A new approach for the treatment of Alzheimer’s disease: insulin-quantum dots

References

• Aderibigbe, B.A., 2018. In situ-based gels for nose to brain delivery for the treatment of neurological diseases. Pharmaceutics, 10 (2), 40. doi: 10.3390/pharmaceutics10020040.
   PubMed Web of Science ®Google Scholar
• Albrecht, C., and Joseph, R. 2008. Lakowicz: Principles of fluorescence spectroscopy, 3rd Edition. Analytical and bioanalytical chemistry, 390 (5), 1223–1224. doi: 10.1007/s00216-007-1822-x.
   Google Scholar
• Aydin, A.C., 2020. Alzheimer disease and dementia. Journal of literature pharmacy sciences, 9 (2), 125–136. doi: 10.5336/pharmsci.2019-71813.
   Google Scholar
• Bahadur, S., and Pathak, K., 2012. Physicochemical and physiological considerations for efficient nose-to-brain targeting. Expert opinion on drug delivery, 9 (1), 19–31. doi: 10.1517/17425247.2012.636801.
   PubMed Web of Science ®Google Scholar
• Ban, M.M., et al., 2018. In-situ gel for nasal drug delivery. International journal of development research, 8, 18763–18769.
   Google Scholar
• Brus, L.E., 1983. A simple model for the ionization potential, electron affinity, and aqueous redox potentials of small semiconductor crystallites. The journal of chemical physics, 79 (11), 5566–5571. doi: 10.1063/1.445676.
   Web of Science ®Google Scholar
• Camlik, G., et al., 2022. Development of composite carbon quantum dots-insulin formulation for oral administration. Journal of drug delivery science and technology, 76, 103833. doi: 10.1016/j.jddst.2022.103833.
   Web of Science ®Google Scholar
• de la Monte, S.M., and Wands, J.R., 2005. Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimer’s disease. Journal of alzheimer’s disease: JAD, 7 (1), 45–61. doi: 10.3233/JAD-2005-7106.
   PubMed Web of Science ®Google Scholar
• Deb, J., et al., 2016. Collectıon, purıfıcatıon and phytochemıcal screenıng of a natural gum for oral controlled drug delıvery system.
   Google Scholar
• Dhas, N.L., Kudarha, R.R., and Mehta, T.A., 2019. Intranasal delivery of nanotherapeutics/nanobiotherapeutics for the treatment of Alzheimer’s disease: A proficient approach. Critical Reviews™ in therapeutic drug carrier systems, 36 (5), 373–447. doi: 10.1615/CritRevTherDrugCarrierSyst.2018026762.
   PubMed Web of Science ®Google Scholar
• Erdő, F., et al., 2018. Evaluation of intranasal delivery route of drug administration for brain targeting. Brain research bulletin, 143, 155–170. doi: 10.1016/j.brainresbull.2018.10.009.
   PubMed Web of Science ®Google Scholar
• FABRICANT ND. 1957. The Topical Temperature of Clinically Normal Nasal and Pharyngeal Mucous Membranes. AMA arch otolaryngol, 66, 275–277. doi: 10.1001/archotol.1957.03830270033006.
   PubMedGoogle Scholar
• Fong, J. F. Y., Ng, Y. H., and Ng, S. M., 2018. Chapter 7 – Carbon dots as a new class of light emitters for biomedical diagnostics and therapeutic applications. In: Alexandru Mihai Grumezescu, ed. Fullerens, Graphenes and Nanotubes. Cambridge, MA: William Andrew Publishing, 227–295. doi: 10.1016/B978-0-12-813691-1.00007-5.
   Google Scholar
• Gerozissis, K., 2003. Brain ınsulin: regulation, mechanisms of action and functions. Cellular and molecular neurobiology, 23 (1), 1–25. doi: 10.1023/A:1022598900246.
   PubMed Web of Science ®Google Scholar
• Giuliano, E., et al., 2018. Mucosal applications of poloxamer 407-based hydrogels: an overview. Pharmaceutics, 10 (3), 159. doi: 10.3390/pharmaceutics10030159.
   PubMed Web of Science ®Google Scholar
• Hagiwara, K., Horikoshi, S., and Serpone, N., 2021. Photoluminescent Carbon Quantum Dots: Synthetic Approach-es and Photophysical Properties. Chemistry (weinheim an der bergstrasse, Germany), 27 (37), 9466–9481. doi: 10.1002/chem.202100823.
