The tiny big world of solid lipid nanoparticles and nanostructured lipid carriers: an updated review

References

• Abdel Fadeel, D.A., Kamel, R., and Fadel, M., 2020. PEGylated lipid nanocarrier for enhancing photodynamic therapy of skin carcinoma using curcumin: in-vitro/in-vivo studies and histopathological examination. Scientific reports, 10 (1), 10435.
   PubMed Web of Science ®Google Scholar
• Abdel-Mageed, H.M., Ezz, N., and Radwan, R., 2019a. Bio-inspired trypsin-chitosan cross-linked enzyme aggregates: a versatile approach for stabilization through carrier-free immobilization. BioTechnologia, 100 (3), 301–309.
   Google Scholar
• Abdel-Mageed, H.M., et al., 2021a. Nanoparticles in nanomedicine: a comprehensive updated review on current status, challenges and emerging opportunities. Journal of microencapsulation, 38 (6), 414–436.
   PubMed Web of Science ®Google Scholar
• Abdel-Mageed, H.M., et al., 2021b. Biotechnology approach using watermelon rind for optimization of α-amylase enzyme production from Trichoderma virens using response surface methodology under solid-state fermentation. Folia microbiologica. https://doi.org/https://doi.org/10.1007/s12223-021-00929-2
   PubMed Web of Science ®Google Scholar
• Abdel-Mageed, H.M., et al., 2021c. Engineering lipase enzyme nano-powder using nano spray dryer BÜCHI B-90: experimental and factorial design approach for a stable biocatalyst production. Journal of pharmaceutical innovation, 16 (4), 759–771.
   Web of Science ®Google Scholar
• Abdel-Mageed, H.M., et al., 2019b. Bioconjugation as a smart immobilization approach for α-amylase enzyme using stimuli-responsive Eudragit-L100 polymer: a robust biocatalyst for applications in pharmaceutical industry. Artificial cells, nanomedicine, and biotechnology, 47 (1), 2361–2368.
   PubMed Web of Science ®Google Scholar
• Abuelezz, N., et al., 2020. Nanocurcumin alleviates insulin resistance and pancreatic deficits in polycystic ovary syndrome rats: insights on PI3K/AkT/mTOR and TNF-α modulations. Life sciences, 256, 118003.
   PubMed Web of Science ®Google Scholar
• Adams, D., et al., 2017. Trial design and rationale for APOLLO, a phase 3, placebo-controlled study of patisiran in patients with hereditary ATTR amyloidosis with polyneuropathy. BMC neurology, 17 (1), 181.
   PubMed Web of Science ®Google Scholar
• Akanda, M., et al., 2021. Bioconjugated solid lipid nanoparticles (SLNs) for targeted prostate cancer therapy. International journal of pharmaceutics, 599, 120416.
   PubMed Web of Science ®Google Scholar
• Almeida, H., et al., 2017. Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen. Pharmaceutical development and technology, 22 (3), 336–349.
   PubMed Web of Science ®Google Scholar
• Apostolou, M., et al., 2021. The effects of solid and liquid lipids on the physicochemical properties of nanostructured lipid carriers. Journal of pharmaceutical sciences, 110 (8), 2859–2872.
   PubMed Web of Science ®Google Scholar
• Banerjee, I., et al., 2019. A peptide-modified solid lipid nanoparticle formulation of paclitaxel modulates immunity and outperforms dacarbazine in a murine melanoma model. Biomaterials science, 7 (3), 1161–1178.
   PubMed Web of Science ®Google Scholar
• Bari, E., et al., 2021. 3D bioprinted scaffolds containing mesenchymal stem/stromal lyosecretome: next generation controlled release device for bone regenerative medicine. Pharmaceutics, 13 (4), 515.
   PubMed Web of Science ®Google Scholar
• Begines, B., et al., 2020. Polymeric nanoparticles for drug delivery: recent developments and future prospects. Nanomaterials, 10 (7), 1403.
   Web of Science ®Google Scholar
• Bhalekar, M.R., et al., 2017. Formulation of piperine solid lipid nanoparticles (SLN) for treatment of rheumatoid arthritis. Drug development and industrial pharmacy, 43 (6), 1003–1010.
