Producing the sour cherry pit oil nanoemulsion and evaluation of its anti-cancer effects on both breast cancer murine model and MCF-7 cell line

References

• Afoulous, S., et al., 2013. Chemical composition and anticancer, antiinflammatory, antioxidant and antimalarial activities of leaves essential oil of Cedrelopsis grevei. Food and chemical toxicology, 56, 352–362.
   PubMed Web of Science ®Google Scholar
• Ahmad, N., et al., 2018. Ultrasonication techniques used for the preparation of novel Eugenol-Nanoemulsion in the treatment of wounds healings and anti-inflammatory. Journal of drug delivery science and technology, 46, 461.
   Web of Science ®Google Scholar
• Attivi, D., et al., 2005. Formulation of insulin-loaded polymeric nanoparticles using response surface methodology. Drug development and industrial pharmacy, 31 (2), 179–189.
   PubMed Web of Science ®Google Scholar
• Bak, I., et al., 2010. Isolation and analysis of bioactive constituents of sour cherry (Prunus cerasus) seed kernel: an emerging functional food. Journal of medicinal food, 13 (4), 905–910.
   PubMed Web of Science ®Google Scholar
• Ben-Arye, E., et al., 2012. Integrative oncology research in the Middle East: weaving traditional and complementary medicine in supportive care. Supportive care in cancer, 20 (3), 557–564.
   PubMed Web of Science ®Google Scholar
• Borthakur, P., et al., 2016. Nanoemulsion: preparation and its application in food industry. In: A.M. Grumezescu, ed. Emulsions. London: Academic Press, 153–191.
   Google Scholar
• Bou, D.D., et al., 2013. Chemical composition and cytotoxicity evaluation of essential oil from leaves of Casearia sylvestris, its main compound α-zingiberene and derivatives. Molecules, 18 (8), 9477–9487.
   PubMed Web of Science ®Google Scholar
• Boyle, P. and Levin, B., 2008. World cancer report 2008. Lyon: IARC Press, International Agency for Research on Cancer.
   Google Scholar
• Constantinides, P.P., Chaubal, M.V., and Shorr, R., 2008. Advances in lipid nanodispersions for parenteral drug delivery and targeting. Advanced drug delivery reviews, 60 (6), 757–767.
   PubMed Web of Science ®Google Scholar
• Constantinides, P.P., Han, J., and Davis, S.S., 2006. Advances in the use of tocols as drug delivery vehicles. Pharmaceutical research, 23 (2), 243–255.
   PubMed Web of Science ®Google Scholar
• Cui, Y., et al., 2007. β-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor γ expression and reactive oxygen species production in MCF-7 cancer cells. European journal of cancer, 43 (17), 2590–2601.
   PubMed Web of Science ®Google Scholar
• Dawane, J.S. and Pandit, V.A., 2012. Understanding redox homeostasis and its role in cancer. Journal of clinical and diagnostic research, 6 (10), 1796.
   PubMedGoogle Scholar
• DeBerardinis, R.J., et al., 2008. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell metabolism, 7 (1), 11–20.
   PubMed Web of Science ®Google Scholar
• Ferlay, J., et al., 2006. Estimates of the cancer incidence and mortality in Europe in 2006. Annals of oncology, 18 (3), 581–592.
   Web of Science ®Google Scholar
• Fogang, H.P., et al., 2014. In vitro biological activities of seed essential oils from the Cameroonian spices Afrostyrax lepidophyllus Mildbr. and Scorodophloeus zenkeri harms rich in sulfur‐containing compounds. Chemistry & biodiversity, 11 (1), 161–169.
   PubMed Web of Science ®Google Scholar
• Fryd, M.M. and Mason, T.G., 2012. Advanced nanoemulsions. Annual review of physical chemistry, 63 (1), 493–518.
   PubMedGoogle Scholar
• Ghosh, V., et al., 2013. Cinnamon oil nanoemulsion formulation by ultrasonic emulsification: investigation of its bactericidal activity. Journal of nanoscience and nanotechnology, 13 (1), 114–122.
   PubMed Web of Science ®Google Scholar
• Greenberg, P.A., et al., 1996. Long-term follow-up of patients with complete remission following combination chemotherapy for metastatic breast cancer. Journal of clinical oncology, 14 (8), 2197–2205.
