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Original Articles

Development of folic acid–loaded nanostructured lipid carriers for topical delivery: preparation, characterisation and ex vivo investigation

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Pages 366-383 | Received 13 Nov 2019, Accepted 24 Apr 2020, Published online: 07 May 2020

References

  • Abd El-Alim, S.H., et al., 2019. Comparative study of liposomes, ethosomes and transfersomes as carriers for enhancing the transdermal delivery of diflunisal: In vitro and in vivo evaluation. International journal of pharmaceutics, 563, 293–303.
  • Abdel-Salam, F.S., et al., 2017a. Anti-inflammatory sunscreen nanostructured lipid carrier formulations. Journal of drug delivery science and technology, 37, 13–19.
  • Abdel-Salam, F.S., et al., 2017b. Nanostructured lipid carriers as semisolid topical delivery formulations for diflucortolone valerate. Journal of liposome research, 27 (1), 41–55.
  • Abla, M.J. and Banga, A.K., 2014. Formulation of tocopherol nanocarriers and in vitro delivery into human skin. International journal of cosmetic science, 36 (3), 239–246.
  • Adeyeye, M.C., et al., 2002. Viscoelastic evaluation of topical creams containing microcrystalline cellulose/sodium carboxymethyl cellulose as stabilizer. AAPS pharmscitech, 3 (2), 16–25.
  • Akhtar, M.J., Khan, M.A., and Ahmad, I., 1999. Photodegradation of folic acid in aqueous solution. Journal of pharmaceutical and biomedical analysis, 19 (3–4), 269–275.
  • Al-Okbi, S.Y., et al., 2017. Enhanced prevention of progression of non alcoholic fatty liver to steatohepatitis by incorporating pumpkin seed oil in nanoemulsions. Journal of molecular liquids, 225, 822–832.
  • Al-Shammary, F. J., et al., 1990. Analytical profile of folic acid. In: K. Florey, ed. Analytical profiles of drug substances. San Diego, CA: Academic Press, Inc., 221–259.
  • Asfour, M.H., Kassem, A.A., and Salama, A., 2019. Topical nanostructured lipid carriers/inorganic sunscreen combination for alleviation of all-trans retinoic acid-induced photosensitivity: Box-Behnken design optimization, in vitro and in vivo evaluation. European journal of pharmaceutical sciences, 134, 219–232.
  • Bahari, A.S.L. and Hamishehkar, H., 2016. The impact of variables on particle size of solid lipid nanoparticles and nanostructured lipid carriers; a comparative literature review. Advanced pharmaceutical bulletin, 6 (2), 143–151.
  • Barclay, B. J., 2006. B complex vitamin compositions that protect against cellular damage caused by ultraviolet light. United States Patent 7018623 B2.
  • Barker, D. E., 1994. Human skin cleansing and wrinkle-reducing cream. United States Patent 5360824.
  • Basha, M., et al., 2015. Benzocaine loaded solid lipid nanoparticles: Formulation design, in vitro and in vivo evaluation of local anesthetic effect. Current drug delivery, 12 (6), 680–692.
  • Beloqui, A., et al., 2016. Nanostructured lipid carriers: promising drug delivery systems for future clinics. Nanomedicine: Nanotechnology, biology and medicine, 12 (1), 143–161.
  • Bhalekar, M.R., et al., 2009. Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery. AAPS pharmscitech, 10 (1), 289–296.
  • Čerpnjak, K., et al., 2013. Lipid-based systems as a promising approach for enhancing the bioavailability of poorly water-soluble drugs. Acta pharmaceutica, 63 (4), 427–445.
  • Chaudhary, S., et al., 2015. Development, optimization and evaluation of long chain nanolipid carrier for hepatic delivery of silymarin through lymphatic transport pathway. International journal of pharmaceutics, 485 (1–2), 108–121.
  • Chen, C.C., et al., 2010. Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. European journal of pharmaceutics and biopharmaceutics, 74 (3), 474–482.
  • De Vringer, T., 1992. Topical preparation containing a suspension of solid lipid particles. European Patent 91200664.
  • Duarte, J.C., Schellart, W.P., and Cruden, A.R., 2014. Rheology of petrolatum–paraffin oil mixtures: Applications to analogue modelling of geological processes. Journal of structural geology, 63, 1–11.
  • Dubey, A., Prabhu, P., and Kamath, J., 2012. Nanostructured lipid carriers: A novel topical drug delivery system. International journal of PharmTech research, 4, 705–714.
