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Original Articles

A mechanistic study of the effect of transferrin conjugation on cytotoxicity of targeted liposomes

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Pages 548-558 | Received 14 Jul 2018, Accepted 05 Nov 2018, Published online: 30 Nov 2018

References

  • Ali, I., 2011. Nano anti-cancer drugs: pros and cons and future perspectives. Current cancer drug targets, 11 (2), 131–134.
  • Ali, I., et al., 2013a. Curcumin-I Knoevenagel’s condensates and their Schiff’s bases as anticancer agents: synthesis, pharmacological and simulation studies. Bioorganic & medicinal chemistry, 21, 3808–3820.
  • Ali, I., et al., 2017. Insights into the pharmacology of new heterocycles embedded with oxopyrrolidine rings: DNA binding, molecular docking, and anticancer studies. Journal of molecular liquids, 234, 391–402.
  • Ali, I., et al., 2015. Heterocyclic scaffolds: centrality in anticancer drug development. Current drug targets, 16 (7), 711–734.
  • Ali, I., et al., 2016. Advances in nanocarriers for anticancer drugs delivery. Current medicinal chemistry, 23 (20), 2159–2187.
  • Ali, I., et al., 2013b. Synthesis, DNA binding, hemolytic, and anti-cancer assays of curcumin I-based ligands and their ruthenium (III) complexes. Medicinal chemistry research, 22 (3), 1386–1398.
  • Ali, I., et al., 2013c. Glutamic acid and its derivatives: candidates for rational design of anticancer drugs. Future medicinal chemistry, 5 (8), 961–978.
  • Ali, I., et al., 2013d. Platinum compounds: a hope for future cancer chemotherapy. Anti-cancer agents in medicinal chemistry, 13 (2), 296–306.
  • Ali, I., et al., 2013. Design and synthesis of thalidomide based dithiocarbamate Cu(II), Ni(II) and Ru(III) complexes as anticancer agents. Polyhedron, 56, 134–143.
  • Ali, I., et al., 2014. Anticancer metallodrugs of glutamic acid sulphonamides: in silico, DNA binding, hemolysis and anticancer studies. RSC advances, 4 (56), 29629–29641.
  • Banerjee, A., et al., 2017a. Strategies for targeted drug delivery in treatment of colon cancer: current trends and future perspectives. Drug discovery today, 22 (8), 1224–1232.
  • Banerjee, K., Banerjee, S., and Mandal, M., 2017. Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions. Journal of colloid and interface science, 491, 98–110.
  • Banu, H., et al., 2015. Doxorubicin loaded polymeric gold nanoparticles targeted to human folate receptor upon laser photothermal therapy potentiates chemotherapy in breast cancer cell lines. Journal of photochemistry and photobiology. B, biology, 149, 116–128.
  • Bao, W., et al., 2015. PLGA-PLL-PEG-Tf-based targeted nanoparticles drug delivery system enhance antitumor efficacy via intrinsic apoptosis pathway. International journal of nanomedicine, 10, 557–566.
  • Chiu, R.Y., et al., 2014. Improving the systemic drug delivery efficacy of nanoparticles using a transferrin variant for targeting. Journal of controlled release: official journal of the controlled release society, 180, 33–41.
  • Di Martino, A., et al., 2016. Polysaccharide-based nanocomplexes for co-encapsulation and controlled release of 5-fluorouracil and temozolomide. European journal of pharmaceutical sciences: official journal of the European federation for pharmaceutical sciences, 92, 276–286.
  • Dilnawaz, F., Singh, A., and Sahoo, S.K., 2012. Transferrin-conjugated curcumin-loaded superparamagnetic iron oxide nanoparticles induce augmented cellular uptake and apoptosis in K562 cells. Acta biomater, 8 (2), 704–719.
  • Eloy, J.O., et al., 2014. Liposomes as carriers of hydrophilic small molecule drugs: strategies to enhance encapsulation and delivery. Colloids and surfaces. B, biointerfaces, 123, 345–363.
  • Eltayeb, S.E., et al., 2016. Antitumor activity of transferrin-modified- artemether lipid nanospheres in cancer cell lines. Journal of drug delivery science and technology, 31, 118–129.
  • Giulio, A.D., et al., 1991. Encapsulation of ampicillin in reverse-phase evaporation liposomes: a direct evaluation by derivative spectrophotometry. International journal of pharmaceutics, 74 (2–3), 183–188.