   PubMed Web of Science ®Google Scholar
• Hsu, H., et al., 2017. Preparation of carotenoid extracts and nanoemulsions from Lycium barbarum L. and their effects on growth of HT-29 colon cancer cells. Nanotechnology, 28 (13), 135103.
   PubMed Web of Science ®Google Scholar
• Hutchinson, L., 2010. Breast cancer: challenges, controversies, breakthroughs. Nature reviews. Clinical oncology, 7 (12), 669–670.
   PubMed Web of Science ®Google Scholar
• Jaiswal, M., Dudhe, R., and Sharma, P.K., 2015. Nanoemulsion: an advanced mode of drug delivery system. Biotech, 5 (2), 123–127.
   Google Scholar
• Jiang, Q., Wong, J., and Ames, B.N., 2004. Gamma-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms. Annals of the New York academy of sciences, 1031 (1), 399–400.
   PubMedGoogle Scholar
• Ju, J., et al., 2010. Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis, 31 (4), 533–542.
   PubMed Web of Science ®Google Scholar
• Kabat, G.C., et al., 2009. Longitudinal study of serum carotenoid, retinol, and tocopherol concentrations in relation to breast cancer risk among postmenopausal women. The American journal of clinical nutrition, 90 (1), 162–169.
   PubMed Web of Science ®Google Scholar
• Keawsa-Ard, S., et al., 2012. Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale. Natural product communications. 7, 955–958.
   PubMed Web of Science ®Google Scholar
• Khan, I., et al., 2018. In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis. Scientific reports, 8 (1), 144.
   PubMedGoogle Scholar
• Korlesky, N.M., et al., 2016. Extraction and characterization of montmorency sour cherry (Prunus cerasus L.) pit oil. Journal of the American oil chemists' society, 93 (7), 995–1005.
   Web of Science ®Google Scholar
• Kumar, H. and Kumar, V., 2018. Ultrasonication assisted formation and stability of water-in-oil nanoemulsions: optimization and ternary diagram analysis. Ultrasonics sonochemistry, 49, 79–88.
   PubMed Web of Science ®Google Scholar
• Kumar, P., et al., 2018. Cytotoxicity of phloroglucinol engineered silver (Ag) nanoparticles against MCF-7 breast cancer cell lines. Materials chemistry and physics, 220, 402–408.
   Web of Science ®Google Scholar
• Mahato, R., 2017. Nanoemulsion as targeted drug delivery system for cancer therapeutics. Journal of pharmaceutical sciences and pharmacology, 3 (2), 83–97.
   Google Scholar
• Merisko-Liversidge, E., McGurk, S.L., and Liversidge, G.G., 2004. Insulin nanoparticles: a novel formulation approach for poorly water soluble Zn-insulin. Pharmaceutical research, 21 (9), 1545–1553.
   PubMed Web of Science ®Google Scholar
• Migotto, A., et al., 2018. Multifunctional nanoemulsions for intraductal delivery as a new platform for local treatment of breast cancer. Drug delivery, 25 (1), 654–667.
   PubMed Web of Science ®Google Scholar
• Odriozola-Serrano, I., Oms-Oliu, G., and Martin-Belloso, O., 2014. Nanoemulsion-based delivery systems to improve functionality of lipophilic components. Frontiers in nutrition, 1, 24.
   PubMedGoogle Scholar
• Paim, L.F.N.A., et al., 2018. Poiretia latifolia essential oil as a promising antifungal and anti-inflammatory agent: chemical composition, biological screening, and development of a nanoemulsion formulation. Industrial crops and products, 126, 280–286.
   Web of Science ®Google Scholar
• Pan, Y., et al., 2002. Relationship between drug effects and particle size of insulin-loaded bioadhesive microspheres. Acta pharmacologica sinica, 23 (11), 1051–1056.
   PubMed Web of Science ®Google Scholar
• Park, Y., et al., 2015. β-Carotene-induced apoptosis is mediated with loss of Ku proteins in gastric cancer AGS cells. Genes & nutrition, 10 (4), 467–467.
   PubMed Web of Science ®Google Scholar
• Parkin, D.M., et al., 2005. Global cancer statistics, 2002. CA: a cancer journal for clinicians, 55 (2), 74–108.
   PubMed Web of Science ®Google Scholar
• Periasamy, V.S., Athinarayanan, J., and Alshatwi, A.A., 2016. Anticancer activity of an ultrasonic nanoemulsion formulation of Nigella sativa L. essential oil on human breast cancer cells. Ultrasonics sonochemistry, 31, 449–455.
