A comprehensive parametric study for understanding the combined millifluidic and dripping encapsulation process and characterisation of oil-loaded capsules

References

• Abang, S., Chan, E.-S., and Poncelet, D., 2012. Effects of process variables on the encapsulation of oil in ca-alginate capsules using an inverse gelation technique. Journal of microencapsulation, 29(5), 417–428.
   PubMed Web of Science ®Google Scholar
• Akbari, M., Rahimi, M., and Fattahi, A., 2017. Evaluation of microparticles formation by external gelationin a microfluidic system. Chemical engineering and processing: process intensification, 117, 171–178.
   Web of Science ®Google Scholar
• Angadi, S.C., Manjeshwar, L.S., and Aminabhavi, T.M., 2012. Novel composite blend microbeads of sodium alginate coated with chitosan for controlled release of amoxicillin. International journal of biological macromolecules, 51 (1-2), 45–55.
   PubMed Web of Science ®Google Scholar
• Burey, P., et al., 2008. Hydrocolloid gel particles: formation, characterization, and application. Critical reviews in food science and nutrition, 48(5), 361–377.
   PubMed Web of Science ®Google Scholar
• Chan, E.S., 2011. Preparation of Ca-alginate beads containing high oil content: Influence of process variables on encapsulation efficiency and bead properties. Carbohydrate polymers, 84 (4), 1267–1275.
   Web of Science ®Google Scholar
• Chan, E.S., et al., 2009. Prediction models for shape and size of ca-alginate macrobeads produced through extrusion–dripping method. Journal of colloid and interface science, 338 (1), 63–72.
   PubMed Web of Science ®Google Scholar
• Chung, B.G., et al., 2012. Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering. Lab on a chip, 12(1), 45–59.
   PubMed Web of Science ®Google Scholar
• Cramer, C., Fischer, P., and Windhab, E.J., 2004. Drop formation in a co-flowing ambient fluid. Chemical engineering science, 59(15), 3045–3058.
   Web of Science ®Google Scholar
• Daemi, H., and Barikani, M., 2012. Synthesis and characterization of calcium alginate nanoparticles, sodium homopolymannuronate salt and its calcium nanoparticles. Scientia iranica, 19 (6), 2023–2028.
   Web of Science ®Google Scholar
• Davarci, F., et al., 2017. The influence of solution viscosities and surface tension on calcium-alginate microbead formation using dripping technique. Food hydrocolloids., 62, 119–127.
   Web of Science ®Google Scholar
• Deng, C., et al., 2017. Numerical and experimental study of oil-in-water (O/W) droplet formation in a co-flowing capillary device. Colloids and surfaces A: Physicochemical and engineering aspects, 533, 1–8.
   Web of Science ®Google Scholar
• Dowding, P.J., et al., 2004. Oil coreâ∧’ polymer shell microcapsules prepared by internal phase separation from emulsion droplets. I. Characterization and release rates for microcapsules with polystyrene shells. Langmuir: the ACS journal of surfaces and colloids, 20(26), 11374–11379.
   PubMed Web of Science ®Google Scholar
• Eqbal, M.D., and Gundabala, V., 2017. Controlled fabrication of multi-core alginate microcapsules. Journal of colloid and interface science, 507, 27–34.
   PubMed Web of Science ®Google Scholar
• Erni, P., et al., 2009. Continuous flow structuring of anisotropic biopolymer particles. Advances in colloid and interface science, 150(1), 16–26.
   PubMed Web of Science ®Google Scholar
• Faidi, A., et al., 2019. Application of sodium alginate extracted from a Tunisian brown algae Padina pavonica for essential oil encapsulation: microspheres preparation, characterization and in vitro release study. International journal of biological macromolecules, 136, 386–394.
   PubMed Web of Science ®Google Scholar
• Gaonkar, A.G., 1991. Surface and interfacial activities and emulsion characteristics of some food hydrocolloids. Food hydrocolloids., 5(4), 329–337.
   Web of Science ®Google Scholar
• Gurdeniz, G., Tokatli, F., and Ozen, B., 2007. Differentiation of mixtures of monovarietal olive oils by mid-infrared spectroscopy and chemometrics. European journal of lipid science and technology, 109(12), 1194–1202.
   Web of Science ®Google Scholar
• Haldar, K., and Chakraborty, S., 2018. Role of chemical reaction and drag force during drop impact gelation process. Colloids and surfaces A: physicochemical and engineering aspects, 559, 401–409.
   Web of Science ®Google Scholar
• Harkins, W.D., and Brown, F.E., 1919. The determination of surface tension (free surface energy), and the weight of falling drops: the surface tension of water and benzene by the capillary height method. Journal of the American chemical society, 41 (4), 499–524.
