175
Views
1
CrossRef citations to date
0
Altmetric
Research Articles

Quality by design endorsed atorvastatin-loaded nanostructured lipid carriers embedded in pH-responsive gel for melanoma

, , , , , , , & show all
Pages 27-44 | Received 03 Jul 2023, Accepted 08 Nov 2023, Published online: 07 Dec 2023

References

  • Abdelaal, M.Y., et al., 2007. Chitosan-based interpolymeric pH-responsive hydrogels for in vitro drug release. Journal of applied polymer science, 103 (5), 2864–2874. doi: 10.1002/app.25154.
  • Alam, T., et al., 2015. Optimization of nanostructured lipid carriers of lamotrigine for brain delivery: in vitro characterization and in vivo efficacy in epilepsy. Expert opinion on drug delivery, 12 (2), 181–194. doi: 10.1517/17425247.2014.945416.
  • Alt, N., et al., 2016. Determination of critical quality attributes for monoclonal antibodies using quality by design principles. Biologicals, 44 (5), 291–305. doi: 10.1016/j.biologicals.2016.06.005.
  • Arora, A., et al., 2020. Intranasal delivery of tetrabenazine nanoemulsion via olfactory region for better treatment of hyperkinetic movement associated with Huntington’s disease: Pharmacokinetic and brain delivery study. Chemistry and physics of lipids, 230, 104917. doi: 10.1016/j.chemphyslip.2020.104917.
  • Augustine, R., 2018. Skin bioprinting: a novel approach for creating artificial skin from synthetic and natural building blocks. Progress in biomaterials, 7 (2), 77–92. doi: 10.1007/s40204-018-0087-0.
  • Aven, T., 2016. Risk assessment and risk management: review of recent advances on their foundation. European journal of operational research, 253 (1), 1–13. doi: 10.1016/j.ejor.2015.12.023.
  • Bagasariya, D., et al., 2022. Biomimetic nanotherapeutics: Employing nanoghosts to fight melanoma. European journal of pharmaceutics and biopharmaceutics, 177, 157–174. doi: 10.1016/j.ejpb.2022.06.014.
  • Barakat, L., et al., 2013. Comparison of efficacy and safety of rosuvastatin, atorvastatin and pravastatin among dyslipidemic diabetic patients. ISRN pharmacology, 2013, 146579–146577. doi: 10.1155/2013/146579.
  • Budianto, E., Muthoharoh, S.P., and Nizardo, N.M., 2015. Effect of crosslinking agents, pH and temperature on swelling behavior of cross-linked chitosan hydrogel. Asian journal of applied sciences, 3 (5), 2321–0893.
  • Chand, P., et al., 2021. Design and evaluation of cabazitaxel loaded NLCs against breast cancer cell lines. Colloids and surfaces, 199, 111535. doi: 10.1016/j.colsurfb.2020.111535.
  • Charankumar, K., et al., 2023. Quality by design (QbD) abetted development of pioglitazone incorporated liposomes-loaded hyaluronic acid-based in situ hydrogel for the management of melanoma. Journal of drug delivery science and technology, 84, 104453. doi: 10.1016/j.jddst.2023.104453.
  • Chaudhari, V.S., et al., 2021. Quercetin and piperine enriched nanostructured lipid carriers (NLCs) to improve apoptosis in oral squamous cellular carcinoma (FaDu cells) with improved biodistribution profile. European journal of pharmacology, 909, 174400. doi: 10.1016/j.ejphar.2021.174400.
  • Comito, F., et al., 2022. Emerging Novel Therapeutic Approaches for Treatment of Advanced Cutaneous Melanoma. Cancers, 14 (2), 271. doi: 10.3390/cancers14020271.
  • Costa, C.P., et al., 2021. Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery: toxicological effect of surface charge on human neuronal cells. International journal of pharmaceutics, 607, 120933. doi: 10.1016/j.ijpharm.2021.120933.
  • Culbertson, A., and Huey, S., 2022. Recognizing recurrence of melanoma in an emergency department patient: a case study. Advanced emergency nursing journal, 44 (2), 109–115. doi: 10.1097/TME.0000000000000402.
  • Daniel, B., and DeCoster, M.A., 2004. Quantification of sPLA2-induced early and late apoptosis changes in neuronal cell cultures using combined TUNEL and DAPI staining. Brain research, 13 (3), 144–150. doi: 10.1016/j.brainresprot.2004.04.001.
  • Delgado, D., et al., 2011. Understanding the mechanism of protamine in solid lipid nanoparticle-based lipofection: The importance of the entry pathway. European journal of pharmaceutics and biopharmaceutics, 79 (3), 495–502. doi: 10.1016/j.ejpb.2011.06.005.
  • Demierre, M.F., et al., 2005. Statins and cancer prevention. Nature reviews. Cancer, 5 (12), 930–942. doi: 10.1038/nrc1751.
  • Famta, P., et al., 2022a. Quality by design (QbD) assisted fabrication & evaluation of simvastatin loaded nano-enabled thermogel for melanoma therapy. International journal of pharmaceutics, 628, 122270. doi: 10.1016/j.ijpharm.2022.122270.
