Thiolated okra chitosan nanoparticles: preparation and optimisation as intranasal drug delivery agents

References

• Ahuja, M., and Kumar, A., 2013. Gum ghatti–chitosan polyelectrolyte nanoparticles: Preparation and characterization. International journal of biological macromolecules, 61, 411–415.
   PubMed Web of Science ®Google Scholar
• Albrecht, K., et al., 2006. Preparation of thiomer microparticles and in vitro evaluation of parameters influencing their mucoadhesive properties. Drug development and industrial pharmacy, 32 (10), 1149–1157.
   PubMed Web of Science ®Google Scholar
• Ameena, K., et al., 2010. Isolation of the mucilages from Hibiscus rosasinensis linn. and Okra (Abelmoschus esculentus linn.) and studies of the binding effects of the mucilages. Asian pacific journal of tropical medicine, 3 (7), 539–543.
   Web of Science ®Google Scholar
• Apu, A.S., et al., 2009. Investigation of in vitro release kinetics of carbamazepine from Eudragit® RS PO and RL PO matrix tablets. Tropical journal of pharmaceutical research, 8 (2).
   Web of Science ®Google Scholar
• Arora, G., et al., 2011. Formulation and evaluation of controlled release matrix mucoadhesive tablets of domperidone using Salvia plebeian gum. Journal of advanced pharmaceutical technology and research, 2 (3), 163–169.
   PubMedGoogle Scholar
• Bernela, M., Ahuja, M., and Thakur, R., 2016. Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles. Carbohydrate polymers, 143, 18–24.
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch, A., 2005. Thiomers: a new generation of mucoadhesive polymers. Advanced drug delivery reviews, 57 (11), 1569–1582.
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch, A., Schwarz, V., and Steininger, S., 1999. Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharmaceutical research, 16 (6), 876–881.
   PubMed Web of Science ®Google Scholar
• Borchard, G., et al., 1996. Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro. Journal of controlled release, 39 (2-3), 131–138.
   Web of Science ®Google Scholar
• Brar, V., and Kaur, G., 2018. Preparation of chitosan okra nanoparticles: optimization and evaluation as mucoadhesive nasal drug delivery system. Pharmaceutical nanotechnology, 6, 1–12.
   Google Scholar
• Brar, V., and Kaur, G., 2018b. Preparation and Characterization of Polyelectrolyte Complexes of Hibiscus esculentus (Okra) Gum and Chitosan. International journal of biomaterials, 2018, 1–7.
   Google Scholar
• Chen, J.J., 2010. Parkinson's disease: health-related quality of life, economic cost, and implications of early treatment. American journal of managed care, 16, S87–S93.
   PubMed Web of Science ®Google Scholar
• Dang, J.M., and Leong, K.W., 2006. Natural polymers for gene delivery and tissue engineering. Advanced drug delivery reviews, 58 (4), 487–499.
   PubMed Web of Science ®Google Scholar
• de Alvarenga, P.C., Mottin, M.A.C., and Ayres, E., 2016. Preparation and Characterization of Okra Mucilage (Abelmoschus esculentus) Edible Films. Macromolecular symposium., 367, 90–100.
   Google Scholar
• de Oliveira, E.F., Paula, H.C.B., and de Paula, R.C.M., 2014. Alginate/cashew gum nanoparticles for essential oil encapsulation. Colloids and surfaces. B, biointerfaces, 113, 146–151.
   PubMed Web of Science ®Google Scholar
• Dias, S.F.L., et al., 2016. Acetylated cashew gum-based nanoparticles for transdermal delivery of diclofenac diethyl amine. Carbohydrate polymers, 143, 254–261.
   PubMed Web of Science ®Google Scholar
• Dicharry, R.M., et al., 2006. Wheat gluten-thiolated poly(vinyl alcohol) blends with improved mechanical properties. Biomacromolecules, 7 (10), 2837–2844.
   PubMed Web of Science ®Google Scholar
• Dobrynin, A.V., 2008. Theory and simulations of charged polymers: From solution properties to polymeric nanomaterials. Current opinion in colloid and interface science, 13 (6), 376–388.
   Web of Science ®Google Scholar
• Duchěne, D., Touchard, F., and Peppas, N.A., 1988. Pharmaceutical and medical aspects of bioadhesive systems for drug administration. Drug development and industrial pharmacy., 14 (2-3), 283–318.
   Web of Science ®Google Scholar
• Emeje, M., et al., 2011. Extraction and physicochemical characterization of a new polysaccharide obtained from the fresh fruits of Abelmoschus esculentus. Iran journal of pharmaceutical research, 10, 237–246.
   PubMed Web of Science ®Google Scholar
• Felter, S.P., et al., 2006. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food and chemical toxicology : an international journal published for the british industrial biological research association, 44 (4), 462–475.
