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Nano-lipidic formulation and therapeutic strategies for Alzheimer’s disease via intranasal route

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Pages 572-593 | Received 01 May 2021, Accepted 24 Sep 2021, Published online: 09 Nov 2021

References

  • Abe, K., et al., 2020. Influence of plasma matrix metalloproteinase levels on longitudinal changes in Alzheimer’s disease (AD) biomarkers and cognitive function in patients with mild cognitive impairment due to AD registered in the Alzheimer’s disease neuroimaging initiative da. Journal of the neurological sciences, 416, 116989.
  • Aderibigbe, B.A., 2018. In situ-based gels for nose to brain delivery for the treatment of neurological diseases. Pharmaceutics, 10 (2), 40.
  • Al Arifi, M.N., 2020. Evaluation of knowledge of Alzheimer disease among health university students in Riyadh, Saudi Arabia. Saudi pharmaceutical journal, 28 (8), 911–915.
  • Alam, M.I., et al., 2013. Intranasal infusion of nanostructured lipid carriers (NLC) containing CNS acting drug and estimation in brain and blood. Drug delivery, 20 (6), 247–251.
  • Aminu, N., et al., 2020. The influence of nanoparticulate drug delivery systems in drug therapy. Journal of drug delivery science and technology, 60, 101961.
  • Anton, N., and Vandamme, T.F., 2011. Nano-emulsions and micro-emulsions: clarifications of the critical differences. Pharmaceutical research, 28 (5), 978–985.
  • Arya, M.A., et al., 2019. Nanotechnology approaches for enhanced CNS delivery in treating Alzheimer’s disease. Journal of drug delivery science and technology, 51, 297–309.
  • Arya, R.K.K., and Juyal, V., 2017. Polymer -lipid hybrid nanoparticles for brain targeting through intranasal delivery. Journal of drug delivery and therapeutics, 7 (4), 129–136.
  • Bachmann, M.F., and Jennings, G.T., 2010. Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns. Nature reviews immunology, 10 (11), 787–796.
  • Bakr, M.M., Shukr, M.H., and ElMeshad, A.N., 2020. In situ hexosomal gel as a promising tool to ameliorate the transnasal brain delivery of vinpocetine: central composite optimization and in vivo biodistribution. Journal of pharmaceutical sciences, 109 (7), 2213–2223.
  • Ban, C., et al., 2020. Enhancing the oral bioavailability of curcumin using solid lipid nanoparticles. Food chemistry, 302, 125328.
  • Batist, G., et al., 2002. Myocet (liposome-encapsulated doxorubicin citrate): a new approach in breast cancer therapy. Expert opinion on pharmacotherapy, 3 (12), 1739–1751.
  • Battaglia, L., et al., 2018. Lipid nanoparticles for intranasal administration: application to nose-to-brain delivery. Expert opinion on drug delivery, 15 (4), 369–378.
  • Batzu, L., Westman, E., and Pereira, J.B., 2020. Cerebrospinal fluid progranulin is associated with increased cortical thickness in early stages of Alzheimer's disease. Neurobiology of aging, 88, 61–70.
  • Bonferoni, M.C.G., et al., 2019. Nanoemulsions for “nose-to-brain” drug delivery. Pharmaceutics, 11 (2), 84.
  • Chatterjee, B., et al., 2019. Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing challenges. International journal of pharmaceutics, 565, 258–268.
  • Chatzitaki, A.T., et al., 2020. Chitosan-coated PLGA nanoparticles for the nasal delivery of ropinirole hydrochloride: In vitro and ex vivo evaluation of efficacy and safety. International journal of pharmaceutics, 589, 119776.
  • Citron, M., 2010. Alzheimer's disease: strategies for disease modification. Nature reviews drug discovery, 9 (5), 387–398.
  • Copeland, C., and Stabenfeldt, S.E., 2020. Leveraging the dynamic blood-brain barrier for central nervous system nanoparticle-based drug delivery applications. Current opinion in biomedical engineering, 14, 1–8.
  • Corace, G., et al., 2014. Multifunctional liposomes for nasal delivery of the anti-Alzheimer drug tacrine hydrochloride. Journal of liposome research, 24 (4), 323–335.
  • Dá Mesquita, S., et al., 2016. Insights on the pathophysiology of Alzheimer's disease: the crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system. Neuroscience and biobehavioral reviews, 68, 547–562.