  • Elnaggar, Y.S., El-Massik, M.A., and Abdallah, O.Y., 2011. Fabrication, appraisal, and transdermal permeation of sildenafil citrate-loaded nanostructured lipid carriers versus solid lipid nanoparticles. International journal of nanomedicine, 6, 3195–3205.
  • El-Salamouni, N.S., et al., 2015. Effect of sterilization on the physical stability of brimonidine-loaded solid lipid nanoparticles and nanostructured lipid carriers. International journal of pharmaceutics, 496 (2), 976–983.
  • Fang, J.Y., et al., 2008. Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). European journal of pharmaceutics and biopharmaceutics, 70 (2), 633–640.
  • Farouk, A., Fikry, R., and Mohsen, M., 2016. Chemical composition and antioxidant activity of ocimum basilicum l. Essential oil cultivated in Madinah Monawara, Saudi Arabia and its comparison to the Egyptian chemotype. Journal of essential oil-bearing plants, 19 (5), 1119–1128.
  • Firooz, A., Nafisi, S., and Maibach, H.I., 2015. Novel drug delivery strategies for improving econazole antifungal action. International journal of pharmaceutics, 495 (1), 599–607.
  • Fischer, F., et al., 2011. Folic acid and creatine improve the firmness of human skin in vivo. Journal of cosmetic dermatology, 10 (1), 15–23.
  • Freitas, C. and Müller, R.H., 1999. Correlation between long-term stability of solid lipid nanoparticles (SLN™) and crystallinity of the lipid phase. European journal of pharmaceutics and biopharmaceutics, 47 (2), 125–132.
  • Gaba, B., et al., 2015. Nanostructured lipid carrier system for topical delivery of terbinafine hydrochloride. Bulletin of faculty of pharmacy Cairo university, 53 (2), 147–159.
  • Gaspar, L. and Campos, P.M., 2003. Rheological behavior and the SPF of sunscreens. International journal of pharmaceutics, 250 (1), 35–44.
  • Gazzali, A.M., et al., 2016. Stability of folic acid under several parameters. European journal of pharmaceutical sciences, 93, 419–430.
  • Ghadially, R., Halkier-Sorensen, L., and Elias, P.M., 1992. Effects of petrolatum on stratum corneum structure and function. Journal of the American academy of dermatology, 26 (3), 387–396.
  • Gomes, M.J., et al., 2014. Lipid nanoparticles for topical and transdermal application for alopecia treatment: Development, physicochemical characterization, and in vitro release and penetration studies. International journal of nanomedicine, 9, 1231–1242.
  • Grams, Y.Y. and Bouwstra, J.A., 2002. Penetration and distribution of three lipophilic probes in vitro in human skin focusing on the hair follicle. Journal of controlled release, 83 (2), 253–262.
  • Gulbake, A., et al., 2010. Solid lipid nanoparticles bearing oxybenzone: In-vitro and in-vivo evaluation. Journal of microencapsulation, 27 (3), 226–233.
  • Hamilton, N., 2002. Cosmetics to support skin metabolism. United States Patent 0044913 A1.
  • Han, Y., et al., 2016. Nanostructured lipid carriers as novel drug delivery system for lung cancer gene therapy. Pharmaceutical development and technology, 21 (3), 277–281.,
  • Hojerová, J., Medovcíková, A., and Mikula, M., 2011. Photoprotective efficacy and photostability of fifteen sunscreen products having the same label SPF subjected to natural sunlight. International journal of pharmaceutics, 408 (1-2), 27–38.
  • Hu, F.Q., et al., 2005. Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system. Colloids and surfaces B: biointerfaces, 45 (3-4), 167–173.
  • Hu, F.Q., et al., 2006. Preparation and characteristics of monostearin nanostructured lipid carriers. International journal of pharmaceutics, 314 (1), 83–89.
  • Iqbal, M.A., et al., 2012. Nanostructured lipid carriers system: recent advances in drug delivery. Journal of drug targeting, 20 (10), 813–830.
  • Jayalakshmi, V., et al., 1999. Characterisation of paraffin waxes by DSC and high temperature GC. Petroleum science and technology, 17 (7–8), 843–856.
  • Joshi, R., et al., 2001. Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity. Free radical biology and medicine, 30 (12), 1390–1399.
