Preparation of intravenous injection nanoformulation via co-assemble between cholesterylated gemcitabine and cholesterylated mPEG: enhanced cellular uptake and intracellular drug controlled release

References

• Andersson R, Aho U, Nilsson BI, Peters GJ, Pastor-Anglada M, Rasch W, Sandvold ML. Gemcitabine chemoresistance in pancreatic cancer: molecular mechanisms and potential solutions. Scand J Gastroenterol, 2009;44(7):782–6.
   PubMed Web of Science ®Google Scholar
• Bekkara-Aounallah F, Gref R, Othman M, Reddy LH, Pili B, Allain V, Bourgaux C, Hillaireau H, Lepêtre-Mouelhi S, Desmaële D, et al. Novel PEGylated nanoassemblies made of self-assembled squalenoyl nucleoside analogues. Adv Funct Mater, 2008;18:3715–25.
   Web of Science ®Google Scholar
• Bergman AM, Pinedo HM, Peters GJ. Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine). Drug Resist Update, 2002;5(1):19–33.
   PubMed Web of Science ®Google Scholar
• Bhattacharyya J, Chilkoti A. Genetically encoded chimeric polypeptide nanoparticles for gemcitabine delivery to solid tumors. Cancer Res, 2014;74(Suppl. 19):4481.
   Web of Science ®Google Scholar
• Colonna C, Conti B, Perugini P, Pavanetto F, Modena T, Dorati R, Iadarola P, Genta I. Site-directed PEGylation as successful approach to improve the enzyme replacement in the case of prolidase. Int J Pharm, 2008;358(1):230–7.
   PubMed Web of Science ®Google Scholar
• Couvreur P, Stella B, Reddy LH, Hillaireau H, Dubernet C, Desmaële D, Lepêtre-Mouelhi S, Rocco F, Dereuddre-Bosquet N, Clayette P, et al. Squalenoyl nanomedicines as potential therapeutics. Nano Lett, 2006;6(11):2544–8.
   PubMed Web of Science ®Google Scholar
• Djuric Z, Heilbrun LK, Lababidi S, Everett-Bauer CK, Fariss MW. Growth inhibition of MCF-7 and MCF-10A human breast cells by α-tocopheryl hemisuccinate, cholesteryl hemisuccinate and their ether analogs. Cancer Lett, 1997;111(1):133–9.
   PubMed Web of Science ®Google Scholar
• Duangjai A, Luo K, Zhou Y, Yanga JY, Kopečeka J. Combination cytotoxicity of backbone degradable HPMA copolymer gemcitabine and platinum conjugates toward human ovarian carcinoma cells. Eur J Pharm Biopharm, 2014;87(1):187–96.
   PubMed Web of Science ®Google Scholar
• Han X-P, Li Z-B, Sun J, Luo C, Li L, Liu Y-H, Du Y-Q, Qiu S-H, Ai X-Y, Wu CN, et al. Stealth CD44-targeted hyaluronic acid supramolecular nanoassemblies for doxorubicin delivery: probing the effect of uncovalent pegylation degree on cellular uptake and blood long circulation. J Control Release, 2015;197:29–40.
   PubMed Web of Science ®Google Scholar
• Harris JM, Zalipsky S. 1997. Introduction to chemistry and biological applications of poly (ethylene glycol). In: Zalipsky S, Harris JM, eds. Poly (ethylene glycol) chemistry: biotechnical and biomedical applications. Washington D.C., American Chemical Society, pp. 5–6.
   Google Scholar
• Hatakeyama H, Akita H, Harashima H. A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. Adv Drug Deliv Rev, 2011;63(3):152–60.
   PubMed Web of Science ®Google Scholar
• Kiyota T, Takahashi Y, Watcharanurak K, Nishikawa M, Ohara S, Ando M, Watanabe Y, Takakura Y. Enhancement of anticancer effect of interferon-γ gene transfer against interferon-γ-resistant tumor by depletion of tumor-associated macrophages. Mol Pharm, 2014;11(5):1542–9.
   PubMed Web of Science ®Google Scholar
• Kobayashi H, Brechbiel MW. Nano-sized MRI contrast agents with dendrimer cores. Adv Drug Deliv Rev, 2005;57(15):2271–86.
   PubMed Web of Science ®Google Scholar
• Law B, Tung CH. Proteolysis: a biological process adapted in drug delivery, therapy, and imaging. Bioconjugate Chem, 2009;20(9):1683–95.
   PubMed Web of Science ®Google Scholar
• Mackey JR, Mani RS, Selner M, Mowles D, Young JD, Belt JA, Crawford CR, Cass CE. Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. Cancer Res, 1998;58(19):4349–57.
   PubMed Web of Science ®Google Scholar
• Matsuda A, Sasaki T. Antitumor activity of sugar-modified cytosine nucleosides. Cancer Sci, 2004;95(2):105–11.
   PubMed Web of Science ®Google Scholar
• Mittal G, Sahana DK, Bhardwaj V, Kumar MNVR. Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. J Control Release, 2007;119(1):77–85.
   PubMed Web of Science ®Google Scholar
• Owens DE, Peppas NA. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm, 2006;307(1):93–102.
   PubMed Web of Science ®Google Scholar
• Sahana DK, Mittal G, Bhardwaj V, Kumar MNVR. PLGA nanoparticles for oral delivery of hydrophobic drugs: influence of organic solvent on nanoparticle formation and release behavior in vitro and in vivo using estradiol as a model drug. J Pharm Sci, 2008;97(4):1530–42.
   PubMed Web of Science ®Google Scholar
• Sato N, Kobayashi H, Hiraga A, Saga T, Togashi K, Konoshi J, Brechbiel MW. Pharmacokinetics and enhancement patterns of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores. Magn Reson Med, 2001;46(6):1169–73.
   PubMed Web of Science ®Google Scholar
• Venkat RD, Bhardwaj V. Can controversial nanotechnology promise drug delivery. Chem Rev, 2013;113(3):1686–735.
   PubMed Web of Science ®Google Scholar
• Xu Y-Y, Meng H-J, Du F, Lu W, Liu S-Y, Huang J, Yu J-H. Cathepsin B-sensitive cholesteryl hemisuccinate–gemcitabine prodrug nanoparticles: enhanced cellular uptake and intracellular drug controlled release. RSC Adv, 2015;5(9):6985–92.
   Web of Science ®Google Scholar
• Xu Y-Y, Geng J-Q, An P, Xu Y, Huang J, Lu W, Liu S-Y, Yu J-H. Preparation of intravenous injection nanoformulation of VESylated gemcitabine by co-assembly with TPGS and its anti-tumor activity in pancreatic tumor-bearing mice. Int J Pharm, 2015;495(2):792–7.
   PubMed Web of Science ®Google Scholar