   PubMed Web of Science ®Google Scholar
• Hoyer, S., 2002. The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update. Journal of neural transmission (vienna, Austria: 1996), 109 (3), 341–360. doi: 10.1007/s007020200028.
   PubMed Web of Science ®Google Scholar
• Jha, S., et al., 2018. Pharmaceutical potential of quantum dots. Artificial cells, nanomedicine, and biotechnology, 46 (sup1), 57–65. doi: 10.1080/21691401.2017.1411932.
   PubMed Web of Science ®Google Scholar
• Karthivashan, G., et al., 2018. Therapeutic strategies and nano-drug delivery applications in management of aging Alzheimer’s disease. Drug delivery, 25 (1), 307–320. doi: 10.1080/10717544.2018.1428243.
   PubMed Web of Science ®Google Scholar
• Keller, L.-A., Merkel, O., and Popp, A., 2022. Intranasal drug delivery: opportunities and toxicologic challenges during drug development. Drug delivery and translational research, 12 (4), 735–757. doi: 10.1007/s13346-020-00891-5.
   PubMed Web of Science ®Google Scholar
• Kuang, H., et al., 2011. Recent developments in analytical applications of quantum dots. TrAC trends in analytical chemistry, 30 (10), 1620–1636. doi: 10.1016/j.trac.2011.04.022.
   Web of Science ®Google Scholar
• Li, W., et al., 2012. Pharmacokinetic behavior and efficiency of acetylcholinesterase inhibition in rat brain after intranasal administration of galanthamine hydrobromide loaded flexible liposomes. Environmental toxicology and pharmacology, 34 (2), 272–279. doi: 10.1016/j.etap.2012.04.012.
   PubMed Web of Science ®Google Scholar
• Lindemann, J., et al., 2002. Nasal mucosal temperature during respiration. Clinical otolaryngology and allied sciences, 27 (3), 135–139. doi: 10.1046/j.1365-2273.2002.00544.x.
   PubMed Web of Science ®Google Scholar
• Liu, P.-P., et al., 2019. History and progress of hypotheses and clinical trials for Alzheimer’s disease. Signal transduction and targeted therapy, 4 (1), 29. doi: 10.1038/s41392-019-0063-8.
   PubMed Web of Science ®Google Scholar
• Masters, C.L., et al., 2015. Alzheimer’s disease. Nature reviews disease primers, 1 (1), 15056. doi: 10.1038/nrdp.2015.56.
   PubMed Web of Science ®Google Scholar
• Meenakshi, P., Hetal, T., and Kasture, P.V., 2010. Preparation and evaluation of thermoreversible formulations of flunarizine hydrochloride for nasal delivery. International journal of pharmacy and pharmaceutical sciences, 2, 116–120.
   Google Scholar
• Mirtchev, P., et al., 2012. Solution phase synthesis of carbon quantum dots as sensitizers for nanocrystalline TiO2 solar cells. Journal of materials chemistry, 22 (4), 1265–1269. doi: 10.1039/C1JM14112K.
   Web of Science ®Google Scholar
• Muntimadugu, E., et al., 2016. Intranasal delivery of nanoparticle en-capsulated tarenflurbil: A potential brain targeting strategy for Alzheimer’s disease. European journal of pharmaceutical sciences, 92, 224–234. doi: 10.1016/j.ejps.2016.05.012.
   PubMed Web of Science ®Google Scholar
• Nair, A., et al., 2020. Natural carbon-based quantum dots and their applications in drug delivery: A review. Biomedicine & pharmacotherapy = biomedecine & pharmacotherapie, 132, 110834. doi: 10.1016/j.biopha.2020.110834.
   PubMed Web of Science ®Google Scholar
• Nasatto, P.L., et al., 2015. Methylcellulose, a cellulose derivative with original physical properties and extended applications. Polymers (basel), 7 (5), 777–803. doi: 10.3390/polym7050777.
   Web of Science ®Google Scholar
• NazanKartal, G., 2020. Content analysıs on dementıa news ın press medıa. Journal, 11, 211–219.
   Google Scholar
• Nemoto, T., et al., 2014. New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: Amyloid-β1–42-induced reduction of proinsulin level via glycogen synthase kinase-3β. Cellular signalling, 26 (2), 253–259. doi: 10.1016/j.cellsig.2013.11.017.
