References
- Abdel-Moneim, A., et al., 2013. Beneficial therapeutic effects of Nigella sativa and/or Zingiber officinale in HCV patients in Egypt. EXCLI journal, 12, 943.
- Abdelwahab, S.I., et al., 2013. Thymoquinone-loaded nanostructured lipid carriers: preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular administration. International journal of nanomedicine, 8, 2163.
- Ait Mbarek, L., et al., 2007. Anti-tumor properties of blackseed (Nigella sativa L.) extracts. Brazilian journal of medical and biological research, 40 (6), 839–847.
- Akhtar, J., et al., 2014. Nanomulsion as a carrier for efficient delivery of metformin. Current drug delivery, 11 (2), 243–252.
- Akhtar, J., et al., 2016. Nanoemulsion: for improved oral delivery of repaglinide. Drug delivery, 23 (6), 2026–2034.
- Akhtar, J., 2015. Novel oral nanoemulsion based drug delivery system of antidiabetic drugs. (dissertation). Lucknow, India: Integral University India.
- Al-Ghamdi, M.S., 2001. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. Journal of ethnopharmacology, 76 (1), 45–48.
- Ali, B.H., and Blunden, G., 2003. Pharmacological and toxicological properties of Nigella sativa. Phytotherapy research, 17 (4), 299–305.
- Al-Oqail, M.M., et al., 2017. Nigella sativa seed oil suppresses cell proliferation and induces ROS dependent mitochondrial apoptosis through p53 pathway in hepatocellular carcinoma cells. South African journal of botany, 112, 70–78.
- Alotaibi, F.O., Gulam, M., and Alka, A., 2018. Study of enhanced anti-inflammatory potential of nigella sativa in topical nanoformulation. International journal of pharmacy and pharmaceutical sciences, 10 (7), 1–7.
- Arias, J., et al., 2011. Lipid-based drug delivery systems for cancer treatment. Current drug targets, 12 (8), 1151–1165.
- Aungst, B.J., 1993. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. Journal of pharmaceutical sciences, 82 (10), 979–987.
- Awad, A., Kamel, R., and Elsayed Sherief, M.A., 2011. Effect of thymoquinone on hepatorenal dysfunction and alteration of CYP3A1 and spermidine/spermine N-1-acetyl-transferase gene expression induced by renal ischaemia–reperfusion in rats. Journal of pharmacy and pharmacology, 63 (8), 1037–1042.
- Baharetha, H.M., et al., 2013. Proapoptotic and antimetastatic properties of supercritical CO2 extract of Nigella sativa Linn. against breast cancer cells. Journal of medicinal food, 16 (12), 1121–1130.
- Bali, V., Ali, M., and Ali, J., 2010. Study of surfactant combinations and development of a novel nanoemulsion for minimizing variations in bioavailability of ezetimibe. Colloids and surfaces B, 76 (2), 410–420.
- Bewley, J. D. and Black M., 1994. Seeds: physiology of development and germination. New York, US: Plenum.
- Bhardwaj, A., and Hartland, S., 1994. Dynamics of emulsification and demulsification of water in crude oil emulsions. Industrial & engineering chemistry research, 33, 1271–1279.
- Boskabady, M.H., Mohsenpoor, N., and Takaloo, L., 2010. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine, 17 (10), 707–713.
- Burcham, D.L., et al., 1997. Improved oral bioavailability of the hypocholesterolemic DMP 565 in dogs following oral dosing in oil and glycol solutions. Biopharmaceutics & drug disposition, 18 (8), 737–742.
- Burits, M. and Bucar, F., 2000. Antioxidant activity of Nigella sativa essential oil. Phytotherapy research, 14 (5), 323–328.
- Calligaris, S., et al., 2015. Nanoemulsions as delivery systems of hydrophobic silybin from silymarin extract: effect of oil type on silybin solubility, in vitro bioaccessibility and stability. LWT-Food science and technology, 63 (1), 77–84.
- Coban, S., et al., 2010. The effects of Nigella sativa on bile duct ligation induced-liver injury in rats . Cell biochemistry and function, 28 (1), 83–88.
- Collnot, E.M., Ali, H., and Lehr, C.M., 2012. Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa. Journal of controlled release: official journal of the controlled release society, 161 (2), 235–246.
- Elkady, A.I., 2012. Crude extract of Nigella sativa inhibits proliferation and induces apoptosis in human cervical carcinoma HeLa cells. African journal of biotechnology, 11 (64), 12710–12720.
- El–Serag, H.B. and Rudolph, K.L., 2007. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132, 2557–2576.
- Faiyazuddin, M., et al., 2010. Production, characterization, in vitro and ex vivo studies of babchi oil-encapsulated nanostructured solid lipid carriers produced by a hot aqueous titration method. Die Pharmazie-An international journal of pharmaceutical sciences, 65 (5), 348–355.
- Fraga, M., et al., 2008. Evaluation of the toxicity of oligonucleotide/cationic nanoemulsion complexes on Hep G2 cells through MTT assay. Die Pharmazie-An international journal of pharmaceutical sciences, 63 (9), 667–670.