   PubMed Web of Science ®Google Scholar
• Gum, J.R., et al., 1992. The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region. The journal of biological chemistry, 267 (30), 21375–21383.
   PubMed Web of Science ®Google Scholar
• Gupta, A.P., and Verma, D.K., 2014. Preparation and characterization of carboxymethyl guar gum nanoparticles. International journal of biological macromolecules, 68, 247–250.
   PubMed Web of Science ®Google Scholar
• Haque, S., et al., 2014. Development and evaluation of brain targeted intranasal alginate nanoparticles for treatment of depression. Journal of psychiatric research, 48 (1), 1–12.
   PubMed Web of Science ®Google Scholar
• Illum, L., 2000. Transport of drugs from the nasal cavity to the central nervous system. European journal of pharmaceutical sciences : official journal of the european federation for pharmaceutical sciences, 11 (1), 1–18.
   PubMed Web of Science ®Google Scholar
• Jana, S., et al., 2013. Development of chitosan-based nanoparticles through inter-polymeric complexation for oral drug delivery. Carbohydrate polymers, 98 (1), 870–876.
   PubMed Web of Science ®Google Scholar
• Jiménez-Castellanos, M.R., Zia, H., and Rhodes, C.T., 1993. Mucoadhesive drug delivery systems. Drug development and industrial pharmacy., 19 (1-2), 143–194.
   Web of Science ®Google Scholar
• Kafedjiiski, K., et al., 2007. Synthesis and in vitro evaluation of thiolated hyaluronic acid for mucoadhesive drug delivery. International journal of pharmaceutics, 343 (1-2), 48–58.
   PubMed Web of Science ®Google Scholar
• Kaur, G., Singh, D., and Brar, V., 2014. Bioadhesive okra polymer based buccal patches as platform for controlled drug delivery. International journal of biological macromolecules, 70, 408–419.
   PubMed Web of Science ®Google Scholar
• Kaur, H., et al., 2012. Synthesis, characterization and evaluation of thiolated tamarind seed polysaccharide as a mucoadhesive polymer. Carbohydrate polymers, 90 (4), 1543–1549.
   PubMed Web of Science ®Google Scholar
• Kean, T., and Thanou, M., 2010. Biodegradation, biodistribution and toxicity of chitosan. Advanced drug delivery reviews, 62 (1), 3–11.
   PubMed Web of Science ®Google Scholar
• Lambert, J. B., et al., 1987. Introduction to organic spectroscopy. New York, United States: Macmillan Publishing Company.
   Google Scholar
• Longer, M.A., and Robinson, J.R., 1986. Fundamental-aspects of bioadhesion. Pharmaceutics international, 7, 114–117.
   Google Scholar
• Madihally, S.V., and Matthew, H.W.T., 1999. Porous chitosan scaffolds for tissue engineering. Biomaterials, 20 (12), 1133–1142.
   PubMed Web of Science ®Google Scholar
• Mahajan, H.S., et al., 2013. Thiolated xyloglucan: Synthesis, characterization and evaluation as mucoadhesive in situ gelling agent. Carbohydrate polymers, 91 (2), 618–625.
   PubMed Web of Science ®Google Scholar
• Masalova, O., et al., 2013. Alginate and chitosan gel nanoparticles for efficient protein entrapment. Physics procedia, 40, 69–75.
   Google Scholar
• Matricardi, P., et al., 2013. Interpenetrating polymer networks polysaccharide hydrogels for drug delivery and tissue engineering. Advanced drug delivery reviews, 65 (9), 1172–1187.
   PubMed Web of Science ®Google Scholar
• Md, S., et al., 2013. Bromocriptine loaded chitosan nanoparticles intended for direct nose to brain delivery: pharmacodynamic, pharmacokinetic and scintigraphy study in mice model. European journal of pharmaceutical sciences: official journal of the European federation for pharmaceutical sciences, 48 (3), 393–405.
   PubMed Web of Science ®Google Scholar
• Mistry, A., Stolnik, S., and Illum, L., 2009. Nanoparticles for direct nose-to-brain delivery of drugs. International journal of pharmaceutics, 379 (1), 146–157.
   PubMed Web of Science ®Google Scholar
• Müller, M., 2014. Polyelectrolyte Complexes in the Dispersed and Solid State II. Berlin: Springer.
   Google Scholar
• Müller, R.H., Jacobs, C., and Kayser, O., 2001. Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future. Advanced drug delivery reviews, 47 (1), 3–19.
   PubMed Web of Science ®Google Scholar
• Murali, R., Vidhya, P., and Thanikaivelan, P., 2014. Thermoresponsive magnetic nanoparticle-aminated guar gum hydrogel system for sustained release of doxorubicin hydrochloride. Carbohydrate polymers, 110, 440–445.