   PubMed Web of Science ®Google Scholar
• Ozsoy, Y., 2008. Particulate carriers for nasal administration. Kumar, M.N.V.R., Handbook of Particulate Drug Delivery; Vol. 2, Chapter 8, CA, USA: American Scientific Publisher, 143–164.
   Google Scholar
• Ozsoy, Y., and Güngör, S., 2011. Nasal route: an alternative approach for antiemetic drug delivery. Expert opinion on drug delivery, 8 (11), 1439–1453. doi: 10.1517/17425247.2011.607437.
   PubMed Web of Science ®Google Scholar
• Ozsoy, Y., Gungor, S., and Cevher, E., 2009. Nasal delivery of high molecular weight drugs. Molecules (basel, Switzerland), 14 (9), 3754–3779. doi: 10.3390/molecules14093754.
   PubMed Web of Science ®Google Scholar
• Pires, A., et al., 2009. Intranasal drug delivery: How, why, and what for? Journal of pharmacy & pharmaceutical sciences, 12 (3), 288–311. doi: 10.18433/j3nc79.
   PubMed Web of Science ®Google Scholar
• Rekha, M.R., and Sharma, C.P., 2009. Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption. Journal of controlled release, 135 (2), 144–151. doi: 10.1016/j.jconrel.2009.01.011.
   PubMed Web of Science ®Google Scholar
• Selkoe, D.J., 2000. The origins of alzheimer diseasea ıs for amyloid. JAMA, 283 (12), 1615–1617. doi: 10.1001/jama.283.12.1615.
   PubMed Web of Science ®Google Scholar
• Shin, Y., et al., 2018. D-cycloserine nasal formulation development for anxiety disorders by using polymeric gels. Drug discoveries & therapeutics, 12 (3), 142–153. doi: 10.5582/ddt.2018.01017.
   PubMed Web of Science ®Google Scholar
• Sims-Robinson, C., et al., 2010. How does diabetes accelerate Alzheimer disease pathology? Nature reviews. Neurology, 6 (10), 551–559. doi: 10.1038/nrneurol.2010.130.
   PubMed Web of Science ®Google Scholar
• Song, Y., et al., 2019. Carbon quantum dots from roasted Atlantic salmon (Salmo salar L.): Formation, bio-distribution, and cytotoxicity. Food chemistry, 293, 387–395. doi: 10.1016/j.foodchem.2019.05.017.
   PubMed Web of Science ®Google Scholar
• Song, Y., et al., 2020. Protein corona formation of human serum albumin with carbon quantum dots from roast salmon. Food & function, 11 (3), 2358–2367. doi: 10.1039/c9fo02967b.
   PubMed Web of Science ®Google Scholar
• Sood, S., Jain, K., and Gowthamarajan, K., 2014. Intranasal therapeutic strategies for management of Alzheimer’s disease. Journal of drug targeting, 22 (4), 279–294. doi: 10.3109/1061186X.2013.876644.
   PubMed Web of Science ®Google Scholar
• Swamy, N.G.N., and Abbas, Z., 2012. Mucoadhesive in situ gels as nasal drug delivery systems: An overview. Asian journal of pharmaceutical sciences, 7, 168–180.
   Google Scholar
• Wang, X., et al., 2019. A mini review on carbon quantum dots: preparation, properties, and electrocatalytic application. Frontiers in chemistry, 7, 671. doi: 10.3389/fchem.2019.00671.
   PubMed Web of Science ®Google Scholar
• Yang, Z.-Z., et al., 2013. Enhanced brain distribution and pharmacodynamics of rivastigmine by liposomes following intranasal administration. International journal of pharmaceutics, 452 (1-2), 344–354. doi: 10.1016/j.ijpharm.2013.05.009.
   PubMed Web of Science ®Google Scholar
• Yerlikaya, F., et al., 2021. Formation of quantum water in nano-particulate systems. Journal of drug delivery science and technology, 63, 102456. doi: 10.1016/j.jddst.2021.102456.
   Web of Science ®Google Scholar
• Zhao, D., et al., 2013. Luminescent ZnO quantum dots for sensitive and selective detection of dopamine. Talanta, 107, 133–139. doi: 10.1016/j.talanta.2013.01.006.
   PubMed Web of Science ®Google Scholar