57
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

Ethylcellulose microparticles enhance 3,3′-diindolylmethane anti-hypernociceptive action in an animal model of acute inflammatory pain

, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 528-541 | Received 17 Feb 2020, Accepted 20 Aug 2020, Published online: 01 Sep 2020

References

  • Arunkumar, P., et al., 2016. Synthesis, characterizations, in vitro and in vivo evaluation of Etoricoxib-loaded Poly (Caprolactone) microparticles-a potential Intra-articular drug delivery system for the treatment of Osteoarthritis. Journal of biomaterials science. polymer edition, 27 (4), 303–316.
  • Bale, S., et al., 2016. Overview on therapeutic applications of microparticulate drug delivery systems. Critical reviews in therapeutic drug carrier systems, 33 (4), 309–361.
  • Banerjee, S., et al., 2011. Attenuation of multi-targeted proliferation-linked signaling by 3,3′-diindolylmethane (DIM): from bench to clinic. Mutation research, 728 (1–2), 47–66.
  • Behera, B.C., et al., 2008. Characterization of glipizide-loaded polymethacrylate microspheres prepared by an emulsion solvent evaporation method. Tropical journal of pharmaceutical research, 7 (1), 879–885.
  • Bhokare, S.G., et al., 2015. Biodegradable polymer based nanoparticles: a novel approach. International journal of pharmaceutical sciences review and research, 35 (1), 43–52.
  • Bruschi, M.L., 2015. Mathematical models of drug release. In: Strategies to modify the drug release from pharmaceutical systems. Cambridge, UK: Woodhead Publishing, 63–86.
  • Bushnell, M.C., Čeko, M., and Low, L.A., 2013. Cognitive and emotional control of pain and its disruption in chronic pain. Nature reviews neuroscience, 14 (7), 502–511.
  • Carter, G.T., et al., 2014. Side effects of commonly prescribed analgesic medications. Physical medicine and rehabilitation clinics of North America, 25 (2), 457–470.
  • Chen, C., et al., 2013. In vivo and in vitro study on the role of 3,3′-diindolylmethane in treatment and prevention of nasopharyngeal carcinoma. Carcinogenesis, 34 (8), 1815–1821.
  • Cruz, L., et al., 2010. Microencapsulation of sodium alendronate reduces drug mucosal damage in rats. Drug delivery, 17 (4), 231–237.,
  • Deshmukh, R., Wagh, P., and Naik, J., 2016. Solvent evaporation and spray drying technique for micro- and nanospheres/particles preparation: a review. Drying technology, 34 (15), 1758–1772.
  • Deshmukh, R.K., and Naik, J.B., 2014. Aceclofenac microspheres: quality by design approach. Materials science & engineering. C, materials for biological applications, 36 (1), 320–328.
  • Ferreira, L.M., et al., 2015. Formulation of gastroresistant tablets containing sodium alendronate-loaded blend microparticles. Brazilian journal of pharmaceutical sciences, 51 (2), 324.
  • Freiberg, S., and Zhu, X.X., 2004. Polymer microspheres for controlled drug release. International journal of pharmaceutics, 282 (1–2), 1–18.
  • Han, F.Y., et al., 2015. Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain. Journal of pharmaceutical sciences, 104 (7), 2334–2344.
  • Hegen, M., et al., 2008. Utility of animal models for identification of potential therapeutics for rheumatoid arthritis. Annals of the rheumatic diseases, 67 (11), 1505–1515.
  • Heinrich, S., 2020. Dynamic flowsheet simulation of solids processes. Hamburg, Germany: Dynamic Flowsheet Simulation of Solids Processes. Springer Nature Switzerland AG 2020.
  • Hickey, A. J., and Giovagnoli, S., 2018. Pharmaceutical powder and particles. 1st ed. Research Triangle Park, NC; Perugia, Italy: Springer Nature Switzerland AG.
  • Higdon, J.V., et al., 2007. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacological research, 55 (3), 224–236.
  • Higuchi, T., 1963. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. Journal of pharmaceutical sciences, 52 (12), 1145–1149.
  • Jain, S.K., et al., 2005. Calcium silicate based microspheres of repaglinide for gastroretentive floating drug delivery: Preparation and in vitro characterization. Journal of controlled release: official journal of the controlled release society, 107 (2), 300–309.,
  • Jang, Y., et al., 2018. Nociceptive roles of TRPM2 ion channel in pathologic pain. Molecular neurobiology, 55 (8), 6589–6600.
  • Julius, D., and Basbaum, A.I., 2001. Molecular mechanisms of nociception. Nature, 413 (6852), 203–210.
  • Kim, E.J., et al., 2010. 3,3′-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators. Molecular carcinogenesis, 49 (7), 672–683.