   PubMed Web of Science ®Google Scholar
• Ogaji, I., and Nnoli, O., 2014. Film coating potential of okra gum using paracetamol tablets as a model drug. Asian journal of pharmaceutics, 4. doi:10.4103/0973-8398.68464
   Google Scholar
• Palei, N.N., Mamidi, S.K., and Rajangam, J., 2016. Formulation and evaluation of lamivudine sustained release tablet using okra mucilage. Journal of applied pharmaceutical science, 6, 69–75.
   Google Scholar
• Pitombeira, N.A.O., et al., 2015. Self-assembled nanoparticles of acetylated cashew gum: Characterization and evaluation as potential drug carrier. Carbohydrate polymers, 117, 610–615.
   PubMed Web of Science ®Google Scholar
• Posadowska, U., Brzychczy-Wloch, M., and Pamula, E., 2016. Injectable gellan gum-based nanoparticles-loaded system for the local delivery of vancomycin in osteomyelitis treatment. Journal of material science: materials in medicine, 27 (9).
   PubMed Web of Science ®Google Scholar
• Rajkumari, A., et al., 2012. Studies on the development of colon specific drug delivery system of ibuprofen using polysaccharide extracted from Abelmoschus esculentus L.,(Moench). Asian journal of pharmaceutical sciences., 7, 67–74.
   Google Scholar
• Rehman, S.U., et al., 2015. HPLC determination of esculin and esculetin in rat plasma for pharmacokinetic studies. Journal of chromatographic science, 53 (8), 1322–1327.
   PubMed Web of Science ®Google Scholar
• Rejman, J., et al., 2004. Size-dependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis. Biochemical journal, 377 (1), 159–169.
   PubMed Web of Science ®Google Scholar
• Schapira, A.H.V., et al., 2006. Novel pharmacological targets for the treatment of Parkinson's disease. Nature reviews. Drug discovery, 5 (10), 845–854.
   PubMed Web of Science ®Google Scholar
• Sharma, N., Madan, P., and Lin, S., 2016. Effect of process and formulation variables on the preparation of parenteral paclitaxel-loaded biodegradable polymeric nanoparticles: A co-surfactant study. Asian journal of pharmaceutical sciences., 11 (3), 404–416.
   Web of Science ®Google Scholar
• Sharma, R., and Ahuja, M., 2011. Thiolated pectin: Synthesis, characterization and evaluation as a mucoadhesive polymer. Carbohydrate polymers., 85 (3), 658–663.
   Web of Science ®Google Scholar
• Song, J., et al., 2012. Anti-Parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models? Journal of ethnopharmacology, 139 (3), 698–711.
   PubMed Web of Science ®Google Scholar
• Tan, C., et al., 2016. Polysaccharide-based nanoparticles by chitosan and gum arabic polyelectrolyte complexation as carriers for curcumin. Food hydrocolloids, 57, 236–245.
   Web of Science ®Google Scholar
• Ugwoke, M.I., et al., 2005. Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives. Advanced drug delivery reviews, 57 (11), 1640–1665.
   PubMed Web of Science ®Google Scholar
• Ugwoke, M.I., Verbeke, N., and Kinget, R., 2001. The biopharmaceutical aspects of nasal mucoadhesive drug delivery. The journal of pharmacy and pharmacology, 53 (1), 3–22.
   PubMed Web of Science ®Google Scholar
• Valente, J.F.A., et al., 2013. Microencapsulated chitosan–dextran sulfate nanoparticles for controled delivery of bioactive molecules and cells in bone regeneration. Polymer, 54 (1), 5–15.
   Web of Science ®Google Scholar
• Wang, J., et al., 2014. Optimization of reaction conditions by RSM and structure characterization of sulfated locust bean gum. Carbohydrate polymers, 114, 375–383.
   PubMed Web of Science ®Google Scholar
• Whistler, R.L., and Conrad, H.E., 1954. A crystalline galactobiose from acid hydrolysis of okra mucilage1. Journal of the american chemical society, 76 (6), 1673–1674.
   Web of Science ®Google Scholar
• Xu, W., et al., 2015. Synthesis and characterization of nanoparticles based on negatively charged xanthan gum and lysozyme. Food research international., 71, 83–90.
   Web of Science ®Google Scholar
• Zhao, D.L., et al., 2007a. Anti-apoptotic effect of esculin on dopamine-induced cytotoxicity in the human neuroblastoma SH-SY5Y cell line. Neuropharmacology, 53 (6), 724–732.
   PubMed Web of Science ®Google Scholar
• Zhao, Y., et al., 2007b. Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats 3. Acta pharmacologica sinica., 28 (2), 273–278.
   PubMed Web of Science ®Google Scholar