   PubMed Web of Science ®Google Scholar
• Campos, J.R., et al., 2020. Solid lipid nanoparticles (SLN): prediction of toxicity, metabolism, fate and physicochemical properties, in nanopharmaceuticals. In: R. Shegokar, ed. Expectations and realities of multifunctional drug delivery systems. San Diego, CA: Elsevier, 1–15.
   Google Scholar
• Casalini, T., et al., 2019. Molecular modeling for nanomaterial-biology interactions: opportunities, challenges, and perspectives. Frontiers in bioengineering and biotechnology, 7, 268. a
   PubMed Web of Science ®Google Scholar
• Ceylan, H., et al., 2019. 3D-printed biodegradable microswimmer for theranostic cargo delivery and release. ACS nano, 13 (3), 3353–3362.
   PubMed Web of Science ®Google Scholar
• Chen, C.C., et al., 2010. Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. European journal of pharmaceutics and biopharmaceutics, 74 (3), 474–482.
   PubMed Web of Science ®Google Scholar
• Chirio, D., et al., 2019. Development of solid lipid nanoparticles by cold dilution of microemulsions: curcumin loading, preliminary in vitro studies, and biodistribution. Nanomaterials, 9 (2), 230.
   Web of Science ®Google Scholar
• Christaki, E., Marcou, M., and Tofarides, A., 2020. Antimicrobial resistance in bacteria: mechanisms, evolution, and persistence. Journal of molecular evolution, 88 (1), 26–40.
   PubMed Web of Science ®Google Scholar
• Christophersen, P.C., et al., 2014. Solid lipid particles for oral delivery of peptide and protein drugs II-the digestion of trilaurin protects desmopressin from proteolytic degradation. Pharmaceutical research, 31 (9), 2420–2428.
   PubMed Web of Science ®Google Scholar
• Cullis, P.R. and Hope, M.J., 2017. Lipid nanoparticle systems for enabling gene therapies. Molecular therapy, 25 (7), 1467–1475.
   PubMed Web of Science ®Google Scholar
• Dhiman, N., et al., 2021. Lipid nanoparticles as carriers for bioactive delivery. Frontiers in chemistry, 9, 580118. https://doi.org/https://doi.org/10.3389/fchem.2021.580118
   PubMed Web of Science ®Google Scholar
• dos Santos, J., et al., 2021. 3D printing and nanotechnology: a multiscale alliance in personalized medicine. Advanced functional materials, 31 (16), 20096912009691..
   Web of Science ®Google Scholar
• El-Assal, M.I.A., 2017. Acyclovir loaded solid lipid nanoparticle based cream: a novel drug delivery system. International journal of drug delivery technology, 7, 52–62.
   Google Scholar
• Elbahwy, I.A., et al., 2017. Enhancing bioavailability and controlling the release of glibenclamide from optimized solid lipid nanoparticles. Journal of drug delivery science and technology, 38, 78–89.
   Web of Science ®Google Scholar
• Garcia-Fuentes, M., et al., 2004. Application of NMR spectroscopy to the characterization of PEG-stabilized lipid nanoparticles. Langmuir, 20 (20), 8839–8845.
   PubMed Web of Science ®Google Scholar
• Ghanbarzadeh, S., et al., 2015. Enhanced stability and dermal delivery of hydroquinone using solid lipid nanoparticles. Colloids and surfaces. B, biointerfaces, 136, 1004–1010.
   PubMed Web of Science ®Google Scholar
• González-Paredes, A., et al., 2019. Solid lipid nanoparticles for the delivery of anti-microbial oligonucleotides. European journal of pharmaceutics and biopharmaceutics, 134, 166–177.
   PubMed Web of Science ®Google Scholar
• Gupta, K.M., et al., 2020. Encapsulation of ferulic acid in lipid nanoparticles as antioxidant for skin: mechanistic understanding through experiment and molecular simulation. ACS applied nano materials, 3 (6), 5351–5361.