  • Glavas-Dodov, M., et al., 2005. The effects of lyophilization on the stability of liposomes containing 5-FU. International journal of pharmaceutics, 291 (1–2), 79–86.
  • Guo, Y., et al., 2015. Transferrin-conjugated doxorubicin-loaded lipid-coated nanoparticles for the targeting and therapy of lung cancer. Oncology letters, 9 (3), 1065–1072.
  • Higuchi, M., et al., 1998. Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases. Oncogene, 17 (21), 2753–2760.
  • Huang, Y., et al., 2013. Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles. Biomaterials, 34 (29), 7106–7116.
  • Iba, T., et al., 2013. Neutrophil cell death in response to infection and its relation to coagulation. Journal of intensive care, 1 (1), 13.
  • Imran, A., et al., 2012. Thalidomide: a banned drug resurged into future anticancer drug. Current drug therapy, 7, 13–23.
  • Jayaprakasha, G.K., Chidambara Murthy, K.N., and Patil, B.S., 2016. Enhanced colon cancer chemoprevention of curcumin by nanoencapsulation with whey protein. European journal of pharmacology, 789, 291–300.
  • Jin, H., et al., 2016. Folate-chitosan nanoparticles loaded with ursolic acid confer anti-breast cancer activities in vitro and in vivo. Scientific reports, 6, 30782.
  • Jin, Y., et al., 2011. A 5-fluorouracil-loaded pH-responsive dendrimer nanocarrier for tumor targeting. International journal of pharmaceutics, 420 (2), 378–384.
  • Kawamoto, M., et al., 2011. A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells. BMC cancer, 11, 359–359.
  • Kim, T.-H., Jeong, G.-W., and Nah, J.-W., 2017. Preparation and anticancer effect of transferrin-modified pH-sensitive polymeric drug nanoparticle for targeted cancer therapy. Journal of industrial and engineering chemistry. 54, 298–303.
  • Krishnaiah, Y.S., et al., 2003. In vivo pharmacokinetics in human volunteers: oral administered guar gum-based colon-targeted 5-fluorouracil tablets. European journal of pharmaceutical sciences: official journal of the European federation for pharmaceutical sciences, 19 (5), 355–362.
  • Kuznetsova, N.R., et al., 2012. Hemocompatibility of liposomes loaded with lipophilic prodrugs of methotrexate and melphalan in the lipid bilayer. Journal of controlled release: official journal of the controlled release society, 160 (2), 394–400.
  • Lee, R.J., and Low, P.S., 1995. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro. Biochimica et biophysica acta, 1233 (2), 134–144.
  • Li, X., et al., 2009. Targeted delivery of doxorubicin using stealth liposomes modified with transferrin. International journal of pharmaceutics, 373 (1–2), 116–123.,
  • Liu, H., et al., 2015. Characterization and cytotoxicity studies of DPPC:M2+ novel delivery system for cisplatin thermosensitivity liposome with improving loading efficiency. Colloids and surfaces B: Biointerfaces, 131, 12–20.
  • Liu, M.P., et al., 2016. Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria-caspase-dependent apoptotic pathway. Scientific reports, 6, 34245.
  • Mulik, R.S., et al., 2010. Transferrin mediated solid lipid nanoparticles containing curcumin: enhanced in vitro anticancer activity by induction of apoptosis. International journal of pharmaceutics, 398 (1–2), 190–203.
  • Nag, M., et al., 2016. Transferrin functionalized chitosan-PEG nanoparticles for targeted delivery of paclitaxel to cancer cells. Colloids and surfaces. B, biointerfaces, 148, 363–370.
  • Negi, L.M., et al., 2015. Hyaluronan coated liposomes as the intravenous platform for delivery of imatinib mesylate in MDR colon cancer. International journal of biological macromolecules, 73, 222–235.
  • Pereira, S., et al., 2016. Docetaxel-loaded liposomes: the effect of lipid composition and purification on drug encapsulation and in vitro toxicity. International journal of pharmaceutics, 514 (1), 150–159.
  • Sadhukha, T., and Prabha, S., 2014. Encapsulation in nanoparticles improves anti-cancer efficacy of carboplatin. AAPS PharmSciTech, 15 (4), 1029–1038.
