117
Views
17
CrossRef citations to date
0
Altmetric
Original

Microspheres with pH modulated release: Design and characterization of formulation variables for colonic delivery

, &
Pages 420-431 | Received 07 Feb 2008, Accepted 21 Aug 2008, Published online: 17 Jul 2009

References

  • Akhgari A, Garekani HA, Sadeghi F, Azimaie M. Statistical optimization of indomethacin pellets coated with pH dependent methacrylic polymers for possible colonic drug delivery. Int J Pharm 2005; 305: 22–30
  • Akhgari A, Sadeghi F, Garekani HA. Combination of time-dependent and pH-dependent polymethacrylates as a single coating formulation for colonic delivery of indomethacin pellets. Int J Pharm 2006; 320: 137–142
  • Akiyama Y, Yoshioka M, Horibe H, Hirai S, Kitamori N, Toguchi H. pH-independent controlled-release microspheres using polyglycerol ester-fatty acids. J Pharm Sci 1994; 83: 1600–1607
  • Asghar LF, Chandran S. Multiparticulate formulation -approach to colon specific drug delivery: Current perspectives. J Pharm Pharm Sci 2006; 9: 327–338
  • Ashford M, Fell JT, Attwood D, Woodhead PJ. An in vitro investigation into the suitability of pH-dependent polymers for colonic targeting. Int J Pharm 1993; 91: 193–199
  • Basit AW. Advances in colonic drug delivery. Drugs 2005; 65: 1991–2007
  • Benita S, Donbrow M. Effect of polyisobutylene on ethylcellulose-walled microparticles: Wall structure and thickness of salicylamide and theophylline microparticles. J Pharm Sci 2006; 71: 205–210
  • Bodmeier R, McGinity JW. Polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by solvent evaporation technique, II: Some process parameters influencing the preparation and properties of microspheres. J Microencapsulation 1987; 4: 289–297
  • Bott C, Rudolph MW, Schneider AR, Schirrmacher S, Skalsky B, Petereit HU, et al. In vivo evaluation of a novel pH- and time-based multiunit colonic drug delivery system. Aliment Pharmacol Ther 2004; 20: 347–353
  • Chourasia MK, Jain SK. Design and development of multiparticulate system for targeted drug delivery to colon. Drug Deliv 2004; 11: 201–207
  • Davis SS, Hardy JG, Taylor MJ, Whalley DR, Wilson CG. Comparative study of gastrointestinal transit of a pellet and tablet formulation. Int J Pharm 1984; 21: 167–177
  • Fernández-Hervás MJ, Fell JT. Pectin/chitosan mixtures as coatings for colon-specific drug delivery: An in vitro evaluation. Int J Pharm 1998; 169: 115–119
  • Follonier N, Doelker E. Biopharmaceutical comparison of oral multiple-unit and single-unit sustained-release dosage forms. STP Pharm Sci 1992; 2: 141
  • Friend DR. Colon-specific drug delivery. Adv Drug Deliv Rev 1991; 7: 149–199
  • Hardy FH, Davis SS, Khosla R, Robertson CS. Gastrointestinal transit of small tablets in patients with ulcerative colitis. Int J Pharmacol 1988; 48: 79–82
  • Hinton JM, Lennard-Jonnes JE, Young AC. A new method for studying gut transit times using radioopaque markers. Gut 1969; 10: 842
  • Hull MA, Gardner SH, Hawcroft G. Activity of the non-steroidal anti-inflammatory drug indomethacin against colorectal cancer. Cancer Treatment Rev 2003; 29: 309–320
  • Ibekwe VC, Fadda HM, McConnell EL, Khela MK, Evans DF, Basit AW. Interplay between intestinal pH, transit time and feed status on the in vivo performance of pH responsive ileo-colonic release systems. Pharm Res [Epub ahead of print] 2008
  • Ibekwe VC, Fadda HM, Parsons GE, Basit AW. A comparative in vitro assessment of the drug release performance of pH-responsive polymers for ileo-colonic delivery. Int J Pharm 2006; 308: 52–60
  • Kapitanović S, Čačev T, Antica M, Kralj M, Cavrić G, Krešimir P, et al. Effect of indomethacin on E-cadherin and β-catenin expression in HT-29 colon cancer cells. Exp Mol Path 2006; 80: 91–96
