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Research Article

Polysorbate-80-coated, polymeric curcumin nanoparticles for in vivo anti-depressant activity across BBB and envisaged biomolecular mechanism of action through a proposed pharmacophore model

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Pages 646-655 | Received 27 Apr 2016, Accepted 12 Sep 2016, Published online: 14 Oct 2016

References

  • Ahmed T, Enam SA, Gilani AH. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience, 2010;169:1296–306.
  • Ak T, Gülçin İ. Antioxidant and radical scavenging properties of curcumin. Chem–Biol Interact, 2008;174:27–37.
  • Al-Rubaei ZM, Mohammad TU, Ali LK. Effects of local curcumin on oxidative stress and total antioxidant capacity in vivo study. Pak J Biol Sci, 2014;17:1237–41.
  • Aluf Y, Vaya J, Khatib S, Loboda Y, Finberg JP. Selective inhibition of monoamine oxidase A or B reduces striatal oxidative stress in rats with partial depletion of the nigro-striatal dopaminergic pathway. Neuropharmacology, 2013;65:48–57.
  • Anand P, Kunnumakkara A, Newman R, Aggarwal B. Bioavailability of curcumin: Problems and promises. Mol Pharm, 2007;4:807–18.
  • Azadi A, Hamidi M, Khoshayand MR, Amini M, Rouini MR. Preparation and optimisation of surface-treated methotrexate-loaded nanogels intended for brain delivery. Carbohydrate Polymers, 2012;90:462–71.
  • Badavath VN, Baysal İ, Ucar G, Sinha BN, Jayaprakash V. Monoamine oxidase inhibitory activity of novel pyrazoline analogues: Curcumin based design and synthesis. ACS Med Chem Lett, 2016;7:56–61.
  • Barnham KJ, Masters CL, Bush AI. Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov, 2004;3:205–14.
  • Belviranli M, Okudan N, Atalik KE, Oz M. Curcumin improves spatial memory and decreases oxidative damage in aged female rats. Biogerontology, 2013;14:187–96.
  • Bhutani MK, Bishnoi M, Kulkarni S. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioural, biochemical and neurochemical changes. Pharmacol Biochem Behav, 2009;92:39–43.
  • Chavanpatil MD, Patil Y, Panyam J. Susceptibility of nanoparticle-encapsulated paclitaxel to P-glycoprotein-mediated drug efflux. Int J Pharm, 2006;320:150–6.
  • Choi SI, Kim TI, Kim KS, Kim BY, Ahn SY, Cho HJ, Lee HK, Cho HS, Kim EK. Decreased catalase expression and increased susceptibility to oxidative stress in primary cultured corneal fibroblasts from patients with granular corneal dystrophy type II. Am J Pathol, 2009;175:248–61.
  • Dar A, Khatoon S. Behavioural and biochemical studies of dichloromethane fraction from the areca catechu nut. Pharmacol Biochem Behav, 2000;65:1–6.
  • Das MK, Husain K, Pathak Y. Brain targeted delivery of curcumin using P80-PEG-coated poly (lactide-co-glycolide) nanoparticles. Asian J Chem, 2013;25:S297.
  • Desgouilles SP, Vauthier C, Bazile D, Vacus JL, Grossiord JL, Veillard M, Couvreur P. The Design of nanoparticles obtained by solvent evaporation: A comprehensive study. Langmuir, 2003;19:9504–10.
  • Faisant N, Siepmann J, Benoit JP. PLGA-based microparticles: Elucidation of mechanisms and a new, simple mathematical model quantifying drug release. Eur J Pharm Sci, 2002;15:355–66.
  • Federici E, Multari G, Gallo FR, Palazzino G. Herbal drugs: From traditional use to regulation. Ann Ist Super Sanita, 2005;41:49–54.
