Advanced search
Publication Cover
International Journal of Hyperthermia Volume 18, 2002 - Issue 5
Submit an article Journal homepage
248
Views
34
CrossRef citations to date
0
Altmetric
Research Article

Radiosensitization of heat resistant human tumour cells by 1 hour at 41.1°C and its effect on DNA repair

M. Xu Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA
,
R. J. Myerson Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA
,
W. L Straube Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA
,
E. G. Moros Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA
,
I. Lagroye Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA
,
L. L. Wang Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA
,
J. T. Lee Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA
&
J. L. Roti Roti Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA
 show all
Pages 385-403 | Published online: 09 Jul 2009

  • Overgaard J, Gonzalez DG, Hulshof MGG, Arcangell G, Dabi O, Mella O, Bentzen SM. Randomized trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. Lancet 1995; 345: 540-3.
  • Overgaard J, Gonzalez DG, Hulshof MGGM, Arcangell G, Dahl O, Mella O, Bentzen SM. Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicentre randomized trial by the European Society for Hyperthermic Oncology. Int J Hyperthermia 1996; 12: 3-20.
  • Vernon CC, Hand JW, Field SB, Machin D, Whaley JB, Vanderzee J, Van Putten WLJ, Van Rhoon GC, Van Dijk JDP, Gonzalez DG, Liu FF, Goodman P, Sherar M. Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer results from five randomized controlled trials. Int J Radiat Oncol Biol Phys 1996; 35: 731-44.
  • Sneed PK, Stauffer PR, McDermott MW, Diedrich CJ, Lamborn KR, Prados MD, Chang S, Weaver KA, Spry L, Malec MK, Lamb SA, Voss B, Davis RL, Wara WM, Larson DA, Phillips TL, Cutin PH. Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost ± hyperthermia for glioblastomamultiforme. Int J Radiat Oncol Biol Phys 1998; 40: 287-95.
  • Vanderzee J, Gonzalez GD, Van Rhoon GC, VanDijk JD, Van Putten WL, Hart AA. Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group. Lancet 2000; 355: 1119-25.
  • Kampinga HH, Dikomey E. Hyperthermic radiosensitization: mode of action and clinical relevance. Int J Radiat Biol 2001; 77: 399-408.
  • Myerson RJ, Moros E, Roti Roti JL. Hyperthermia In: Ferez CA, Brady LW, eds. Principles and Practice of Radiation Oncology, Philadelphia: Lippincott-Raven Publishers, 1997; 637-84.
  • Myerson RJ, Straube WL, Moros EG, Emami BN, Lee HK, Ferez CA, Taylor ME. Simultaneous superficial hyperthermia and external radiotherapy: report of thermal dosimetry and tolerance to treatment Int J Hyperthermia 1999; 15: 251-66.
  • Oleson JR, Dewhirst MW, Harrelson JM, Leopold KA, Samulski TV, Tso CY. Tumor temperature distributions predict hyperthermia effect Int J Radiat Oncol Biol Phys 1989; 16: 559-70.
  • Myerson RJ, Ferez CA, Emami BN, Straube W, Kusker RR, Leybovich L, Von Gerichten D. Tumor control in long-term survivors following superficial hyperthermia. Int J Radiat Oncol Biol Phys 1990; 18: 1123-9.
  • Mackey MA, Anolik SL, Roti Roti JL. Changes in heat and radiation sensitivity during long duration, moderate hyperthermia in HeLa S3 cells. Int J Radiat Oncol Biol Phys 1992; 24: 543-50.
  • Raaphorst GP, Heller DP, Bussey A, Ng CE. Thermal radiosensitization by 41°C hyperthermia during low dose-rate irradiation in human normal and tumor cell lines. Int J Hyperthermia 1994; 10: 263-70.
  • Xu M, Wright WD, Higashikubo R, Wang L-L, Roti Roti JL. Thermal radiosensitization of human tumour cell lines with different sensitivities to 41.10C. Int J Hyperthermia 1999; 15: 279-90.
  • Mills ME, Meyn RE. Effects of hyperthermia on repair of radiation-induced DNA strand breaks. Radiat Res 1981; 87: 314-28.