- Franken, N.A., et al., 2006. Clonogenic assay of cells in vitro. Nature protocols, 1 (5), 2315.
- Ghali, W., et al., 2014. Extracts from medicinal plants inhibit cancer cell proliferation, induce apoptosis in ovary, lung and neuronal cancer cell lines. Cancer & metabolism, 2 (1), P21.
- Hauss, D.J., 2007. Oral lipid-based formulations. Advanced drug delivery reviews, 59 (7), 667–676.
- Hua, L., et al., 2004. Preparation, evaluation, and NMR characterization of vinpocetine microemulsion for transdermal delivery. Drug development and industrial pharmacy, 30 (6), 657–666.
- Islam, M.H., Ahmad, I.Z., and Salman, M.T., 2013. In vivo evaluation of anti-inflammatory and analgesic activities of Nigella sativa seed during germination. International journal of pharmacy and pharmaceutical sciences, 5 (4), 451–454.
- Jaafari, A., et al., 2007. Chemical composition and antitumor activity of different wild varieties of Moroccan thyme. Brazilian journal of pharmacognosy, 17 (4), 477–491.
- Jadhav, K.R., et al., 2006. Applications of microemulsion based drug delivery system. Current drug delivery, 3 (3), 267–273.
- Jafari, S.M., et al., 2008. Re-coalescence of emulsion droplets during high-energy emulsification. Food hydrocolloids, 22 (7), 1191–1202.
- Kaleem, S., et al., 2016. Eupalitin induces apoptosis in prostate carcinoma cells through ROS generation and increase of caspase‐3 activity. Cell biology international, 40 (2), 196–203.
- Kamal, A. and Ahmad, I.Z., 2014. Phytochemical studies of different phases of germination of Nigella sativa Linn-a medicinally important plant. Methods, 9 (10), 11–12.
- Kanter, M., Coskun, O., and Budancamanak, M., 2005. Hepatoprotective effects of Nigella sativa L and Urticadioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World journal of gastroenterology, 11 (42), 6684.
- Kararli, T.T., et al., 1992. Oral delivery of a renin inhibitor compound using emulsion formulations. Pharmaceutical research, 09 (7), 888–893.
- Karimi, M., et al., 2010. Extract from Asteraceae Brachylaena ramiflora induces apoptosis preferentially in mutant p53-expressing human tumor cells. Carcinogenesis, 31 (6), 1045–1053.
- Khazaei, S., et al., 2017. Promotion of HepG2 cell apoptosis by flower of Allium atroviolaceum and the mechanism of action. BMC complementary and alternative medicine, 17 (1), 104.
- Kommuru, T.R., et al., 2001. Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. International journal of pharmaceutics, 212 (2), 233–246.
- Kreilgaard, M., Pedersen, E.J., and Jaroszewski, J.W., 2000. NMR characterization and transdermal drug delivery potential of microemulsion systems. Journal of controlled release, 69 (3), 421–433.
- Kumar, H., Dharamveer, K. M. K., and Saraf, A. S., 2009. Preparation, characterization and in vivo anti-ulcer evaluation of ranitidine-loaded floating microparticles. Proceedings of the National Conference on Innovations in Drug Delivery and Research. Patiala, India.
- Lawrence, M.J. and Rees, G.D., 2000. Microemulsion-based media as novel drug delivery systems. Advanced drug delivery reviews, 45 (1), 89–121.
- Liu, Y., Miyoshi, H., and Nakamura, M., 2007. Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles. International journal of cancer, 120 (12), 2527–2537.
- Lovelyn, C. and Attama, A.A., 2011. Current state of nanoemulsions in drug delivery. Journal of biomaterials and nanobiotechnology, 02 (05), 626.
- Malcolmson, C., et al., 1998. Effect of oil on the level of solubilization of testosterone propionate into nonionic oil‐in‐water microemulsions. Journal of pharmaceutical sciences, 87 (1), 109–116.
- McClements, D.J. and Li, Y., 2010. Structured emulsion-based delivery systems: controlling the digestion and release of lipophilic food components. Advances in colloid and interface science, 159 (2), 213–228.
- Mehnert, W. and Mader, K., 2001. Solid lipid nanoparticles: production, characterization and applications. Advanced drug delivery reviews, 47 (2–3), 165–196.
- Müller, R.H., Mäder, K., and Gohla, S., 2000. Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. European journal of pharmaceutics and biopharmaceutics: official journal of arbeitsgemeinschaft fur pharmazeutische verfahrenstechnik e.v, 50 (1), 161–177.
- Mustafa, G., et al., 2009. Preparation and characterization of oil in water nano-reservoir systems for improved oral delivery of atorvastatin. Current nanoscience, 5 (4), 428–440.
- Omar, A., et al., 2017. Cytotoxicity assay for herbal melanin derived from Nigella sativa seeds using in vitro cell lines. IOSR-Journal of humanity and social science, 22 (10), 43–51.
- Parveen, R., et al., 2010. Stability‐indicating HPTLC method for quantitative estimation of silybin in bulk drug and pharmaceutical dosage form. Biomedical chromatography, 24 (6), 639–647.