   Google Scholar
• Hosseini, S.M., et al., 2013. Incorporation of essential oil in alginate microparticles by multiple emulsion/ionic gelation process. International journal of biological macromolecules, 62, 582–588.
   PubMed Web of Science ®Google Scholar
• Hu, B., et al., 2019. All-natural food-grade hydrophilic-hydrophobic core-shell microparticles: facile fabrication based on gel-network-restricted antisolvent method. ACS applied materials and interfaces, 11(12), 11936–11946.
   PubMed Web of Science ®Google Scholar
• Hu, Y., et al., 2012. Shape controllable microgel particles prepared by microfluidic combining external ionic crosslinking. Biomicrofluidics, 6(2), 26502–265029.
   PubMed Web of Science ®Google Scholar
• Katona, J.M., Sovilj, V.J., and Petrović, L.B., 2010. Microencapsulation of oil by polymer mixture–ionic surfactant interaction induced coacervation. Carbohydrate polymers, 79 (3), 563–570.
   Web of Science ®Google Scholar
• Kriegel, C., et al., 2009. Electrospinning of chitosan-poly (ethylene oxide) blend nanofibers in the presence of micellar surfactant solutions. Polymer, 50 (1), 189–200.
   Web of Science ®Google Scholar
• Lan, W., Li, S., and Luo, G., 2015. Numerical and experimental investigation of dripping and jetting flow in a coaxial micro-channel. Chemical engineering science, 134, 76–85.
   Web of Science ®Google Scholar
• Larosa, C., et al., 2018. Characterisation of bare and tannase-loaded calcium alginate beads by microscopic, thermogravimetric, FTIR and XRD analyses. International journal of biological macromolecules, 115, 900–906.
   PubMed Web of Science ®Google Scholar
• Lee, B., Ravindra, P., and Chan, E., 2013. Size and shape of calcium alginate beads produced by extrusion dripping. Chemical engineering and technology, 36, 1627–1642.
   Web of Science ®Google Scholar
• Li, J., Kim, S.Y., Chen, X., and Park, H.J., 2016. Calcium-alginate beads loaded with gallic acid: preparation and characterization. LWT-Food science and technology, 68, 667–673.
   Web of Science ®Google Scholar
• Lim, G.-P., et al., 2016. Influence of process variables and formulation composition on sphericity and diameter of Ca-alginate-chitosan liquid core capsule prepared by extrusion dripping method. Particulate science and technology, 34(6), 681–690.
   Web of Science ®Google Scholar
• Martins, E., et al., 2017a. Monodisperse core-shell alginate (micro)-capsules with oil core generated from droplets millifluidic. Food hydrocolloids., 63, 447–456.
   Web of Science ®Google Scholar
• Martins, E., Poncelet, D., and Renard, D., 2017b. A novel method of oil encapsulation in core-shell alginate microcapsules by dispersion-inverse gelation technique. Reactive and functional polymers, 114, 49–57.
   Web of Science ®Google Scholar
• Martins, E., et al., 2017c. Oil encapsulation techniques using alginate as encapsulating agent: applications and drawbacks. Journal of microencapsulation, 34(8), 754–771.
   PubMed Web of Science ®Google Scholar
• Mathiowitz, E., 1999. Encyclopedia of controlled drug delivery. New York: Wiley-Interscience.
   Google Scholar
• Mishra, M., 2015. Handbook of encapsulation and controlled release. New York: CRC press.
   Google Scholar
• Moghadam, H., et al., 2008. Electro-spray of high viscous liquids for producing mono-sized spherical alginate beads. Particuology, 6 (4), 271–275.
   Web of Science ®Google Scholar
• Mokhtari, S., Jafari, S.M., and Assadpour, E., 2017. Development of a nutraceutical nano-delivery system through emulsification/internal gelation of alginate. Food chemistry, 229, 286–295.
   PubMed Web of Science ®Google Scholar
• Moon, S.-K., Cheong, I.W., and Choi, S.-W., 2014. Effect of flow rates of the continuous phase on droplet size in dripping and jetting regimes in a simple fluidic device for coaxial flow. Colloids and surfaces A: Physicochemical and engineering aspects, 454, 84–88.
   Web of Science ®Google Scholar
• Morales, E., et al., 2017. Alginate/shellac beads developed by external gelation as a highly efficient model system for oil encapsulation with intestinal delivery. Food hydrocolloids., 70, 321–328.
   Web of Science ®Google Scholar
• Nativel, F., et al., 2018. Application of millifluidics to encapsulate and support viable human mesenchymal stem cells in a polysaccharide hydrogel. International journal of molecular sciences, 19(7), 1952. 1952.
   PubMed Web of Science ®Google Scholar
• Natrajan, D., et al., 2015. Formulation of essential oil-loaded chitosan-alginate nanocapsules. Journal of food and drug analysis, 23, 560–568.
