Advanced search
Publication Cover
International Journal of Hyperthermia Volume 18, 2002 - Issue 6: Hyperthermia and the Immune System
Submit an article Journal homepage
427
Views
36
CrossRef citations to date
0
Altmetric
Research Article

Cancer immunotherapy: stress proteins and hyperthermia

M. H. Manjili Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
,
X.-Y. Wang Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
,
J. Park Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
,
I. J. Macdonald Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
,
Y. Li Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
,
R. C. A. A. Van Schie Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
&
J. R. Subjeck Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
 show all
Pages 506-520 | Published online: 09 Jul 2009

  • Tissieres A, Mitchell H, Tracy U. Protein synthesis in salivary glands of drosophila melanogasten relation to chromosome puffs. J MoI Biol 1974; 85: 389-98.
  • Schlessinger J, Shechter Y, Willingham MC, Pastan I. Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells. Proc Natl Acad Sd USA 1978; 75: 2659-63.
  • Hightower L. Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides. J Cell Physiol 1980; 102: 407-27.
  • Gething M, Sambrook J. Protein folding in the cell. Nature 1992; 355: 33-45.
  • Morimoto R, Tissieres A, Georgopoulos C. The Biology of hsp and Molecular Chaperones. New York: Cold Spring Harbor Laboratory Press, 1994.
  • Gething MJ. Role and regulation of the ER chaperone BiP. Semin Cell Dev Biol 1999; 10: 465-72.
  • Black AR and Subjeck JR. The biology and physiology of the heat shock and glucoseregulated stress protein systems. Methods Achieve Exp Pathol. Basel: Karger, 1991; 126-66.
  • Easton DP, Kaneko Y, Subjeck JR. The hspl 10 and Grp170 stress proteins: newly recognized relatives of the Hsp70s. Cell Stress Chaperones 2000; 5: 276-90.
  • Sciandra JJ, Subjeck JR, Hughes CS. Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation. Proc Natl Acad Sci USA 1984; 81: 4843-7.
  • Solheim J. Class I MHC molecules: assembly and antigen presentation. Immunol Rev 1999; 172: 11-19.
  • Skowronek M, Hendershot L, Haas I. The variable domain of nonassembled Ig light chains determines both their half-life and binding to the chaperone BiP. Proc Natl Acad Sd USA 1998; 95: 1574-8.
  • Blond-Elguindi S, Cwirla W, Dower W, Lipshutz R, Sprang S, Sambrook J, Gething M. Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP. Cell 1993; 75: 717-28.
  • Gragerov A, Gottesman M. Different peptide binding specificities of hsp70 family members. J MoI Biol 1994; 241: 133-5.
  • Rudiger S, Germeroth L, Schneider-Mergener J, Bukau B. Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries. EMBO J 1997; 16: 1501-7.
  • Takenaka I, Leung S, McAndrew S, Brown J, Hightower L. Hsc70-binding peptides selected from a phage peptide library that resemble organellar targeting sequences. J Biol Chem 1995; 270: 19839-44.
  • Fourie A, Sambrook J, Gething M. Common and divergent peptide binding specificities of hsp70 molecular Chaperones. J Biol Chem 1994; 269: 30470-8.
  • Rassow J, Ahsen O, Borner U, Pfanner N. Molecular Chaperones: towards a characterization of the heat-shock protein 70 family. Trends Cell Biol 1997; 7: 129-33.
  • Suzue K, Zhou X, Eisen HN, Young RA. Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway. Proc Natl Acad Sci USA 1997; 94: 13146-51.
  • Wells AD, Rai SK, Salvato MS, Band H, Malkovsky M. hsp72-mediated augmentation of MHC class I surface expression and endogenous antigen presentation, hit Immunol 1998; 10: 609-17.
  • Castellino F, Boucher PE, Eichelberg K, Mayhew M, Rothman JE, Houghton AN, Germain RN. Receptor-mediated uptake of antigen/hsp complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. J Exp Med 2000; 191: 1957-64.
  • Singh-Jasuja H, Scherer HU, HiIf N, Arnold-Schild D, Rammensee HG, Toes RE, Schild H. The hsp gp96 induces maturation of dendritic cells and down-regulation of its receptor. Eur J Immunol 2000; 30: 2211-5.