   Web of Science ®Google Scholar
• Gupta, K.M., Das, S., and Chow, P.S., 2021. Molecular dynamics simulations to elucidate translocation and permeation of active from lipid nanoparticle to skin: complemented by experiments. Nanoscale, 13 (30), 12916–12928.
   PubMed Web of Science ®Google Scholar
• Hallan, S.S., et al., 2021. Challenges in the physical characterization of lipid nanoparticles. Pharmaceutics, 13 (4), 549.
   PubMed Web of Science ®Google Scholar
• Hamishehkar, H., et al., 2016. Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia. Drug development and industrial pharmacy, 42 (6), 846–853.
   PubMed Web of Science ®Google Scholar
• Hauser, E.A., 1955. The history of colloid science: in memory of Wolfgang Ostwald. Journal of chemical education, 32 (1), 2.
   Google Scholar
• He, C., et al., 2021a. A solid lipid coated calcium peroxide nanocarrier enables combined cancer chemo/chemodynamic therapy with O2/H2O2 self-sufficiency. Acta biomaterialia, 122, 354–364.
   PubMed Web of Science ®Google Scholar
• He, X.L., et al., 2021b. Solid lipid nanoparticles loading with curcumin and dexanabinol to treat major depressive disorder. Neural regeneration research, 16 (3), 537–542.
   PubMed Web of Science ®Google Scholar
• Hou, X., et al., 2021. Lipid nanoparticles for mRNA delivery. Nature reviews. Materials, 6, 1–17. https://doi.org/https://doi.org/10.1038/s41578-021-00358-0
   Web of Science ®Google Scholar
• Jain, A.K. and Thareja, S., 2020. Solid lipid nanoparticles. In: I. Bhushan, V. Singh, and D. Tripathi, eds. Nanomaterials and environmental biotechnology. Cham, Switzerland: Springer, 221–249.
   Google Scholar
• Jaiswal, P., Gidwani, B., and Vyas, A., 2016. Nanostructured lipid carriers and their current application in targeted drug delivery. Artificial cells, nanomedicine, and biotechnology, 44 (1), 27–40.
   PubMed Web of Science ®Google Scholar
• Ji, P., et al., 2016. Naringenin-loaded solid lipid nanoparticles: preparation, controlled delivery, cellular uptake, and pulmonary pharmacokinetics. Drug design, development and therapy, 10, 911–925.
   PubMed Web of Science ®Google Scholar
• Joshi, M.D. and Müller, R.H., 2009. Lipid nanoparticles for parenteral delivery of actives. European journal of pharmaceutics and biopharmaceutics, 71 (2), 161–172.
   PubMed Web of Science ®Google Scholar
• Joshi, M. and Patravale, V., 2008. Nanostructured lipid carrier (NLC) based gel of celecoxib. International journal of pharmaceutics, 346 (1-2), 124–132.
   PubMed Web of Science ®Google Scholar
• Kamaraj, S.-K., 2020. The perspective on bio-nano interface technology for covid-19. Frontiers in nanotechnology, 2, 586250.
   Google Scholar
• Kang, J.H., et al., 2019. Preparation and evaluation of tacrolimus-loaded thermosensitive solid lipid nanoparticles for improved dermal distribution. International journal of nanomedicine, 14, 5381–5396.
   PubMed Web of Science ®Google Scholar
• Keck, C.M. and Müller, R.H., 2013. Nanotoxicological classification system (NCS) - a guide for the risk-benefit assessment of nanoparticulate drug delivery systems. European journal of pharmaceutics and biopharmaceutics, 84 (3), 445–448.
   PubMed Web of Science ®Google Scholar
• Keck, C.M., et al., 2014. Formulation of solid lipid nanoparticles (SLN): the value of different alkyl polyglucoside surfactants. International journal of pharmaceutics, 474, 33–41. https://doi.org/https://doi.org/10.1016/J.IJPHARM.2014.08.008
   Google Scholar
• Kowalski, P.S., et al., 2019. Delivering the messenger: advances in technologies for therapeutic mRNA delivery. Molecular therapy, 27 (4), 710–728.