  • Kinget R, Kalala W, Vervoort L, Mooter GU. Colonic drug targeting. J Drug Target 1998; 6: 129–149
  • Krishnaiah YSR, Satyanarayana S, Rama Prasad YV, Narasimha RS. Evaluation of guar gum as a compression coat for drug targeting to colon. Int J Pharm 1998; 171: 137–146
  • Krishnamachari Y, Madan P, Lin S. Development of pH- and time-dependent oral microparticles to optimize budesonide delivery to ileum and colon. Int J Pharm 2007; 338: 238–247
  • Lamprecht A, Yamamoto H, Takeuchi H, Kawashima Y. A pH sensitive microspheres for the colonic delivery of the immunosuppressive drug tacrolimus. Eur J Pharm Biopharm 2004; 58: 37–43
  • Lamprecht A, Yamamoto H, Takeuchi H, Kawashima Y. Microsphere design for the colonic delivery of 5-fluorouracil. J Contr Rel 2003; 90: 313–322
  • Mandayam S, Huang R, Tarnawski AS, Chiou SK. Roles of survivin isoforms in the chemopreventive actions of NSAIDS on colon cancer cells. Apoptosis 2007; 12: 1109–1116
  • Marsh CC, Sachuna AA, Sundstrom WR. A review of selected investigational non steroidal anti inflammatory drugs of the 1980's. Pharmacotherapy 1986; 6: 10–25
  • Mastiholimath VS, Dandagi PM, Jain SS, Gadad AP, Kulkarni AR. Time and pH dependent colon specific, pulsatile delivery of theophylline for nocturnal asthma. Int J Pharm 2007; 328: 49–56
  • Mehta KA, Kislalioglu MS, Phuapradit W, Mallick AW, Shah NH. Release performance of a poorly soluble drug from a novel, Eudragit-based multi-unit erosion matrix. Int J Pharm 2001; 213: 7–12
  • Meissner Y, Ubrich N, El Ghazouani F, Maincent P, Lamprecht A. Low molecular weight heparin loaded pH-sensitive microparticles. Int J Pharm 2007; 335: 147–153
  • Paharia A, Yadav AK, Rai G, Jain SK, Pancholi SS, Agrawal GP. Eudragit-coated pectin microparticles of 5-fluorouracil for colon targeting. AAPS Pharm Sci Tech 2007; 8: 12
  • Pharmacopeia of India. 1996
  • Price JM, Davis SS, Wilding IR. Characterization of colonic transit of nondisintegrating tablets in healthy subjects. Dig Dis Sci 1993; 38: 1015–1021
  • Ritger PL, Peppas NA. A simple equation for the description of solute release. I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J Contr Rel 1987; 5: 23–36
  • Rodriguez M, Vila-Jato JL, Torres D. Design of a new multi-particulate system for potential site-specific and controlled drug delivery to the colonic region. J Contr Rel 1998; 55: 67–77
  • Rubinstein A. Approaches and opportunities in colon-specific drug delivery. Crit Rev Ther Drug Carrier Syst 1995; 12: 101–149
  • Rubinstein A. Colonic drug delivery. Drug Discov Today Technol 2005; 2: 33–37
  • Sajeev C, Vinay G, Archna R, Saha RN. Oral controlled release formulation of diclofenac sodium by microencapsulation with ethyl cellulose. J Microencapsulation 2002; 19: 753–760
  • Sinha VR, Kumria R. Binders for colon specific drug delivery: An in vitro evaluation. Int J Pharm 2002; 249: 23–31
  • Watts PJ, Barrow L, Steed KP, Wilson CG, Spiller RC, Melia CD, et al. The transit rate of different-sized model dosage forms through the human colon and the effects of a lactulose-induced catharsis. Int J Pharmacol 1992; 87: 215–221
  • Wu B, Deng D, Lu Y, Wu W. Biphasic release of indomethacin from HPMC/pectin/calcium matrix tablet: II. Influencing variables, stability and pharmacokinetics in dogs. Eur J Pharm Biopharm 2007; 67: 707–714
  • Yuksel N, Turkoglu M, Baykara T. Modelling of the solvent evaporation method for the preparation of controlled release acrylic microspheres using neural networks. J Microencapsulation 2000; 17: 541–551

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.