  • Binder R, Han DK, Srivastava PK., CD91 : a receptor for hsp gp96. Nat Immunol 2000; 2: 151-5.
  • Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC, Calderwood SK. Hsp70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 2000; 6: 435-42.
  • Ohashi K, Burkart V, Flohe S, KoIb H, Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 2000; 164: 558-61.
  • Vabulas RM, Ahmad-Nejad P, Da Costa C, Mietheke T, Kirschening CJ, Hacker H, Wagner H. Endocytosed hsp60s use toll-like receptor 2 (tlr2) and tlr4 to activate the toll/ interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 2001; 276: 31332-9.
  • Gallucci S, Matzinger P. Danger signals: SOS to the immune system. Curr Opin Immunol 2001; 13: 114-9.
  • Basu S, Binder RJ, Ramalingam T, Srivastava PK. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity 2001; 14: 303-13.
  • Potter NS, Harding CV. Neutrophib process exogenous bacteria via an alternate class I MHC processing pathway for presentation of peptides to T lymphocytes. J Immunol 2001;167: 2538-46.
  • Chu NR, Wu HB, Wu T, Boux LJ, Siegel MI, Mizzen LA. Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising mycobacterium Bovis Bacille Calmette-Guerin (BCG) hsp65 and HPV16 E7. Clin Exp Immunol 2000; 121: 216-25.
  • Chen W, Syldath U, Bellmann K, Burkart V, KoIb H. Human 60-kDa heat-shock protein: a danger signal to the innate immune system. J Immunol 1999; 162: 3212-9.
  • Roigas J, Wallen ES, Loening SA, Moseley PL. Heat shock protein (HSP72) surface expression enhances the lysis of a human renal cell carcinoma by IL-2 stimulated NK cells. Adv Exp Med Biol 1998; 451: 225-9.
  • Roben J, Menoret A, Cohen N. Cell surface expression of the endoplasmic reticular heat shock protein gp96 is phylogenitically conserved. J Immunol 2001; 163: 4133-9.
  • Arosa FA, De Jesus O, Porto G, Carmo AM, De Sousa M. Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules. J Biol Chem 1999; 274: 16917-22.
  • Melcher A, Todryk S, Hardwick N, Ford M, Jacobson M, Vile RG. Tumor immunogenicity is determined by the mechanism of cell death via induction of hsp expression. Nat Med 1998; 4: 581-7.
  • Srivastava PK, Menoret A, Basu S, Binder RJ, McQuade KL. Heat shock proteins come of age: primitive functions acquire new roles in an adaptive world. Immunity 1998; 8: 65765.
  • Srivastava PK, Deleo A, Old LJ. Tumor rejection antigens of chemically induced sarcomas of inbred mice. Proc Natl Acad Sci USA 1986; 83: 3407-11.
  • Ullrich SJ, Robinson EA, Law L, Willingham WM, Appella EA. Mouse tumor-specific transplantation antigen is a heat shock-related protein. Proc Natl Acad Sci USA 1986; 83: 3121-5.
  • Udono H, Srivastava PK. Hsp70-associated peptides elicit specific cancer immunity. J Exp Med 1993; 178: 1391-6.
  • Srivastava PK. Peptide-binding hsp in the endoplasmic reticulum: role in immune response to cancer and in antigen presentation Adv Cancer Res 1993; 62: 153-77.
  • Udono H, Srivastava PK. Comparison of tumor-specific immunogenicities of stressinduced proteins gp96, hsp90, and hsp70. J Immunol 1994; 152: 5398-403.
  • Welch WJ, Kang HS, Beckmann RP, Mizzen LA. Response of mammalian cells to metabolic stress; changes in cell physiology and structure/function of stress protein. Curr Top Microbiol Immunol 1991; 167: 31-55.
  • Tamura Y, Peng P, Kang L, Daou M, Srivastava PK. Immunotherapy of tumor with autologous tumor-derived hsp preparations. Science 1997; 278: 117-20.
  • Kovalchin JT, Murthy AS, Horattas MC, Guyton DP, Chandawarkar RY. Determinants of efficacy of immunotherapy with tumor-derived heat shock protein gp96. Cancer Immunity 2001; 1: 7.
  • Nicchitta C. Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone grp94/gp96. Curr Opin Immunol 1998; 10: 103-9.
  • Basu S, Srivastava PK, Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunity. J Exp Med 1999; 189: 797802.