  • Famta, P., et al., 2022b. Tumor-promoting aftermath post-chemotherapy: A focus on breast cancer. Life sciences, 310, 121125. doi: 10.1016/j.lfs.2022.121125.
  • Famta, P., et al., 2023. Quality by design endorsed fabrication of Ibrutinib-loaded human serum albumin nanoparticles for the management of leukemia. European journal of pharmaceutics and biopharmaceutics, 190, 94–106. doi: 10.1016/j.ejpb.2023.07.008.
  • Garcia-Ruiz, C., Morales, A., and Fernandez-Checa, J.C., 2012. Statins and protein prenylation in cancer cell biology and therapy. Anti-cancer agents in medicinal chemistry, 12 (4), 303–315. doi: 10.2174/187152012800228715.
  • Garg, N.K., et al., 2017. Quality by Design (QbD)-enabled development of aceclofenac loaded-nano structured lipid carriers (NLCs): an improved dermatokinetic profile for inflammatory disorder(s). International journal of pharmaceutics, 517 (1-2), 413–431. doi: 10.1016/j.ijpharm.2016.12.010.
  • Ghasemiyeh, P., and Mohammadi-Samani, S., 2018. Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages. Research in pharmaceutical sciences, 13 (4), 288–303. doi: 10.4103/1735-5362.235156.
  • Gilani, S.J., et al., 2021. Chitosan coated luteolin nanostructured lipid carriers: optimization, in vitro-ex vivo assessments and cytotoxicity study in breast cancer cells. Coatings, 11 (2), 158. doi: 10.3390/coatings11020158.
  • Grela, E., Kozłowska, J., and Grabowiecka, A., 2018. Current methodology of MTT assay in bacteria – A review. Acta histochemica, 120 (4), 303–311. doi: 10.1016/j.acthis.2018.03.007.
  • Hu, T., et al., 2020. Cholesterol-lowering drug pitavastatin targets lung cancer and angiogenesis via suppressing prenylation-dependent Ras/Raf/MEK and PI3K/Akt/mTOR signaling. Anti-cancer drugs, 31 (4), 377–384. doi: 10.1097/CAD.0000000000000885.
  • Huang, A.C., and Zappasodi, R., 2022. A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance. Nature immunology, 23 (5), 660–670. doi: 10.1038/s41590-022-01141-1.
  • Istvan, E.S., and Deisenhofer, J., 2001. Structural mechanism for statin inhibition of HMG-CoA reductase. Science, 292 (5519), 1160–1164. doi: 10.1126/science.1059344.
  • Jain, K., Sood, S., and Gowthamarajan, K., 2015. Optimization of artemether-loaded NLC for intranasal delivery using central composite design. Drug delivery, 22 (7), 940–954. doi: 10.3109/10717544.2014.885999.
  • Javed, M.N., et al., 2019. QbD applications for the development of nanopharmaceutical products. In: S. Beg and S. Hasnain, eds. Pharmaceutical quality by design: Principles and applications. Amsterdam: Elsevier, 229–253.
  • Konstantinopoulos, P.A., Karamouzis, M.V., and Papavassiliou, A.G., 2007. Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets. Nature reviews drug discovery, 6 (7), 541–555. doi: 10.1038/nrd2221.
  • Mahmood, A., et al., 2021. Luliconazole loaded lyotropic liquid crystalline nanoparticles for topical delivery: QbD driven optimization, in-vitro characterization and dermatokinetic assessment. Chemistry and physics of lipids, 234, 105028. doi: 10.1016/j.chemphyslip.2020.105028.
  • Namjoshi, S., et al., 2020. Quality by design: development of the quality target product profile (QTPP) for semisolid topical products. Pharmaceutics, 12 (3), 287. doi: 10.3390/pharmaceutics12030287.
  • Oishi, T., et al., 2020. Creation of novel large dataset comprising several granulation methods and the prediction of tablet properties from critical material attributes and critical process parameters using regularized linear regression models including interaction terms. International journal of pharmaceutics, 577, 119083. doi: 10.1016/j.ijpharm.2020.119083.
  • Patel, D., et al., 2012. Nanostructured lipid carriers (NLC)-based gel for the topical delivery of aceclofenac: preparation, characterization, and in vivo evaluation. Scientia pharmaceutica, 80 (3), 749–764. doi: 10.3797/scipharm.1202-12.
  • Prabhu, P., and Patravale, V., 2016. Dissolution enhancement of atorvastatin calcium by co-grinding technique. Drug delivery and translational research, 6 (4), 380–391. doi: 10.1007/s13346-015-0271-x.
  • Pramod, K., et al., 2016. Pharmaceutical product development: a quality by design approach. International journal of pharmaceutical investigation, 6 (3), 129–138. doi: 10.4103/2230-973X.187350.
  • Pushpakom, S., et al., 2019. Drug repurposing: progress, challenges and recommendations. Nature reviews. Drug discovery, 18 (1), 41–58. 1doi: 10.1038/nrd.2018.168.