  • Dai, T., Jiang, K., and Lu, W., 2018. Liposomes and lipid disks traverse the BBB and BBTB as intact forms as revealed by two-step Förster resonance energy transfer imaging. Acta pharmaceutica sinica. B, 8 (2), 261–271.
  • de Marie, S., Janknegt, R., and Bakker-Woudenberg, I.A., 1994. Clinical use of liposomal and lipid-complexed amphotericin B. The journal of antimicrobial chemotherapy, 33 (5), 907–916.
  • Dhas, N., and Mehta, T., 2020. Cationic biopolymer functionalized nanoparticles encapsulating lutein to attenuate oxidative stress in effective treatment of Alzheimer's disease: a non-invasive approach. International journal of pharmaceutics, 586, 119553.
  • dos Santos Rodrigues, B., Kanekiyo, T., and Singh, J., 2020. In vitro and in vivo characterization of CPP and transferrin modified liposomes encapsulating pDNA. Nanomedicine: nanotechnology, biology, and medicine, 28, 102225.
  • Doskocz, J., et al., 2020. The effect of lipid phase on liposome stability upon exposure to the mechanical stress. Biochimica et biophysica acta. Biomembranes, 1862 (9), 183361,
  • Dwivedi, P., Kumar Tekade, R., and Kumar Jain, N., 2013. Nanoparticulate carrier mediated intranasal delivery of insulin for the restoration of memory signaling in Alzheimer’s disease. Current nanoscience, 9 (1), 46–55.
  • E. Eleraky, N., et al., 2020. Nanostructured lipid carriers to mediate brain delivery of temazepam: design and in vivo study. Pharmaceutics, 12 (5), 451.
  • Eid, H.M., et al., 2019. Transfersomal nanovesicles for nose-to-brain delivery of ofloxacin for better management of bacterial meningitis: formulation, optimization by Box-Behnken design, characterization and in vivo pharmacokinetic study. Journal of drug delivery science and technology, 54, 101304.
  • Erdő, F., et al., 2018. Evaluation of intranasal delivery route of drug administration for brain targeting. Brain research bulletin, 143, 155–170.
  • Fatouh, A.M., Elshafeey, A.H., and Abdelbary, A., 2017. Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics. Drug design, development and therapy, 11, 1815–1825.
  • Fortuna, A., et al., 2014. Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules. European journal of pharmaceutics and biopharmaceutics, 88 (1), 8–27.
  • Gartziandia, O., et al., 2015. Chitosan coated nanostructured lipid carriers for brain delivery of proteins by intranasal administration. Colloids and surfaces. B, biointerfaces, 134, 304–313.
  • Ghasemiyeh, P., and Mohammadi-Samani, S., 2018. Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages. Research in pharmaceutical sciences, 13 (4), 288–303.
  • Giunchedi, P., Gavini, E., and Bonferoni, M.C., 2020. Nose-to-brain delivery. Pharmaceutics, 12 (2), 138.
  • Grabrucker, A.M., 2014. Nanoparticles as blood-brain barrier permeable CNS targeted drug delivery systems. Topics in medicinal chemistr, 10, 71–89.
  • Haider, M., et al., 2020. Nanostructured lipid carriers for delivery of chemotherapeutics: a review. Pharmaceutics, 12 (3), 288.
  • Haider, M.F., et al., 2018. Optimization of rivastigmine nanoemulsion for enhanced brain delivery: in-vivo and toxicity evaluation. Journal of molecular liquids, 255, 384–396.
  • Hao, J., et al., 2016. Fabrication of an ionic-sensitive in situ gel loaded with resveratrol nanosuspensions intended for direct nose-to-brain delivery. Colloids and surfaces. B, biointerfaces, 147, 376–386.
  • Harilal, S., et al., 2019. Advancements in nanotherapeutics for Alzheimer's disease: current perspectives. The journal of pharmacy and pharmacology, 71 (9), 1370–1383.
  • Harilal, S., et al., 2020. Revisiting the blood-brain barrier: a hard nut to crack in the transportation of drug molecules. Brain research bulletin, 160, 121–140.
  • Hersh, D.S., et al., 2016. Evolving drug delivery strategies to overcome the blood brain barrier. Current pharmaceutical design, 22 (9), 1177–1193.