  • Kim, E.J., et al., 2009a. Oral administration of 3,3′-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. The journal of nutrition, 139 (12), 2373–2379.
  • Kim, Y.H., et al., 2009b. 3,3′-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. Inflammatory bowel diseases, 15 (8), 1164–1173.
  • Kohli, S., Sharma, M., and Pal, A., 2016. Ethylcellulose floating microspheres of antidiabetic agent: In vitro and in vivo evaluation. International journal of applied pharmaceutics, 9 (1), 44–49.
  • Kumar, K.H., and Elavarasi, P., 2016. Definition of pain and classification of pain disorders. Journal of advanced clinical & research insights, 3, 87–90.
  • Lanas, Á., 2006. Nuevos avances en efectos adversos por AINE en el tracto gastrointestinal advances in the adverse effects of NSAIDS. Gastroenterología y hepatología, 29 (Supl 3), 16–22.
  • Li, M., Rouaud, O., and Poncelet, D., 2008. Microencapsulation by solvent evaporation: State of the art for process engineering approaches. International journal of pharmaceutics, 363 (1–2), 26–39.
  • Li, X.J., et al., 2013a. 3,3′-Diindolylmethane suppresses the growth of gastric cancer cells via activation of the Hippo signaling pathway. Oncology reports, 30 (5), 2419–2426.
  • Li, Y., et al., 2013b. Antioxidant function of isoflavone and 3,3′-diindolylmethane: are they important for cancer prevention and therapy? Antioxidants & redox signaling, 19 (2), 139–150.
  • Lomakin, S.M., et al., 2011. Thermal degradation of biodegradable blends of polyethylene with cellulose and ethylcellulose. Thermochimica acta, 521 (1–2), 66–73.
  • Lopes, C.M., Lobo, J.M.S., and Costa, P., 2005. Formas farmacêuticas de liberação modificada: polímeros hidrifílicos. Revista Brasileira de Ciências farmacêuticas, 41 (2), 143–154.
  • Luo, Y., et al., 2013. Encapsulation of indole-3-carbinol and 3,3′-diindolylmethane in zein/carboxymethyl chitosan nanoparticles with controlled release property and improved stability. Food chemistry, 139 (1–4), 224–230.
  • Manadas, R., Pina, M.E., and Veiga, F., 2002. A dissolução in vitro na previsão da absorção oral de fármacos em formas farmacêuticas de liberação modificada. Revista Brasileira de Ciência do solo, 38 (4), 376.
  • Manchikanti, L., et al., 2010. Therapeutic use. Abuse, and nonmedical use of opioids: a ten-year perspective, 2000 (2), 401–435.
  • Maruthanila, V.L., Poornima, J., and Mirunalini, S., 2014. Attenuation of carcinogenesis and the mechanism underlying by the influence of indole-3-carbinol and its metabolite 3,3′-diindolylmethane: A therapeutic marvel. Advances in pharmacological sciences, 2014, 832161.
  • Mattiazzi, J., et al., 2019. 3,3′-Diindolylmethane nanoencapsulation improves its antinociceptive action: Physicochemical and behavioral studies. Colloids and surfaces. B, biointerfaces, 181 (May), 295–304.
  • Murase, S.K., et al., 2015. Electrosprayed poly(butylene succinate) microspheres loaded with indole derivatives: A system with anticancer activity. European polymer journal, 71, 196–209.
  • Murtaza, G., 2012. Ethylcellulose microparticles: a review. Acta poloniae Pharmaceutica – drug research, 69 (1), 11–22.
  • O’Donnell, P.B., and McGinity, J.W., 1997. Preparation of microspheres by the solvent evaporation technique. Advanced drug delivery reviews, 28 (1), 25–42.
  • Park, C.-W., et al., 2012. Preparation and in vivo evaluation of spray dried matrix type controlled-release microparticles of tamsulosin hydrochloride for orally disintegrating tablet. Drug development and industrial pharmacy, 38 (10), 1179–1187.
  • Patel, B., et al., 2012. Preparation and evaluation of ethyl cellulose microspheres prepared by emulsification – solvent evaporation method. International journal for research in management and pharmacy, 1 (1), 82–91.
  • Raffin, R.P., et al., 2008. Increasing sodium pantoprazole photostability by microencapsulation: Effect of the polymer and the preparation technique. European journal of pharmaceutics and biopharmaceutics: official journal of arbeitsgemeinschaft fur pharmazeutische verfahrenstechnik e.v, 69 (3), 1014–1018.
  • Ren, K., and Dubner, R., 1999. Inflammatory models of pain and hyperalgesia. ILAR journal, 40 (3), 111–118.
