β-carotene and α-tocopherol coencapsulated in nanostructured lipid carriers of murumuru (Astrocaryum murumuru) butter produced by phase inversion temperature method: characterisation, dynamic in vitro digestion and cell viability study

References

• Aillon, K.L., et al., 2009. Effects of nanomaterial physicochemical properties on in vivo toxicity. Advanced drug delivery reviews, 61 (6), 457–466.
   PubMed Web of Science ®Google Scholar
• Anton, N., and Benoit, J.P., Saulnier P., 2008. Design and production of nanoparticles formulated from nano-emulsion templates—a review. Journal of controlled release, 128, 85–199.
   Web of Science ®Google Scholar
• Anton, N. and Vandamme, T.F., 2009. The universality of low-energy nano-emulsification. International journal of pharmaceutics, 377 (1–2), 142–147.
   PubMed Web of Science ®Google Scholar
• Bertram, J.S. and Vine, A.L., 2005. Cancer prevention by retinoids and carotenoids: independent action on a common target. Biochimica et biophysica acta, 1740, 170–178.
   PubMed Web of Science ®Google Scholar
• Bonnaire, L.S., et al., 2008. Influence of lipid physical state on the in vitro digestibility of emulsified lipids. Journal of agricultural and food chemistry, 56 (10), 3791–3797.
   PubMed Web of Science ®Google Scholar
• Borrin, T.R., et al., 2018. Technological and sensory evaluation of pineapple ice creams incorporated with curcumin-loaded nanoemulsions obtained by the emulsion inversion point method. International journal of dairy technology, 71 (2), 491–500.
   Web of Science ®Google Scholar
• Bovi, G.G., Petrus, R.R., and Pinho, S.C., 2017. Production and physicochemical characterization of buriti (Mauritia flexuosa L.) oil nanoemulsions and feasibility of incorporation in isotonic sports drink. International journal of food science and technology, 52 (10), 2201–2209.
   Web of Science ®Google Scholar
• Brito-Oliveira, T.C., et al., 2017. Encapsulation of beta-carotene in solid lipid microparticles stabilized with hydrolyzed soy protein isolate: production parameters, influence of alpha-tocopherol coencapsulation and stability under stress conditions. Journal of food science, 82 (3), 659–669.
   PubMed Web of Science ®Google Scholar
• Cao-Hoang, L., Fougere, R., and Wache, Y., 2010. Increase in stability and change in supramolecular structure of beta-carotene through encapsulation into polylactic acid nanoparticles. Food chemistry, 24, 42–49.
   Google Scholar
• Ciappellano, S.C., et al., 2016. In vitro toxicity assessment of oral nanocarriers. Advanced drug delivery reviews, 106 (Pt B), 381–401.
   PubMed Web of Science ®Google Scholar
• Cornacchia, L. and Roos, Y.H., 2011. Stability of β-carotene in protein-stabilized oil-in-water delivery systems. Journal of agricultural and food chemistry, 59 (13), 7013–7702.
   PubMed Web of Science ®Google Scholar
• de Carli, C., Moraes-Lovison, M., and Pinho, S.C., 2018. Production, physicochemical stability of quercetin-loaded nanoemulsions and evaluation of antioxidant activity in spreadable chicken pâtés. LWT – food science and technology, 98, 154–161.
   Web of Science ®Google Scholar
• Doktorovova, S., Souto, E.B., and Silva, A.M., 2014. Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers – a systematic review of in vitro data. European journal of pharmaceuticals and biopharmaceuticals, 87 (1), 1–18.
   PubMed Web of Science ®Google Scholar
• Fraser, P.D. and Bramley, P.M., 2004. The biosynthesis and nutritional uses of carotenoids. Progress in lipid research, 43 (3), 228–265.
   PubMed Web of Science ®Google Scholar
• Gao, S. and McClements, D.J., 2016. Formation and stability of solid lipid nanoparticles fabricated using phase inversion temperature method. Colloids and surfaces A: physicochemical and engineering aspects, 499, 79–87.
   Web of Science ®Google Scholar
• Gomes, G.V.L., et al., 2017. Physico-chemical stability and in vitro digestion of beta-carotene-loaded lipid nanoparticles of cupuacu butter (Theobroma grandiflorum) produced by phase inversion temperature (PIT) method. Journal of food engineering, 192, 93–102.
   Web of Science ®Google Scholar
• Guerra, A., et al., 2012. Relevance and challenges in modeling human gastric and small intestinal digestion. Trends in biotechnology, 30 (11), 591–600.
   PubMed Web of Science ®Google Scholar
• Gupta, A., et al., 2016. Nanoemulsions: formation, properties and applications. Soft matter, 12 (11), 2826–2841.
   PubMed Web of Science ®Google Scholar
• Hentschel, A., et al., 2008. β-Carotene-loaded nanostructured lipid carriers. Journal of food science, 73, 1–6.
   PubMed Web of Science ®Google Scholar
• Hugger, E.D., et al., 2002. A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. Journal of pharmaceutical sciences, 91 (9), 1991–2001.
   PubMed Web of Science ®Google Scholar
• Hur, S.J., Decker, E.A., and McClements, D.J., 2009. Influence of initial emulsifier type on microstructural changes occurring in emulsified lipids during in vitro digestion. Food chemistry, 114 (1), 253–262.
   Web of Science ®Google Scholar
• Kiss, L., et al., 2013. Kinetic analysis of the toxicity of pharmaceutical excipients Cremophor EL and RH40 on endothelial and epithelial cells. Journal of pharmaceutical sciences, 102 (4), 1173–1181.