   PubMed Web of Science ®Google Scholar
• Kreuter, J., 2007. Nanoparticles-a historical perspective. International journal of pharmaceutics, 331 (1), 1–10.
   PubMed Web of Science ®Google Scholar
• Kulkarni, J.A., Cullis, P.R., and van der Meel, R., 2018. Lipid nanoparticles enabling gene therapies: from concepts to clinical utility. Nucleic acid therapeutics, 28 (3), 146–157.
   PubMed Web of Science ®Google Scholar
• Kuo, Y.-C. and Liang, C.-T., 2011. Inhibition of human brain malignant glioblastoma cells using carmustine-loaded catanionic solid lipid nanoparticles with surface anti-epithelial growth factor receptor. Biomaterials, 32 (12), 3340–3350.
   PubMed Web of Science ®Google Scholar
• Kurakula, M., et al., 2016. Solid lipid nanoparticles for transdermal delivery of avanafil: optimization, formulation, in-vitro and ex-vivo studies. Journal of liposome research, 26 (4), 288–296.
   PubMed Web of Science ®Google Scholar
• Lee, S.J., et al., 2020. Integrating cold atmospheric plasma with 3D printed bioactive nanocomposite scaffold for cartilage regeneration. Materials science & engineering. C, materials for biological applications, 111, 110844. https://doi.org/https://doi.org/10.1016/j.msec.2020.110844
   PubMed Web of Science ®Google Scholar
• Lin, C.H., et al., 2017. Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers. Journal of food and drug analysis, 25 (2), 219–234.
   PubMed Web of Science ®Google Scholar
• Liu, Y.J., et al., 2015. Modulating drug release and enhancing the oral bioavailability of torcetrapib with solid lipid dispersion formulations. AAPS PharmSciTech, 16 (5), 1091–1100.
   PubMed Web of Science ®Google Scholar
• Madan, J., et al., 2013. Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells. Nanomedicine, 9 (4), 492–503.
   PubMed Web of Science ®Google Scholar
• Magalhães, J., et al., 2020. Lipid nanoparticles biocompatibility and cellular uptake in a 3D human lung model. Nanomedicine, 15 (3), 259–271. https://doi.org/https://doi.org/10.2217/nnm-2019-0256
   PubMed Web of Science ®Google Scholar
• Mishra, V., et al., 2018. Solid lipid nanoparticles: emerging colloidal nano drug delivery system. Pharmaceutics, 10 (4), 191.
   PubMed Web of Science ®Google Scholar
• Mitchell, M.J., et al., 2021. Engineering precision nanoparticles for drug delivery. Nature reviews. Drug discovery, 20 (2), 101–124. https://doi.org/https://doi.org/10.1038/s41573-020-0090-8s
   PubMed Web of Science ®Google Scholar
• Montoto, S.S., Muraca, G., and Ruiz, M.E., 2020. Solid lipid nanoparticles for drug delivery: pharmacological and biopharmaceutical aspects. Frontiers in molecular biosciences, 7, 587997.
   PubMed Web of Science ®Google Scholar
• Müller, R.H., Mäder, K., and Gohla, S., 2000. Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art. European journal of pharmaceutics and biopharmaceutics, 50 (1), 161–177.
   PubMed Web of Science ®Google Scholar
• Müller, R.H., Radtke, M., and Wissing, S.A., 2002a. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Advanced drug delivery reviews, 54 (1), S131–S155.
   PubMed Web of Science ®Google Scholar
• Müller, R.H., Radtke, M., and Wissing, S.A., 2002b. Nanostructured lipid matrices for improved microencapsulation of drugs. International journal of pharmaceutics, 242 (1–2), 121–128.
   PubMed Web of Science ®Google Scholar
• Neves, A.R., Queiroz, J.F., and Reis, S., 2016. Brain-targeted delivery of resveratrol using solid lipid nanoparticles functionalized with apolipoprotein E. Journal of nanobiotechnology, 14, 27.
   PubMed Web of Science ®Google Scholar
• Neves, A.R., et al., 2017. Apo E-functionalization of Solid Lipid Nanoparticles enhances brain drug delivery: uptake mechanism and transport pathways. Bioconjugate chemistry, 28 (4), 995–1004.