  • Dewey WC, Freeman ML, Raaphorst GP, Clark EP, Wong RSL, Highfield DP, Spiro IS, Tomasovic SP, Denman DL, Coss RA. Cell biology of hyperthermia and radiation. In: Meyn R, Withers HR, eds. Radiation Biology in Cancer Research, New York: Raven Press, 1980; 589-621.
  • Raaphorst GP. Thermal radiosensitization in vitro. In: U rano M, Douple R, eds. Hyperthermia and Oncology, The Netherlands: VSP Publishers, 1989; 17-51.
  • Xu M, Wright WD, Higashikubo R, Roti Roti JL. Chronic thermotoleran with continued cell proliferation. Int J Hyperthermia 1996; 12: 645-60.
  • Malyapa RS, Ahern EW, Straube WL, Moros EG, Pickard WF, Roti Roti JL. Measurement of DNA damage after exposure to 2450MHz electromagnetic radiation. Radial Res 1997; 148: 608-17.
  • Walker JA, Boreham DR, Unrau P, Duncan AM. Chromosome content and ultrastructure of radiation-induced micronuclei, Mutagenesis 1996; 11: 419-24.
  • Olive PL, Wlodek D, Durand RE, Banath JP. Factors influencing DNA migration from individual cells subjected to gel electrophoresis. Exp Cell Res 1992; 198: 259-67.
  • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-5.
  • VanderWaal RP, Higashikubo R, Xu M, Roti Roti JL. Cytometric methods to analyze thermal effects. Methods Cell Biol 2001; 64: 269-86.
  • Hawkins RB. A microdosimetric-kinetc model for the sensitization of V79 cells to radiation by incorporation of bromodeoxyuridine. Radiat Res 2000; 155: 698-702.
  • Ben-Hur E, Elkind MM. Thermally enhanced radioresponse of cultured Chinese hamster cells: damage and repair of single-stranded DNA and a DNA complex. Radiat Res 1974; 59: 484-95.
  • Dikomey E. Effect of hyperthermia at 41 and 45°C on repair of radiation-induced DNA strand breaks in CHO cells. Int J Radial Biol 1982; 41: 603-14.
  • Warters RL, Lyons BW, Axtell-Bartlett J. Inhibition of repair of radiation-induced DNA damage by thermal shock in Chinese hamster ovary cells. Int J Radiat Biol 1987; 51: 50517.
  • Zhu WG, Seno JD, Beck BD, Dynlacht JR. Translocation of Mre11 from the nucleus to the cytoplasm as a mechanism of radiosensitization by heat. Radial Res 2001; 156:95-102.
  • Dolganov GM, Maser RS, Novikov A, Chong LT, Bressan DA, Petrini JHJ. Human Rad 50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. MoI Cell Biol 1996; 16:483241.
  • Trujillo KM, Yuan S-SF, Lee EY-HP, Sung P. Nuclease activities in a complex of human recombination and DNA repair factors Rad 50, Mre 11, and p95. J Biol Chem 1998; 273: 21447-50.
  • Bressan DA, Boxter BK, Petrini JHJ. The Mre 11-Rad 50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in saccharomyces cerevisiae. MoI Cell Biol 1999; 19: 7681-7.
  • Petrini JH. The mammalian Mrell-rad 50-nbs1 protein complex: integration of functions in the cellular DNA-damage response. Am J Human Genet 1999; 64: 1264-9.
  • Yamaguchi-Iwai Y, Sonoda E, Sasaki MS, Morrison C, Haraguchi T, Hiraoka Y, Yamaahita YM, Yagi T, Takata M, Price C, Kakazu N, Takeda S. Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J 1999: 18: 661929.
  • Paull TT, Geliert M. A mechanistic basis for Mre11-directed DNA joining at microhomologies. Proc Natl Acad Sci 2000; 97: 6409-14.
  • Zhu X-D, Kuster B, Mann M, Petrini JHJ, DeLange T. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nature Genet 2000; 25: 347-52.
  • Fukuda T, Sumiyoshi T, Takahashi M, Kataoka T, Asahara T, Inui H, Watatani M, Yasutomi M, Kamada N, Miyagawa K. Alteration of the double-strand break repair gene Mre11 in cancer. Cancer Res 2001; 61: 23-6.