  • Wang X-Y, Kazim L, Repasky EA, Subjeck JR. Characterization of hsp 110 and glucoseregulated protein 170 as cancer vaccines and the effect of fever-range hyperthermia on vaccine activity. J Immunol 2001; 166: 490-7.
  • Janetzki S, Palla D, Rosenhauer V, Lochs H, Lewis JJ, Srivastava PK. Immunization of cancer patients with autologous cancer-derived hsp gp96 preparations: a pilot study. Int J Cancer 2000; 88: 232-8.
  • Vanaja DK, Grossmann ME, Celis E, Young CYF. Tumor prevention and antitumor immunity with hsp 70 induced by 15-deoxy- ?12,14-prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells. Cancer Res 2000; 60: 4714-8.
  • Yoshida A, Nagata T, Uchijima M, Koide Y. Protective CTL response is induced in the absence of CD4+ T cells and IFN-gamma by gene gun DNA vaccination with a minigene encoding a CTL epitope of Listeria monocytogenes. Vaccine 2001; 19: 4297-306.
  • Heike M, Weinmann A, Bethke K, Galle PR. Stress protein/peptide complexes drive from autologous tumor tissue as tumor vaccines. Biochem Pharm 1999; 58: 1381-7.
  • Menoret A, Chandawarkar R. Heat-shock protein-based anticancer immunotherapy: an idea whose time has come. Semin Oncol 1998; 25: 654-60.
  • Blachere NE, Li Z, Chandawarkar RY, Suto R, Jaikaria NS, Basu S, Udono H, Srivastava PK., Hsp-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. J Exp Med 1997; 186: 1315-22.
  • Ciupitu A-M, Petersson M, O'Donnell CL, Williams K, Jindal S, Kiessling R, Welsh RM. Immunization with a lymphocytic choriomeningitis virus peptide mixed with hsp 70 results in protective antiviral immunity and specific cytotoxic T lymphocytes. J Exp Med 1998; 187:685-91.
  • Moroi Y, Mayhew M, Trcka J, Hoe MH, Takechi Y, Hard FU, Rothman JE, Houghton AN. Induction of cellular immunity by immunization with novel hybrid peptides complexed to hsp70. Proc Natl Acad Sci USA 2000; 97: 3485-90.
  • Barrios C, Lussow AR, Van Embden J, Van Der Zee R, Rappuoli R, Costantino P, Louis JA, Lambert PH, Del Giudice G. Mycobacterial heat-shock proteins as carrier molecules. II: the use of the 70-kDa mycobacterial heat-shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guerin priming. Eur J Immunol 1992; 22: 1365-72.
  • Roman E, Moreno C. Synthetic peptides non-covalentty bound to bacterial hsp70 elicit peptide-specific T-cell responses in vivo. Immunology 1996; 88: 487-92.
  • Arnold D, Faath S, Rammensee H, Schild H. Crossing-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with hsp gp96. J Exp Med 1995; 182: 885-9.
  • Chen C-H, Wang T-L, Hung C-F, Yang Y, Young RA, Pardoll DM, Wu T-C. Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene. Cancer Res 2000; 60: 1035-42.
  • Hsu KF, Hung CF, Cheng WF, He L, Slater LA, Ling M, Wu TC. Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis hsp 70 to an antigen. Gene Ther 2001; 8: 376-83.
  • Suzue K, Young RA. Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24. J Immunol 1996; 156: 873-6.
  • Horwitz MS, Bradley LM, Harbertson J, Krahl T, Lee J, Sarvetnick N. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat Med 1999; 4: 781-795.
  • Könen-Waisman S, Cohen A, Fridkin M, Cohen IR. Self heat-shock protein (hsp60) peptide serves in a conjugate vaccine against a lethal pneumococcal infection. J Infect Dis 1999; 179:403-13.
  • Young DB, Mehlert A, Smith DF. Stress proteins and infectious diseases. In: Morimoto RI, Tissieres A, Georgopoulos C, eds. Stress proteins in biology and medicine. New York, NY: Cold Spring Harbor Laboratory, 1990: 131-65.
  • Schild H, Arnold-Schild D, Lammert E, Rammensee H-G. Stress proteins and immunity mediated by cytotoxic T lymphocytes. Curr Opin Immunol 1999; 11: 109-13.
