Advanced search
Publication Cover
International Journal of Hyperthermia Volume 19, 2003 - Issue 2
Submit an article Journal homepage
293
Views
13
CrossRef citations to date
0
Altmetric
Research Article

A lipophilic free radical initiator, 2,2′-azobis (2,4-dimethylvaleronitrile) (AMVN) enhances caspase-dependent apoptosis induced by hyperthermia

F.-J. Li Department of Industrial Hygiene and Occupational Disease, School of Public Health, China Medical University, Shenyang, 110001, China
,
T. Kondo Department of Radiological Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, 930-0194, Japan
,
Q.-L. Zhao Department of Radiological Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, 930-0194, Japan
,
Y. Hayashi Department of Public Health, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, 930-0194, Japan
,
R. Ogawa Department of Radiological Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, 930-0194, Japan
,
Z.-G. Cui Department of Radiological Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, 930-0194, Japan
&
L. B. Feril, Jr Department of Radiological Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, 930-0194, Japan
 show all
Pages 165-177 | Published online: 09 Jul 2009

  • Hall EJ. Radiobiology for the Radiologist, 5th edn. Philadelphia, PA: Lippincott Williams & Wilkins, 2000; 495-520.
  • Krishna MC, Dewhirst MWH, Friedman S, Cook JA, Degraff W, Samuni A, Russo A, Mitchell B. Hyperthermic sensitization by the radical initiator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). I. In vitro studies. Int J Hyperthermia 1994; 10: 271-8.
  • Li F-J, Kondo T, Zhao Q-L, Tanabe K, Ogawa R, Li M, Arai Y. Enhancement of hyperthermia-induced apoptosis by a free radical initiator, 2,2'-azobis (2-amidinopropane) dihydrochloride, in human histiocytic lymphoma U937 cells. Free Radie Res 2001; 35: 281-99.
  • Niki E. Free radical initiators as source of water- or lipid-soluble peroxyl radicals. Methods Enzymol 1990; 186: 100-8.
  • Tyurina YY, Tyurin VA, Carta G, Quinn PJ, Schor NF, Kagan VE. Direct evidence for antioxidant effect of bcl-2 in PC12 rat pheochromocytoma cells. Arch Biochem Biophys 1997; 344: 413-23.
  • Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ. Bcl-2 function in an antioxidant pathway to prevent apoptosis. Cell 1993; 75: 241-51.
  • Decaudin D, Geley S, Hirsch T, Castedo M, Marchetti P, Macho A, Kofler R, Kroemer G. Bcl-2 and Bcl-xl antagonize the mitochondria! dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res 1997; 57: 62-7.
  • Kim CN, Wang XD, Huang Y, Ibrado AM, Liu LD, Fang GF, Bhalla K. Overexpression of Bcl-xl inhibits Ara-C-induced mitochondria! loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res 1997; 57: 3115-20.
  • Sellins KS, Cohen JJ. Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes. J Immunol 1987; 139: 3199-206.
  • Li M, Kondo T, Zhao Q-L, Li F-J, Tanabe K, Arai Y, Zhou ZC, Kasuya M. Apoptosis induced by cadmium in human lymphoma U937 cells through Ca2+-calpain and caspase-mitochondria-dependent pathways. J Biol Chem 2000; 275: 39702-9.
  • Kameda K, Kondo T, Tanabe K, Zhao Q-L, Seto H. The role of intracellular Ca2+ in apoptosis induced by hyperthermia and its enhancement by verapamil in U937 cells. Int J Radiat Oncol Biol Phys 2001; 49: 1369-79.
  • Castedo M, Macho A, Zamzami N, Hirsch T, Marchetti P, Uriel, L, Kroemer G. Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo. Eur J Immunol 1995; 25: 3277-84.
  • Macho A, Hirsch T, Marzo I, Marchetti P, Dallaporta B, Susin SA, Zamzami N. Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis. J Immunol 1997; 158: 4612-19.
  • Fabisiak JP, Tyurina YY, Tyurin VA, Lazo JS, Kagan VE. Random versus selective membrane phospholipid oxidation in apoptosis: role of phosphatidylserine. Biochemistry 1998; 37: 13781-90.
  • Kroemer G, Zamzami N, Susin SA. Mitochondria! control of apoptosis. Immunol Today 1997; 18: 44-51.
  • Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-12.
  • Zamzami N, Marchetti P, Castedo M, Decaudin D, Macho A, Hirsch T, Susin SA, Petit PX, Mignotte B, Kroemer G. Sequential reduction of mitochondrial transmenbrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 1995; 182: 367-77.
  • Macdonald G, Shi LF, Velde CV, Lieberman J, Greenberg AH. Mitochondria-dependent and -independent regulation of granzyme B-induced apoptosis. J Exp Med 1999; 189: 131-43.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.