  • Raina, H., Kaur, S., and Jindal, A.B., 2017. Development of efavirenz loaded solid lipid nanoparticles: risk assessment, quality-by-design (QbD) based optimisation and physicochemical characterisation. Journal of drug delivery science and technology, 39, 180–191. doi: 10.1016/j.jddst.2017.02.013.
  • Rangaraj, N., et al., 2020. QbD aided development of ibrutinib-loaded nanostructured lipid carriers aimed for lymphatic targeting: evaluation using chylomicron flow blocking approach. Drug delivery and translational research, 10 (5), 1476–1494. doi: 10.1007/s13346-020-00803-7.
  • Resh, M.D., 1996. Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins. Cellular signalling, 8 (6), 403–412. doi: 10.1016/s0898-6568(96)00088-5.
  • Rogala, P., et al., 2022. Long-term outcomes of targeted therapy after first-line immunotherapy in braf-mutated advanced cutaneous melanoma Patients-Real-World Evidence. Journal of clinical medicine, 11 (8), 2239. doi: 10.3390/jcm11082239.
  • Sabzichi, M., et al., 2017. Chrysin loaded nanostructured lipid carriers (NLCs) triggers apoptosis in MCF-7 cancer cells by inhibiting the Nrf2 pathway. Process biochemistry, 60, 84–91. doi: 10.1016/j.procbio.2017.05.024.
  • Sahu, P., et al., 2019. pH triggered and charge attracted nanogel for simultaneous evaluation of penetration and toxicity against skin cancer: In-vitro and ex-vivo study. International journal of biological macromolecules, 128, 740–751. doi: 10.1016/j.ijbiomac.2019.01.147.
  • Sakellari, G.I., et al., 2021. Formulation design, production and characterisation of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the encapsulation of a model hydrophobic active. Food hydrocolloids for health, 1, 100024. doi: 10.1016/j.fhfh.2021.100024.
  • Shah, S., et al., 2022. Quality by design steered development of Niclosamide loaded liposomal thermogel for melanoma: in vitro and ex vivo evaluation. European journal of pharmaceutics and biopharmaceutics, 180, 119–136. doi: 10.1016/j.ejpb.2022.09.024.
  • Shah, S., et al., 2023. Quality by design accredited self-nanoemulsifying delivery of ibrutinib for extenuating the fast-fed variability, ameliorating the anticancer activity and oral bioavailability in prostate cancer. Journal of drug delivery science and technology, 89, 105052. doi: 10.1016/j.jddst.2023.105052.
  • Shekhar Maurya, C., and Sarkar, C., 2022. Characterization of highly stable water-based magnetorheological gel using OPTIGEL-WX as an additive: the study of magneto-induced rheological and viscoelastic properties. Journal of industrial and engineering chemistry, 110, 137–149. doi: 10.1016/j.jiec.2022.02.043.
  • Singh, A., et al., 2006. External stimuli response on a novel chitosan hydrogel crosslinked with formaldehyde. Bulletin of materials science, 29 (3), 233–238. doi: 10.1007/BF02706490.
  • Sleire, L., et al., 2017. Drug repurposing in cancer. Pharmacological research, 124, 74–91. doi: 10.1016/j.phrs.2017.07.013.
  • Sreelatha, T., Subramanyam, M.V., and Prasad, M.N.G., 2019. Early detection of skin cancer using melanoma segmentation technique. Journal of medical systems, 43 (7), 190. doi: 10.1007/s10916-019-1334-1.
  • Switzer, B., et al., 2022. Managing metastatic melanoma in 2022: a clinical review. JCO oncology practice, 18 (5), 335–351. doi: 10.1200/OP.21.00686.
  • Theodosakis, N., et al., 2019. Inhibition of isoprenylation synergizes with MAPK blockade to prevent growth in treatment-resistant melanoma, colorectal, and lung cancer. Pigment cell & melanoma research, 32 (2), 292–302. doi: 10.1111/pcmr.12742.
  • Tyndall, A., Du, W., and Breder, C.D., 2017. Regulatory watch: The target product profile as a tool for regulatory communication: advantageous but underused. Nature reviews drug discovery, 16 (3), 156–156. doi: 10.1038/nrd.2016.264.
  • van Meerloo, J., Kaspers, G.J.L., and Cloos, J., 2011. Cell sensitivity assays: the MTT assay. Methods in molecular biology, 731, 237–245. doi: 10.1007/978-1-61779-080-5_20.
  • Vitorino, C., et al., 2020. QbD-driven development of intranasal lipid nanoparticles for depression treatment. European journal of pharmaceutics and biopharmaceutics, 153, 106–120. doi: 10.1016/j.ejpb.2020.04.011.
  • Wu, L., et al., 2020. Repaglinide-loaded nanostructured lipid carriers with different particle sizes for improving oral absorption: preparation, characterization, pharmacokinetics, and in situ intestinal perfusion. Drug delivery, 27 (1), 400–409. doi: 10.1080/10717544.2019.1689313.
  • Zhang, Z., et al., 2020. Overcoming cancer therapeutic bottleneck by drug repurposing. Signal transduction and targeted therapy, 5 (1), 113. doi: 10.1038/s41392-020-00213-8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.