  • Hiemenz, J.W., and Walsh, T.J., 1996. Lipid formulations of amphotericin B: recent progress and future directions. Clinical infectious diseases, 22 (Suppl 2), S133–S44.
  • Huang, M., et al., 2015. GM1-modified lipoprotein-like nanoparticle: multifunctional nanoplatform for the combination therapy of Alzheimer's disease. ACS nano, 9 (11), 10801–10816.
  • Huang, S., et al., 2020. Improved physicochemical properties of curcumin-loaded solid lipid nanoparticles stabilized by sodium caseinate-lactose maillard conjugate. Journal of agricultural and food chemistry, 68 (26), 7072–7081.
  • Ibaraki, H., et al., 2020. The effects of surface properties of liposomes on their activity against Pseudomonas aeruginosa PAO-1 biofilm. Journal of drug delivery science and technology, 57, 101754.
  • Imbimbo, B.P., Lombard, J., and Pomara, N., 2005. Pathophysiology of Alzheimer’s disease. Neuroimaging clinics of North America, 1 15 (4), 727–753.
  • Islam, S.U., et al., 2020. Intranasal delivery of nanoformulations: a potential way of treatment for neurological disorders. Molecules, 25 (8), 1929.
  • Janknegt, R., et al., 1992. Liposomal and lipid formulations of amphotericin B. Clinical pharmacokinetics. Clinical pharmacokinetics, 23 (4), 279–291.
  • Jiang, Y., et al., 2019. The optimization design of lactoferrin loaded hupa nanoemulsion for targeted drug transport via intranasal route. International journal of nanomedicine, 14, 9217–9234.
  • Jnaidi, R., Almeida, A.J., and Gonçalves, L.M., 2020. Solid lipid nanoparticles and nanostructured lipid carriers as smart drug delivery systems in the treatment of glioblastoma multiforme. Pharmaceutics, 12 (9), 860.
  • Jojo, G.M., et al., 2019. Formulation and optimization of intranasal nanolipid carriers of pioglitazone for the repurposing in Alzheimer's disease using Box-Behnken design. Drug development and industrial pharmacy, 45 (7), 1061–1072.
  • Joshi, M., and Patravale, V., 2006. Formulation and evaluation of nanostructured lipid carrier (NLC)-based gel of valdecoxib. Drug development and industrial pharmacy, 32 (8), 911–918.
  • Joshi, M., and Patravale, V., 2008. Nanostructured lipid carrier (NLC) based gel of celecoxib. International journal of pharmaceutics, 346 (1–2), 124–132.
  • Juliano, R.L., et al., 1987a. Mechanism of the selective toxicity of amphotericin B incorporated into liposomes. Molecular pharmacology, 31 (1), 1–11.
  • Juliano, R.L., et al., 1987b. Membrane-to-membrane transfer of lipophilic drugs used against cancer or infectious disease. Annals of the New York academy of sciences, 507, 89–103.
  • Kreuter, J., et al., 2002. Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier. Journal of drug targeting, 10 (4), 317–325.
  • Kumar, M., et al., 2014. Intranasal delivery of streptomycin sulfate (STRS) loaded solid lipid nanoparticles to brain and blood. International journal of pharmaceutics, 461 (1–2), 223–233.
  • Kumar, R., et al., 2020. Preparation, characterization and in vitro cytotoxicity of Fenofibrate and Nabumetone loaded solid lipid nanoparticles. Materials science & engineering. C, materials for biological applications, 106, 110184.
  • Lerner, E.N., Van Zanten, E.H., and Stewart, G.R., 2004. Enhanced delivery of octreotide to the brain via transnasal iontophoretic administration. Journal of drug targeting, 12 (5), 273–280.
  • Li, W., et al., 2012. Pharmacokinetic behavior and efficiency of acetylcholinesterase inhibition in rat brain after intranasal administration of galanthamine hydrobromide loaded flexible liposomes. Environmental toxicology and pharmacology, 34 (2), 272–279.
  • Lippens, R.J.J., 1999. Liposomal daunorubicin (DaunoXome) in children with recurrent or progressive brain tumors. Pediatric hematology and oncology, 16 (2), 131–139.
  • Lobaina Mato, Y., 2019. Nasal route for vaccine and drug delivery: features and current opportunities. International journal of pharmaceutics, 572, 118813.