  • Feng SS, Huang G. Effects of emulsifiers on the controlled release of paclitaxel (Taxol®) from nanospheres of biodegradable polymers. J Control Release, 2001;71:53–69.
  • Firenzuoli F, Gori L. Herbal Medicine Today: Clinical and Research Issues. Evidence-based Complem Alternat Med, 2007;4:37–40.
  • Frey BCN, Andreazza AC, Kunz MC, Gomes FA, Quevedo JO, Salvador M, Gonã§Alves CA, Kapczinski FV. Increased oxidative stress and DNA damage in bipolar disorder: A twin-case report. Progr Neuro-Psychopharmacol Biol Psychiatry, 2007;31:283–5.
  • Gandhi S, Abramov A. Mechanism of oxidative stress in neurodegeneration. Oxidative Med Cell Longevity, 2012;2012:428010.
  • Girgin Sagin F, Sozmen EY, Ersoz B, Mentes G. Link between monoamine oxidase and nitric oxide. NeuroToxicol, 2004;25:91–9.
  • Grabovac V, Bernkop-Schnirch A. Development and in vitro evaluation of surface modified poly(lactide-co-glycolide) nanoparticles with chitosan-4-thiobutylamidine. Drug Dev Industrial Pharm, 2007;33:767–74.
  • Gulyaev AE, Gelperina SE, Skidan IN, Antropov AS, Kivman GY, Kreuter J. Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles. Pharm Res, 1999;16:1564–9.
  • Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J, 2013;15:195–218.
  • Halliwell B. 1998. Free radicals and oxidative damage in biology and medicine: An introduction. In Reznick AZ, Packer L, Sen CK, Holloszy JO, Jackson MJ, editors. Oxidative stress in skeletal muscle. Basel: Birkhäuser Basel, pp. 1–27.
  • Hassan W, Noreen H, Castro-Gomes V, Mohammadzai I, Da Rocha JB, Landeira-Fernandez J. Association of oxidative stress with psychiatric disorders. Curr Pharm Des, 2016;22:2960–74.
  • Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci, 1963;52:1145–9.
  • Imlay JA. The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium. Nat Rev Micro, 2013;11:443–54.
  • Karolewicz B, Paul IA. Group housing of mice increases immobility and antidepressant sensitivity in the forced swim and tail suspension tests. Eur J Pharmacol, 2001;415:197–201.
  • Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE, Wang PS. The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication (NCS-R). JAMA, 2003;289:3095–105.
  • Kirsch I. Antidepressants and the placebo effect. Zeitschr Psychol, 2014;222:128–34.
  • Kreuter J, Alyautdin RN, Kharkevich DA, Ivanov AA. Passage of peptides through the blood–brain barrier with colloidal polymer particles (nanoparticles). Brain Res, 1995;674:171–4.
  • Kreuter J, Ramge P, Petrov V, Hamm S, Gelperina SE, Engelhardt B, Alyautdin R, Von Briesen H, Begley DJ. Direct evidence that polysorbate-80-coated poly (butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharma Res, 2003;20:409–16.
  • Kreuter J, Shamenkov D, Petrov V, Ramge P, Cychutek K, Koch-Brandt C, Alyautdin R. Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood–brain barrier. J Drug Target, 2002;10:317–25.
  • Kulkarni S, Bhutani M, Bishnoi M. Antidepressant activity of curcumin: Involvement of serotonin and dopamine system. Psychopharmacology, 2008;201:435–42.
  • Lao LL, Venkatraman SS, Peppas NA. Modelling of drug release from biodegradable polymer blends. Eur J Pharm Biopharm, 2008;70:796–803.
  • Lü JM, Wang X, Marin-Muller C, Wang H, Lin PH, Yao Q, Chen C. Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev Mol Diagnostics, 2009;9:325–41.
  • Mahakunakorn P, Tohda M, Murakami Y, Matsumoto K, Watanabe H, Vajaragupta O. Cytoprotective and cytotoxic effects of curcumin: Dual action on H2O2-induced oxidative cell damage in NG108-15 cells. Biol Pharm Bull, 2003;26:725–8.