   PubMed Web of Science ®Google Scholar
• Petsev, D.N., 2004. Emulsions: structure, stability and interactions (Vol. 4). New York: Elsevier.
   Google Scholar
• Pistritto, G., et al., 2016. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging, 8 (4), 603.
   PubMedGoogle Scholar
• Porter, A.G. and Janicke, R.U., 1999. Emerging roles of caspase-3 in apoptosis. Cell death & differentiation, 6 (2), 99–104.
   PubMed Web of Science ®Google Scholar
• Portt, L., et al., 2011. Anti-apoptosis and cell survival: a review. Biochimica et biophysica acta, 1813 (1), 238–259.
   PubMed Web of Science ®Google Scholar
• Praveen Kumar, G. and Divya, A., 2015. Nanoemulsion based targeting in cancer therapeutics. Medicinal chemistry, 5, 272–284.
   Google Scholar
• Salopek, B., Krasic, D., and Filipovic, S., 1992. Measurement and application of zeta-potential. Rudarsko-geolosko-naftni zbornik, 4 (1), 147.
   Google Scholar
• Sarker, D.K., 2005. Engineering of nanoemulsions for drug delivery. Current drug delivery, 2 (4), 297–310.
   PubMedGoogle Scholar
• Stetefeld, J., McKenna, S.A., and Patel, T.R., 2016. Dynamic light scattering: a practical guide and applications in biomedical sciences. Biophysical reviews, 8 (4), 409–427.
   PubMedGoogle Scholar
• Sznarkowska, A., et al., 2017. Inhibition of cancer antioxidant defense by natural compounds. Oncotarget, 8 (9), 15996.
   PubMedGoogle Scholar
• Tadros, T., et al., 2004. Formation and stability of nano-emulsions. Advances in colloid and interface science, 108, 303–318.
   PubMed Web of Science ®Google Scholar
• Teixeira, M., et al., 2017. d-α-tocopherol nanoemulsions: size properties, rheological behavior, surface tension, osmolarity and cytotoxicity. Saudi pharmaceutical journal, 25 (2), 231–235.
   PubMed Web of Science ®Google Scholar
• Thanos, C., et al., 2003. Improving relative bioavailability of dicumarol by reducing particle size and adding the adhesive poly (fumaric-co-sebacic) anhydride. Pharmaceutical research, 20 (7), 1093–1100.
   PubMed Web of Science ®Google Scholar
• Unger, E.C., et al., 2004. Therapeutic applications of lipid-coated microbubbles. Advanced drug delivery reviews, 56 (9), 1291–1314.
   PubMed Web of Science ®Google Scholar
• Vila, A., et al., 2005. PLA-PEG particles as nasal protein carriers: the influence of the particle size. International journal of pharmaceutics, 292 (1–2), 43–52.
   PubMed Web of Science ®Google Scholar
• Wasan, K.M., 2007. Role of lipid excipients in modifying oral and parenteral drug delivery: basic principles and biological examples. New York: John Wiley & Sons.
   Google Scholar
• Xin, X., et al., 2013. Influence of CTAB and SDS on the properties of oil-in-water nano-emulsion with paraffin and span 20/Tween 20. Colloids and surfaces A: physicochemical and engineering aspects, 418, 60–67.
   Web of Science ®Google Scholar
• Yılmaz, C. and Gökmen, V., 2013. Compositional characteristics of sour cherry kernel and its oil as influenced by different extraction and roasting conditions. Industrial crops and products, 49, 130–135.
   Web of Science ®Google Scholar
• Yılmaz, F.M., et al., 2018. Sour cherry by-products: compositions, functional properties and recovery potentials – a review. Critical reviews in food science and nutrition, 2, 1–15.
   Google Scholar
• Yousefzadi, M., et al., 2014. Toxicity of essential oil of Satureja khuzistanica: in vitro cytotoxicity and anti-microbial activity. Journal of immunotoxicology, 11 (1), 50–55.
   PubMed Web of Science ®Google Scholar
• Yukuyama, M.N., et al., 2017. Challenges and future prospects of nanoemulsion as a drug delivery system. Current pharmaceutical design, 23 (3), 495–508.
   PubMed Web of Science ®Google Scholar