   PubMed Web of Science ®Google Scholar
• Neves, A.R., et al., 2015. Solid lipid nanoparticles as a vehicle for brain-targeted drug delivery: two new strategies of functionalization with apolipoprotein E. Nanotechnology, 26 (49), 495103.
   PubMed Web of Science ®Google Scholar
• Ortiz, A.C., et al., 2021. Development of a nanostructured lipid carrier (NLC) by a low-energy method, comparison of release kinetics and molecular dynamics simulation. Pharmaceutics, 13 (4), 531. pharmaceutics13040531
   PubMed Web of Science ®Google Scholar
• Oumzil, K., et al., 2016. Solid lipid nanoparticles for image-guided therapy of atherosclerosis. Bioconjugate chemistry, 27 (3), 569–575.
   PubMed Web of Science ®Google Scholar
• Pandya, N.T., et al., 2018. Solid lipid nanoparticles as an efficient drug delivery system of olmesartan medoxomil for the treatment of hypertension. Colloids and surfaces. B, biointerfaces, 165, 37–44.
   PubMed Web of Science ®Google Scholar
• Pastor, F., et al., 2018. An RNA toolbox for cancer immunotherapy. Nature reviews. Drug discovery, 17 (10), 751–767.
   PubMed Web of Science ®Google Scholar
• Prathipati, B., et al., 2021. Neuroprotective effects of curcumin loaded solid lipid nanoparticles on homocysteine induced oxidative stress in vascular dementia. Current research in behavioral sciences, 2, 100029. doi.org/https://doi.org/10.1016/j.crbeha.2021.100029.
   Google Scholar
• Permana, A.D., et al., 2019. Solid lipid nanoparticle-based dissolving microneedles: a promising intradermal lymph targeting drug delivery system with potential for enhanced treatment of lymphatic filariasis. Journal of controlled release, 316, 34–52.
   PubMed Web of Science ®Google Scholar
• Pink, D.L., et al., 2021. Interplay of lipid and surfactant: impact on nanoparticle structure. Journal of colloid and interface science, 597, 278–288.
   PubMed Web of Science ®Google Scholar
• Pink, D.L., et al., 2019. On the structure of solid lipid nanoparticles. Small, 15 (45), e1903156.
   PubMed Web of Science ®Google Scholar
• Sathya, S., et al., 2018. α-Bisabolol loaded solid lipid nanoparticles attenuates Aβ aggregation and protects Neuro-2a cells from Aβ induced neurotoxicity. Journal of molecular liquids, 264, 431–441.
   Web of Science ®Google Scholar
• Shah, R.M., et al., 2016. Microwave-assisted formulation of solid lipid nanoparticles loaded with non-steroidal anti-inflammatory drugs. International journal of pharmaceutics, 515 (1–2), 543–554.
   PubMed Web of Science ®Google Scholar
• Sharma, R.K., et al., 2013. Solid lipid nanoparticles as a carrier of metformin for transdermal delivery. International journal of drug delivery, 5, 137–145.
   Google Scholar
• Shinde, S.V., et al., 2019. Lipid nanoparticles for transdermal delivery of celecoxib: an in vitro and in vivo investigation. Indian drugs, 56, 38–48.
   Google Scholar
• Siafaka, P.I., et al., 2016. Surface modified multifunctional and stimuli responsive nanoparticles for drug targeting: current status and uses. International journal of molecular sciences, 17 (9), 1440.
   PubMed Web of Science ®Google Scholar
• Silva, A.C., et al., 2012. Long-term stability, biocompatibility and oral delivery potential of risperidone-loaded solid lipid nanoparticles. International journal of pharmaceutics, 436 (1–2), 798–805.
   PubMed Web of Science ®Google Scholar
• Sonawane, R., et al., 2014. Solid lipid nanoparticles-loaded topical gel containing combination drugs: an approach to offset psoriasis. Expert opinion on drug delivery, 11 (12), 1833–1847.