  • Makadia HK, Siegel SJ. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers (Basel), 2011;3:1377–97.
  • Manaenko A, Chen H, Kammer J, Zhang JH, Tang J. Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood–brain barrier in a mice haemorrhage model. J Neurosci Methods, 2011;195:206–10.
  • Mathew A, Fukuda T, Nagaoka Y, Hasumura T, Morimoto H, Yoshida Y, Maekawa T, Venugopal K, Kumar DS. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease. PLoS One, 2012;7:e32616.
  • Mehlum L, Ramberg M, Tørmoen AJ, Haga E, Diep LM, Stanley BH, Miller AL, Sund AM, Grøholt B. Dialectical behaviour therapy compared with enhanced usual care for adolescents with repeated suicidal and self-harming behaviour: Outcomes over a one-year follow-up. J Am Acad Child Adolesc Psychiatry, 2016;55:295–300.
  • Menniti-Ippolito F, Mazzanti G, Vitalone A, Firenzuoli F, Santuccio C. Surveillance of suspected adverse reactions to natural health products: the case of propolis. Drug Saf, 2008;31:419–23.
  • Mora-Huertas CE, Fessi H, Elaissari A. Polymer-based nanocapsules for drug delivery. Int J Pharm, 2010;385:113–42.
  • Moses M, Brem H, Langer R. 2003. Novel delivery systems in cancer chemotherapy. Narberth, PA: Science & Medicine, Inc.
  • Mukerjee A, Vishwanatha JK. Formulation, characterisation, and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res, 2009;29:3867–75.
  • Müller R. 1991. Colloidal carriers for controlled drug delivery and targeting: Modification, characterisation, and in vivo distribution. Boca Raton, FL: CRC Press.
  • Nagasaka H, Inoue I, Inui A, Komatsu H, Sogo T, Murayama K, Murakami T, Yorifuji T, Asayama K, Katayama S, et al. Relationship between oxidative stress and antioxidant systems in the liver of patients with Wilson disease: Hepatic manifestation in Wilson disease as a consequence of augmented oxidative stress. Pediatr Res, 2006;60:472–7.
  • Nimse SB, Pal D. Free radicals, natural antioxidants, and their reaction mechanisms. RSC Adv, 2015;5:27986–8006.
  • Porsolt R, Bertin A, M J. Behavioural despair in mice: A primary screening test for antidepressants. Arch Int Pharmacodyn Ther, 1977;229:327–36.
  • Qin XY, Cheng Y, Yu LC. Potential protection of curcumin against intracellular amyloid β-induced toxicity in cultured rat prefrontal cortical neurons. Neurosci Lett, 2010;480:21–4.
  • Rajakumar DV, Rao MN. Antioxidant properties of dehydrozingerone and curcumin in rat brain homogenates. Mol Cell Biochem, 1994;140:73–9.
  • Rajeswari A, Sabesan M. Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin, and its metabolite tetrahydrocurcumin, in a model of Parkinson’s disease induced by MPTP neurodegeneration in mice. Inflammopharmacology, 2008;16:96–9.
  • Reeta KH, Mehla J, Gupta YK. Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats. Eur J Pharmacol, 2010;644:106–12.
  • Ryter SW, Kim HP, Hoetzel A, Park JW, Nakahira K, Wang X, Choi AM. Mechanisms of cell death in oxidative stress. Antioxid Redox Signal, 2007;9:49–89.
  • Sahoo N, Manchikanti P, Dey SH. Herbal drug patenting in India: IP potential. J Ethnopharmacol, 2011;137:289–97.
  • Samojlik I, Mijatovic V, Gavaric N, Krstin S, Bozin B. Consumers' attitude towards the use and safety of herbal medicines and herbal dietary supplements in Serbia. Int J Clin Pharm, 2013;35:835–40.