  • Rogers, T.L., and Wallick, D., 2011. Reviewing the use of ethylcellulose, methylcellulose and hypromellose in microencapsulation. Part 2: techniques used to make microcapsules. Drug development and industrial pharmacy, 37 (11), 1259–1271.
  • Rogers, T.L., and Wallick, D., 2012a. Reviewing the use of ethylcellulose, methylcellulose and hypromellose in microencapsulation. Part 3: applications for microcapsules. Drug development and industrial pharmacy, 38 (5), 521–539.
  • Rogers, T.L., and Wallick, D., 2012b. Reviewing the use of ethylcellulose, methylcellulose and hypromellose in microencapsulation. Part 1: materials used to formulate microcapsules. Drug development and industrial pharmacy, 38 (2), 129–157.
  • Roy, S., et al., 2013. Studies on aqueous solubility of 3, 3 0 -diindolylmethane derivatives using cyclodextrin inclusion complexes. Journal of molecular structure, 1036, 1–6.
  • Samad, T.A., et al., 2001. Interleukin-1 b -mediated induction of Cox-2 in the CNS contributes to in ammatory pain hypersensitivity. Nature, 410 (6827), 471–475.,
  • dos Santos, P.P., et al., 2016. Biodegradable polymers as wall materials to the synthesis of bioactive compound nanocapsules. Trends in food science & technology, 53, 23–33.
  • Scholz, J., and Woolf, C.J., 2002. Can we conquer pain? Nature neuroscience, 5 (S11), 1062–1067.
  • Shanmugarathinam, A., Vidhyeswari, D., and Puratchikody, A., 2011. Formulation, characterization and in-vitro evaluation of acrylic polymer loaded aceclofenac microspheres. International journal of pharma and bio sciences, 2 (2), 253–257.
  • Sharma, M., Kohli, S., and Dinda, A., 2015. In-vitro and in-vivo evaluation of repaglinide loaded floating microspheres prepared from different viscosity grades of HPMC polymer. Saudi pharmaceutical journal, 23 (6), 675–682.
  • Sharma, M., Kohli, S., and Dinda, A., 2014. Floating microspheres of repaglinide: formulation, optimization, characterization and in vitro evaluation. International journal of chemical sciences 12 (4), 1259–1272.
  • Sharma, M., Kohli, S., and Pal, A., 2017. Preparation and evaluation of controlled release floating microspheres of repaglinide: optimization and in-vitro studies. Asian journal of pharmaceutical and clinical research 10 (3), 103–107.
  • Taraballi, F., et al., 2014. Potential avoidance of adverse analgesic effects using a biologically “smart” hydrogel capable of controlled bupivacaine release. Journal of pharmaceutical sciences, 103 (11), 3724–3732.
  • Vallejo, F., Tomás-Barberán, F.A., and Garcia-Viguera, C., 2002. Glucosinolates and vitamin C content in edible parts of broccoli florets after domestic cooking. European food research and technology, 215 (4), 310–316.
  • Vasanthi, H.R., Mukherjee, S., and Das, D.K., 2009. Potential health benefits of broccoli- a chemico-biological overview. Mini reviews in medicinal chemistry, 9 (6), 749–759.
  • Velasquez, A.A., et al., 2014. Risedronate-loaded Eudragit S100 microparticles formulated into tablets. Pharmaceutical development and technology, 19 (3), 263–268.
  • Verhoeven, D.T., et al., 1996. Epidemiological studies on brassica vegetables and cancer risk. Cancer epidemiology, biomarkers & prevention: a publication of the American association for cancer research, cosponsored by the American society of preventive oncology, 5 (9), 733–748.
  • Vilos, C., and Velasquez, L.A., 2012. Therapeutic strategies based on polymeric microparticles. Journal of biomedicine & biotechnology, 2012, 672760.
  • Wongrakpanich, S., et al., 2018. A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly. Aging and disease, 9 (1), 143–150.
  • Woolf, C.J., and Salter, M.W., 2000. Neuronal plasticity: increasing the gain in pain. Science, 288 (5472), 1710–1765.
  • Wu, T., et al., 2014. 3,3′-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition. Experimental and therapeutic medicine, 7 (6), 1635–1638.
  • Wu, T.-Y., et al., 2015. Pharmacokinetics and pharmacodynamics of 3,3′-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes. Journal of pharmacokinetics and pharmacodynamics, 42 (4), 401–408.
  • Zamani, Z., et al., 2015. Development and evaluation of thymol microparticles using cellulose derivatives as controlled release dosage form. Iranian journal of pharmaceutical research, 14 (4), 1031–1040.
  • Zayed, M.A., et al., 2017. Investigation of naproxen drug using mass spectrometry, thermal analyses and semi-empirical molecular orbital calculation. Arabian journal of chemistry, 10 (3), 351–359.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.