  • Joshi, M. and Patravale, V., 2006. Formulation and evaluation of nanostructured lipid carrier (NLC)-based gel of valdecoxib. Drug development and industrial pharmacy, 32 (8), 911–918.
  • Joshi, M. and Patravale, V., 2008. Nanostructured lipid carrier (NLC) based gel of celecoxib. International journal of pharmaceutics, 346 (1–2), 124–132.
  • Junyaprasert, V.B., et al., 2012. Physicochemical properties and skin permeation of Span 60/Tween 60 niosomes of ellagic acid. International journal of pharmaceutics, 423 (2), 303–311.
  • Kamel, R. and Mostafa, D.M., 2015. Rutin nanostructured lipid cosmeceutical preparation with sun protective potential. Journal of photochemistry and photobiology B: biology, 153, 59–66.
  • Kasetvatin, C., Rujivipat, S., and Tiyaboonchai, W., 2015. Combination of elastic liposomes and low frequency ultrasound for skin permeation enhancement of hyaluronic acid. Colloids and surfaces B: biointerfaces, 135, 458–464.
  • Kassem, A.A., Abd El-Alim, S.H., and Asfour, M.H., 2017. Enhancement of 8-methoxypsoralen topical delivery via nanosized niosomal vesicles: Formulation development, in vitro and in vivo evaluation of skin deposition. International journal of pharmaceutics, 517 (1–2), 256–268.
  • Kassem, A.A., et al., 2016. Self-nanoemulsifying drug delivery system (SNEDDS) with enhanced solubilization of nystatin for treatment of oral candidiasis: Design, optimization, in vitro and in vivo evaluation. Journal of molecular liquids, 218, 219–232.
  • Katuwavila, N.P., et al., 2016. Improved delivery of caffeic acid through liposomal encapsulation. Journal of nanomaterials, 2016, 1–7.
  • Kaur, A., Goindi, S. and Katare, O.P., 2016. Formulation, characterisation and in vivo evaluation of lipid-based nanocarrier for topical delivery of diflunisal. Journal of microencapsulation, 33 (5), 475–486.
  • Keck, C.M. and Muller, R.H., 2013. Nanotoxicological classification system (NCS) - a guide for the risk-benefit assessment of nanoparticulate drug delivery systems. European journal of pharmaceutics and biopharmaceutics, 84 (3), 445–448.
  • Kheradmandnia, S., et al., 2010. Preparation and characterization of ketoprofen-loaded solid lipid nanoparticles made from beeswax and carnauba wax. Nanomedicine: Nanotechnology, biology and medicine, 6 (6), 753–759.
  • Knott, A., et al., 2008. A novel treatment option for photoaged skin. Journal of cosmetic dermatology, 7 (1), 15–22.
  • Lacerda, S., Cerize, N., and Ré, M., 2011. Preparation and characterization of carnauba wax nanostructured lipid carriers containing benzophenone‐3. International journal of cosmetic science, 33 (4), 312–321.
  • Lademann, J., et al., 2007. Nanoparticles-An efficient carrier for drug delivery into the hair follicles. European journal of pharmaceutics and biopharmaceutics, 66 (2), 159–164.
  • Lashkari, O. and Ghomashchi, R., 2007. The implication of rheology in semi-solid metal processes: An overview. Journal of materials processing technology, 182 (1-3), 229–240.
  • Lippacher, A., Müller, R.H., and Mäder, K., 2001. Preparation of semisolid drug carriers for topical application based on solid lipid nanoparticles. International journal of pharmaceutics, 214 (1-2), 9–12.
  • Liu, J., et al., 2007. Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. International journal of pharmaceutics, 328 (2), 191–195.
  • Loo, C.H., et al., 2013. Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion. International journal of nanomedicine, 8, 13–22.
  • Luyt, A.S. and Krupa, I., 2008. Thermal behaviour of low and high molecular weight paraffin waxes used for designing phase change materials. Thermochimica acta, 467 (1-2), 117–120.
  • Marwah, H., et al., 2016. Permeation enhancer strategies in transdermal drug delivery. Drug delivery, 23 (2), 564–578.,
  • Matias, R., et al., 2014. A UV spectrophotometric method for the determination of folic acid in pharmaceutical tablets and dissolution tests. Analytical methods, 6 (9), 3065–3071.
  • Mitri, K., et al., 2011. Lipid nanocarriers for dermal delivery of lutein: Preparation, characterization, stability and performance. International journal of pharmaceutics, 414 (1-2), 267–275.