  • Chamankhah M, Xiao W. Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance. Nucl Acids Res 1999; 27: 2072-9.
  • Maser RS, Monsen KJ, Nelms BE, Petrini JHJ. hMre11 and h Rad 50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. MoI Cell Biol 1997; 17: 6087-96.
  • Carney JP, Masser RS, Olivares H, Davis EM, LeBeau M, Yates III JR, Hays L, Morgan WF, Petrini JHJ. The hmrel l/hRad50 protein complex and nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 1998; 93: 477-86.
  • Ryu S, Brown LS, Kim S-H, Khil MS, Jae-Ho K. Preferential radiosensitization of human prostatic carcinoma cells by mild hyperthermia Int J Radiat Oncol Biol Phys 1996; 34: 133-8.
  • Shidnia H, Hornback N, Ford G, Shen R-N. Clinical experience with hyperthermia in conjunction with radiation therapy. Oncology 1993; 50: 353-61.
  • Myerson RJ, Scott CB, Emami B, Sapozink MD, Samulski TV. A phase I/II study to evaluate radiation therapy and hyperthermia for deep-seated tumors: a report of RTOG 89-08. Int J Hyperthermia 1996; 12: 449-59.
  • Gonzalez Gonzalez D, Van Dijk JDP, Blank LECM. Radiation and hyperthermia Euro J Cancer 1995; 31: 1351-5.
  • Gerweck LE, Gillette EL, Dewey WC. Effect of heat and radiation on synchronous Chinese hamster cells: killing and repair. Radiat Res 1975; 64: 611-23.
  • Sapareto SA, Hopwood LE, Dewey WC. Combined effects of X irradiation and hyperthermia on CHO cells for various temperatures and orders of application. Radiat Res 1978; 73: 221-33.
  • Kampinga HH, Hiemstra YS, Konings AW, Dikoney E. Correlation between slowly repairable double-strand break and thermal radiosensitization in the human HeLa S3 cell line. Int J Radiat Biol 1997; 72: 293-301.
  • Iliakis G, Seaner R. A DNA double-strand break repair-deficient mutant of CHO cells shows reduced radiosensitization after exposure to hyperthermic temperatures in the plateau phase of growth. Int J Hyperthermia 1990; 6: 801-12.
  • Raaphorst GP, Thakar M, Ng CE. Thermal radiosensitization in two pairs of CHO wildtype and radiation-sensitiw mutant cell lines. Int J Hyperthermia 1993; 9: 383-91.
  • Kampinga HH, Kanon B, Konings AWT, Stackhouse MA, Bedford JS. Thermal radiosensitization in heat- and radiation-sensiti\e mutants of CHO cells. Int J Radiat Biol 1993; 64: 225-30.
  • Komatsu K, Kubota N, Gallo M Okumura Y, Lieber MR. The seid factor on human chromosome 8 restores V(D) recombination in addition to double-strand break repair. Cancer Res 1995; 55: 1774-9.
  • Woudstra EC, Konings AW, Jeggo PA, Kampinga HH. Role of DNA-PK subunits in radiosensitization by hyperthermia Radiat Res 1999; 152: 214-8.
  • Paques F, Haber JE. Multiple pathways of recombination induced by double-strand breaks in saccharomyces cerevisiae. Microbiol MoI Biol Rev 1999; 63: 349-404.
  • DeJager M, Dronkert MLG, Modesti M, Beerens CEMT, Kanaar R, vanGent DC. DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways. Nucl Acids Res 2001; 29: 1317-25.
  • Paull TT, Geliert M. The 3' to 5' exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks. MoI Cell Biol 1998; 1: 969-79.
  • Lewis LK, Resnick MA. Tying up loose ends: nonhomologous endjoining in saccharomyces cerevisiae. Mutat Res 2000; 451: 71-89.
  • Jeggo PA. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat Res 1998; 150: 80-91.
  • Mirzoeva OK, Petrini JHJ. DNA damage-dependent nuclear dynamics of the Mre11 complex. MoI Cell Biol 2001; 21: 281-8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.