   PubMed Web of Science ®Google Scholar
• Pereda, M., Poncelet, D., and Renard, D., 2019. Characterization of core-shell alginate capsules. Food biophysics, 14 (4), 467–478.
   Web of Science ®Google Scholar
• Piornos, J.A., et al., 2017. Highly efficient encapsulation of linseed oil into alginate/lupin protein beads: optimization of the emulsion formulation. Food hydrocolloids., 63, 139–148.
   Web of Science ®Google Scholar
• Rahimi, M., Khorrami, A.S., and Rezai, P., 2019. Effect of device geometry on droplet size in co-axial flow-focusing microfluidic droplet generation devices. Colloids and surfaces A: physicochemical and engineering aspects, 570, 510–517.
   Web of Science ®Google Scholar
• Ren, P.-W., et al., 2010. Monodisperse alginate microcapsules with oil core generated from a microfluidic device. Journal of colloid and interface science, 343 (1), 392–395.
   PubMed Web of Science ®Google Scholar
• Ribeiro, A.N.J., et al., 2005. Chitosan-reinforced alginate microspheres obtained through the emulsification/internal gelation technique. European journal of pharmaceutical sciences: official journal of the European federation for pharmaceutical sciences, 25 (1), 31–40.
   PubMed Web of Science ®Google Scholar
• Routh, A.F., and Russel, W.B., 1999. A process model for latex film formation: limiting regimes for individual driving forces. Langmuir, 15 (22), 7762–7773.
   Web of Science ®Google Scholar
• Saha, D., and Bhattacharya, S., 2010. Hydrocolloids as thickening and gelling agents in food: a critical review. Journal of food science and technology, 47(6), 587–597.
   PubMed Web of Science ®Google Scholar
• Shi, P., et al., 2011. Parametric analysis of shape changes of alginate beads. Powder technology, 210 (1), 60–66.
   Web of Science ®Google Scholar
• Souza, A., et al., 2004. A thermoanalytic and kinetic study of sunflower oil. Brazilian journal of chemical engineering, 21(2), 265–273.
   Web of Science ®Google Scholar
• Su, R., et al., 2011. Encapsulation of probiotic Bifidobacterium longum BIOMA 5920 with alginate–human-like collagen and evaluation of survival in simulated gastrointestinal conditions. International journal of biological macromolecules, 49 (5), 979–984.
   PubMed Web of Science ®Google Scholar
• Ueng, S.W., et al., 2004. In vivo study of biodegradable alginate antibiotic beads in rabbits. Journal of orthopaedic research: official publication of the orthopaedic research society, 22(3), 592–599.
   PubMed Web of Science ®Google Scholar
• Volić, M., et al., 2018. Alginate/soy protein system for essential oil encapsulation with intestinal delivery. Carbohydrate polymers, 200, 15–24.
   PubMed Web of Science ®Google Scholar
• Wang, M., et al., 2019a. Influence of ionic strength on the thermostability and flavor (allyl methyl disulfide) release profiles of calcium alginate microgels. Food hydrocolloids., 93, 24–33.
   Web of Science ®Google Scholar
• Wang, Q., et al., 2015. Alginate droplets pre-crosslinked in microchannels to prepare monodispersed spherical microgels. Colloids and surfaces A: physicochemical and engineering aspects, 482, 371–377.
   Web of Science ®Google Scholar
• Wang, W., Waterhouse, G.I.N., and Sun-Waterhouse, D., 2013. Co-extrusion encapsulation of canola oil with alginate: effect of quercetin addition to oil core and pectin addition to alginate shell on oil stability. Food research international, 54(1), 837–851.
   Web of Science ®Google Scholar
• Wang, X., et al., 2019b. Production of highly monodisperse millimeter‐sized double‐emulsion droplets in a coaxial capillary device. Chemical engineering & technology, 42(6), 1330–1340.
   Web of Science ®Google Scholar
• Wohl, M., 1968. Isothermal laminar flow of non-Newtonian fluids in pipes. Chemical engineering, 18–21.
   Google Scholar
• Wyss, A., Von Stockar, U., and Marison, I.W., 2004. Production and characterization of liquid-core capsules made from cross-linked acrylamide copolymers for biotechnological applications. Biotechnology and bioengineering, 86(5), 563–572.
   PubMed Web of Science ®Google Scholar
• Yang I.H. & El-Genk, M. S. 2011. Parametric analysis of microdroplet formation in co-axial co-flowing immiscible liquids in microtubes. International conference on nanochannels, microchannels, and minichannels, 587–596.
   Google Scholar
• Yu, M., et al., 2018. Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers. Nature communications, 9(1), 2607–2611.
   PubMed Web of Science ®Google Scholar