  • Moghddam, S.M., et al., 2017. Optimization of nanostructured lipid carriers for topical delivery of nimesulide using Box-Behnken design approach. Artificial cells, nanomedicine, and biotechnology, 45 (3), 617–624.
  • Montenegro, L., et al., 2016. From nanoemulsions to nanostructured lipid carriers: a relevant development in dermal delivery of drugs and cosmetics. Journal of drug delivery science and technology, 32, 100–112.
  • Muchow, M., Maincent, P., and Müller, R.H., 2008. Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery. Drug development and industrial pharmacy, 34 (12), 1394–1405.
  • Muèller, R.H., Maèder, K., and Gohla, S., 2000. Solid lipid nanoparticles (SLN) for controlled drug delivery–a review of the state of the art. European journal of pharmaceutics and biopharmaceutics, 50, 161–177.
  • Müller, R., et al., 2007. Nanostructured lipid carriers (NLC) in cosmetic dermal products. Advanced drug delivery reviews, 59 (6), 522–530.
  • Muller, R.H., Gohla, S., and Keck, C.M., 2011. State of the art of nanocrystals-Special features, production, nanotoxicology aspects and intracellular delivery. European journal of pharmaceutics and biopharmaceutics, 78 (1), 1–9.
  • Nam, S.H., Ji, X.Y., and Park, J.S., 2011. Investigation of tacrolimus loaded nanostructured lipid carriers for topical drug delivery. Bulletin of the Korean chemical society, 32 (3), 956–960.
  • Natarajan, V.T., et al., 2014. Multifaceted pathways protect human skin from UV radiation. Nature chemical biology, 10 (7), 542–551.
  • Nesseem, D., 2011. Formulation of sunscreens with enhancement sun protection factor response based on solid lipid nanoparticles. International journal of cosmetic science, 33 (1), 70–79.
  • Nikolić, S., et al., 2011. Skin photoprotection improvement: Synergistic interaction between lipid nanoparticles and organic UV filters. International journal of pharmaceutics, 414 (1-2), 276–284.
  • Obeidat, W.M., et al., 2010. Preservation of nanostructured lipid carriers (NLC). European journal of pharmaceutics and biopharmaceutics, 76 (1), 56–67.
  • Pardeike, J., Hommoss, A., and Müller, R.H., 2009. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. International journal of pharmaceutics, 366 (1–2), 170–184.
  • Pardeshi, C., et al., 2012. Solid lipid based nanocarriers: An overview. Acta pharmaceutica, 62 (4), 433–472.
  • Park, E.K. and Song, K.W., 2010. Rheological evaluation of petroleum jelly as a base material in ointment and cream formulations: steady shear flow behavior. Archives of pharmacal research, 33 (1), 141–150.
  • Patel, P.A. et al., 2013. Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A. International journal of pharmaceutics, 446 (1-2), 16–23.
  • Patra, S., et al., 2016. The next generation cell-penetrating peptide and carbon dot conjugated nano-liposome for transdermal delivery of curcumin. Biomaterials science, 4 (3), 418–429.
  • Poonia, N., et al., 2016. Nanostructured lipid carriers: Versatile oral delivery vehicle. Future science OA., 2 (3), FSO135.
  • Pople, P.V. and Singh, K.K., 2013. Development and evaluation of colloidal modified nanolipid carrier: Application to topical delivery of tacrolimus, Part II–In vivo assessment, drug targeting, efficacy, and safety in treatment for atopic dermatitis. European journal of pharmaceutics and biopharmaceutics, 84 (1), 72–83.
  • Pradhan, M., Singh, D., and Singh, M.R., 2017. Fabrication, optimization and characterization of triamcinolone acetonide loaded nanostructured lipid carriers for topical treatment of psoriasis: Application of Box Behnken design, in vitro and ex vivo studies. Journal of drug delivery science and technology, 41, 325–333.
  • Rahman, H.S., et al., 2013. Zerumbone-loaded nanostructured lipid carriers: Preparation, characterization, and antileukemic effect. European journal of pharmaceutics and biopharmaceutics, 8, 2769–2781.
  • Rajinikanth, P.S. and Chellian, J., 2016. Development and evaluation of nanostructured lipid carrier-based hydrogel for topical delivery of 5-fluorouracil. International journal of nanomedicine, 11, 5067–5077.