  • Huang Q, Richmond JFL, Suzue K, Eisen HN, Young RA. Elicitation of CTLs by mycobacterial hsp70 fusion proteins maps to a discrete domain and is CD4+ T cellindependent. J Exp Med 2000; 191: 403-8.
  • Restifo NP, Esquivel F, Asher AL, Stotter H, Barth RJ, Bennink JR, Mule JJ, Yewdell JW, Rosenberg S. Defective presentation of endogenous antigens by a murine sarcoma. Implications for the failure of an anti-tumor immune response. J Immunol 1991; 147: 1453-9.
  • Lukacs KV, Lowrie DB, Stokes RW, Colston MJ. Tumor cells transfected with bacterial hsp gene lose tumorigenicity and induce protection against tumors. J Exp Med 1993; 178: 343-8.
  • Blachere NE, Udono H, Janetzki S, Li Z, Heike M, Srivastava PK. Hsp vaccines against cancer. J Immunother 1993; 14: 352-6.
  • Heikema A, Agsteribbe E, Wiscjut J, Huckriede A. Generation of hsp-based vaccines by intracellular loading of gp96 with antigenic peptides. Immunol Lett 1997; 57: 69-74.
  • Suto R, Srivastava PK. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 1995; 269: 1585-8.
  • Menoret A, Patry Y, Burg C, Le Pendu J. Co-segregation of tumor immunogenicity with expression of inducible but not constitutive hsp70 in rat colon carcinomas. J Immunol 1995; 155: 740-7.
  • Clark PR, Menoret A. The inducible Hsp70 as a marker of tumor immunogenicity. Cell Stress Chaperones 2001; 6: 121-5.
  • Shah A, Unger E, Bain MD, Bruce R, Bodkin J, Ginnetti J, Wang W-C, Seon B, Stewart CC, Evans SE. Cytokine and adhesion molecule expression in primary human endothelial cells stimulated with fever-range hypertheria. Int J Hyperthermia 2002; 18: 534-551.
  • Okamoto M, Tazawa K, Kawagoshi T, Maeda M, Honda T, Sakamoto T, Tsukada K. The combined effect against colon-26 cells of heat treatment and immunization with heat treated colon-26 tumour cell extract. Int J Hyperthermia 2000; 16: 263-73.
  • Di YP, Repasky EA, Subjeck JR. The distribution of hsp70, protein kinase C and spectrin is altered in lymphocytes during a fever-like hyperthermia exposure. J Cell Physiol 1997; 172: 44-54.
  • Wang X-Y, Ostberg JR, Repasky EA. Effect of fever-like whole-body hyperthermia on lymphocyte spectrin distribution, protein kinase C activity, and uropod formation. J Immunol 1999; 162: 3378-87.
  • Wang WC, Goldman LM, Schleider DM, Appenheimer MM, Subjeck JR, Repasky EA, Evans SS. Fever-range hyperthermia enhances L-selectin-dependent adhesion of lymphocytes to vascular endothelium. J Immunol 1998; 160: 961-9.
  • Ostberg JR, Repasky EA. Comparison of the effects of two different whole body hyperthermia protocols on the distribution of murine leukocyte populations. Int J Hyperthermia 2000; 16: 29-43.
  • Burd R, Dziedzic TS, Xu Y, Caligiuri MA, Subjeck JR, Repasky EA. Tumor cell apoptosis, lymphocyte recruitment and tumor vascular changes are induced by low temperature, long duration (fever-like) whole body hyperthermia. J Cell Physiol 1998; 177: 13747.
  • Evans SS, Frey M, Schleider DM, Bruce RA, Wang W-C, Repasky EA, Appenheimer MM. Regulation of leukocyte-endothelial cell interactions in tumor immunity. In: Mihich E and Croce C, eds, The Biology of Tumors. New York: Plenum Press, 1998; 273-86.
  • Evans SS, Schleider DM, Bowman L, Francis M , Kansas GS, Black JD. Dynamic association of L-selectin with the lymphocyte cytoskeletal matrix. J Immunol 1999; 162: 361524.
  • Evans SS, Wang WC, Bain MD, Burd R, Ostberg JR, Repasky EA. Fever-range hyperthermia dynamically regulates lymphocyte delivery to high endothelial venules. Blood 2001; 97: 2727-33.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.