- Pathan, S.A., et al., 2011. Stability‐indicating ultra‐performance liquid chromatography method for the estimation of thymoquinone and its application in biopharmaceutical studies. Biomedical chromatography, 25 (5), 613–620.
- Piemi, M.P., et al., 1999. Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs. Journal of controlled release, 58 (2), 177–187.
- Puri, V., 2017. A Study on Nano Emulsion (Emulgel). International journal of advances in pharmaceutics, 1 (3), 27–55.
- Randhawa, M.A. and Alghamdi, M.S., 2011. Anticancer activity of Nigella sativa (black seed) - a review. The American journal of Chinese medicine, 39 (6), 1075–1091.
- Rooney, S. and Ryan, M.F., 2005. Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticancer research, 25 (3B), 2199–2204.
- Darvesh, A., Aggarwal, B., and Bishayee, A., 2012. Curcumin and liver cancer: a review. Current pharmaceutical biotechnology, 13 (1), 218–228.
- Samargh, S., Afshari, J.T., and Davoodi, S., 2010. Modulation of programmed cell death by honey bee in human prostate adenocarcinoma. Journal of medicinal plants research, 4 (23), 2551–2556.
- Samarghandian, S., Azimi‐Nezhad, M., and Farkhondeh, T., 2018. Thymoquinone‐induced antitumor and apoptosis in human lung adenocarcinoma cells. Journal of cellular physiology, 2018. doi: 10.1002/jcp.27710 [Epub ahead of print].
- Schwendener, R.A. and Schott, H., 1996. Lipophilic 1-b-D-arabinofuranosyl cytosine derivatives in liposomal formulations for oral and parenteral antileukemic therapy in the murine L1210 leukemia model. Journal of cancer research and clinical oncology, 122 (12), 723–726.
- Serajuddin, A., 1999. Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. Journal of pharmaceutical sciences, 88 (10), 1058–1066.
- Shafiq, H., et al., 2014. Cardio-protective and anti-cancer therapeutic potential of Nigella sativa. Iranian journal of basic medical sciences, 17 (12), 967.
- Shafiq, S., et al., 2007. Development and bioavailability assessment of ramipril nanoemulsion formulation. European journal of pharmaceutics and biopharmaceutics, 66 (2), 227–243.
- Shafiq-Un-Nabi, S., et al., 2007. Formulation development and optimization using nanoemulsion technique: a technical note. AAPS pharmscitech, 8 (2), E12–E17.
- Siddiqui, S., et al., 2015. Cissus quadrangularis Linn exerts dose‐dependent biphasic effects: osteogenic and anti‐proliferative, through modulating ROS, cell cycle and Runx2 gene expression in primary rat osteoblasts. Cell proliferation, 48 (4), 443–454.
- Singh, A., et al., 2013. Nanocarrier based formulation of Thymoquinone improves oral delivery: stability assessment, in vitro and in vivo studies. Colloids surface B, 102, 822–832.
- Stella, V., et al., 1978. Enhancement of bioavailability of a hydrophobic amine antimalarial by formulation with oleic acid in a soft gelatin capsule. Journal of pharmaceutical sciences, 67 (10), 1375–1377.
- Tabassum, H., Ahmad, A., and Ahmad, I.Z., 2018. Nigella sativa L. and its bioactive constituents as hepatoprotectant: a review. Current pharmaceutical biotechnology, 19 (1), 43–67.
- Talegaonkar, S., et al., 2009. Design and development of oral oil-in-water nanoemulsion formulation bearing atorvastatin. In vitro assessment. Journal of dispersion science technology, 30, 1–12.
- Thiagarajan, P., 2011. Nanoemulsions for drug delivery through different routes. Research in biotechnology, 17 (3), 2.
- Thiruganesh, R., Uma Devi, S.K., 2010. Solid lipid nanoparticle and nanoparticle lipid carrier for controlled drug delivery – a review of state of art and recent advances. International journal of nanoparticles, 3 (1), 32–52.
- Tuorkey, M.J., 2017. Therapeutic potential of Nigella sativa oil against cyclophosphamide-induced DNA damage and hepatotoxicity. Nutrition and cancer, 69 (3), 498–504.
- Valster, A., et al., 2005. Cell migration and invasion assays. Methods, 37 (2), 208–215.
- Van der Laan, J. W., and De George, J. J., 2010. Global Approach in Safety Testing: ICH Guidelines Explained. Vol. 5. New York: Springer Science & Business Media.
- Wu, W., Wang, Y., and Que, L., 2006. Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system. European journal of pharmaceutics and biopharmaceutics: official journal of arbeitsgemeinschaft fur pharmazeutische verfahrenstechnik e.v, 63 (3), 288–294.
- Yildiz, F., et al., 2008. Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver. World journal of gastroenterology, 14 (33), 5204.
- Yuan, Y., et al., 2006. Investigation of microemulsion system for transdermal delivery of meloxicam. International journal of pharmaceutics, 321 (1-2), 117–123.,
- Zhao, Y., et al., 2010. Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: formulation and bioavailability studies. International journal of pharmaceutics, 383 (1-2), 170–177.