  • Ruktanonchai, U., et al., 2009. Physicochemical characteristics, cytotoxicity, and antioxidant activity of three lipid nanoparticulate formulations of alpha-lipoic acid. AAPS pharmscitech, 10 (1), 227–234.
  • Salavkar, S.M., Tamanekar, R.A., and Athawale, R.B., 2011. Antioxidants in skin ageing–Future of dermatology. International journal of green pharmacy, 5 (3), 161–168.
  • Sanad, R.A., et al., 2010. Formulation of a novel oxybenzone-loaded nanostructured lipid carriers (NLCs). AAPS pharmscitech, 11 (4), 1684–1694.
  • Shah, P.P., et al., 2012. Enhanced skin permeation using polyarginine modified nanostructured lipid carriers. Journal of control release, 161 (3), 735–745.
  • Shah, R.M., et al., 2016. Encapsulation of clotrimazole into solid lipid nanoparticles by microwave-assisted microemulsion technique. Applied materials today, 5, 118–127.
  • Singh, S., et al., 2016. Development and evaluation of ultra-small nanostructured lipid carriers: novel topical delivery system for athlete’s foot. Drug delivery and translational research, 6 (1), 38–47.
  • Soliman, S.M., et al., 2010. Formulation of microemulsion gel systems for transdermal delivery of celecoxib: In vitro permeation, anti-inflammatory activity and skin irritation tests. Drug discoveries and therapeutics, 4 (6), 459–471.
  • Souto, E. and Müller, R., 2006. The use of SLN® and NLC® as topical particulate carriers for imidazole antifungal agents. Die pharmazie, 61, 431–437.
  • Souto, E.B. and Müller, R.H., 2008. Cosmetic features and applications of lipid nanoparticles (SLN®, NLC®). International journal of cosmetic science, 30 (3), 157–165.
  • Souto, E., et al., 2004. Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. International journal of pharmaceutics, 278 (1), 71–77.
  • Suwannateep, N., et al., 2012. Encapsulated curcumin results in prolonged curcumin activity in vitro and radical scavenging activity ex vivo on skin after UVB-irradiation. European journal of pharmaceutics and biopharmaceutics, 82 (3), 485–490.
  • Tanner, T. and Marks, R., 2008. Delivering drugs by the transdermal route: review and comment. Skin research and technology, 14 (3), 249–260.
  • Teeranachaideekul, V., et al., 2007. Cetyl palmitate-based NLC for topical delivery of coenzyme Q(10) - development, physicochemical characterization and in vitro release studies. European journal of pharmaceutics and biopharmaceutics, 67 (1), 141–148.
  • Teeranachaideekul, V., et al., 2008a. Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC. Journal of controlled release, 128 (2), 134–141.
  • Teeranachaideekul, V., et al., 2008b. Physicochemical characterization and in vitro release studies of ascorbyl palmitate-loaded semi-solid nanostructured lipid carriers (NLC gels). Journal of microencapsulation, 25 (2), 111–120.
  • Tiwari, S., Mistry, P., and Patel, V., 2014. SLNs based on co-processed lipids for topical delivery of terbinafine hydrochloride. Journal of pharmaceutics and drug development, 2, 1–8.
  • Trivedi, D., et al., 2019. Evaluation of the physicochemical and thermal properties of folic acid: Influence of the energy of consciousness healing treatment. Scholarly Journal of food and nutrition, 1, 142–149.
  • Van Der Rhee, H., et al.; Department of Dermatology, Hagaziekenhuis, P.O. Box 40551, Leyweg 275, 2504 Den Haag, Zuid-Holland, the Netherlands 2016. Sunlight: For better or for worse? A review of positive and negative effects of sun exposure. Cancer research frontiers, 2 (2), 156–183.
  • Wissing, S.A. and Muller, R.H., 2001. A novel sunscreen system based on tocopherol acetate incorporated into solid lipid nanoparticles. International journal of cosmetic science, 23 (4), 233–243.
  • Yata, V.K., Banerjee, S., and Ghosh, S.S., 2014. Folic acid conjugated-bio polymeric nanocarriers: Synthesis, characterization and in vitro delivery of prodrug converting enzyme. Advanced science, engineering and medicine, 6 (4), 388–392.
  • Younis, I.R., et al., 2009. Influence of pH on the dissolution of folic acid supplements. International journal of pharmaceutics, 367 (1-2), 97–102.

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