science ®Google Scholar
• Cevher E, Orhan Z, Mülazımoğlu L, Şensoy D, Alper M, Yıldız Y, Özsoy Y. Characterization of biodegradable chitosan microspheres containing vancomycin and treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with prepared microspheres. International Journal of Pharmaceutics 2006; 317: 127–135
   PubMed Web of Science ®Google Scholar
• Changez M, Koul V, Dinda AK. Efficacy of antibiotics-loaded interpenetrating network (IPNs) hydrogel based on poly (acrylic acid) and gelatine for treatment of experimental osteomyelitis: In vivo study. Biomaterials 2005; 26: 2095–2104
   PubMed Web of Science ®Google Scholar
• Christiansen K. Fusidic acid adverse drug reactions. International Journal of Antimicrobial Agents 1999; 12: S3–S9
   PubMed Web of Science ®Google Scholar
• Council Directive 86/609/EEC. European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Official Journal of the Council of the European Commission Letters 1986; 358: 1–48
   Google Scholar
• Cui F, Cun D, Tao A, Yang M, Shi K, Zhao M, Guan Y. Preparation and characterization of melittin-loaded poly (DL-lactic acid) or poly (DL-lactic-co-glycolic acid) microspheres made by the double emulsion method. Journal of Controlled Release 2005; 107: 310–319
   PubMed Web of Science ®Google Scholar
• De S, Robinson DH. Particle size and temperature effect on the physical stability of PLGA nanospheres and microspheres containing bodipy. AAPS Pharmaceutical Science and Technology. 2004; 5, article 53
   Google Scholar
• Garvin KL, Miyano JA, Robinson D, Giger D, Novak J, Radio S. Polylactide/polyglycolide antibiotic implants in the treatment of osteomyelitis. A canine model. Journal of Bone and Joint Surgery [American] 1994; 76: 1500–1506
   Google Scholar
• Gitelis S, Brebach GT. The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant. Journal of Orthopaedic Surgery 2002; 10: 53–60
   Google Scholar
• Gursel I, Korkusuz F, Turesin F, Alaeddinoglu NG, Hasirci V. In vivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis. Biomaterials 2001; 22: 73–80
   PubMed Web of Science ®Google Scholar
• Henry SL, Galloway KP. Local antibacterial therapy for the management of orthopaedic infections. Pharmacokinetic considerations. Clinical Pharmacokinetics 1995; 29: 36–45
   PubMed Web of Science ®Google Scholar
• Huneault LM, Lussier B, Dubreuil P, Chouinard L, Desevaux C. Prevention and treatment of experimental osteomyelitis in dogs with ciprofloxacin-loaded crosslinked high amylose starch implants. Journal of Orthopaedic Research 2004; 22: 1351–1357
   PubMed Web of Science ®Google Scholar
• Kanellakopoulou K, Galanakis N, Giamarellos-Bourboulis EJ, Rifiotis C, Papakostas K, Andreopoulos A, Dounis E, Karagianakos P, Giamarellou H. Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a biodegradable system of lactic acid polymer releasing pefloxacin. Journal of Antimicrobial Chemotherapy 2000; 46: 311–314
   PubMed Web of Science ®Google Scholar
• Lazarettos J, Efstathopoulos N, Papagelopoulos PJ, Savvidou OD, Kanellakopoulou K, Giamarellou H, Giamarellos-Bourboulis EJ, Nikolaou V, Kapranou A, Papalois A, Papachristou G. A bioresorbable calcium phosphate delivery system with teicoplanin for treating MRSA osteomyelitis. Clinical Orthopaedics and Related Research 2004; 423: 253–258
   Google Scholar
• Le Ray AM, Chiffoleau S, Iooss P, Grimandi G, Gouyette A, Daculsi G, Merle C. Vancomycin encapsulation in biodegradable poly (ε-caprolacton) microparticles for bone implantation. Influence of the formulation process on size, drug loading, in vitro release and cytocompatibility. Biomaterials 2003; 24: 443–449
   PubMed Web of Science ®Google Scholar
• Mader JT, Landon GC, Calhoun J. Antimicrobial treatment of osteomyelitis. Clinical Orthopaedics and Related Research 1993; 295: 87–95
   Google Scholar