   PubMed Web of Science ®Google Scholar
• Souto, E., Almeida, A., and Müller, R., 2007. Lipid nanoparticles (SLN®, NLC®) for cutaneous drug delivery: structure, protection and skin effects. Journal of biomedical nanotechnology, 3 (4), 317–331.
   Web of Science ®Google Scholar
• Subramaniam, B., Siddik, Z.H., and Nagoor, N.H., 2020. Optimization of nanostructured lipid carriers: understanding the types, designs, and parameters in the process of formulations. Journal of nanoparticle research, 22 (6), 141. https://doi.org/https://doi.org/10.1007/s11051-020-04848-0
   Web of Science ®Google Scholar
• Taratula, O., et al., 2013. Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA. Journal of controlled release, 171 (3), 349–357.
   PubMed Web of Science ®Google Scholar
• Tatke, A., et al., 2018. In situ gel of triamcinolone acetonide-loaded solid lipid nanoparticles for improved topical ocular delivery: tear kinetics and ocular disposition studies. Nanomaterials, 9 (1), 33.
   Web of Science ®Google Scholar
• Tupal, A., et al., 2016. Dermal delivery of doxorubicin-loaded solid lipid nanoparticles for the treatment of skin cancer. Journal of microencapsulation, 33 (4), 372–380.
   PubMed Web of Science ®Google Scholar
• Üstündağ-Okur, N., et al., 2015. Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery: evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis. Expert opinion on drug delivery, 12 (11), 1791–1807.
   PubMed Web of Science ®Google Scholar
• Vaghasiya, H., Kumar, A., and Sawant, K., 2013. Development of solid lipid nanoparticles based controlled release system for topical delivery of terbinafine hydrochloride. European journal of pharmaceutical sciences, 49 (2), 311–322.
   PubMed Web of Science ®Google Scholar
• Wang, F., Kream, R.M., and Stefano, G.B., 2020. An evidence based perspective on mRNA-SARS-CoV-2 vaccine development. Medical science monitor, 26, e924700.
   PubMed Web of Science ®Google Scholar
• Wang, Q., et al., 2018. Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles. International journal of pharmaceutics, 550 (1–2), 24–34.
   PubMed Web of Science ®Google Scholar
• Wavikar, P., Pai, R., and Vavia, P., 2017. Nose to brain delivery of rivastigmine by in situ gelling cationic nanostructured lipid carriers: enhanced brain distribution and pharmacodynamics. Journal of pharmaceutical sciences, 106 (12), 3613–3622.
   PubMed Web of Science ®Google Scholar
• Wissing, S.A. and Müller, R.H., 2001. Solid lipid nanoparticles (SLN)–a novel carrier for UV blockers. Die pharmazie, 56 (10), 783–786.
   PubMed Web of Science ®Google Scholar
• Wissing, S.A. and Müller, R.H., 2003. Cosmetic applications for solid lipid nanoparticles (SLN). International journal of pharmaceutics, 254 (1), 65–68.
   PubMed Web of Science ®Google Scholar
• Yoon, G., Park, J.W., and Yoon, I.S., 2013. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery. Journal of pharmaceutical investigation, 43 (5), 353–362.
   Google Scholar
• Zhang, J., et al., 2015. Biotinylated epidermal growth factor surface modified lipid nanoparticles to enhance the targeting efficiency in liver cancer therapy. Journal of biomaterials and tissue engineering, 5 (2), 135–141.
   Web of Science ®Google Scholar
• Zhang, H., et al., 2020. Aerosolizable lipid nanoparticles for pulmonary delivery of mRNA through design of experiments. Pharmaceutics, 12 (11), 1042.
   PubMed Web of Science ®Google Scholar
• Zhang, J., et al., 2014. 3D-printed magnetic Fe3O4/MBG/PCL composite scaffolds with multifunctionality of bone regeneration, local anticancer drug delivery and hyperthermia. Journal of materials chemistry. B, 2 (43), 7583–7595.
   PubMed Web of Science ®Google Scholar
• Zhuang, C.Y., et al., 2010. Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability. International journal of pharmaceutics, 394 (1–2), 179–185.
   PubMed Web of Science ®Google Scholar