   PubMed Web of Science ®Google Scholar
• Komaiko, J. and McClements, D.J., 2015. Low-energy formation of edible nanoemulsions by spontaneous emulsification: factors influencing particle size. Journal of food engineering, 146, 122–128.
   Web of Science ®Google Scholar
• Li, H., et al., 2016. Size-exclusive effect of nanostructured lipid carriers on oral drug delivery. International journal of pharmaceutics, 511 (1), 524–537.
   PubMed Web of Science ®Google Scholar
• Loh, J.W., et al., 2010. Uptake and cytotoxicity of chitosan nanoparticles in human liver cells. Toxicology and applied pharmacology, 249 (2), 148–157.
   PubMed Web of Science ®Google Scholar
• Mambrim, M.C.T. and Barrera-Arellano, D., 1997. Caracterización de aceites de frutos de palmeras de la región amazónica del Brasil. Grasas y aceites, 48, 154–158.
   Web of Science ®Google Scholar
• Matsaridou, I., et al., 2012. The influence of surfactant HLB and oil/surfactant ratio on the formation and properties of self-emulsifying pellets and microemulsion reconstitution. AAPS PharmSciTech, 13 (4), 1319–1330.
   PubMed Web of Science ®Google Scholar
• McClements, D.J. and Rao, J., 2011. Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity. Critical reviews in food science and nutrition, 51 (4), 285–330.
   PubMed Web of Science ®Google Scholar
• Ménard, O. et al., 2014. Validation of a new in vitro dynamic system to simulate infant digestion. Food chemistry, 145, 1039–1045.
   Google Scholar
• Montenegro, L., et al., 2012. Idebenone-loaded solid lipid nanoparticles for drug delivery to the skin: in vitro evaluation. International journal of pharmaceutics, 434 (1–2), 169–174.
   PubMed Web of Science ®Google Scholar
• Müller, R.H., Mäder, K., and Gohla, S., 2000. Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. European journal of pharmaceutics and biopharmaceutics, 50 (1), 161–177.
   PubMed Web of Science ®Google Scholar
• Pan, Y., Tikekar, R.V., and Nitin, N., 2016. Distribution of a model bioactive within solid lipid nanoparticles and nanostructured lipid carriers influences its loading efficiency and oxidative stability. International journal of pharmaceutics, 511 (1), 322–330.
   PubMed Web of Science ®Google Scholar
• Pinheiro, A.C., Coimbra, M.A., and Vicente, A.A., 2016. In vitro behaviour of curcumin nanoemulsions stabilized by biopolymer emulsifiers – effect of interfacial composition. Food hydrocolloids, 52, 460–467.
   Web of Science ®Google Scholar
• Pinho, S. C., de Carli, C., and Moraes-Lovison, M., 2018. Nanoemulsions produced by low energy methods: fundamentals and food applications. In: Rai R, Aswathanarayan JB, eds. Nanotechnology applications in the food industry. 1st ed. Boca Raton: CRC Press, 221–236.
   Google Scholar
• Rege, B.D., Kao, J.P.Y., and Polli, J.E., 2002. Effects of nonionic surfactants on membrane transporters in Caco-2 monolayers. International journal of pharmaceutical sciences, 16, 237–246.
   Google Scholar
• Reis, P.M., et al., 2008. Influence of surfactants on lipase fat digestion in a model gastro-intestinal system. Food biophysics, 3 (4), 370–381.
   PubMed Web of Science ®Google Scholar
• Relkin, P. and Shukat, R., 2012. Food protein aggregates as vitamin-matrix carriers: impact of processing conditions. Food chemistry, 134 (4), 2141–2148.
   PubMed Web of Science ®Google Scholar
• Salvia-Trujillo, L., et al., 2013. Modulating β-carotene bioaccessibility by controlling oil composition and concentration in edible nanoemulsions. Food chemistry, 39, 878–884.
   Web of Science ®Google Scholar
• Sek, L., et al., 2002. Evaluation of the in-vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products. Journal of pharmacy and pharmacology, 54 (1), 29–41.
   PubMed Web of Science ®Google Scholar
• Severino, P., et al., 2014. Solid lipid nanoparticles for hydrophilic biotech drugs: optimization and cell viability studies (Caco-2 and HEPG-2 cell lines). European journal of medicinal chemistry, 81, 28–34.
   PubMed Web of Science ®Google Scholar
• Shinoda, K. and Saito, H., 1968. The effect of temperature on the phase equilibria and the types of dispersions of the ternary system composed of water, cyclohexane, and nonionic surfactant. Journal of colloid and interface science, 26 (1), 70–74.
   Web of Science ®Google Scholar
• Tanaka, M., et al., 2003. Evidence for interpenetration of core triglycerides into surface phospholipid monolayers in lipid emulsions. Langmuir, 19 (13), 5192–5196.
   Web of Science ®Google Scholar
• Tikekar, R.V. and Nitin, N., 2011. Effect of physical state (solid vs. liquid) of lipid core on the rate of transport of oxygen and free radicals in solid lipid nanoparticles and emulsion. Soft matter, 7 (18), 8149–8158.
   Web of Science ®Google Scholar
• Tokle, T., et al., 2012. Impact of dietary fiber coatings on behavior of protein-stabilized lipid droplets under simulated gastrointestinal conditions. Food and function, 3 (1), 58–66.
   PubMed Web of Science ®Google Scholar
• Vighi, E., et al., 2013. Design flexibility influencing the in vitro behavior of cationic SLN as a nonviral gene vector. International journal of pharmaceutics, 440 (2), 161–169.
   PubMed Web of Science ®Google Scholar