  • Loyse, A., et al., 2013. Cryptococcal meningitis: improving access to essential antifungal medicines in resource-poor countries. The lancet. Infectious diseases, 13 (7), 629–637.
  • Madane, R.G., and Mahajan, H.S., 2016. Curcumin-loaded nanostructured lipid carriers (NLCs) for nasal administration: design, characterization, and in vivo study. Drug delivery, 23 (4), 1326–1334.
  • Maritim, S., Boulas, P., and Lin, Y., 2021. Comprehensive analysis of liposome formulation parameters and their influence on encapsulation, stability and drug release in glibenclamide liposomes. International journal of pharmaceutics, 592, 120051.
  • Martins, P.P., Smyth, H.D.C., and Cui, Z., 2019. Strategies to facilitate or block nose-to-brain drug delivery. International journal of pharmaceutics, 570, 118635.
  • Masjedi, M., et al., 2020. Nose-to-brain delivery of sumatriptan-loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation. The journal of pharmacy and pharmacology, 72 (10), 1341–1351.
  • Md, S., et al., 2015. Nanoneurotherapeutics approach intended for direct nose to brain delivery. Drug development and industrial pharmacy, 41 (12), 1922–1934.
  • Mischler, R., and Metcalfe, I.C., 2002. Inflexal V a trivalent virosome subunit influenza vaccine: production. Vaccine, 20 (Suppl 5), B17–23.
  • Mittal, D., et al., 2014. Insights into direct nose to brain delivery: current status and future perspective. Drug delivery, 21 (2), 75–86.
  • Mohamed, S., et al., 2020. Novel lipid-polymer hybrid nanoparticles incorporated in thermosensitive in situ gel for intranasal delivery of terbutaline sulphate. Journal of microencapsulation, 37 (8), 577–594.
  • Moura, M.C.P.A., et al., 2019. Microemulsions and nanoemulsions applied to iron ore flotation. Journal of materials research and technology, 8 (3), 978–2986.
  • Muntimadugu, E., et al., 2016. Intranasal delivery of nanoparticle encapsulated tarenflurbil: a potential brain targeting strategy for Alzheimer’s disease. European journal of pharmaceutical sciences, 92, 224–234.
  • Narayan, R., et al., 2016. Development of risperidone liposomes for brain targeting through intranasal route. Life sciences, 163, 38–45.
  • Nasr, M., and Wahdan, S.A., 2019. Neuroprotective effects of novel nanosystems simultaneously loaded with vinpocetine and piracetam after intranasal administration. Life sciences, 226 (l), 117–129.
  • Neupane, Y.R., et al., 2014. Lipid based nanocarrier system for the potential oral delivery of decitabine: formulation design, characterization, ex vivo, and in vivo assessment. International journal of pharmaceutics, 477 (1-2), 601–612.
  • Northfelt, D.W., et al., 1996. Doxorubicin encapsulated in liposomes containing surface-bound polyethylene glycol: pharmacokinetics, tumor localization, and safety in patients with AIDS-related Kaposi's sarcoma. Journal of clinical pharmacology, 36 (1), 55–63.
  • Oz, M., Petroianu, G., and Lorke, D.E., 2016. α7-nicotinic acetylcholine receptors: new therapeutic avenues in Alzheimer’s disease. Neuromethods, 13 (5), 613–622.
  • Pardeike, J., et al., 2011. Development of an Itraconazole-loaded nanostructured lipid carrier (NLC) formulation for pulmonary application. International journal of pharmaceutics, 419 (1–2), 329–338.
  • Pashirova, T.N., et al., 2018. Mixed cationic liposomes for brain delivery of drugs by the intranasal route: the acetylcholinesterase reactivator 2-PAM as encapsulated drug model. Colloids and surfaces. B, biointerfaces, 171, 358–367.
  • Patel, M.R., et al., 2016. Paliperidone microemulsion for nose-to-brain targeted drug delivery system: pharmacodynamic and pharmacokinetic evaluation. Drug delivery, 23 (1), 346–354.
  • Patel, S., et al., 2011. Brain targeting of risperidone-loaded solid lipid nanoparticles by intranasal route. Journal of drug targeting, 19 (6), 468–474.
  • Pires, P.C., and Santos, A.O., 2018. Nanosystems in nose-to-brain drug delivery: a review of non-clinical brain targeting studies. Journal of controlled release, 270, 89–100.