  • Sarandol A, Sarandol E, Eker SS, Erdinc S, Vatansever E, Kirli S. Major depressive disorder is accompanied with oxidative stress: Short-term antidepressant treatment does not alter oxidative-antioxidative systems. Hum Psychopharmacol, 2007;22:67–73.
  • Sen T, Samanta SK. Medicinal plants, human health, and biodiversity: A broad review. Adv Biochem Eng Biotechnol, 2015;147:59–110.
  • Shaikh J, Ankola DD, Beniwal V, Singh D, Kumar MNVR. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci, 2009;37:223–30.
  • Shen L, Ji HF. Theoretical study on physicochemical properties of curcumin. Spectrochim Acta Part A, 2007;67:619–23.
  • Singh R, Navneet C, Singh V. In-silico study of herbal compounds (bacailin, curcumin, and dronabinol) as novel MAO inhibitors for Parkinson’s disease treatment. Int J Life Sci Pharma Res, 2012;2:L81–98.
  • Steel Z, Marnane C, Iranpour C, Chey T, Jackson JW, Patel V, Silove D. The global prevalence of common mental disorders: A systematic review and meta-analysis 1980–2013. Int J Epidemiol, 2014;43:476–93.
  • Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology (Berl), 1985;85:367–70.
  • Thankamma A, Radhika LG, Soudamini C. Detection and estimation of Curcumba longa in ayurvedic preparations. Anc Sci Life, 1995;15:43–52.
  • Vauthier C, Dubernet C, Chauvierre C, Brigger I, Couvreur P. Drug delivery to resistant tumours: the potential of poly (alkyl cyanoacrylate) nanoparticles. J Control Release, 2003;93:151–60.
  • Weinreb O, Amit T, Bar-Am O, Youdim MB. Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and beta-amyloid in aging and Alzheimer's disease. Br J Pharmacol, 2016;173:2080–94.
  • Wu HF, Chen K, Shih JC. Site-directed mutagenesis of monoamine oxidase A and B: Role of cysteines. Mol Pharmacol, 1993;43:888–93.
  • Yusuf M, Khan M, Al-Ghamdi SBA, Maghrabi IA. Modified methods of extraction of polyene antioxidants piperine, curcumin and β-carotene. Indian Res J Pharm Sci, 2016;8:471–85.
  • Yusuf M, Khan M, Khan R, Ahmed B. Preparation, characterisation, in vivo and biochemical evaluation of brain targeted piperine solid lipid nanoparticles in an experimentally induced Alzheimer disease model. J Drug Target, 2013;21:300–11.
  • Yusuf M, Khan RA, Ahmed B. Syntheses and anti-depressant activity of 5-amino-1,3,4-thiadiazole-2-thiol imines and thiobenzyl derivatives. Bioorg Med Chem, 2008;16:8029–34.
  • Yusuf M, Khan RA, Khan M, Ahmed B. Plausible antioxidant biomechanics and anticonvulsant pharmacological activity of brain-targeted β-carotene nanoparticles. Int J Nanomedicine, 2012;7:4311–22.
  • Zhang ZY, Jiang M, Fang J, Yang MF, Zhang S, Yin YX, Li DW, Mao LL, Fu XY, Hou YJ, et al. Enhanced therapeutic potential of nano-curcumin against subarachnoid haemorrhage-induced blood-brain barrier disruption through inhibition of inflammatory response and oxidative stress. Mol Neurobiol, 2015. [Epub ahead of print]. doi: 10.1007/s12035-015-9635-y.
  • Zolnik BS, Burgess DJ. Effect of acidic pH on PLGA microsphere degradation and release. J Control Release, 2007;122:338–44.
  • Zolnik BS, Leary PE, Burgess DJ. Elevated temperature accelerated release testing of PLGA microspheres. J Control Release, 2006;112:293–300.

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