• Mendel V, Simanowski HJ, Scholz HC, Heymann H. Therapy with gentamicin-PMMA beads, gentamicin-collagen sponge, and cefazolin for experimental osteomyelitis due to staphylococcus aureus in rats. Archives of Orthopaedic and Trauma Surgery 2005; 125: 363–368
   PubMed Web of Science ®Google Scholar
• Mousset B, Benoit MA, Delloye C, Bouillet R, Gillard J. Biodegradable implants for potential use in bone infection. An in vitro study of antibiotic-loaded calcium sulphate. International Orthopaedics 1995; 19: 157–161
   PubMed Web of Science ®Google Scholar
• Nie L, Nicolau DP, Tessier PR, Kourea HP, Browner BD, Nightingale CH. Use of a bioabsorbable polymer for the delivery of ofloxacin during experimental osteomyelitis treatment. Journal of Orthopaedic Research 1998; 16: 76–79
   PubMedGoogle Scholar
• Norden CW. Experimental osteomyelitis. I. A description of the model. Journal of Infectious Diseases 1970; 122: 410–418
   PubMed Web of Science ®Google Scholar
• O'hara P, Hickey AJ. Respirable PLGA microspheres containing rifampicin for the treatment of tuberculosis: Manufacture and characterization. Pharmaceutical Research 2000; 17: 955–961
   PubMed Web of Science ®Google Scholar
• O'reilly T, Mader JT. Rat model of bacterial osteomyelitis of the tibia. Handbook of animal models of infection, experimental model in antimicrobial chemotherapy, O Zak, MA Sande. Academic Press, San Diego 1999; 560–575
   Google Scholar
• Orhan Z, Cevher E, Mülazimoglu L, Gürcan D, Alper M, Araman A, Özsoy Y. The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres. Their evaluation in an animal osteomyelitis model. Journal of Bone and Joint Surgery [British] 2006; 88-B: 270–275
   Google Scholar
• Prior S, Gamazo C, Irache JM, Merkle HP, Gander B. Gentamicin encapsulation in PLA/PLGA microspheres in view of treating Brucella infections. Journal of Controlled Release 2000; 30: 201–211
   Google Scholar
• Rahman A, Hoffman NE. High-performance liquid chromatographic determination of fusidic acid in plasma. Journal of Chromatography B 1988; 433: 159–166
   Web of Science ®Google Scholar
• Rutledge B, Huyette D, Day D, Anglen J. Treatment of osteomyelitis with local antibiotics delivered via bioabsorbable polymer. Clinical Orthopaedics and Related Research 2003; 411: 280–287
   Google Scholar
• Solberg BD, Gutow AP, Baumgaertner MR. Efficacy of gentamycin-impregnated resorbable hydroxyapatite cement in treating osteomyelitis in a rat model. Journal of Orthopaedic Trauma 1999; 13: 102–106
   PubMed Web of Science ®Google Scholar
• Tsourvakas S, Hatzigrigoris P, Tsibinos A, Kanellakopoulou K, Giamarellou H, Dounis E. Pharmacokinetic study of fibrin clot-ciprofloxacin complex: An in vitro and in vivo experimental investigation. Archives of Orthopaedic and Trauma Surgery 1995; 114: 295–297
   PubMedGoogle Scholar
• Turnidge J. Fusidic acid pharmacology, pharmacokinetics and pharmacodynamics. International Journal of Antimicrobial Agents 1999; 12: S23–S34
   PubMed Web of Science ®Google Scholar
• Waldvogel FA, Medoff G, Swartz MN. Osteomyelitis: A review of clinical features, therapeutic considerations and unusual aspects. New England Journal of Medicine 1970; 282: 198–206, 260–266, 316–322
   PubMed Web of Science ®Google Scholar
• Wang J, Calhoun JH, LeFrock J, Mader JT. The roles and effectiveness of adjunctive therapy in the management of musculoskeletal infections. Muskuloskeletal infections, JH Calhoun, JT Mader. Marcel Dekker, New York 2003; 555–585
   Google Scholar
• Yang YY, Wan JP, Chung TS, Pallathadka PK, Ng S, Heller J. POE-PEG-POE triblock copolymeric microspheres containing protein. I. Preparation and characterization. Journal of Controlled Release 2001; 75: 115–128
   PubMed Web of Science ®Google Scholar
• Zidan AS, Sammour OA, Hammad MA, Megrab NA, Hussain MD, Khan MA, Habib MJ. Formulation of anastrozole microparticles as biodegradable anticancer drug carriers. AAPS Pharmaceutical Science and Technology. 2006; 7, Article 61
   Google Scholar