  • Pokharkar, V., Patil-Gadhe, A., and Palla, P., 2017. Efavirenz loaded nanostructured lipid carrier engineered for brain targeting through intranasal route: in-vivo pharmacokinetic and toxicity study. Biomedicine & pharmacotherapy, 94, 150–164.
  • Puligundla, P., et al., 2017. Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols. Journal of functional foods, 34, 139–151.
  • Pyo, Y.C., et al., 2020. Chitosan-coated nanostructured lipid carriers of fenofibrate with enhanced oral bioavailability and efficacy. Colloids and surfaces. B, biointerfaces, 196, 111331.
  • Qian, S., He, L., et al., 2018. Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease. Life sciences, 207, 428–435.
  • Rajput, A.P., and Butani, S.B., 2019. Resveratrol anchored nanostructured lipid carrier loaded in situ gel via nasal route: formulation, optimization and in vivo characterization. Journal of drug delivery science and technology, 51, 214–233.
  • Robinson, R.F., and Nahata, M.C., 1999. A comparative review of conventional and lipid formulations of amphotericin B. Journal of clinical pharmacy and therapeutics, 24 (4), 249–257.
  • Sabir, F., Ismail, R., and Csoka, I., 2020. Nose-to-brain delivery of antiglioblastoma drugs embedded into lipid nanocarrier systems: status quo and outlook. Drug discovery today, 25 (1), 185–194.
  • Salem, H.F., et al., 2019. Brain targeting of resveratrol through intranasal lipid vesicles labelled with gold nanoparticles: in vivo evaluation and bioaccumulation investigation using computed tomography and histopathological examination. Journal of drug targeting, 27 (10), 1127–1134.
  • Scheideler, M., Vidakovic, I., and Prassl, R., 2020. Lipid nanocarriers for microRNA delivery. Chemistry and physics of lipids, 226, 104837.
  • Shah, B., et al., 2015a. Application of quality by design approach for intranasal delivery of rivastigmine loaded solid lipid nanoparticles: effect on formulation and characterization parameters. European journal of pharmaceutical sciences, 78, 54–66.
  • Shah, B., et al., 2016. Intranasal delivery of venlafaxine loaded nanostructured lipid carrier: risk assessment and QbD based optimization. Journal of drug delivery science and technology, 33, 37–50.
  • Shah, B.M., et al., 2015b. Nose to brain microemulsion-based drug delivery system of rivastigmine: formulation and ex-vivo characterization. Drug delivery, 22 (7), 918–930.
  • Shinde, R.L., and Devarajan, P.V., 2017. Docosahexaenoic acid-mediated, targeted and sustained brain delivery of curcumin microemulsion. Drug delivery, 24 (1), 152–161.
  • Singh, A., et al., 2020. Silymarin encapsulated nanoliquid crystals for improved activity against beta amyloid induced cytotoxicity. International journal of biological macromolecules, 149, 1198–1206.
  • Sintov, A.C., 2020. AmyloLipid nanovesicles: a self-assembled lipid-modified starch hybrid system constructed for direct nose-to-brain delivery of curcumin. International journal of pharmaceutics, 588, 119725.
  • Sonali, S, et al., 2016. RGD-TPGS decorated theranostic liposomes for brain targeted delivery. Colloids and surfaces B: Biointerfaces, 147, 129–141.
  • Sood, S., Jain, K., and Gowthamarajan, K., 2014. Optimization of curcumin nanoemulsion for intranasal delivery using design of experiment and its toxicity assessment. Colloids and Surfaces B Biointerfaces, 113, 330–337.
  • Teixeira, M.I., et al., 2020. Current insights on lipid nanocarrier-assisted drug delivery in the treatment of neurodegenerative diseases. European journal of pharmaceutics and biopharmaceutics, 149, 192–217.
  • Teleanu, D.M., et al., 2019. Nanomaterials for drug delivery to the central nervous system. Nanomaterials, 9 (3), 371.
  • Tong-Un, T., et al., 2010. Nasal administration of quercetin liposomes improves memory impairment and neurodegeneration in animal model of Alzheimer’s disease. American journal of agricultural and biological science, 5 (3), 286–293.