  • Saleem, K., et al., 2013. Nanodrugs: magic bullets in cancer chemotherapy. Topics anti cancer research, 58, 437–494.
  • Shen, B., He, P.-J., and Shao, C.-L., 2013. Norcantharidin induced DU145 cell apoptosis through ROS-mediated mitochondrial dysfunction and energy depletion. PloS one, 8 (12), e84610.
  • Shigehiro, T., et al., 2014. Efficient drug delivery of Paclitaxel glycoside: a novel solubility gradient encapsulation into liposomes coupled with immunoliposomes preparation. PloS one, 9 (9), e107976.
  • Siddik, Z.H., 2003. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene, 22 (47), 7265–7279.
  • Singh, R.P., et al., 2016. Transferrin receptor targeted PLA-TPGS micelles improved efficacy and safety in docetaxel delivery. International journal of biological macromolecules, 83, 335–344.
  • Śliwka, L., et al., 2016. The comparison of MTT and CVS assays for the assessment of anticancer agent interactions. PloS one, 11 (5), e0155772
  • Soni, V., Kohli, D.V., and Jain, S.K., 2008. Transferrin-conjugated liposomal system for improved delivery of 5-fluorouracil to brain. Journal of drug targeting, 16 (1), 73–78.
  • Stowe, D.F., and Camara, A.K., 2009. Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function. Antioxidants & redox signaling, 11, 1373–1414.
  • Sun, W., et al., 2008. Preparation and evaluation of N(3)-O-toluyl-fluorouracil-loaded liposomes. International journal of pharmaceutics, 353 (1–2), 243–250.
  • Sun, Y., and Sun, Z.L., 2016. Transferrin-conjugated polymeric nanomedicine to enhance the anticancer efficacy of edelfosine in acute myeloid leukemia. Biomedicine & pharmacotherapy = biomedecine & pharmacotherapie, 83, 51–57.
  • Szwed, M., et al., 2014. Induction of apoptosis by doxorubicin-transferrin conjugate compared to free doxorubicin in the human leukemia cell lines. Chemico-biological interactions, 220, 140–148.
  • Thakur, R., Das, A., and Chakraborty, A., 2014. The fate of anticancer drug, ellipticine in DPPC and DMPC liposomes upon interaction with HSA: A photophysical approach. Journal of photochemistry and photobiology B, biology, 130, 122–131.
  • Waheed, A., et al., 2013. Inhibition of human breast and colorectal cancer cells by Viburnum foetens L. extracts in vitro. Asian pacific journal of tropical disease, 3 (1), 32–36,
  • Wang, H., and Joseph, J.A., 1999. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free radical biology & medicine, 27, 612–616.
  • Wang, R., et al., 2016. Enhancing the antitumor effect of methotrexate in intro and in vivo by a novel targeted single-walled carbon nanohorn-based drug delivery system. RSC advances, 6 (53), 47272–47280.
  • Wang, X., et al., 2017. Targeting of growth factors in the treatment of hepatocellular carcinoma: the potentials of polysaccharides. Oncology letters, 13 (3), 1509–1517.
  • Wang, Y., et al., 2015. Targeted delivery of 5-fluorouracil to HT-29 cells using high efficient folic acid-conjugated nanoparticles. Drug delivery, 22 (2), 191–198.
  • Zeng, X., Morgenstern, R., and Nyström, A.M., 2014. Nanoparticle-directed sub-cellular localization of doxorubicin and the sensitization breast cancer cells by circumventing GST-mediated drug resistance. Biomaterials, 35 (4), 1227–1239.
  • Zhang, H., et al., 2015. Transferrin-mediated fullerenes nanoparticles as Fe(2+)-dependent drug vehicles for synergistic anti-tumor efficacy. Biomaterials, 37, 353–366.
  • Zhang, M., et al., 2016. Edible ginger-derived nano-lipids loaded with doxorubicin as a novel drug-delivery approach for colon cancer therapy. Molecular therapy: the journal of the American society of gene therapy, 24 (10), 1783–1796.
  • Zhang, N., et al., 2008. 5-Fluorouracil: mechanisms of resistance and reversal strategies. Molecules (basel, Switzerland), 13 (8), 1551–1569.
  • Zununi Vahed, S., et al., 2017. Liposome-based drug co-delivery systems in cancer cells. Materials science & engineering. C, materials for biological applications, 71, 1327–1341.

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