  • Trucillo, P., and Reverchon, E., 2021. Production of PEG-coated liposomes using a continuous supercritical assisted process. The journal of supercritical fluids, 167, 105048.
  • Ul Islam, S., et al., 2020. Intranasal delivery of nanoformulations: a potential way of treatment for neurological disorders. Molecules, 25 (8), 1929.
  • Urandur, S., et al., 2018. Anisamide-anchored lyotropic nano-liquid crystalline particles with AIE effect: a smart optical beacon for tumor imaging and therapy. ACS applied materials & interfaces, 10 (15), 12960–12974.
  • van Leeuwen, E., Hampton, M.B., and Smyth, L.C.D., 2020. Redox signalling and regulation of the blood-brain barrier. The international journal of biochemistry & cell biology, 125, 105794.
  • Vieira, D.B., and Gamarra, L.F., 2016. Getting into the brain: liposome-based strategies for effective drug delivery across the blood-brain barrier. International journal of nanomedicine, 11, 5381–5414.
  • Vishwakarma, N., et al., 2019. Lipid-based nanocarriers for lymphatic transportation. AAPS PharmSciTech, 20 (2), 83.
  • Wan, Y., et al., 2020. Meta-analysis of the Alzheimer’s disease human brain transcriptome and functional dissection in mouse models. Cell reports, 32 (2), 107908.
  • Wavikar, P., Pai, R., and Vavia, P., 2017. Nose to brain delivery of rivastigmine by in situ gelling cationic nanostructured lipid carriers: enhanced brain distribution and pharmacodynamics. Journal of pharmaceutical sciences, 106 (12), 3613–3622.
  • Wavikar, P.R., and Vavia, P.R., 2015. Rivastigmine-loaded in situ gelling nanostructured lipid carriers for nose to brain delivery. Journal of liposome research, 25 (2), 141–149.
  • Weissig, V., Pettinger, T.K., and Murdock, N., 2014. Nanopharmaceuticals (part 1): products on the market. International journal of nanomedicine, 9, 4357–4373.
  • Wen, M.M., et al., 2017. Nanotechnology-based drug delivery systems for Alzheimer's disease management: technical, industrial, and clinical challenges. Journal of controlled release, 245, 95–107.
  • Wilson, B., and Geetha, K.M., 2020. Neurotherapeutic applications of nanomedicine for treating Alzheimer's disease. Journal of controlled release, 325, 25–37.
  • Wu, H., et al., 2012. A novel small Odorranalectin-bearing cubosomes: preparation, brain delivery and pharmacodynamic study on amyloid-β₂₅₋₃₅-treated rats following intranasal administration. European journal of pharmaceutics and biopharmaceutics, 80 (2), 368–378.
  • Wu, Y., et al., 2020. Predicting Alzheimer's disease based on survival data and longitudinally measured performance on cognitive and functional scales. Psychiatry research, 291, 113201.
  • Xu, Y., Wei, L., and Wang, H., 2020. Progress and perspectives on nanoplatforms for drug delivery to the brain. Journal of drug delivery science and technology, 57, 101636.
  • Yang, H., 2010. Nanoparticle-mediated brain-specific drug delivery, imaging, and diagnosis. Pharmaceutical research, 27 (9), 1759–1771.
  • Yang, S.J., et al., 2020. Functional linear regression model with randomly censored data: predicting conversion time to Alzheimer’s disease. Computational statistics & data analysis, 150, 107009.
  • Yang, Z.Z., et al., 2013. Enhanced brain distribution and pharmacodynamics of rivastigmine by liposomes following intranasal administration. International journal of pharmaceutics, 452 (1–2), 344–354.
  • Yu, J., et al., 2020. Remote loading paclitaxel-doxorubicin prodrug into liposomes for cancer combination therapy. Acta pharmaceutica sinica. B, 10 (9), 1730–1740.
  • Zhang, Y., et al., 2021. Brain-targeted delivery of obidoxime, using aptamer-modified liposomes, for detoxification of organophosphorus compounds. Journal of controlled release, 329, 1117–1128.
  • Zheng, X., et al., 2015. Intranasal H102 peptide-loaded liposomes for brain delivery to treat Alzheimer's disease. Pharmaceutical research, 32 (12), 3837–3849.
  • Zhou, Y., et al., 2018. Crossing the blood-brain barrier with nanoparticles. Journal of controlled release, 270, 290–303.

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